PDR (Psychiatric Disorder Repository, http://medbio.top/PDR/home) is a comprehensive resource for psychiatric disorder research, containing curated information on genomics, epigenomics, transcriptomics, proteomics, and animal experiments associated with over 101 DSM-5 recognized disorders. With over 180,000 multi-omics relationships and over 40,000 genes across 7 species, PDR offers insights into the complex genetic mechanisms underlying psychiatric disorders. Its user-friendly platform can facilitate the discovery of generic organizing principles of psychiatric disorders.