proid	pmid	organismid	tissue	diagnosis	familycontrol	method	description	disease	class
1	11074872	9606	Brain	DSM-IV	Case-control based	Western blotting	The selective down regulation of RELN and GAD67 in prefrontal cortex of patients with schizophrenia and bipolar discorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis.	Bipolar Disorder	Proteome
2	11074872	9606	Brain	DSM-IV	Case-control based	Western blotting	The selective down regulation of RELN and GAD67 in prefrontal cortex of patients with schizophrenia and bipolar discorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis.	Schizophrenia	Proteome
3	15363659	9606	Blood(Serum)	Others	Case-control based//Family based	Nephelometric Method	These results indicate altered regulation of transferrin and ceruloplasmin in autistic children who lose acquired language skills.	Autism Spectrum Disorder	Proteome
4	16480819	9606	Blood	DSM-IV	Case-control based	ELISA	Serum BDNF levels were decreased in manic(p=0.019)and depressed(p=0.027)BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic(r=-0.37, p=0.005)and depressive(r=-0.30, p=0.033)symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD.	Bipolar Disorder	Proteome
5	16637010	9606	Blood	DSM-IV	Case-control based	Western blotting	Resultant protein spots were compared between control and disease groups. Statistical analysis indicated that 35 spots were differentially expressed in one or more groups.(Table 2)	Major Depressive Disorder	Proteome
6	16944669	9606	Blood		Case-control based		CRP levels were higher in all groups of sleep disordered subjects, compared to healthy controls(Table 1). Age, sex, HLApositivity, and treatment with stimulants or antidepressants did not influence these concentrations, but CRP levels increased with increased BMI(r=0.38, p<.001). After adjusting for BMI, the CRP levels were higher only in the hypocretin-deficient subjects(Table 2).	Narcolepsy	Proteome
7	16983391	10116	Brain		Case-control based	Western blotting	N-3 PUFA deprivation significantly decreased frontal cortex BDNF protein by 30%(n=10, P=0.040)and BDNF mRNA by 63%(n=6, P=0.040)compared to levels in n-3 PUFA-adequate rats(Figures 1a and b).	Bipolar Disorder	Proteome
8	17189958	9606	Blood(Serum)	DSM-IV//ADOS-G//ADI-R	Case-control based	LC-MS//MS	Of these, five peptide components corresponding to four known proteins had an effect size >0.99 with a P<0.05 and a Mascot identification score of 30 or greater for autism compared to controls. The four proteins were: Apolipoprotein (apo) B-100, Complement Factor H Related Protein (FHR1), Complement C1q and Fibronectin 1 (FN1). In addition, apo B-100 and apo A-IV were higher in children with high compared to low functioning autism.	Autism Spectrum Disorder	Proteome
9	17347881	9606	Blood(Plasma)	Others	Case-control based	ELISA	When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p<.042), TD controls (p<.0015), and DD controls (p<.004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group.	Autism Spectrum Disorder	Proteome
10	19034380	9606	Brain(ATL)	DSM-IV	Case-control based	Shotgun	Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression.	Schizophrenia	Proteome
11	19367726	9606	Saliva	Others	Case-control based	HPLC-ESI-IT-MS	Phosphorylation level of four specific salivary phospho-peptides, namely statherin, histatin 1 (both, p < 0.0001) and acidic proline-rich proteins (both entire and truncated isoforms) (p < 0.005) was found significantly lower in autistic patients, with hypo-phosphorylation of at least one peptide observed in 18 ASD subjects (66%).	Autism Spectrum Disorder	Proteome
12	19913919	9606	Blood		Case-control based	Western blotting	Protein levels for most of the proteins studied were reduced in the patient groups compared with controls, although the patterns of these decreases differed from protein to protein and did not always achieve statistical significance(Figure 1 shows quantitative measurements for some ERK pathway proteins).	Bipolar Disorder	Proteome
13	19913919	9606	Blood		Case-control based	Western blotting	Protein levels for most of the proteins studied were reduced in the patient groups compared with controls, although the patterns of these decreases differed from protein to protein and did not always achieve statistical significance(Figure 1 shows quantitative measurements for some ERK pathway proteins).	Schizophrenia	Proteome
14	19913919	9606	Blood		Case-control based	Western blotting	Protein levels for most of the proteins studied were reduced in the patient groups compared with controls, although the patterns of these decreases differed from protein to protein and did not always achieve statistical significance(Figure 1 shows quantitative measurements for some ERK pathway proteins).	Major Depressive Disorder	Proteome
15	19913919	9606	Brain(PFC)		Case-control based	Western blotting	In individuals with schizophrenia, levels of B-raf, MEK1, MEK2, RSK1, CREB, and Rap1 were all significantly reduced compared with matched controls(B-raf: 48% of control, t=2.73, df=28, p=0.01; MEK1: 53% of control, t=3.47, df=28, p=0.002; MEK2: 52% of control, t=2.349, df=28, p=0.0261; RSK1: 41% of control, t=2.58, df=26, p=0.0158; CREB: 23% of control, t=4.12, df=28, p=0.0003; Rap1: 48% of control, t=2.136, df=28, p=0.0416).	Schizophrenia	Proteome
16	19913919	9606	Brain(PFC)		Case-control based	Western blotting	Conversely, levels of four proteins were reduced in individuals with MDD(MEK1, MEK2, CREB, Rap1), and levels of only two proteins were reduced in individuals with BPD(B-raf, MEK1).	Bipolar Disorder	Proteome
17	19913919	9606	Brain(PFC)		Case-control based	Western blotting	Conversely, levels of four proteins were reduced in individuals with MDD(MEK1, MEK2, CREB, Rap1), and levels of only two proteins were reduced in individuals with BPD(B-raf, MEK1).	Major Depressive Disorder	Proteome
18	20478355	9606	Blood(Plasma)	Others	Case-control based	ELISA	In patients leptin concentrations significantly increased, while adiponectin did not significantly change. Leptin values in patients were significantly higher than those found in controls at each time; adiponectin values did not differ at each time between patients and controls.	Autism Spectrum Disorder	Proteome
19	20544265	9606	Blood(Serum)	Others	Case-control based	ELISA	This is the first report demonstrating the increased serum levels of EGF in children with autism. This study suggests that increased levels of EGF might have an importance in the pathophysiology of autism	Autism Spectrum Disorder	Proteome
20	20662941	9606	Blood(Plasma)	Others	Case-control based	ELISA	By substantiating the previously observed increase in BDNF levels in autistic children in a larger patient set, and suggesting a genetic association between NTRK2 and autism, this study integrates evidence from multiple levels supporting the hypothesis that alterations in BDNF/tyrosine kinase B (TrkB) signaling contribute to an increased vulnerability to autism	Autism Spectrum Disorder	Proteome
21	20957522	9606	Brain(B-cells)	DSM-IV	Family based	Western blotting//q-PCR	Four proteins relevant to immuno-pathway, including IKKα that was up-regulated and Tyk2, EIF4G1 and PRKCI that were down-regulated, were identified differentially expressed in autistic versus non-autistic siblings.	Autism Spectrum Disorder	Proteome
22	21187413	9606	Blood	DSM-IV	Case-control based	Western blotting	In particular,we found in peripheral blood mononuclear cells(PBMCs)of healthy humans that these genetic variants interact in conferring individual variability in AKT1 protein levels and phosphorylation of GSK-3脦虏.	Schizophrenia	Proteome
23	21315782	9606	Cell lines(SK-N-MC cells)		Case-control based	Western blotting	The results indicate significant upregulation of HDAC2 protein levels at 12h(p<0.01), 24h(p<0.0001)and 48h(p<0.0001)of Tat treatment compared to control cultures(Fig. 2a).	Neurocognitive Disorder Due to HIV	Proteome
24	21375533	10116	Brain(Hippocampus//Cortex）	Others	Case-control based	ELISA	Behavioral deficit in ethanol-exposed pups was associated with enhanced acetylcholinesterase activity, increased oxidative-nitrosative stress, cytokine (TNF-伪, IL-1尾 and TGF-尾), nuclear factor kappa beta and caspase 3 levels in both cerebral cortex and hippocampus.聽	Fetal Alcohol Spectrum Disorder	Proteome
25	21397625	10116	Brain		Case-control based		Of the 54,tandem mass spectroscopy successfully identified 39 differentially expressed unique proteins and 2 post-translationally modified proteins(Tables 1 & 2).	Alcohol Use Disorder	Proteome
26	21397625	10116	Brain		Case-control based		The expression levels of 54 protein spots were significantly different between the ethanol(n=6)and air(n=7)treated groups. Of the 54, tandem mass spectroscopy successfully identified 39 differentially expressed unique proteins and 2 post-translationally modified proteins(Tables 1 & 2).	Alcohol Use Disorder	Proteome
27	21731612	9606	Blood(Plasma)	DSM-IV//ADI-R//CARS	Case-control based	ELISA//Western Blotting	We have observed that sAPPα levels are increased and BDNF levels decreased in the plasma of patients with severe autism as compared to controls. Further, we show that Aβ1-40, Aβ1-42, and sAPPβ levels are significantly decreased in the plasma of patients with severe autism.	Autism Spectrum Disorder	Proteome
28	21772061	9606	Blood		Case-control based		Thus, imbalance in ADNP/ADNP2 expression in the brain may impact disease progression in schizophrenia.	Schizophrenia	Proteome
29	22169944	9606	Cerebrospinal fluid	ICD-10	Case-control based	Western blotting	Table 1 Regulated Proteins in Cerebrospinal Fluid of Depressed Patients	Major Depressive Disorder	Proteome
30	22228753	9606	Brain//Cell lines(HEK293T cells)	DSM-IV	Case-control based	Affymetrix Microarray//qRT-PCR	While NPAS3 mRNA was unaltered, reduced NPAS3 protein expression was detected in a subpopulation of people with schizophrenia.	Schizophrenia	Proteome
31	22323074	9606	Blood(Serum)	DSM-IV	Case-control based	ELISA	Serum anti-GAD65 antibodies may be a common marker of subgroups of patients with autism and ADHD.	Autism Spectrum Disorder	Proteome
32	22348616	9606	Blood	DSM-IV	Case-control based	ELISA	A role for the protein that mediates the rate-limiting step of steroidogenesis, the 18 kDa Translocator Protein(TSPO), has been suggested in the pathophysiology of Adult Separation Anxiety Disorder (ASAD).	Separation Anxiety Disorder	Proteome
33	22420334	9606	Blood(Serum)	DSM-IV	Case-control based	ELISA	S100B protein levels were elevated in autistic children and significantly correlated to autistic severity. This may indicate the presence of an underlying neuropathological condition in autistic patients	Autism Spectrum Disorder	Proteome
34	22420334	9606	Blood	DSM-IV	Case-control based	Chemical assay	Autistic children had significantly higher serum S100B protein levels than healthy controls(P<0.001). Children with severe autism had significantly higher serum S100B protein than patients with mild to moderate autism(P=0.01). Increased serum levels of antiribosomal P antibodies were found in 40.6% of autistic children. There were no significant correlations between serum levels of S100B protein and antiribosomal P antibodies(P=0.29).	Autism Spectrum Disorder	Proteome
35	22832852	9606	Brain(PFC)		Case-control based	Western blotting	Table 2 Differentially expressed proteins in all post mortem brains from MDD patients compared with controls((b)MDD-P vs controls)	Major Depressive Disorder	Proteome
36	22832852	9606	Brain(PFC)		Case-control based	Western blotting	Table 2 Differentially expressed proteins in all post mortem brains from MDD patients compared with controls((c)MDD-P vs MDD-NP)	Major Depressive Disorder	Proteome
37	22832852	9606	Brain(PFC)		Case-control based	Western blotting	Table 2 Differentially expressed proteins in all post mortem brains from MDD patients compared with controls((a)MDD-NP vs controls)	Major Depressive Disorder	Proteome
38	22832856	9606	Blood(Plasma)	DSM-IV	Case-control based	SELDI-TOF-MS//MALDI-TOF//TOF-MS//ESI-FTICR-MS	Three differentially expressed peptides with mass-charge (m/z) values of 2020 ± 1, 1864 ± 1 and 1978 ± 1 Da in the heparin plasma of children with ASD that were significantly changed as compared with the peptide pattern of the non-ASD control group are reported here.	Autism Spectrum Disorder	Proteome
39	22928102	9606	Blood(Plasma)	DSM-IV//ADOS	Case-control based	Fluorogenic Substrates Assay	In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD	Autism Spectrum Disorder	Proteome
40	23093381	9606	Blood		Case-control based	Western blotting	No significant differences in plasma membrane RGS4 and cytosolic RGS10 protein expression were observed between schizophrenic subjects, non-diagnosed suicides, and control subjects.	Schizophrenia	Proteome
41	23174390	10090	Embryo	Others	Case-control based	Microsphere-based Multiplex Immunoassay	Prenatal alcohol exposure acutely results in a significant elevation of IL-6, G-CSF and the KC, which are known to affect N-methyl-D-aspartate receptors.	Fetal Alcohol Spectrum Disorder	Proteome
42	23345080	10090	Brain		Case-control based	Chemical assay	As expected, the C57BL/6Snca-/- mice showed a higher expression level of CB1 receptor in the hippocampus and amygdala compared with the C57BL/6Snca+/+mice(Figure 1a).	Alcohol Use Disorder	Proteome
43	23593384	10090	Brain		Case-control based	Western blotting	Western blotting demonstrated an upregulation of Lcn-2 protein after stress(Fig. 4B and 4C; n=3; p,0.01)suggesting that the transcriptional regulation of the Lcn-2 gene is accompanied by analogous changes in protein synthesis.	Depressive Disorder	Proteome
44	23673188	9606	Blood	ICD-10	Case-control based	ELISA	It was observed that both VEGFA mRNA and protein levels were significantly higher in patients suffering from rDD comparing with the controls(Table 1).	Depressive Disorder	Proteome
45	23727007	10116	Blood		Case-control based	Western blotting	Table 1. Differential proteins identified by MALDI-TOF/TOF MS	Major Depressive Disorder	Proteome
46	23915421	9606	Brain	DSM-IV	Case-control based	Western blotting	Western blot analysis revealed that KLF11 levels were significantly increased by 44 percent(p<0.03)in alcohol-dependent subjects compared to controls(Figure 1A and B)	Alcohol Use Disorder	Proteome
47	23988380	9606	Blood	DSM-IV	Case-control based	Western blotting	In patients with severe CSA(AHI 芒鈥奥	Central Sleep Apnea	Proteome
48	23995706	9606	Blood		Case-control based	Chemical assay	Associated with OSA	Obstructive Sleep Apnea Hypopnea	Proteome
49	24009062	9606	Blood	CARS	Case-control based	ELISA	The mean serum level of Dhh in patients with autism(1.38脗卤0.50 ng/ml)was significantly lower(p=0.0003)than that of normal controls(1.73脗卤0.37 ng/ml). There was no significant relationship between the serum level of Dhh and the CARS score(p=0.28), age(p=0.51)or gender(p=0.76).	Autism Spectrum Disorder	Proteome
50	24521633	9606	Blood(Serum)	DSM-IV	Case-control based	ELISA	Our preliminary findings show that enhanced serum NGF concentration may be used as a potential diagnostic tool in autism, however, further studies including a large number of patients are required to confirm the findings	Autism Spectrum Disorder	Proteome
51	24560881	9606	Blood	DSM-III-R	Case-control based	Western blotting	Finally, an increased ratio of HK1 protein in the extrasynaptic membrane/mitochondrial fraction was found in subjects with schizophrenia, suggesting that HK1 protein is abnormally partitioned in this illness.	Schizophrenia	Proteome
52	24687421	9606	Blood(Serum)	ICD-10	Case-control based	Tricine Gel Electrophoresis//LC-MS//MS	Overall, we found increased levels of apolipoproteins ApoA1 and ApoA4, involved in cholesterol metabolism and of serum paraoxanase/arylesterase 1, involved in preventing oxidative damage, in the sera of children with ASD, compared with their matched controls.	Autism Spectrum Disorder	Proteome
53	24767008	9606	Blood	DSM-IV	Case-control based	Chemical assay	sBDNF showed significantly lower levels in patients with depressive episodes or manic episodes.The best cut-off for sBDNF in discriminating depressed patient from healthy control was r33,000 pg/ml(AUC=0.891, sensitivity of 84%, and specificity of 80%). Moreover, the best cut-off for sBDNF in discriminating mania patients' group from healthy control was r29,500 pg/ml,(AUC=0.984, a sensitivity of 96%, and specificity of 86.7%).	Depressive Episodes	Proteome
54	24767008	9606	Blood	DSM-IV	Case-control based	Chemical assay	sBDNF showed significantly lower levels in patients with depressive episodes or manic episodes.The best cut-off for sBDNF in discriminating depressed patient from healthy control was r33,000 pg/ml(AUC=0.891, sensitivity of 84%, and specificity of 80%). Moreover, the best cut-off for sBDNF in discriminating mania patients' group from healthy control was r29,500 pg/ml,(AUC=0.984, a sensitivity of 96%, and specificity of 86.7%).	Manic Episodes	Proteome
55	24839933	10090	Blood		Case-control based	ELISA	In addition, Trim32 knockout mice showed reduced anxiety and depressive behaviors and hyperactivities compared with Trim32 wild-type mice under normal and mild stress conditions.We conclude that TRIM32 plays important roles in regulation of hyperactivities and positively regulates the development of anxiety and depression disorders induced by chronic stress.	Anxiety Disorder	Proteome
56	24872081	9606	Cell lines(SH-SY5Y cells)		Case-control based	Immunofluorescence	These results highlight the key role played by p73 and microRNA in Tat-treated neurons leading to their deregulation and it deciphers mechanistically one of the pathways used by Tat to cause neuronal dysfunction that contributes to the development of HAND.	Neurocognitive Disorder Due to HIV	Proteome
57	24878430	9606	Blood	DSM-IV	Case-control based	ELISA	The relative expression of FBXO45 in SCZ case with R108C mutation was relatively low when compared to 50 schizophrenia patients and 52 healthy controls.	Schizophrenia	Proteome
58	24881089	9606	Blood		Case-control based	Chemical assay	Monocyte chemoattractant protein-1(MCP-1)were signifcantly higher in OSA children.	Obstructive Sleep Apnea Hypopnea	Proteome
59	24993056	9606	Blood	DSM-IV	Case-control based	Immunofluorescence	In the subjects with schizoaffective disorder, mean GAD65 protein levels were 19.4% lower and were correlated with GAD65 mRNA levels.	Schizophrenia	Proteome
60	25191916	9606	Blood	DSM-IV	Case-control based	ELISA	One-way analysis of variance significantly demonstrated lower serum BDNF, MBP, and GFAP levels(F=16.504, P<.001; F=207.209, P<.001; F=33.668, P<.001, respectively)but higher serum IL-6 and S100脦虏 concentrations(F=15.250, P<.001; F=12.751, P<.001, respectively)among patients with schizophrenia.	Schizophrenia	Proteome
61	25218871	9606	Blood	DSM-IV	Case-control based	ELISA	Our results demonstrate that DISC1 protein levels in human lymphocytes are correlated with the diagnosis of schizophrenia independent of smoking and thus present a potential biomarker. Reduced DISC1 protein levels in lymphocytes of healthy individuals exposed to nicotine suggest that peripheral DISC1 could have potential for monitoring the effects of psychoactive substances.	Schizophrenia	Proteome
62	25292222	9606	Brain		Case-control based	Western blotting	GluN2B protein levels were decreased by 43% in the left hemisphere of schizophrenia subjects compared to controls(p=0.012).	Schizophrenia	Proteome
63	25300441	9606	Blood		Case-control based	ELISA	Youth with FXS-associated ASD(n=12)showed increased sAPP脦卤 processing compared to age-, gender- and IQ-match youth with idiopathic ASD(n=11).	Autism Spectrum Disorder	Proteome
64	25333879	9606	Cell lines(SH-SY5Y cells)		Case-control based	Western blotting	Here, we report on thorough biochemical and cell biological analyses of the aggregation propensity of TRIOBP, identifying the TRIOBP-1 splice variant as the principal aggregation-prone species, yielding insight into the mechanisms by which this arises and demonstrating that it has the capability to alter the morphology of neuron-like cells in culture.	Schizophrenia	Proteome
65	25376789	9606	Blood		Case-control based	Western blotting	Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.	Schizophrenia	Proteome
66	25433904	9606	Blood	DSM-IV	Case-control based	ELISA	Among these, the novel observation of reduced ATP1A3 expression is supported by strong genetic evidence indicating it may contribute to psychosis and cognitive impairment phenotypes.	Schizophrenia	Proteome
67	25444166	10090	Brain		Case-control based	Western blotting	The levels of DNMT1 and TET1 proteins were also increased in both FC and HP of PRS offspring at PND75 compared to controls(Figure 2C and 2D).	Schizophrenia	Proteome
68	25542305	9606	Blood		Case-control based	Western blotting	Our studies show for the first time a critical role for the schizophrenia-associated gene NOS1AP in cortical patterning, which may contribute to underlying pathophysiology seen in schizophrenia.	Schizophrenia	Proteome
69	25549848	9606	Brain(PFC)	DSM-IV	Case-control based	Western blotting	These results show the specific up-regulation of 14-3-3脦虏 and 14-3-3脦露 proteins in PFC of SZ subjects and suggest a possible down-regulation of both proteins by antipsychotic treatment.	Schizophrenia	Proteome
70	25626423	9606	Saliva	Others	Case-control based	LC-MS//MS	Our results indicate that this is an effective method for identification of salivary protein biomarkers, support the concept that immune system and gastrointestinal disturbances may be present in individuals with ASDs and point toward the need for larger studies in behaviorally-characterized individuals	Autism Spectrum Disorder	Proteome
71	25669692	9606	Blood(Plasma)	Others	Case-control based	ELISA	Plasma HMGB1 levels were significantly higher in individuals with autism than in controls (13.8+/-11.7 ng/ml vs. 7.90+/-4.0 ng/ml, p<0.02).	Autism Spectrum Disorder	Proteome
72	25818630	9606	Brain		Case-control based	Immunohistochemistry	MAP2-IR was significantly reduced in Sz subjects compared to their matched control pairs(Fig. 3)[primary model: F(1,18)=18.32; p=0.001 and secondary model: F(1,33)=13.88;p=0.001].	Schizophrenia	Proteome
73	25846779	9606	Blood		Case-control based	ELISA	Levels of GFAP immunoreactivity(ir)were significantly elevated(P=0.008)in anterior cingulate cortex(Brodmann area 24; BA24)white matter of ASD donors compared to control donors. In contrast, GFAP-ir levels were similar in BA24 gray matter from ASD and control donors. MOG-ir was also similar in both BA24 white and gray matter from ASD and control donors.	Autism Spectrum Disorder	Proteome
74	25907107	10090	Blood		Case-control based	ELISA	The transcription factor Specificity Protein 4(SP4)is important for neurodevelopment and is genetically associated with both schizophrenia and bipolar disorder.	Bipolar Disorder	Proteome
75	25930075	9606	Brain	DSM-IV	Case-control based	Western blotting	The level of CNPase protein from subjects with MDD was significantly lower(44%)than that of matched controls(paired t-test, t=2.279, df=13, p=0.04), Fig. 7).	Major Depressive Disorder	Proteome
76	25944409	10090	Brain		Case-control based	ELISA	A significant decrease in DNA methylation of CNR1 gene promoter was revealed in the prefrontal cortex of addict-like mice, which was associated with an up regulation of CB1 protein expression in the same brain area. The pharmacological blockade(rimonabant 3 mg/kg; i.p.)of CB1 receptor during the late training period reduced the percentage of mice that accomplished addiction criteria, which is in agreement with the reduced performance of CB1 knockout mice in this operant training.	Eating Disorder	Proteome
77	25956630	9606	Brain(PFC)	DSM-IV	Case-control based	Western blotting	Table 4 Western Blotting Results for RAC1, Homer 1, APP, and STEP. Values Expressed as Ratios to 脦虏-actin and Neuronal Specific Enolase in Lateral Cerebella.	Schizophrenia	Proteome
78	25956630	9606	Brain(PFC)	DSM-IV	Case-control based	Western blotting	Table 4 Western Blotting Results for RAC1, Homer 1, APP, and STEP. Values Expressed as Ratios to 脦虏-actin and Neuronal Specific Enolase in Lateral Cerebella.	Bipolar Disorder	Proteome
79	25956630	9606	Brain(PFC)	DSM-IV	Case-control based	Western blotting	Table 4 Western Blotting Results for RAC1, Homer 1, APP, and STEP. Values Expressed as Ratios to 脦虏-actin and Neuronal Specific Enolase in Lateral Cerebella.	Major Depressive Disorder	Proteome
80	26134254	10116	Brain		Case-control based		Supplementary Table S1. Differential Proteins Identified by iTRAQ Proteomics	Major Depressive Disorder	Proteome
81	26211447	9606	Blood		Case-control based		Subfield-specific hippocampal molecular pathology exists in human psychosis tissue which could underlie this neuronal hyperactivity, including increased GluN2B-containing NMDA receptors in hippocampal CA3, along with increased postsynaptic density protein-95(PSD-95)along with augmented dendritic spines on the pyramidal neuron apical dendrites.	Schizophrenia	Proteome
82	26260078	9606	Brain	DSM-III-R//DSM-IV	Case-control based	Immunohistochemistry	Two postsynaptic proteins important for spine formation and glutamatergic signaling were also decreased- spinophilin(-17.40%, p=0.042)and PSD-95(-34.06%, p=0.015).	Schizophrenia	Proteome
83	26260078	9606	Brain	DSM-III-R//DSM-IV	Case-control based	Immunohistochemistry	In the glomeruli of schizophrenia cases compared to their matched controls,we found significant decreases in three presynaptic proteins which play crucial roles in vesicular glutamate transport-synapsin IIa(-18.05%, p=0.019), synaptophysin(-24.08% p=0.0016)and SNAP-25(-23.9%, p=0.046).	Schizophrenia	Proteome
84	26290361	9606	Saliva	DSM-IV-TR	Case-control based	Two-dimensional PAGE	Table 2 Summary of proteins identified by LC-MS/MS from the picked 2D gel spots which are differentially expressed between participants with ASD and controls.	Autism Spectrum Disorder	Proteome
85	26290361	9606	Saliva	DSM-IV-TR	Case-control based	Two-dimensional PAGE	Several proteins were found to be decreased in ASD compared to controls. Only proteins that were found in spots with a P-value <0.05 and a fold change >1.7 were considered significant. This stringent criterion allows for true changes to be considered and for artefacts to be ignored. The following proteins were significantly reduced in ASD.	Autism Spectrum Disorder	Proteome
86	26290361	9606	Saliva	DSM-IV-TR	Case-control based	Two-dimensional PAGE	The same selection criterion was applied for the selection of proteins found to be increased in ASD relative to controls. The following proteins were identified.	Autism Spectrum Disorder	Proteome
87	26296899	9606	Urine	CHAT	Case-control based	ELISA	Peptide sequence with significant match score was for kininogen-1(KNG-1)-50(spot-1), IgG1 heavy chain variable region-35(spot-2)and mannan-binding lectin serine protease-2 isoform-2 precursor-45(spot-3).	Autism Spectrum Disorder	Proteome
88	26296899	9606	Urine	CHAT	Case-control based	ELISA	Increased urinary kininogen-1 level in all the autistic children and the possibility of this protein as a diagnostic marker need further investigation.	Autism Spectrum Disorder	Proteome
89	26364548	9606	Blood	DSM-IV	Case-control based	Immunohistochemistry	Our findings suggest that GABA production is markedly reduced in a subset of boutons in the PFC of schizophrenia subjects and that this reduction likely occurs after the maturation of GABAergic boutons.	Schizophrenia	Proteome
90	26370672	9606	Blood	DSM-IV	Case-control based	ELISA	Lower uE3(AOR for<10th percentile vs. 25th-74th percentiles=1.21, 95 % CI 1.06-1.37), and higher MSAFP(AOR=1.21, 95 % CI 1.07-1.37 for > 90th percentile)were significantly associated with ASD.	Autism Spectrum Disorder	Proteome
91	26414898	9606	Blood		Case-control based	Chemical assay	Among children who had hsCRP levels measured pre- and post-AT(n=155), mean hsCRP levels pre-AT were 0.98脗卤1.91 mg/L and were signifcantly reduced post-AT(0.63脗卤2.24 mg/dL; P=0.011).	Obstructive Sleep Apnea Hypopnea	Proteome
92	26421900	9606	Blood	DSM-IV	Case-control based	Western blotting	The protein expression of KIF17 in schizophrenic postmortem brains was significantly lower than that in controls.	Schizophrenia	Proteome
93	26424323	9606	Blood	DSM-IV	Case-control based	ELISA	RGS4 mRNA and protein levels were significantly lower in schizophrenia subjects and were positively correlated across all subjects.	Schizophrenia	Proteome
94	26431870	9606	Blood	DSM-IV	Case-control based	Western blotting	However, because VB6 is not a homeostatic component, it is better to monitor the endogenous PCO and PEN levels as a diagnostic marker for CS-type schizophrenia.	Schizophrenia	Proteome
95	26462472	9606	Blood	DSM-IV	Case-control based	ELISA	The results negate that CASPR2 antibodies play a role in the pathogenesis of Tourette syndrome and do not support the assumption that anti-neuronal antibodies are involved.	Tourette's Disorder	Proteome
96	26479762	9606	Blood(Serum)	DSM-IV//CARS	Case-control based	ELISA	Our preliminary study suggests that low levels of serum 伪-syn and tau may be implicated in the relationship between synaptic activity and autism	Autism Spectrum Disorder	Proteome
97	26479762	9606	Blood	CARS	Case-control based	ELISA	The results indicated that the mean serum 脦卤-syn and serum tau levels were significantly(p<0.001)lower in children with ASD as compared with normal cases(33.01脗卤20.78 and 55.19脗卤15.34 ng/mL and 241.23脗卤290.5 and 509.78脗卤269.25 ng/mL, respectively). 	Autism Spectrum Disorder	Proteome
98	26485547	9606	Cell lines(ONS cells)	DSM-IV	Case-control based	ELISA	We used discovery-based proteomics and targeted functional analyses to reveal reductions in 17 ribosomal proteins, with an 18% decrease in the total ribosomal signal intensity in schizophrenia-patient-derived ONS cells.	Schizophrenia	Proteome
99	26506154	10116	Brain		Case-control based	Immunohistochemistry	We also found that levels of postsynaptic density protein-95(PSD-95)were significantly lower in the low-escape group compared to naive or high-escape rats(Fig 2C).	Posttraumatic Stress Disorder	Proteome
100	26506154	10116	Brain		Case-control based	Immunohistochemistry	There was a significant decrease in SGK1 protein levels in PFC(dissections included prelimbic, infralimbic, and cingulate PFC)of low-escape rats, compared to naive, similar to the decrease in PTSD subjects(Fig 2B).	Posttraumatic Stress Disorder	Proteome
101	26541453	9606	Blood	DSM-IV	Case-control based	ELISA	In a functional follow-up analysis of this finding, we tested an independent cohort of 10 patients treated with olanzapine and found that baseline levels of plasma H-FABP and expression of the binding partner for H-FABP, fatty acid translocase(CD36), on monocytes predicted the reduction of psychotic symptoms(p=0.040, F=6.0, 脦虏=116.3 and p=0.012, F=11.9, 脦虏=-0.0054, respectively).	Schizophrenia	Proteome
102	26541453	9606	Blood	DSM-IV	Case-control based	ELISA	Data analysis showed the most significant relationship between pre-treatment levels of heart-type fatty acid binding protein(H-FABP)and response to olanzapine(p=0.008, F=8.6, 脦虏=70.4 in the discovery cohort and p=0.003, F=15.2, 脦虏=24.4 in the validation cohort, adjusted for relevant confounding variables).	Schizophrenia	Proteome
103	26657596	9606	Blood	DSM-IV	Case-control based	Western blotting	Inpatients with elevated C-reactive protein displayed increased aggressive behavior compared to patients with normal CRP levels(<1 mg/dL).	Schizophrenia	Proteome
104	26691363	9606	Blood	DSM-IV	Case-control based	ELISA	The serum levels of IHH and SHH were significantly higher in autistic subjects than those of control subjects. There was significant correlation between age and IHH(r=0.176, p=0.03), BDNF and severe IHH(r=0.1763, p=0.003), and severe BDNF and severe SHH(r=0.143, p<0.001). However, there were no significant relationships among the serum levels of SHH, IHH and BDNF and the CARS score, age or gender.	Autism Spectrum Disorder	Proteome
105	26764136	9606	Blood(Serum)	Others	Case-control based	On-bead Magnetic Screening//MS//ELISA//Gel Electrophoresis//Coomassie Blue Staining	One of these peptoids was studied further and found to bind significantly higher levels (>2-fold) of the IgG1 subtype in serum from TD boys (n = 60) compared to ASD boys (n = 74), as well as compared to older adult males (n = 53). Together these data suggest that ASD boys have reduced levels (>50%) of an IgG1 antibody, which resembles the level found normally with advanced age.	Autism Spectrum Disorder	Proteome
106	26792082	9606	Brain		Case-control based	Western blotting	We found no evidence that major PUFA levels in BA8 are involved in the etiology of schizophrenia. Although FABP3 expression was not correlated with any of the major PUFAs, it might play a novel role in the pathology of BA8 in a subset of patients with schizophrenia.	Schizophrenia	Proteome
107	26876311	9606	Brain		Case-control based	Western blotting	Using mass spectrometry, we identified 219 new and known palmitoylated candidate proteins. We then assayed protein S-palmitoylation in DLPFC in paired schizophrenia and comparison subjects, and found in schizophrenia a 20% decrease in palmitoylation across proteins of most molecular masses measured.(Supplemental table 1.Palmitoyl candidates identified from human dorsolateral prefrontal cortex.)	Schizophrenia	Proteome
108	26887202	10116	Blood		Case-control based	ELISA	After the treatment for 21 days, compared to the model group, the number of the apoptotic cells, the expression levels of hippocampal Bax and Caspase--3 proteins, and the contents of serum and hippocampal MDA were notably decreased in the EA and medication groups(P<0.01), whereas, Bcl-2 protein expression levels, and serum and hippocampal SOD and GSH-Px activity were notably up-regulated in the EA and medication groups(P<0.01).	Learning Disorder	Proteome
109	26938821	9606	Blood	DSM-IV-TR	Case-control based	ELISA	PLA2 concentrations were higher in patients with schizophrenia, whereas protein S100 concentrations were not. Higher concentrations of PLA2 were positively correlated with the duration of illness and number of episodes, as determined by multivariate analysis.	Schizophrenia	Proteome
110	26946106	10116	Blood		Case-control based	ELISA	Our goal was to compare the transmembrane signaling mediated by MOP receptors in control rats and in a recently developed rat model of schizophrenia. Taken together in our rat model of schizophrenia, MOP receptor mediated G-proteins have a reduced stimulatory activity compared to membrane preparations taken from control animals.	Schizophrenia	Proteome
111	26948503	9606	Blood	DSM-IV	Case-control based	ELISA	Reduced ABCB1 expression in habenular capillaries might contribute to increased brain levels of proinflammatory cytokines in patients with schizophrenia, while decreased expression of this protein in a subpopulation of medial habenular neurons(which are probably purinergic)might be related to abnormalities of purines and their receptors found in this disease.	Schizophrenia	Proteome
112	27030512	9606	Blood	DSM-IV	Case-control based	Western blotting	Expression of the 14-3-3脦虏 protein was signifcantly reduced in SZ patients(-1.28-fold, p=0.026, Fig. 2a).	Schizophrenia	Proteome
113	27030512	9606	Blood	DSM-IV	Case-control based	Western blotting	Te decrease in 14-3-3脦碌 protein levels(-1.24-fold, p=0.021, Fig. 2b)was comparable to the decrease in 14-3-3脦碌 mRNA levels(-1.22-fold, p<0.001, Fig. 1c).	Schizophrenia	Proteome
114	27030512	9606	Blood	DSM-IV	Case-control based	Western blotting	Additionally, the 14-3-3脦鲁(-1.29-fold, p=0.038, Fig. 2c),14芒鈧€	Schizophrenia	Proteome
115	27081377	9606	Blood(Plasma)	ADI	Case-control based	ELISA	Our results support the hypothesis of OT deficiency in autism. The \paradoxical\" associations of OT levels and social skills in children with autism indicate disturbances at various levels of OT system"	Autism Spectrum Disorder	Proteome
116	27091401	9606	Blood(Serum)	CARS	Case-control based	Colorimetry	Our data suggests that the decreased serum SOD levels could be implicated in the pathophysiology and progression of autism in Chinese children and can be used as an independent risk indicator of ASD	Autism Spectrum Disorder	Proteome
117	27222290	9606	Cell lines(HEK293T cells)		Case-control based	ELISA	Taken together, our combined genetic, experimental and modelling evidence suggests that NC_000023.10:g.69665044dupG variant alters SAP102 protein abundance, which is the most plausible cause of moderate non-syndromic ID this family.	Intellectual Disability	Proteome
118	27236410	9606	Blood	DSM-IV	Case-control based	ELISA	This study provides evidence indicating these proteins are decreased in schizophrenia: CSNK1E, involved in circadian molecular clock signaling, FABP4 with possible implication in synapse functioning, and NEFH, important for cytoarchitecture organization.In this second cohort, CSNK1E, FABP4 and NEFH were reduced in the schizophrenia group while ALDH1A1 did not significantly change.	Schizophrenia	Proteome
119	27246309	9606	Plasma	DSM-5	Case-control based	Western blotting	Significant changes were evidenced for a total of 12 proteins. Of these, ten were identified as proteins involved in the acute inflammatory response including alpha-2-macroglobulin, alpha-1-antitrypsin, haptoglobin, fibrinogen, serum transferrin, prealbumin, apolipoprotein A-I apolipoprotein A-IV, apolipoprotein J, and serum albumin.(Table 1. Identified plasma proteins by MS/MS)	Autism Spectrum Disorder	Proteome
120	27263429	10116	Brain(Hippocampus)	Others	Case-control based	Multiplex Cytokine Assay//Pierce Microplate BCA Protein Assay	In summary, our findings of a unique cytokine profile in PAE rats, during a period when the brain is maturing and being remodeled, provide insight into factors that may underlie some of the long-term negative health consequence observed in children with FASD	Fetal Alcohol Spectrum Disorder	Proteome
121	27263429	10116	Brain(Hippocampus//Prefrontal cortex)	Others	Case-control based	Multiplex Cytokine Assay//Pierce Microplate BCA Protein Assay	In summary, our findings of a unique cytokine profile in PAE rats, during a period when the brain is maturing and being remodeled, provide insight into factors that may underlie some of the long-term negative health consequence observed in children with FASD	Fetal Alcohol Spectrum Disorder	Proteome
122	27263429	10116	Brain(Prefrontal cortex）	Others	Case-control based	Multiplex Cytokine Assay//Pierce Microplate BCA Protein Assay	In summary, our findings of a unique cytokine profile in PAE rats, during a period when the brain is maturing and being remodeled, provide insight into factors that may underlie some of the long-term negative health consequence observed in children with FASD	Fetal Alcohol Spectrum Disorder	Proteome
123	27263429	10116	Brain(Hypothalamus)	Others	Case-control based	Multiplex Cytokine Assay//Pierce Microplate BCA Protein Assay	In summary, our findings of a unique cytokine profile in PAE rats, during a period when the brain is maturing and being remodeled, provide insight into factors that may underlie some of the long-term negative health consequence observed in children with FASD	Fetal Alcohol Spectrum Disorder	Proteome
124	27323094	9606	Blood		Case-control based		As compared with the control group, the CRP levels in the OSAS group were significantly increased(P<0.05). ANOVA showed that CRP levels in the three subgroups differ; statistically significant differences between the mild and severe OSA patients were observed(P<0.05).	Obstructive Sleep Apnea Hypopnea	Proteome
125	27412497	9606	Blood	DSM-IV	Case-control based	ELISA	The mean serum G72 protein values were 495.90脗卤152.03 pg/ml in the schizophrenia group and 346.10脗卤102.08 pg/ml in the healthy control group.	Schizophrenia	Proteome
126	27550734	9606	Blood		Case-control based	ELISA	Treatment-resistant subjects had significantly higher TH and GAD67 levels than controls(an increase of 121.0%, P=0.0003 and 58.7%, P=0.004, respectively).	Schizophrenia	Proteome
127	27667096	9606	Blood	DSM-IV-TR	Case-control based	Chemical assay	No deficiency of thiamine and TMP in plasma of children with ASD was found.	Autism Spectrum Disorder	Proteome
128	27669496	9606	Blood		Case-control based	ELISA	The elevation of serum hsCRP in patients was not affected by gender, family history(P>0.05), and clinical classification of schizophrenia(P>0.05). However, the elevation of hsCRP was suppressed by the medical treatment for schizophrenia with acute agitation(P<0.05).	Schizophrenia	Proteome
129	27870441	9606	Blood		Case-control based		It is important to note that ADNP is sexually regulated in the brains of birds, mice, and men and in lymphocytes of patients suffering from schizophrenia.	Schizophrenia	Proteome
130	27956739	10090	Blood		Case-control based	Western blotting	Thus ANK3芒鈧劉s important association with human bipolar susceptibility may arise from imbalance between AnkG function in interneurons and principal cells and resultant excessive circuit sensitivity and output.	Bipolar Disorder	Proteome
131	28035416	9606	Blood//Cell lines(HEK293A)		Case-control based	ELISA	We conclude that pallidin indirectly regulates the transcriptional activity of p38 during neurodevelopment by binding HDAC3 and changing its cellular localization, which leaves p38 uninhibited.	Schizophrenia	Proteome
132	28072411	9606	Blood		Case-control based	ELISA	Further, reverse transcription-quantitative PCR analysis revealed that the early growth response protein 1(EGR1)and miR-30a-5p were remarkably downregulated, whereas neurogenic differentiation factor 1(NEUROD1)was significantly upregulated in PBMNCs from patients in acute psychotic state.	Schizophrenia	Proteome
133	28077936	9606	Plasma	DSM-IV	Case-control based	Chemical assay	Protein carbonylation levels in two proteins, complement component C8 alpha chain and Ig kappa chain C were found to be significantly increased in autistic patients compared with controls.	Autism Spectrum Disorder	Proteome
134	28088366	9606	Blood	CARS	Case-control based	Chemical assay	The results indicated that the mean serum GFAP level was significantly(P<0.001)higher in autistic children as compared to controls(1.71脗卤0.53ng/ml vs. 0.99脗卤0.25ng/ml). There was a significant positive association between serum GFAP levels and CARS scores(r [Pearson]=0.390,P=0.001).	Autism Spectrum Disorder	Proteome
135	28088366	9606	Blood	CARS	Case-control based	ELISA	The results indicated that the mean serum GFAP level was significantly(P<0.001)higher in autistic children as compared to controls(1.71脗卤0.53ng/ml vs. 0.99脗卤0.25ng/ml).	Autism Spectrum Disorder	Proteome
136	28099628	9606	Blood	CARS	Case-control based	ELISA	Concentrations of both S100B and TNF-脦卤 were higher in children with autism before and after adjusting for a priori-selected confounders(age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism.	Autism Spectrum Disorder	Proteome
137	28174109	9606	Blood	PANSS//MOAS	Case-control based	ELISA	Higher levels of hsCRP(p<0.001), lower levels of logIL-10(p<0.001)and higher ratio of hsCRP to IL-10(p<0.001)were observed in the plasma of patients with schizophrenia, compared to healthy controls.	Schizophrenia	Proteome
138	28179641	9606	Blood		Case-control based		Here, we review the most recent studies that help to clarify the roles of SHANK proteins at the synapse, providing insightful mechanistic links to neuropsychiatric disorders.	Autism Spectrum Disorder	Proteome
139	28188811	9606	Blood	DSM-IV	Case-control based	ELISA	Acute paranoid schizophrenia inpatients present a day/night change of S100B serum levels at admission that disappears at discharge.	Paranoid Schizophrenia	Proteome
140	28218896	9606	Cell lines(PC-3 cells)		Case-control based	ELISA//RT-PCR//Luciferase assay//Western blotting	We also found that mRNA and protein expression level of NOS1 in PC-3 cells treated with miR-146a mimics and NOS1 siRNA was substantially down-regulated compared with scramble control, while cells treated with miR-146a inhibitors showed increased expression of NOS1.	Erectile Disorder	Proteome
141	28230289	10090	Blood	DSM-IV	Case-control based	ELISA	This suggests that BCAS1 is a novel myelin-associated protein. BCAS1 knockout mice displayed schizophrenia-like behavioral abnormalities and a tendency toward reduced anxiety-like behaviors.	Schizophrenia	Proteome
142	28292384	9606	Blood	DSM-IV	Case-control based	ELISA	There was no significant difference between the levels of CABIN1 between the 1.12(0.01-8.8)pg/ml and healthy(1.51, 0.12-4.32)pg/ml in children. However, children with mild to moderate autism had higher CABIN1 protein level(1.27 pg/ml, 0.01-10.240)than children with severe autism(0.80 pg/ml, 0.01-4.25, p=0.145). In addition, there was no significant relationships among the serum level of CABIN1 protein, the CARS score, and age.	Autism Spectrum Disorder	Proteome
143	28407444	9606	Blood	ADI-R//ADOS	Case report		We report on a girl and her mildly affected mother with a 275 kb deletion at 18q12.2 involving CELF4 and KIAA1328 whose disruption is not associated with any known disease. The child was diagnosed with syndromic intellectual disability and autism at 6 years of age.	Autism Spectrum Disorder	Proteome
144	28419454	10090	Cell lines(HeLa cells/HEK293T cells)		Case-control based	Western blotting//Immunocytochemistry	Here we observe that in the cerebellum there is a significant increase in Dab1 protein level in the RELN Orl+/- animals compared to wild-type(Figure 5A, 5B), suggesting that reduced Reelin signaling has an impact on this tissue.	Autism Spectrum Disorder	Proteome
145	28477547	9606	Blood		Case-control based	ELISA	In MDD, neither plasma nor CSF G72 levels correlated significantly with depression severity.	Major Depressive Disorder	Proteome
146	28489776	9606	Blood		Case-control based	Meta-analysis	In our meta-analysis, serum CRP/hs-CRP levels were discovered to be higher in OSA patients compared with control subjects.	Obstructive Sleep Apnea Hypopnea	Proteome
147	28500650	10090	Blood		Case-control based	ELISA	Here, we assessed ASD-related phenotypes with particular emphasis on social behavior and cognition in Shank1 mouse mutants in comparison to heterozygous and wildtype littermate controls across development in both sexes.	Autism Spectrum Disorder	Proteome
148	28520763	9606	Blood	AASM	Case-control based	ELISA	ADAR1 P150 protein expression level was significantly increased in the VSO group(22.42脗卤9.33 pg/ml)as compared to that either in the PS(7.6脗卤8.03 pg/ml, p<0.001), MSO(7.92脗卤8.33 pg/ml, p<0.001), or VSOC(6.29脗卤6.83 pg/ml, p<0.001)group(Fig 4A).	Obstructive Sleep Apnea Hypopnea	Proteome
149	28520763	9606	Blood	AASM	Case-control based	ELISA	BIRC3 protein expression was significantly increased in the VSO group(0.31脗卤0.39 pg/ml)as compared to that in the PS(0.05脗卤0.05 pg/ml, p=0.031)or VSOC(0.03脗卤0.05 pg/ml, p=0.033)group(Fig 4D).	Obstructive Sleep Apnea Hypopnea	Proteome
150	28520763	9606	Blood	AASM	Case-control based	ELISA	LGALS3 protein expression level was significantly increased in both the MSO(7.04脗卤3.18 ng/ml, p=0.036)and VSO groups(4.52脗卤1.07 ng/ml, p=0.035)as compared to that in the PS group(4.24脗卤2.35 ng/ml)(Fig 4F).	Obstructive Sleep Apnea Hypopnea	Proteome
151	28520763	9606	Blood	AASM	Case-control based	ELISA	Subgroup analyses revealed that AMOT P130 protein expression was increased in OSA patients with excessive daytime sleepiness, BIRC3 protein expression was decreased in OSA patients with hypertension, and LGALS3 protein expression was increased in OSA patients with chronic kidney disease.	Obstructive Sleep Apnea Hypopnea	Proteome
152	28577577	9606	Blood(Serum)	ADOS//ADI-R//ABAS‐II//DSM-IV	Case-control based	RBM Platform//MSD Platform	The two proteins, thyroid-stimulating hormone (TSH) and interleukin-8 (IL-8), have been previously identified as putative biomarkers for ASD. TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated.	Autism Spectrum Disorder	Proteome
153	28669901	10090	Brain(Prefrontal cortex）	Others	Case-control based	Western Blotting//ELISA	Behavioural effects were associated with an upregulation of pro-inflammatory signalling (Toll-like receptor 4, nuclear factor-kappa B p65, NOD-like receptor protein 3, caspase-1, and interleukin-1b), gliosis, neuronal cell death and a reduction in several structural myelin proteins (myelin-associated glycoprotein, myelin basic protein, myelin proteolipid protein and myelin regulatory factor) in both the prefrontal cortex and hippocampus of adult mice exposed to alcohol	Fetal Alcohol Spectrum Disorder	Proteome
154	28669901	10090	Brain(Prefrontal cortex//Hippocampus)	Others	Case-control based	Western Blotting//ELISA	Behavioural effects were associated with an upregulation of pro-inflammatory signalling (Toll-like receptor 4, nuclear factor-kappa B p65, NOD-like receptor protein 3, caspase-1, and interleukin-1b), gliosis, neuronal cell death and a reduction in several structural myelin proteins (myelin-associated glycoprotein, myelin basic protein, myelin proteolipid protein and myelin regulatory factor) in both the prefrontal cortex and hippocampus of adult mice exposed to alcohol	Fetal Alcohol Spectrum Disorder	Proteome
155	28711670	9606	Blood	DSM-IV	Case-control based	ELISA	However, GFAP values in the patient group were statistically significantly higher(mean脗卤SD: 0.463脗卤0.392 ng/ml)than in the healthy control group(mean脗卤SD:0.256脗卤0.111 ng/ml)(p<0.001).	Autism Spectrum Disorder	Proteome
156	28727685	9606	LUHMES cell	Others	Case-control based	RNAscope	Taken together, this evidence therefore suggests that NRG/ErbB signaling regulates homeostasis of extracellular DA levels either by directly modulating DAergic neurons, conceivably via mechanisms involving the DA transporter (DAT) or catechol-O-methyltransferase, by indirectly modulating neuronal circuits through GABAergic interneurons,or both.	Schizophrenia	Proteome
157	28794131	9606	Blood//Skin fibroblasts		Case-control based	Western blotting	DNAJC12 deficiency appears to result in a more heterogeneous neurological phenotype than originally described.	Intellectual Disability	Proteome
158	28867284	9606	Blood	DSM-IV	Case-control based	ELISA	PTSD was positively correlated with serum CRP levels with PTSD cases more likely to have CRP levels in the clinically-elevated range compared to those without a PTSD diagnosis.	Posttraumatic Stress Disorder	Proteome
159	28947597	9606	Blood	DSM-IV	Case-control based	ELISA	These preliminary findings suggest that including a measure of CRP improves the ability for clinicians to detect cases of mild-to-moderate OSA with true cardiometabolic risk, with implications in improving prognosis and treatment within this clinically gray area.	Obstructive Sleep Apnea Hypopnea	Proteome
160	28993710	9606	Blood//Cell lines(HEK293)	Others	Case-control based	RT-PCR	Claudin-5 variant rs10314 weakly associates with schizophrenia in 22q11DS patients and causes decreased protein expression.	Schizophrenia	Proteome
161	29028081	9606	Blood	DSM-IV	Case-control based	ELISA	OSAS patients showed significantly elevated YKL-40 levels compared to the control group; 102,05(23.14)pg/ml in the control group vs. 144.81(65.53)pg/ml in the OSAS group. A Spearman correlation analysis showed that serum YKL-40 levels were significantly and positively correlated with AHI(r=0.434, p<0.001)and oxygen desaturation index(r=0.374, p<0.001).	Obstructive Sleep Apnea Hypopnea	Proteome
162	29073745	9606	Blood	HAM-D//HAM-A	Case-control based	Western blotting	This study demonstrated significantly higher serum GPER1 levels in the MDD patients than in the controls, a positive correlation was found between GPER1 levels and depression scores and serum GPER1 level was valuable in predicting the presence of depression.	Major Depressive Disorder	Proteome
163	29092799	9606	Brain		Case-control based	Western blotting	These phenotypes are similar to defects observed in human ASD patients,suggesting that the established dABCA knockdown flies are a promising model for ASD.	Autism Spectrum Disorder	Proteome
164	29092799	9606	Brain		Case-control based	Western blotting	These phenotypes are similar to defects observed in human ASD patients,suggesting that the established dABCA knockdown flies are a promising model for ASD.	Schizophrenia	Proteome
165	29092799	9606	Brain		Case-control based	Western blotting	These phenotypes are similar to defects observed in human ASD patients,suggesting that the established dABCA knockdown flies are a promising model for ASD.	Bipolar Disorder	Proteome
166	29110334	9606	Blood		Case-control based	Western blotting	In this case, these areas were affected, showing abnormal TDP-43-positive structures. Further studies are expected to confirm further clinical-pathological correlations to FTLD.	Catatonia Associated With Frontotemporal Dementia	Proteome
167	29172096	9606	Blood		Case-control based	ELISA	The serum AgRP levels of manic group were significantly lower than those of euthymic and control groups.	Manic Episodes	Proteome
168	29197199	9606	Blood	ICD-10	Case-control based	Chemical assay	Serum CRP concentration in veterans with(3.54脗卤1.19 mg/L)and without PTSD(3.24脗卤2.04 mg/L), was significantly higher(p<0.05)compared to control group(1.26脗卤1.06 mg/L).	Posttraumatic Stress Disorder	Proteome
169	29243511	9606	Blood	ASDS	Case-control based		The ASDS sum score was positively associated with C-reactive protein categories in the bivariate analysis( r=0.20, p<0.01).	Acute Stress Disorder	Proteome
170	29274201	9606	Blood	DSM-IV	Case-control based	ELISA	Table 1 Differentially expressed plasma proteins in autistic and age- and sex-matched healthy controls.	Autism Spectrum Disorder	Proteome
171	29298663	9606	Blood	DSM-IV	Case-control based	ELISA	There was no evidence that MDD was associated with the level of CRP titres [aOR=0.95(0.78-1.15); p=0.60)].	Major Depressive Disorder	Proteome
172	29298663	9606	Blood	DSM-IV	Case-control based	ELISA	Adjusting for confounders, the odds of MDD increased with increasing levels of IL-6 [each unit increase in IL-6 titres was associated with an aOR=0.98(95% CI, 0.97-0.99); p<0.001].	Major Depressive Disorder	Proteome
173	29298663	9606	Blood	DSM-IV	Case-control based	ELISA	Participants with low levels of TNF-脦卤 were at reduced risk of MDD compared to participants with no TNF-脦卤 [those with a TNF-脦卤 of 1- <50 pg/ml titres had an aOR=0.35(95% CI,0.10-1.16)], but as the level of TNF-脦卤 increased, the risk of MDD increased, and in particular participants with high levels of TNF-脦卤(of 500 or above)were at a significantly increased risk of MDD [e.g. those with a TNF-脦卤 of 500-<1000 pg/ml titres had an aOR=3.98(95% CI,1.29-12.33)] compared to participants with no TNF-脦卤.	Major Depressive Disorder	Proteome
174	29298990	9606	Cell lines(iPSCs)	Others	Case-control based	Western blotting//q-PCR	Our findings shed new light on the molecular mechanisms underlying diseases associated with DNA damage and provides a novel target (i.e., the TRAX/DISC1/GSK3β complex) for future therapeutic development for mental disorders.	Schizophrenia	Proteome
175	29301595	9606	Blood	DSM-IV	Case-control based	ELISA	The plasma SFRP5 level of OSA patients was not significantly different from that of healthy controls or obese controls. In OSA patients, SFRP5 level correlated positively with triglyceride level(r=0.447, P=0.005)and negatively with LDL-cholesterol level and HDL- cholesterol level(r=-0.472 and P=0.003; r=-0.478 and P=0.002; respectively).	Obstructive Sleep Apnea Hypopnea	Proteome
176	29302076	9606	iPSCs	Others	Case-control based	ES//GS//Immunofluorescence//Three-dimensional Modeling	We observed familial segregation of two rare missense mutations in Chondroitin Sulfate Proteoglycan 4 (CSPG4) (c.391G>A [p.A131T], MAF 7.79×10-5 and c.2702T>G [p.V901G], MAF 2.51×10-3). The CSPG4A131T mutation was absent from the Swedish Schizophrenia Exome Sequencing Study (2536 cases, 2543 controls), while the CSPG4V901G mutation was nominally enriched in cases (11 cases vs. 3 controls, P=0.026, OR 3.77, 95% CI 1.05–13.52).	Schizophrenia	Proteome
177	29306698	9606	Blood	DSM-IV	Case-control based	ELISA	In men, CRP and homocysteine levels were associated with psychosocial dysfunction(interpersonal relationships and financial functioning, respectively). In women, CRP levels correlated with cognitive performance(SCIP total raw score, immediate and delayed verbal learning, and verbal fluency). CRP was a predictor of cognitive performance in women only.	Bipolar Disorder	Proteome
178	29353768	9606	Blood	DSM-IV	Case-control based	ELISA	Total leukocyte and neutrophil counts were measured together with interleukin(IL)-6, IL-8, IL-18, tumor necrosis factor(TNF)-脦卤 and high sensitivity C-reactive protein(hsCRP). Adjusted for confounders, leukocyte counts were 23% higher and neutrophil counts were 30% higher in patients with BD compared with HC. Due to confounding issues it cannot be concluded that differences were related to bipolar disorder per se.	Bipolar Disorder	Proteome
179	29374277	9606	Blood	DSM-IV	Case-control based	ELISA	We demonstrate that the insertion leads to nonsense-mediated decay and that CXorf56 mRNA expression is reduced in the impaired males and female.	Intellectual Disability	Proteome
180	29477585	9606	Blood	DSM-IV	Case-control based	ELISA	MOG and MAG serum levels were significantly higher in MDD patients than in controls.	Major Depressive Disorder	Proteome
181	29496589	9606	Brain		Case-control based	ELISA	TSPO VT was also 31-39% greater in the three primary grey-matter regions of participants with long duration of untreated major depressive disorder compared with healthy participants(p=0脗路00047).	Major Depressive Disorder	Proteome
182	29511299	9606	Brain	Others	Case-control based	Meta-analysis	Findings are summarised for these, which generally show reductions in SNAP-25, PSD-95, synapsin and rab3A protein levels in the hippocampus but inconsistency in other regions.	Schizophrenia	Proteome
183	29522177	10090	Brain(Medial prefrontal cortex)	Others	Case-control based	Western Blotting//Luciferase	miR-214-3p and miR-690 are Increased, β-Catenin Level is Decreased in mPFC of Depressed Mice	Major Depressive Disorder	Proteome
184	29529166	9606	Blood	Others	Case-control based	iTRAQ//ELISA	We identified three proteins from iTRAQ: C-reactive protein (CRP), zinc alpha-2 glycoprotein (AZGP1), and alpha-1 antichymotrypsin (SERPINA3).	Delirium	Proteome
185	29531242	9606	Blood	DSM-IV	Case-control based	Western blotting	DBP levels in BD participants were significantly higher(136%)than in participants without MMD(100%).	Bipolar Disorder	Proteome
186	29754444	9606	Blood(Serum)	Others	Case-control based	ELISA//MALDI-TOF-MS	These findings reveal the exceptional disease etiology of ASD from a serum proteomic perspective, and the identified proteins might be potential biomarkers for ASD diagnosis.	Autism Spectrum Disorder	Proteome
187	29959188	10090	Brain(Hippocampus)	Others	Case-control based	2D-PAGE//Mass Spectrometry	Combining two-dimensional gel electrophoresis (2D-PAGE) for protein separation with nanoUPLC-ESI-q-TOF tandem mass spectrometry, we identified sixty-three protein spots that changed in the hippocampus of mice subjected to chronic restraint stress.	Depressive Disorder	Proteome
188	29959188	10090	Brain(Hippocampus)	Others	Case-control based	2D-PAGE//Mass Spectrometry//Western blotting	Combining two-dimensional gel electrophoresis (2D-PAGE) for protein separation with nanoUPLC-ESI-q-TOF tandem mass spectrometry, we identified sixty-three protein spots that changed in the hippocampus of mice subjected to chronic restraint stress.	Depressive Disorder	Proteome
189	29961565	9606	Cell lines(iPSC)	Others	Case-control based	Immunoprecipitation//Western blotting	While DISC1 has been regularly described as a scaffold protein, the expression of DISC1 appears to be extremely low which is corroborated through both transcriptomic and proteomic data. Our results are also able to provide the first confirmation via immunoprecipitation followed by western for DISC1 interactors identified in Y2H screens including AKAP9, CEP170, and GRIPAP1. With DISC1 being implicated in a variety of psychiatric disorders, we also show a novel set of protein interactors contributing to complex brain disorders.	Neurodevelopmental Disorders	Proteome
190	30057029	9606	NA	Others	Case-control based	WES	FBXO11 encodes a member of the F-Box protein family, constituting a subunit of an E3-ubiquitin ligase complex. This complex is involved in ubiquitination and proteasomal degradation and thus in controlling critical biological processes by regulating protein turnover.	Neurodevelopmental Disorders	Proteome
191	30092259	9606	Blood	K-SADS-PL	Case-control based	PCR	Association of SNAP-25 rs3746544 with long-range FCD in all children with ADHD. Significantly increased long-range FCD of G-allele carriers compared with TT homozygous (uncorrected p<0.001, Alphasim corrected p<0.01).	Attention-Deficit/Hyperactivity Disorder	Proteome
192	30150678	9606	NA	Others	Family based	Western Blotting	We show that loss of MAP1B function affects general cognitive ability through a profound, brain-wide WM deficit with likely disordered or compromised axons.	Intellectual Disability	Proteome
193	30220511	10090	Brain	Others	Case-control based	Western Blotting	We found thatMen1protein and mRNA levels are significantly attenuated in cortex from both CUMS- and LPS-treated mice bywestern blottingand RT-PCR (Figures 1C and 1D).	Depressive Disorder	Proteome
194	30244532	9606	Blood(Plasma)	IRLSSG	Case-control based	2-DE//LC-Chip-MS//MS	In the present study, by a proteomic approach, we found an expression level of 15 protein spots, corresponding to 10 unique proteins, significantly altered in plasma of RLS patients.	Restless Legs Syndrome	Proteome
195	30388402	9606	Blood	Others	Case-control based	Western Blotting	The nuclear factor I (NFI) family of transcription factors play an important role in normal development of multiple organs. Three NFI family members are highly expressed in the brain, and deletions or sequence variants in two of these, NFIA and NFIX, have been associated with intellectual disability (ID) and brain malformations. NFIB, however, has not previously been implicated in human disease. Here, we present a cohort of 18 individuals with mild ID and behavioral issues who are haploinsufficient for NFIB.	Intellectual Disability	Proteome
196	30397230	9606	NA	Others	Case-control based	PCR	Modeling their impact on the three-dimensional structure demonstrates disturbance of critical binding and interaction motifs. Experimental assays with six of the identified mutations show that a subset directly affects ATPase activity, and all but one yield alterations in chromatin remodeling. We implicate de novo CHD3 mutations in a syndrome characterized by intellectual disability, macrocephaly, and impaired speech and language.	Intellectual Disability	Proteome
197	30397230	9606	NA	Others	Case-control based	ES//GS//Immunofluorescence//Three-dimensional Modeling	Taken together, with our research we identify a recognizable neurodevelopmental disorder. We define the phenotypic spectrum associated with mutations in CHD3, and show the effects of several different mutations on ATPase activity and chromatin remodeling capacities. Our findings highlight the importance of chromatin remodeling factors, and specifically the CHD3 protein, in human brain development.	Neurodevelopmental Disorders	Proteome
198	30420267	9606	Blood	Others	Case-control based	Ion Torrent	While no individual gene was significantly associated with schizophrenia after genome-wide correction for multiple testing, we strengthen the evidence that rare exonic variants in the ARC (p = 4.0 × 10–4) and NMDAR (p = 1.7 × 10–5) synaptic complexes are risk factors for schizophrenia.	Schizophrenia	Proteome
199	30527210	9606	NA	Others	Case-control based	NA	Here, they show additional upregulation of RelA and c-Rel subunits in schizophrenia. This is crucial because NF-κB1 and 2 lack transactivation domains and repress target gene expression when bound to DNA as homodimers. NF-κBs require heterodimerization with RelA, RelB, or cRel to activate target gene transcription; their elevation in the absence of corresponding increases in Rel protein(s) would dampen NF-κB immune response pathways.	Schizophrenia	Proteome
200	30531907	9606	NA	Others	Case-control based	Western Blotting	A prototypic disorder involving an altered ubiquitination enzyme is X-linked intellectual disability (XLID)-type Nascimento, related to abnormalities in the UBE2A gene. We identified a novel missense mutation c.277C>G (p.Q93E) in UBE2A. We found that the Q93E mutation yields an enzyme with impaired ability to transfer ubiquitin to lysine, thereby inhibiting product formation. The defect is not rescued by the presence of an E3 ligase (RAD18) toward a specific UBE2A target, PCNA.	Intellectual Disability	Proteome
201	30545964	9606	Brain	Others	Case-control based	RNA-Seq	We identified one hub gene, POU class 3 homeobox 2 (POU3F2), as the master regulator in the disease-associated module for schizophrenia and bipolar disease.	Schizophrenia	Proteome
202	30575805	9606	Blood	MINI	Case-control based	PCR//TaqMan//Immunoblotting	The data reported here suggest that TSPO-VDAC complex upregulation in BD patients, the simultaneous downregulation of mitophagic proteins and NLRP3 inflammasome activation could lead to an accumulation of dysfunctional mitochondria, resulting in inflammation and apoptosis. In summary, the findings of this study provide novel evidence that mitochondrial dysfunction measured in peripheral blood is associated with BD.	Bipolar I Disorder	Proteome
203	30580808	9606	NA	Others	Case-control based	WES	The chromatin-remodeling complex BRG1-associated factor (BAF) plays an essential role in the regulation of gene expression and higher-order chromatin organization by modulating the nucleosome and changing chromatin conformation and accessibility. BAFopathies are a heterogeneous group of disorders caused by mutations in the various subunits composing the BAF complex. The clinical phenotypic spectrum of BAFopathies is wide and involves various human neurodevelopmental disorders. Neurodevelopmental disorders associated with pathogenic variants in BAF chromatin remodeling complex subunits present overlapping clinical phenotype.	Neurodevelopmental Disorders	Proteome
204	30595372	9606	Cell lines(HEK293T)	Others	Case-control based	Pull-down	PP2A is an important holoenzyme for which broad substrate specificity is orchestrated by different subunit compositions: in particular, the B subunits play a pivotal role in determining substrate specificity, regulation, and hence physiologic functions of the different PP2A complexes. With this broad specificity, PP2A is involved in diverse cellular processes, and variants in either of these subunits could therefore cause disease. Here, we report the identification of a syndrome caused by de novo mutations in PPP2CA and characterized by mild to profound ID and DD, behavioral problems, variable types of epilepsy, hypotonia, abnormal head circumference, and brain abnormalities such as corpus callosum abnormalities and ventriculomegaly.	Neurodevelopmental Disorders	Proteome
205	30595372	9606	Cell lines(HEK293T)	Others	Case-control based	Pull-down	So far, detailed studies on de novo mutations in both genes encoding the C subunit (PPP2CA and PPP2CB) have not been reported. Yet, ID- and DD-related mutations in genes involved in C subunit regulation have been identified. we provide functional evidence for a mutation-specific pathophysiological mechanism resulting in at least a common impairment of PP2A-B56δ holoenzyme functionality.	Intellectual Disability	Proteome
206	30610203	9606	Brain	Others	Case-control based	Western Blotting//Genotyping	Here, we combine multiple strategies to identify genetic variations within the CPG2 locus of SYNE1 that influence expression or function of the CPG2 protein. Linking BD associated variation with an underlying cellular dysfunction is an opportunity afforded by only a few GWAS hits in human genetics for neuropsychiatric disorders to date.	Bipolar Disorder	Proteome
207	30617377	9606	Blood	DSM-V	Case-control based	ELISA	This case-control study was conducted in the Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey in 2015. One hundred and four patients diagnosed as having bipolar disorder (DSM5 criteria), and 96 participants were included as healthy controls in this study. A human YKL-40 enzyme-linked immunosorbent assay (ELISA) kit was used to measure the serum YKL-40 levels. As independent variables, we collected data on C-reactive protein (CRP), demographic variables, and medications.	Bipolar Disorder	Proteome
208	30741686	9606	brain	Others	Case-control based	Western Blotting//RT-qPCR	Our data indicate that the level of HSP90, SGT1 and CHP-1 is upregulated in the majority of cases of PD and DLB, which suggests that the examined proteins might be involved in these pathologies	Neurocognitive Disorder With Lewy Bodies	Proteome
209	30890645	9606	NA	Others	Case-control based	Western Blotting	The present results demonstrate a key role of sEH in the pathogenesis of neurodevelopmental disorders in offspring after MIA. The major findings of the present study are as follows: First, expression of sEH protein in the PFC from juvenile offspring after MIA was higher than that of control group.Second, we found higher expression of EPHX2 mRNA in the neurospheres from iPSC of schizophrenia patients compared with healthy controls.	Neurodevelopmental Disorders	Proteome
210	30921354	9606	Cell lines(Lymphoblastoid)	ADI-R	Case-control based	2D-PAGE//MS	By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study.	Autism Spectrum Disorder	Proteome
211	30921354	9606	Cell lines(Lymphoblastoid)	ADI-R	Case-control based	2D-PAGE//MS	Table4 List of the top differentially expressed proteins in ASD with severe language impairment.	Autism Spectrum Disorder	Proteome
212	30921354	9606	Cell lines(Lymphoblastoid)	ADI-R	Case-control based	2D-PAGE//MS //Western blotting	By subgrouping individuals with ASD based on clinical phenotypes, and then performing an integrated transcriptome-proteome analysis, we identified DBI as a novel candidate protein for ASD with severe language impairment. The mechanisms of this protein and its potential use as an ASD biomarker warrant further study.	Autism Spectrum Disorder	Proteome
213	30929742	9606	NA	Others	Case-control based	Lipid-mixing Assay	In total, we identified two single-amino-acid deletions and three non-synonymous variants affecting conserved residues within the C terminus of the VAMP2 SNARE motif. Affected individuals carrying de novo non-synonymous variants involving the C-terminal region presented a more severe phenotype with additional neurological features, including central visual impairment, hyperkinetic movement disorder, and epilepsy or electroencephalography abnormalities.	Neurodevelopmental Disorders	Proteome
214	30941018	9606	Blood(Peripheral blood mononuclear cells)	DSM-IV	Case-control based	iTRAQ//LC-MS//MS	The results showed a total of 41 proteins as differentially expressed in autistic group as compared to control. These proteins are found associated with metabolic pathways, endoplasmic reticulum (ER) stress and protein folding, endocytosis, immune and inflammatory response, plasma lipoprotein particle organization, and cell adhesion.	Autism Spectrum Disorder	Proteome
215	31081034	9606	NA	Others	Case-control based	DNA Binding Assay//Crystallography	The psychiatric risk-associated transcription factor 4 (TCF4) is linked to schizophrenia. Rare TCF4 coding variants are found in individuals with Pitt-Hopkins syndrome—an intellectual disability and autism spectrum disorder.Our analyses indicate, and suggest a structural basis for, the preferential recognition of 5caC by a transcription factor centrally important in brain development.	Schizophrenia	Proteome
216	31174490	9606	Cell lines(BL21 cells)	Others	Case Report	Colorimetric Acetylation Assay	Functional characterization of NAA10-R83H by in vitro acetylation assays revealed a reduced enzymatic activity of monomeric NAA10-R83H. This variant is modelled to have an altered charge density in the acetyl-coenzyme A (Ac-CoA) binding region of NAA10	Attention-Deficit/Hyperactivity Disorder	Proteome
217	31291891	9606	Blood	ICD-10	Case-control based	MS	Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins. Comparison of proteome profiles of different groups revealed 27 proteins being specific for schizophrenia, and 18 – for BD. Protein set in schizophrenia was mostly associated with immune response, cell communication, cell growth and maintenance, protein metabolism and regulation of nucleic acid metabolism.	Bipolar Disorder	Proteome
218	31291891	9606	Serum	ICD-10	Case-control based	MS//ELISA	Purpose of study is revealing significant differences in serum proteomes in schizophrenia and bipolar disorder (BD). Quantitative mass-spectrometry based proteomic analysis was used to quantify proteins in the blood serum samples after the depletion of six major blood proteins. Comparison of proteome profiles of different groups revealed 27 proteins being specific for schizophrenia, and 18 – for BD. Protein set in schizophrenia was mostly associated with immune response, cell communication, cell growth and maintenance, protein metabolism and regulation of nucleic acid metabolism.	Bipolar Disorder	Proteome
219	31296563	9606	NA	Others	Case-control based	NA	O-GlcNAc transferase (OGT) is an X-linked gene product that is essential for normal development of the vertebrate embryo. It catalyses the O-GlcNAc posttranslational modification of nucleocytoplasmic proteins and proteolytic maturation of the transcriptional coregulator Host cell factor 1 (HCF1). Recent studies have suggested that conservative missense mutations distal to the OGT catalytic domain lead to X-linked intellectual disability in boys.	Intellectual Disability	Proteome
220	31327001	9606	Embryonic	Others	Case-control based	Immunostaining	WDFY3 encodes for autophagy-linked FYVE protein (also named ALFY), a large multidomain scaffolding protein implicated in the selective degradation of ubiquitinated protein aggregates by autophagy and clearance of mitochondria via mitophagy.	Neurodevelopmental Disorders	Proteome
221	31477693	9606	Cell lines(iPSC)	DSM-IV	Case-control based	Bradford Assay	Messenger RNA and corresponding protein levels in cells correlate poorly due to variation in processes controlling steady-state mRNA or protein abundances. To investigate whether protein expression is changed in cortical neurons of monozygotic twins discordant for schizophrenia, proteomic analysis was performed at the peptide, phosphopeptide, and protein levels in pairwise comparisons.	Schizophrenia	Proteome
222	31547145	9606	Cerebrospinal fluid	MMSE	Case-control based	ELISA//SRM	The strong associations with cognitive decline further points out VGF as a possible disease stage or prognostic marker for DLB.	Neurocognitive Disorder With Lewy Bodies	Proteome
223	31563744	10090	Feces	Others	Case-control based	Two-dimensional PAGE//LC-MS//MS	Table 1.Identified bacterial proteins in feces of mice*	Anorexia Nervosa	Proteome
224	31585809	9606	NA	Others	Case-control based	PCR//Sanger Sequencing//WES//Western Blotting//HumanCytoSNP-12 300k//RNA-seq//q-PCR	In humans, disruption of nonsense-mediated decay (NMD) has been associated with neurodevelopmental disorders (NDDs) such as autism spectrum disorder and intellectual disability.Here we identified novel protein-coding UPF2 (UP-Frameshift 2) variants in humans with NDD, including speech and language deficits.	Neurodevelopmental Disorders	Proteome
225	31600826	9606	Cell lines(CHO-k1)	Others	Case-control based	immunocytochemistry-flow cytometry.	KCNB1 [NM004975] encodes the KV2.1 voltage-gated potassium (K) channel α-subunit that conducts delayed rectifier K current++, a key modulator of membrane repolarization in electrically excitable cells, including various neuron subtypes.De novo missense variants in KCNB1 are associated with DEE, which includes multiple seizure types, developmental delay (DD), and neuropsychiatric sequelae.	Neurodevelopmental Disorders	Proteome
226	31619735	9606	Brain	Others	Case-control based	ELISA	In this study, protein expression levels of DARPP-32 and CaN were measured by enzyme-linked immunosorbent assay (ELISA) in the prefrontal cortex (PFC), and nucleus accumbens (NAc) of 49 postmortem samples from subjects with schizophrenia, bipolar disorder, and normal controls. We also examined the association between this expression and genetic variants of 8 dopaminergic system-associated molecules for 55 SNPs in the same postmortem samples.	Bipolar Disorder	Proteome
227	31642882	9606	Brain	Others	Case-control based	MS	These findings suggest a robust and highly coordinated rearrangement of the synaptic proteome. In line with unbiased genetic findings, alterations in synaptic levels of postsynaptic proteins were identified, providing a road map to identify the specific cells and circuits that are impaired in individuals with schizophrenia A1.	Schizophrenia	Proteome
228	31759698	9606	Cell lines(293T//iPSC)	Others	Case-control based	Western Blotting	Mammalian SWI/SNF (BAF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the subunit- and domain- specific contributions to complex activities is required to advance mechanistic understanding. Here we examine the molecular, structural, and genome-wide regulatory consequences of recurrent, single- residue mutations in the putative coiled-coil C-terminal domain (CTD) of the SMARCB1 (BAF47) subunit which cause the intellectual disability disorder.	Intellectual Disability	Proteome
229	31788733	9606	Blood	DSM-IV	Case-control based	KASP	In this study, we aimed to replicate previous findings that demonstrated altered CRP levels in BD, and to investigate whether there is an association of peripheral protein expression with genetic variants in the CRP gene.	Bipolar Disorder	Proteome
230	31794024	9606	NA	Others	Family based	RT-PCR	As the TRAPPC4 c.454+3A>G variant resulted in a significant reduction of full-length protein on denaturing PAGE, and TRAPPC4 is a core subunit of the TRAPPII and TRAPPIII complexes. We speculate that the reduced levels of all TRAPPC4-containing complexes (which include TRAPP II and III) account for the cellular phenotypes and the pleiotropic clinical phenotypes.	Intellectual Disability	Proteome
231	31813652	10090	Brain	Others	Case-control based	Immunocytochemistry	Variants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder. However, no upstream regulators of ankyrin-G at synapses are known. Here, we show that ankyrin-G interacts with Usp9X, a neurodevelopmental disorder-associated deubiquitinase (DUB). Usp9X phosphorylation enhances their interaction, decreases ankyrin-G polyubiquitination, and stabilizes ankyrin-G to maintain dendritic spine development.	Neurodevelopmental Disorders	Proteome
232	31836389	9606	iPSC	Others	Case-control based	qRT-PCR//Immunoblotting	Dysregulation of cellular protein synthesis is linked to a variety of diseases. Mutations in EIF2S3, encoding the γ subunit of the heterotrimeric eukaryotic translation initiation factor eIF2, cause MEHMO syndrome, an X-linked intellectual disability disorder. Here, using patient-derived induced pluripotent stem cells, we show that a mutation at the C-terminus of eIF2γ impairs CDC123 promotion of eIF2 complex formation and decreases the level of eIF2–GTP–Met-tRNAiMet ternary complexes.	Intellectual Disability	Proteome
233	31841327	9606	NA	Others	Case-control based	Western Blotting	ULK1, ULK2, and ULK3 have been characterized, very little is known about ULK4. However, recently, deletions in ULK4 have been genetically linked to increased susceptibility to developing schizophrenia, a devastating neuropsychiatric disease with high heritability but few genes identified. Interestingly, ULK4 is a pseudokinase with some unusual mutations in the kinase catalytic motifs. Here, we report the first structure of the human ULK4 kinase at high resolution.	Schizophrenia	Proteome
234	31955054	9606	Blood	SCID-I//SCID-II//CGI-BPID//GAF//BIS-11//HARS//MADRS	Case-control based	Western Blotting//ELISA	A significant decrease of IκBα levels and a significant increase of inflammatory factors, including NFκB, COX2 and iNOS levels were found in patients. On the other hand, a significant decrease was observed for all antioxidant enzymes in patients with BPD, except for HO1. The inflammatory factor NFκB showed a significant positive correlation with impulsivity scores.	Borderline Personality Disorder	Proteome
235	31957460	9606	Blood	DSM-Ⅴ//IGD Scale//Perceived Stress Scale	Case-control based	Immunoassay	We identified elevation of orexin A in the peripheral blood of adolescents with IGD and a negative correlation between Internet gaming time and BDNF in adolescents with IGD.	Internet Gaming Disorder	Proteome
236	32010779	9606	NA	Others	Case-control based	Sanger Sequencing//ES//Immunoblotting//Histone Acylation Assays	Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23). We report that these complexes also catalyze H3K23 propionylation in vitro and in vivo. Immunofluorescence microscopy and ATAC-See revealed the association of this modification with active chromatin.	Neurodevelopmental Disorders	Proteome
237	32065947	9606	Brain	DSM-IV	Case-control based	ELISA//Illumina	The levels of ALDH4A1 protein expression in the PFC and STG in postmortem brains from 24 patients with schizophrenia, 8 patients with bipolar disorder, and 32 controls were assessed using enzyme-linked immunosorbent assay. ALDH4A1 levels were significantly elevated in both the PFC and STG in patients with schizophrenia and tended to elevate in patients with bipolar disorder.	Bipolar Disorder	Proteome
238	32194463	9606	Cerebrospinal fluid	CAM	Case-control based	LC-MS//MS//PRM	We identified and validated several novel CSF proteins that are dysregulated in POD, and revealed several pathways that are relevant to POD development.	Delirium	Proteome
239	32216002	9606	NA	Others	Case-control based	Immunoblotting	The highly disruptive, loss-of-function impact of the de novo R311C mutation in human CaMKK2 provides a compelling functional rationale for being considered a potential rare monogenic cause of bipolar disorder.	Bipolar Disorder	Proteome
240	32245436	9606	Blood	DSM-IV//DSM-V	Case-control based	LC-MS//MS	Ras-related protein Rab-7a, Rho-associated protein kinase 2, and Exportin-7 were identified as potential peripheral protein candidates to distinguish major depressive disorder and bipolar disorder. Further large sample studies with longitudinal designs and validation processes are warranted.	Bipolar Disorder	Proteome
241	32294144	10116	Brain(Hippocampus)	Others	Case-control based	2D-DIGE//MALDI-TOF-MS//MS	The six altered proteins (≥2-fold) were identified in group (+M10) when compared with group (M10) by two-dimensional fluorescence difference gel electrophoresis (2D-DIGE).	Opioid Use Disorder	Proteome
242	32339108	9606	Brain	DSM-IV	Case-control based	MS	Since the molecular mechanism of BD psychosis is elusive, we conducted this study to explore the proteomic differences associated with BD psychosis in the dorsolateral prefrontal cortex (DLPFC; BA9). Postmortem DLPFC gray matter tissues from five pairs of age-matched male BD subjects with and without psychosis history were used. Tissue proteomes were identified and quantified by label-free liquid chromatography tandem mass spectrometry and then compared between groups. Statistical significance was set at q < 0.40 and Log2 fold change (Log2FC) ≥ |1|. Protein groups with differential expression between groups at p < 0.05 were subjected to pathway analysis.	Bipolar Disorder	Proteome
243	32339108	9606	Brain	DSM-IV	Case-control based	MS//Western Blotting	Since the molecular mechanism of BD psychosis is elusive, we conducted this study to explore the proteomic differences associated with BD psychosis in the dorsolateral prefrontal cortex (DLPFC; BA9). Postmortem DLPFC gray matter tissues from five pairs of age-matched male BD subjects with and without psychosis history were used. Tissue proteomes were identified and quantified by label-free liquid chromatography tandem mass spectrometry and then compared between groups. Statistical significance was set at q < 0.40 and Log2 fold change (Log2FC) ≥ |1|. Protein groups with differential expression between groups at p < 0.05 were subjected to pathway analysis.	Bipolar Disorder	Proteome
244	32377000	9606	NA	Others	Case-control based	NA	The expanding list of loci associated with schizophrenia includes numerous genes encoding proteins that are critically regulated by glycosylation. Notable examples include glutamate receptors, voltage gated calcium channels, the dopamine D2 receptor, and complement-associated proteins, all of which have enriched expression in the brain.	Schizophrenia	Proteome
245	32398672	9606	Cerebrospinal fluid	ICD	Case-control based	LC-MS	Here we investigate the cerebrospinal fluid proteome of psychiatric patients focusing on MDD by deep proteomic profiling approach combined with a further validation step using targeted mass spectrometry. We demonstrate profound CSF proteomic changes during on-going depression episodes in MDD patients (n = 40) in comparison to controls (n = 27), schizophrenia spectrum disorder (n = 13), and bipolar disorder patients (n = 11).	Major Depressive Disorder	Proteome
246	32398672	9606	Cerebrospinal fluid	ICD	Case-control based	LC-MS//Immunoblotting	Here we investigate the cerebrospinal fluid proteome of psychiatric patients focusing on MDD by deep proteomic profiling approach combined with a further validation step using targeted mass spectrometry. We demonstrate profound CSF proteomic changes during on-going depression episodes in MDD patients (n = 40) in comparison to controls (n = 27), schizophrenia spectrum disorder (n = 13), and bipolar disorder patients (n = 11).	Major Depressive Disorder	Proteome
247	32399469	9606	NA	Others	Case-control based	NA	EAAT2 is a promising target for elucidating the mechanisms by which the glutamate-glutamine cycle interacts with neuronal systems in mood disorders. Forty EAAT2 studies (published January 1992–January 2018) were identified via a systematic literature search.	Bipolar Disorder	Proteome
248	32415109	9606	Blood	Others	Case-control based	WES	Kinesin superfamily proteins (KIFs) are important molecular motors that control MT organization and dynamics in both axons and dendrites and mediate intracellular transport of various cargo, including vesicles, organelles, cellular proteins and mRNAs, along MTs. The importance of both the force-generating and MT-regulating functions of KIFs for brain development has become evident with loss of function studies demonstrating defects in mitosis, cytokinesis, polarity3, migration, axonal growth and branching, survival and synaptogenesis.	Neurodevelopmental Disorders	Proteome
249	32439851	9606	Cerebrospinal fluid	MINI	Case-control based	Multiplex Immunoassay	To examine the role of neuroplasticity in the pathology of psychiatric disorders, we measured cerebrospinal fluid (CSF) neuroplasticity-associated protein levels. Participants were 94 patients with schizophrenia, 68 with bipolar disorder (BD), 104 with Major Depressive Disorderr (MDD), and 118 healthy controls, matched for age, sex, and ethnicity (Japanese).	Major Depressive Disorder	Proteome
250	32439851	9606	Cerebrospinal fluid	DSM-IV	Case-control based	Multiplex Immunoassay	To examine the role of neuroplasticity in the pathology of psychiatric disorders, we measured cerebrospinal fluid (CSF) neuroplasticity-associated protein levels. Participants were 94 patients with schizophrenia, 68 with bipolar disorder (BD), 104 with major depressive disorder (MDD), and 118 healthy controls, matched for age, sex, and ethnicity (Japanese).	Bipolar Disorder	Proteome
251	32507511	9606	NA	Others	Case-control based	NA	Relatedly, the CHD protein family comprises multiple isoforms with different roles in the distinct stages of neurodevelopment (reviewed in), from the early stages of migration to the maturation of synaptic connectivity.	Neurodevelopmental Disorders	Proteome
252	32507511	9606	NA	Others	Case-control based	NA	Multiple variants affecting negative regulators of the growth factor and amino acid-sensing arms (such as TSC1, TSC2, and PTEN or DEPDC5, NPRL2, and NPRL3, respectively) are known to cause hyperactivation of mTORC1 and have been reported in individuals with NDDs。	Neurodevelopmental Disorders	Proteome
253	32552841	9606	Cerebrospinal fluid	Others	Case-control based	LC//MS	In the discovery cohort, 69 proteins were differentially expressed in DLB compared to controls (p<0.05). Independent cohort replication confirmed VGF, SCG2, NPTX2, NPTXR, PDYN and PCSK1N as candidate biomarkers for DLB.	Neurocognitive Disorder With Lewy Bodies	Proteome
254	32552841	9606	Cerebrospinal fluid	Others	Case-control based	LC//MS//ELISA//SRM	In the discovery cohort, 69 proteins were differentially expressed in DLB compared to controls (p<0.05). Independent cohort replication confirmed VGF, SCG2, NPTX2, NPTXR, PDYN and PCSK1N as candidate biomarkers for DLB.	Neurocognitive Disorder With Lewy Bodies	Proteome
255	32552841	9606	Cerebrospinal fluid	Others	Case-control based	LC//MSn//SRM//ELISA	In the discovery cohort, 69 proteins were differentially expressed in DLB compared to controls (p<0.05). Independent cohort replication confirmed VGF, SCG2, NPTX2, NPTXR, PDYN and PCSK1N as candidate biomarkers for DLB.	Neurocognitive Disorder With Lewy Bodies	Proteome
256	32592865	9606	Cerebrospinal fluid	DSM-IV//DSM-Ⅴ	Case-control based	Proximity Extension Assay	Eight inflammatory proteins (4%), including the key neuron-microglia communication marker CX3CL1 (fractalkine), were significantly upregulated in both Delirium and AD, compared to infectious patients without Delirium. Likewise, 23 proteins (13%) showed downregulation in both Delirium and AD, relative to infectious patients without Delirium	Delirium	Proteome
257	32620897	9606	Blood	Others	Case-control based	WES	The human patients with similar C-terminal UNC80 truncations have basic motor skills, but lack fine motor coordination, do not have speech development, and have severe intellectual disability. Our results establish the subunit composition of the NALCN complex, uncover the inter-subunit interaction domains, reveal the functional significance of regulation of dendritic membrane potential by the sodium-leak channel complex, and provide evidence supporting that genetic variations found in individuals with intellectual disability are the causes for the phenotype observed in patients.	Intellectual Disability	Proteome
258	32703943	9606	NA	Others	Case-control based	NA	FMRP loss-of-function leads to Fragile X syndrome (FXS), a rare genetic developmental condition causing a range of neurological alterations including intellectual disability (ID), learning and memory impairments, autistic-like features and seizures.	Intellectual Disability	Proteome
259	32740913	9606	Blood(Plasma)	DSM-IV-TR//SCID-I//SCID-II//CGI-BPD//GAF//ZKPQ-III	Case-control based	ELISA//Western Blotting	Oxytocin plasma levels were significantly lower in BPD patients compared with controls. In addition, protein expression of oxytocin receptor was significantly reduced in the BPD group	Borderline Personality Disorder	Proteome
260	32748386	9606	Semen	Others	Case-control based	Western Blotting	Also, protamine-2 protein concentrations were quantified by nuclear protein extraction, SDS-Page and western blotting.	Heroin Addiction	Proteome
261	32929213	9606	NA	Others	Case-control based	RNA-seq//Western blotting	Here we report that POU3F2 regulates 42 SCZ-related genes in knockdown and RNA sequencing experiments of human neural progenitor cells (NPCs). Among those SCZ-related genes, TRIM8 (Tripartite motif containing 8) is located in SCZ-associated genetic locus and is aberrantly expressed in patients with SCZ.	Schizophrenia	Proteome
262	32992101	9606	Blood	IRLSSG//ISI//PSQI	Case-control based	LC-MS//MS//MALDI-TOF-MS	Table2.Identified differentially expressed proteins in patients with iRLS compared to healthy controls by mass analysis.	Restless Legs Syndrome	Proteome
263	32992101	9606	Blood	IRLSSG//ISI//PSQI	Case-control based	LC-MS//MS//Western Bloting//MALDI-TOF-MS	Table2.Identified differentially expressed proteins in patients with iRLS compared to healthy controls by mass analysis.	Restless Legs Syndrome	Proteome
264	32992101	9606	Blood	IRLSSG//ISI//PSQI	Case-control based	LC-MS//MS //MALDI-TOF-MS	Table2.Identified differentially expressed proteins in patients with iRLS compared to healthy controls by mass analysis.	Restless Legs Syndrome	Proteome
265	33168801	9606	Cell lines(iPSC//iPSC-NSC)	Others	Case-control based	Immunocytochemistry	Here, we performed quantitative proteomics and whole-genome sequencing (WGS). Quantitative proteomics revealed NLRP2 as the most significantly up-regulated protein in neural stem cells and mature neural cells obtained from BD-patient cell samples. These results are in concordance with our previously published transcriptome analysis. Furthermore, the levels of FEZ2 and CADM2 proteins were also significantly differentially expressed in BD compared to control derived cells. The levels of FEZ2 were significantly downregulated in neural stem cells (NSC) while CADM2 was significantly up-regulated in mature neuronal cell culture. Promising novel candidate mutations were identified in the ANK3, NEK3, NEK7, TUBB, ANKRD1, and BRD2 genes.	Bipolar Disorder	Proteome
266	33398084	9606	NA	Others	Case-control based	Coimmunoprecipitation Assay//Confocal Microscopy//SIM Imaging//PLA//FRAP	The ankyrin-G 190 and Homer1 interaction regulates spine stability, revealing novel mechanisms underlying spine structure that may be relevant to neuropsychiatric disease.	Neurodevelopmental Disorders	Proteome
267	33414502	9606	NA	Others	Case-control based	NA	Collectively, these data indicate the potential of PDE modulators to treat neurodevelopmental diseases characterized by learning and memory impairment, alteration of behaviors associated with depression, and deficits in social interaction.	Neurodevelopmental Disorders	Proteome
268	33436571	9606	Brain	DSM-IV	Case-control based	qRT-PCR	We quantified levels of NF-κB-related mRNAs in the prefrontal cortex of 35 matched pairs of bipolar disorder and unaffected comparison subjects using quantitative PCR. We found that transcript levels were higher in the prefrontal cortex of bipolar disorder subjects for several NF-κB family members, NF-κB activation receptors, and NF-κB-regulated mRNAs, and were lower for an NF-κB inhibitor.	Bipolar Disorder	Proteome
269	33451315	9606	Blood	DSM-IV	Case-control based	MRM	A total of 111 proteins obtained from literature review were subjected to multiple reaction monitoring (MRM)-based protein quantitation. Finally, seven proteins were quantified for plasma specimens of 10 healthy controls and 78 MDD patients (those at baseline and at 6 weeks after antidepressant treatment of either selective serotonin reuptake inhibitors (SSRIs) or mirtazapine).	Major Depressive Disorder	Proteome
270	33526823	9606	Brain	DSM-IV	Case-control based	Phosphoproteomics	Using an unbiased phosphoproteomics approach, we quantified 18 MAP2 phosphopeptides, 9 of which were significantly altered in Sz subjects. Network analysis grouped MAP2 phosphopeptides into three modules, each with a distinct relationship to dendritic spine loss, synaptic protein levels, and clinical function in Sz subjects.	Schizophrenia	Proteome
271	33539520	9606	Blood	CAM-S LF	Case-control based	SOMAscan	Using an unbiased phosphoproteomics approach, we quantified 18 MAP2 phosphopeptides, 9 of which were significantly altered in Sz subjects. Network analysis grouped MAP2 phosphopeptides into three modules, each with a distinct relationship to dendritic spine loss, synaptic protein levels, and clinical function in Sz subjects.	Delirium	Proteome
272	33539520	9606	Blood	CAM-S LF	Case-control based	SOMAscan	Supplemental Table 2B. Up-Regulated and Down-Regulated Proteins between Delirium Cases and Controls at Postoperative day 2 (POD2)	Delirium	Proteome
273	33539520	9606	Blood	CAM-S LF	Case-control based	SOMAscan//ELISA	Supplemental Table 2B. Up-Regulated and Down-Regulated Proteins between Delirium Cases and Controls at Postoperative day 2 (POD2)	Delirium	Proteome
274	33632302	9606	Cell lines(retinal epithelium//embryonic kidney )	Others	Case-control based	RT-PCR//Western Blotting	We present a new recessive coatopathy typified by severe developmental delay and cataracts and variable microcephaly. A homozygous splice donor site variant in Family 1 results in two aberrant transcripts, one of which causes skipping of exon 8 in COPB1 pre-mRNA, and a 36 amino acid in-frame deletion, resulting in the loss of a motif at a small interaction interface between β-COP and β’-COP.	Intellectual Disability	Proteome
275	33656268	9606	NA	Others	Case-control based	ChIP-seq	ChIP‐seq analyses suggested that LDB2 cooperates with the EGR transcription factors, whose genes are associated with schizophrenia, to control synaptogenesis‐related genes including Arc/ARC. These results suggest that the LDB2‐EGR signaling cascade has a role in psychiatric diseases including schizophrenia and bipolar disorder.	Schizophrenia	Proteome
276	33843443	9606	NA	Others	Case-control based	NA	WDR45/WIPI4 is a WD-repeat β-propeller protein that belongs to the WIPI (WD repeat domain, phosphoinositide interacting) family. The precise cellular function of WDR45 is still largely unknown, but deletions or conventional variants in WDR45 can lead to macroautophagy/autophagy defects, malfunctioning mitochondria, endoplasmic reticulum stress and unbalanced iron homeostasis, suggesting that this protein functions in one or more pathways regulating directly or indirectly those processes.	Neurodevelopmental Disorders	Proteome
277	33909990	9606	Blood	Formal cognitive-behavioral assessments	Case-control based	WES//Gene Panel Sequencing//DNAm Microarray	Truncating variants in exons 33 and 34 of the SNF2-related CREBBP activator protein (SRCAP) gene cause the neurodevelopmental disorder (NDD) Floating-Harbor syndrome (FLHS), characterized by short stature, speech delay, and facial dysmorphism. Here, we present a cohort of 33 individuals with clinical features distinct from FLHS and truncating (mostly de novo) SRCAP variants either proximal (n = 28) or distal (n = 5) to the FLHS locus.	Neurodevelopmental Disorders	Proteome
278	33915220	9606	Blood	MINI	Case-control based	Microarray	Major Depressive Disorderr (MDD) and type 2 diabetes mellitus (T2DM) are common public health disorders that often co-occur. This study aims to determine whether gene expression profiles from individuals with MDD or T2DM overlap and if there are any functional interconnectivity between identified genes using protein-protein interaction (PPI).	Major Depressive Disorder	Proteome
279	34016951	10116	Brain(Hippocampus)	DSM-IV	Case-control based	Western Blotting	Total and phosphorylated (p)STAT3 protein levels were also increased in the hippocampus during withdrawal after chronic alcohol exposure.	Alcohol Withdrawal	Proteome
280	34020708	9606	NA	Others	Family based	WES//WGS//Sanger Sequencing	We confirmed that DHX30 is an ATP-dependent RNA helicase, and showed that DHX30 is essential for stress granule assembly in cellular and in vivo models. Missense variants in helicase core motifs lead to a loss of ATPase and helicase activity, concomitant with a gain-of-function with respect to SG formation, and a severe phenotype. In contrast, DHX30 loss-of-function variants are associated with a milder phenotype.	Neurodevelopmental Disorders	Proteome
281	34028503	9606	iPSC	Others	Case-control based	Flow Cytometry//Confocal Microscopy	SLC6A1 variants are associated with a wide spectrum of neurodevelopmental disorders.Because GABA, GABAA receptors, and transporters work in concert to reach a dynamic homeostasis of GABA signalling that influences brain development and regulates GABAergic synaptic neurotransmission and plasticity, the defects in different components in the same pathways eventually converge and give rise to similar disease phenotypes.	Neurodevelopmental Disorders	Proteome
282	34102099	9606	NA	Others	Case-control based	NA	Adaptor protein (AP) complexes mediate selective intracellular vesicular trafficking and polarized localization of somatodendritic proteins in neurons. Disease-causing alleles of various subunits of AP complexes have been implicated in several heritable human disorders, including intellectual disabilities (IDs). Here, we report two bi-allelic and eight de novo heterozygous variants.	Neurodevelopmental Disorders	Proteome
283	34112563	9606	Blood	Telephone-Montreal Cognitive Assessment//PROMIS questionnaires	Case-control based	qRT-PCR	FGF-21, FGF-23, interleukin-6, and monocyte chemotactic protein-3 serum levels were increased postoperatively in patients who developed Delirium after major cardiac surgery.	Delirium	Proteome
284	34161705	9606	NA	Others	Family based	WES	Our work shows the clinical significance of dysfunctional autophagy in humans. We identified five unrelated families with deleterious, recessive variants in human ATG7, a gene encoding an essential effector enzyme for canonical autophagy.	Neurodevelopmental Disorders	Proteome
285	34188164	10090	Blood	Others	Case-control based	Sanger Sequencing//High-throughput Sequencing	Informed by these neurobehavioral features in mouse mutants, we searched for and identified five families with pathogenic NEUROD2 mutations associated with intellectual disability, ASD, hyperactivity, and speech delay, with or without epilepsy. These features overlap with those uncovered in the mouse studies, demonstrating the necessity of NEUROD2 for normal brain development and revealing the region-specific contributions of dysfunctional NEUROD2 to intellectual disability.	Neurodevelopmental Disorders	Proteome
286	34234594	9606	Blood	Others	Case-control based	LC-MS//MS	Among the 243 shared proteins 14 proteins differ considerably, of which 5 were upregulated and 9 were downregulated in RLS compared to healthy controls	Restless Legs Syndrome	Proteome
287	34286667	9606	NA	Others	Case-control based	CRISPR-Cas9//Oxidative Stress Quantification//Western Blotting//Neuronal Differentiation//Micro-electrode Array//Quantitative Polymerase Chain Reaction	Here, we investigate the role in autophagy of KANSL1, a member of the nonspecific lethal complex, which acetylates histone H4 on lysine 16 (H4K16ac) to facilitate transcriptional activation. Loss-of-function of KANSL1 is strongly associated with the neurodevelopmental disorder Koolen-de Vries Syndrome (KdVS).	Neurodevelopmental Disorders	Proteome
288	34330827	9606	Brain	Others	Case-control based	Western Blotting	We show that SCZ patients are characterized by an excess of active CRMP2 not only in their brains (where it is correlated with dendritic abnormalities) but also in their peripheral blood lymphocytes. The abundance of active CRMP2 and insufficiency of opposing inactive p-CRMP2 likely disrupts neuronal function. Because peripheral blood CRMP2 appears to reflect intracerebral processes, it could form the basis of a rapid, minimally invasive, sensitive, and specific clinical diagnostic aid for SCZ in young patients.	Schizophrenia	Proteome
289	34341569	9606	NA	Others	Case-control based	NA	Studies have delineated key roles for IL-6, IL-17, tumour necrosis factor (TNF) and IL-1β in mediating the effects of MIA to the fetus.The general trends indicate an association between biomarkers of maternal inflammation and offspring NDD.	Neurodevelopmental Disorders	Proteome
290	34349225	9606	Cerebrospinal fluid	DSM-IV	Case-control based	Olink Panels//Illumina	The etiopathology of bipolar disorder is largely unknown. We collected cerebrospinal fluid (CSF) samples from two independent case-control cohorts (total n=351) to identify proteins associated with bipolar disorder. A panel of 92 proteins targeted towards central nervous system processes. In a restricted subgroup analysis, we compared only bipolar type 1 with controls.	Bipolar I Disorder	Proteome
291	34349225	9606	Cerebrospinal fluid	DSM-IV	Case-control based	Olink Panels//Illumina	The etiopathology of bipolar disorder is largely unknown. We collected cerebrospinal fluid (CSF) samples from two independent case-control cohorts (total n=351) to identify proteins associated with bipolar disorder. A panel of 92 proteins targeted towards central nervous system processes. In a restricted subgroup analysis, we compared only bipolar type 1 with controls.	Bipolar Disorder	Proteome
292	34358573	10116	Brain(Hippocampus)	Others	Case-control based	LC-MS//MS//Western Blotting	We used proteomics to quantify protein changes in the hippocampus of foot shocks rats. A total of 6151 proteins were quantified and 97 proteins were significantly differentially expressed.	Posttraumatic Stress Disorder	Proteome
293	34358573	10116	Brain(Hippocampus)	Others	Case-control based	LC-MS//MS	We used proteomics to quantify protein changes in the hippocampus of foot shocks rats. A total of 6151 proteins were quantified and 97 proteins were significantly differentially expressed.	Posttraumatic Stress Disorder	Proteome
294	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	LC-MS//MS	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 9 of OUD subjects.	Opioid Use Disorder	Proteome
295	34415653	9606	Brain	Others	Case-control based	Sanger Sequencing	This case of a patient with developmental delay and parkinsonism with PLXNA1 mutation highlights a need for assessing long-term outcomes of individuals with neurodevelopmental disorders, as well as the need for genetic testing in adults. It also suggests that the link between PLXNA1 and α-synuclein should be explored in the future.	Neurodevelopmental Disorders	Proteome
296	34426021	9606	NA	Others	Case-control based	NA	De novo mutations in AUTS2 have been identified in several NDD cases.AUTS2 and RING1B colocalize at promoters of neuronal genes in mouse brain, and brain-specific loss of Auts2 function leads to developmental phenotypes that are in line with AUTS2 NDD mutations.	Neurodevelopmental Disorders	Proteome
297	34426021	9606	NA	Others	Case-control based	NA	Considering the essential role of PRC1 activity and H2AK119ub1 deposition in maintaining transcriptional identity during neurodevelopment, it is not surprising that mutations that affect PR-DUB activities are also associated with rare developmental syndromes.	Neurodevelopmental Disorders	Proteome
298	34426021	9606	NA	Others	Case-control based	NA	ASXL1 mutations have been identified as a cause of Bohring-Opitz syndrome (BOS).BOS patients are characterized by severe ID and dysmorphic features.	Neurodevelopmental Disorders	Proteome
299	34426021	9606	NA	Others	Case-control based	NA	Germline de novo truncating variants in ASXL3 have been found in Bainbridge-Ropers syndrome, a syndrome characterized by a failure to thrive, global developmental delay, feeding problems, hypotonia, dysmorphic features, profound speech delays, and ID. These mutations suggest that ASXL3 plays crucial roles in neuronal development and differentiation.	Neurodevelopmental Disorders	Proteome
300	34426021	9606	NA	Others	Case-control based	NA	Through this program, de novo heterozygous truncating variants in the ASXL2 gene were discovered in six patients with a series of neurodevelopmental phenotypes that included delayed psychomotor development, ID, hypotonia, and macrocephaly. Although these patients shared clinical features with patients carrying ASXL1 (BOS) or ASXL3 (BRS) truncating or splicing pathogenic variants, these truncating variants in ASXL2 underlie a neurodevelopmental syndrome with a clinically recognizable phenotype.	Neurodevelopmental Disorders	Proteome
301	34426021	9606	NA	Others	Case-control based	NA	Rare de novo missense variants in RNF2 have also been reported. These were linked to intrauterine growth retardation, severe IDs, behavioral problems, seizures, feeding difficulties, and dysmorphic features.	Neurodevelopmental Disorders	Proteome
302	34426021	9606	NA	Others	Case-control based	NA	Deep large-scale clinical whole-exome sequencing analysis in patients with neurodevelopmental disorders (NDDs) or psychiatric disorders (such as intellectual disability, ID; developmental delay, DD; and autism spectrum disorders, ASDs) have led to the identification of crucial de novo mutations in many genes involved in chromatin remodeling and histone modifications. Numerous malformation and ID syndromes present de novo mutations in members of both PRC1 and PRC2 complexes.	Neurodevelopmental Disorders	Proteome
303	34426021	9606	NA	Others	Case-control based	NA	Structural modeling of PCGF2 Pro65 mutations suggest loss of affinity because the acidic patch on the histone surface could compromise RING1A/B catalytic activity. Although this requires in vitro and in vivo validation, this scenario suggests that a hypomorphic activity of cPRC1 can compromise specific neurodevelopmental processes.	Neurodevelopmental Disorders	Proteome
304	34426021	9606	NA	Others	Case-control based	NA	The X-linked microphthalmia syndromes comprise a clinically and molecularly diverse group of potentially etiologically heterogeneous disorders. Xp11.4 mutations forms of Lenz microphthalmia syndrome (MCOPS2; MIM 300166) are caused by mutations of the BCL-6 corepressor gene (BCOR). BCOR was originally identified as a partner of the repressor BCL-6 involved in B cell development.	Neurodevelopmental Disorders	Proteome
305	34454697	9606	Brain	Others	Case-control based	PWAS	By integrating genome-wide associations of four common psychiatric disorders and two independent brain proteomes (n = 376 and n = 152, respectively) from the dorsolateral prefrontal cortex, we identified 61 genes (including 48 genes for schizophrenia, 12 genes for bipolar disorder, 5 genes for depression, and 2 genes for attention-deficit/hyperactivity disorder) whose genetically regulated protein abundance levels were associated with risk of psychiatric disorders.	Attention-Deficit/Hyperactivity Disorder	Proteome
306	34454697	9606	Brain	Others	Case-control based	PWAS	By integrating genome-wide associations of four common psychiatric disorders and two independent brain proteomes (n = 376 and n = 152, respectively) from the dorsolateral prefrontal cortex, we identified 61 genes (including 48 genes for schizophrenia, 12 genes for bipolar disorder, 5 genes for depression, and 2 genes for attention-deficit/hyperactivity disorder) whose genetically regulated protein abundance levels were associated with risk of psychiatric disorders.	Schizophrenia	Proteome
307	34456709	9606	Blood	CAM	Case-control based	SOMAscan	In exploratory analyses, we found that POD was associated with changes in the expression level of various proteins, most notably IL-6 and PDE3A.	Delirium	Proteome
308	34500744	9606	Serum	DSM-Ⅴ	Case-control based	2D-DIGE//MS//PMF	The proteomic analysis identified a total of 121 proteins that showed significant changes in protein expression between CUD patients (experimental group) and healthy individuals (control group).	Cannabis Use Disorder	Proteome
309	34500744	9606	Serum	DSM-Ⅴ	Case-control based	2D-DIGE//MS//PMF//Westerning blotting	The proteomic analysis identified a total of 121 proteins that showed significant changes in protein expression between CUD patients (experimental group) and healthy individuals (control group).	Cannabis Use Disorder	Proteome
310	34587489	9606	Fibroblasts	Others	Case-control based	qPCR//Immunoblotting	In conclusion, our findings support that bi-allelic deleterious variants in ABHD16A cause an autosomal-recessive subtype of complicated HSP. ABHD16A PS lipase deficiency results in intellectual disability, progressive spasticity, abnormal corpus callosum, and white matter anomalies, most likely through the dysregulation of lipid species including lyso-PS.	Intellectual Disability	Proteome
311	34635637	10090	Brain(Medial prefrontal cortex//Hippocampus)	Others	Case-control based	Western Blotting	First, we confirmed by western blot that protein levels of Plcb1 were reduced in the brain regions of interest, about 22%, on thePlcb1+/ mice compared to WT in mPFC and HPC (P=0.013 andP=0.018, respectively	Cocaine Addiction	Proteome
312	34653363	9606	NA	Others	Case-control based	qPCR//Immunoblotting//CDG Glycosylation	We report a dominant CDG caused by variants in a subunit of the OST complex caused by de novo and autosomal-dominantly inherited heterozygous missense variants close to the active site of STT3A. Because STT3A is the essential and catalytic subunit of the OST-A, this is likely to disrupt transfer of N-glycans onto recipient glycoproteins, causing a type I CDG. Most CDGs are autosomal-recessive disorders.	Intellectual Disability	Proteome
313	34658843	10116	brain	Others	Case-control based	LC-MS//MS//RT-PCR//Western Blotting	These results not only indicate potential diagnostic biomarkers for po-NCD but also provide directions for further pathological investigations.	Cognitive Disorders	Proteome
314	34658843	9606	serum	Chinese version of the Confusion Assessment Method	Case-control based	Enzyme-Linked Immunosorbent Assays	These results not only indicate potential diagnostic biomarkers for po-NCD but also provide directions for further pathological investigations.	Cognitive Disorders	Proteome
315	34690045	9606	NA	Others	Case-control based	NA	Since KMT2D and KDM6A are thought to form part of the same COMPASS complex , the loss of epigenetic action by either one may affect the same loci, leading to a disease with similar clinical phenotypes.	Neurodevelopmental Disorders	Proteome
316	34690045	9606	NA	Others	Case-control based	NA	That said, one of these factors, a repressive complex called Polycomb repressive complex 2 (PRC2), stands out for its critical role in epigenetic priming and association with NDDs.	Neurodevelopmental Disorders	Proteome
317	34736119	10090	Brain	Others	Case-control based	Fluorometric//Western blotting//RT-qPCR	Herein, a single in utero EtOH exposure, equivalent to 4–6 drinks, enhanced fetal and adult ROS production and depleted protective BRCA1 protein levels in fetal and adult brains, revealing a new mechanism by which EtOH initiates developmental disorders.	Neurodevelopmental Disorders	Proteome
318	34758338	10090	Brain	Others	Case-control based	Electrophysiology//Biochemistry//Immunofluorescence	Here we showed that transient IL-6 elevation via injection into pregnant mice or developing embryos enhanced glutamatergic synapses and led to overall brain hyperconnectivity in offspring into adulthood.	Neurodevelopmental Disorders	Proteome
319	34764280	9606	NA	Others	Case-control based	Cryo-EM Analysis	Here, we report a 5.3 cryo-EM model of OGT. We show OGT is a dimer, providing a structural basis for how some X-linked intellectual disability mutations at the interface may contribute to disease.	Intellectual Disability	Proteome
320	34819353	9606	NA	Others	Case-control based	ChIP-seq	Mutations in the PHIP/BRWD2 chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations in PHIP expression are linked to cancer. Precisely how PHIP functions in these contexts is not fully understood. Here we demonstrate that PHIP is a chromatin-associated CRL4 ubiquitin ligase substrate receptor and is required for CRL4 recruitment to chromatin.	Neurodevelopmental Disorders	Proteome
321	34904718	9606	NA	Others	Case-control based	Quantitative Proteomic Analysis	Proteomic and functional analyses reveal that PDIA3C57Y expression leads to dysregulation of cell adhesion and actin cytoskeleton dynamics, associated with altered integrin biogenesis and reduced neuritogenesis.	Intellectual Disability	Proteome
322	34942119	9606	NA	The Stanford Binet Tests of Intelligence	Case-control based	CMA//TAIL-PCR//RT-qPCR	Neurodevelopmental cognitive disorders provide insights into mechanisms of human brain development. Here, we report an intellectual disability syndrome caused by the loss of APC7, a core component of the E3 ubiquitin ligase anaphase promoting complex (APC).	Intellectual Disability	Proteome
323	34945756	9606	Blood	SADS-L	Case-control based	ELISA	We recruited a total of 185 patients with BD-II and 186 healthy controls. Plasma levels of candidate proteins, BDNF, cytokines (TNF-α, CRP, and interleukin-8 (IL-8)) were assessed from each participant. The correlations between levels of candidate proteins, BDNF, and cytokines were analyzed. In the current study, we thus aimed to clarify the correlations between the candidate plasma proteins of BD-II and cytokine and BDNF levels, in both patients with BD-II and normal controls.	Bipolar II Disorder	Proteome
324	35016969	9606	Saliva	DSM-Ⅴ	Case-control based	LC-MS//MS	The lack of specific pharmacological therapy for Autistic Spectrum Disorder (ASD) and its clinical heterogeneity demand efforts directed toward the identification of biomarkers to aid in diagnosis. Proteomics offers a new perspective for studying the altered proteins associated with autism spectrum disorders (ASD) and we have saliva as an easy-to-collect biological fluid with important biomolecules for investigating biomarkers in various diseases.	Autism Spectrum Disorder	Proteome
325	35051358	9606	NA	Others	Case-control based	ChIP-seq//Western blotting	Nuclear deubiquitinase BAP1 (BRCA1-associated protein 1) is a core component of multiprotein complexes that promote transcription by reversing the ubiquitination of histone 2A (H2A). BAP1 is a tumor suppressor whose germline loss-of-function variants predispose to cancer. To our knowledge, there are very rare examples of different germline variants in the same gene causing either a neurodevelopmental disorder (NDD) or a tumor predisposition syndrome. Here, we report a series of 11 de novo germline heterozygous missense BAP1 variants associated with a rare syndromic NDD.	Neurodevelopmental Disorders	Proteome
326	35074918	9606	NA	Others	Case-control based	GS//ES //immunostaining	We identified a patient exhibiting RTT-like neurological features with a missense mutation in the PHF14 subunit of the TCF20 complex that abolishes the MeCP2–PHF14–TCF20 interaction. Our data demonstrate the critical role of the MeCP2–TCF20 complex for brain function.	Neurodevelopmental Disorders	Proteome
327	35087195	9606	Brain	NEPSY-II//Wechsler Intelligence Scale	Case-control based	fMRI	In particular, PTPN11 encodes Shp-2, a major regulatory protein tyronsine phosphatase in the RAS/MAPK pathway. Most PTPN11 pathogenic variants are associated with altered amino-terminal src-homology 2 (N-SH2)/protein tyrosine phosphatase (PTP) interactions that stabilize Shp-2 protein in the active conformation.	Neurodevelopmental Disorders	Proteome
328	35087195	9606	Brain	NEPSY-II//Wechsler Intelligence Scale	Case-control based	fMRI	The SOS1 gene encodes a guanine nucleotide exchange factor (GEF) that activates Ras and downstream Ras/MAPK signaling; SOS1 gain-of-function pathogenic variants diminish SOS1 protein autoregulation and enhance Ras/MAPK signaling.	Neurodevelopmental Disorders	Proteome
329	35136035	9606	Blood	DSM-IV	Case-control based	Proximity Extension Assay Analysis	We set out to identify novel protein associations with potential as clinically viable biomarkers for bipolar disorder. To this end, we used proximity extension assay to analyze 201 unique proteins in blood serum from two independent cohorts comprising patients with bipolar disorder and healthy controls (total n = 493). We identified 32 proteins significantly associated with bipolar disorder in both case-control cohorts after adjusting for relevant covariates. Twenty-two findings are novel to bipolar disorder, but 10 proteins have previously been associated with bipolar disorder: chitinase-3-like protein 1, C-C motif chemokine 3 (CCL3), CCL4, CCL20, CCL25, interleukin 10, growth/differentiation factor-15, matrilysin (MMP-7), pro-adrenomedullin, and TNF-R1.	Bipolar Disorder	Proteome
330	35176771	9606	Blood	DSM-IV-R	Case-control based	ELISA	Twenty-seven patients (87%) completed 8 weeks of treatment; 74% and 63% were responders at week 4 and 8, respectively. High S100B and low HDL-C levels at baseline were associated with better treatment response at both time points. Low CRP levels were correlated with better response at week 4. Multivariate analysis showed that high baseline S100B levels and low baseline HDL-C levels were good predictors of treatment response at week 4 (R2 = 0.457, P = .001), while S100B was at week 8 (R2 = 0.239, P = .011). Importantly, baseline S100B and HDL-C levels were not associated with depression severity and did not change over time with clinical improvement.	Major Depressive Disorder	Proteome
331	35204828	9606	Brain	NA	Case-control based	RT-PCR//Western Blotting//ELISA	Here, we investigated RasGRP1 mRNA and protein expression in post-mortem DLPFC and hippocampus of SCZ patients and healthy controls, along with RasGRP1 protein content in the serum of an independent cohort of SCZ patients and control subjects. Differences in RasGRP1 expression between SCZ patients and controls were detected both in DLPFC and peripheral blood of samples analyzed. Our results indicate RasGRP1 may mediate risk for SCZ by involving DLPFC and peripheral blood, thus encouraging further studies to explore its possible role as a biomarker of the disease and/or a target for new medication.	Schizophrenia	Proteome
332	35210508	9606	Blood	DSM-IV//DSM-V	Case-control based	LC-MRM-MS	Among the 143 target peptides (85 proteins), 26 peptides (24 proteins) were found to be significant after ANOVA with multiple comparisons (FDR<0.05; Table S3). After adjusting covariates (age, sex, use of antipsychotics mood stabilizers, anti-depressants, and benzodiazepines) through ANCOVA, all peptides except peroxiredoxin 2 (PRDX2) were still significant (Table (Table2).2). Among these 25 peptides, 19 peptides were differentially expressed in the BP group (two peptides were upregulated and 17 peptides were downregulated in BPs, compared to the BD-II and HC groups) after multiple comparisons. Three peptides were significantly different when compared between the BP and BD-II groups (one peptide was upregulated and two were down regulated in the BP group versus the BD-II group). The other two peptides were downregulated in the BP group compared to the HC group.	Bipolar II Disorder	Proteome
333	35348996	9606	Plasma	DSM-V	Case-control based	LC-MS//MS //iTRAQ	In this study, genetic testing was performed on children who were clinically diagnosed with ASD. Children with ASD susceptibility genes and healthy controls were studied. The proteomics of plasma and peripheral blood mononuclear cells (PBMCs) as well as plasma metabolomics were carried out. The results showed that although there was genetic heterogeneity in children with ASD, the differentially expressed proteins (DEPs) in plasma, peripheral blood mononuclear cells, and differential metabolites in plasma could still effectively distinguish autistic children from controls. The mechanism associated with them focuses on several common and previously reported mechanisms of ASD.	Autism Spectrum Disorder	Proteome
334	35348996	9606	Peripheral blood mononuclear cells	DSM-V	Case-control based	LC-MS//MS //iTRAQ	In this study, genetic testing was performed on children who were clinically diagnosed with ASD. Children with ASD susceptibility genes and healthy controls were studied. The proteomics of plasma and peripheral blood mononuclear cells (PBMCs) as well as plasma metabolomics were carried out. The results showed that although there was genetic heterogeneity in children with ASD, the differentially expressed proteins (DEPs) in plasma, peripheral blood mononuclear cells, and differential metabolites in plasma could still effectively distinguish autistic children from controls. The mechanism associated with them focuses on several common and previously reported mechanisms of ASD.	Autism Spectrum Disorder	Proteome
335	35348996	9606	Plasma	DSM-V	Case-control based	LC-MS//MS //iTRAQ//ELISA	In this study, genetic testing was performed on children who were clinically diagnosed with ASD. Children with ASD susceptibility genes and healthy controls were studied. The proteomics of plasma and peripheral blood mononuclear cells (PBMCs) as well as plasma metabolomics were carried out. The results showed that although there was genetic heterogeneity in children with ASD, the differentially expressed proteins (DEPs) in plasma, peripheral blood mononuclear cells, and differential metabolites in plasma could still effectively distinguish autistic children from controls. The mechanism associated with them focuses on several common and previously reported mechanisms of ASD.	Autism Spectrum Disorder	Proteome
336	35361701	9606	Cell lines(Leukocytes)	DSM-IV	Case-control based	Coimmunoprecipitation//Western Blotting	Levels of the D2R-DISC1 complex were elevated in the peripheral blood samples of patients with schizophrenia from 3 independent cohorts, and were normalized with antipsychotic treatment. Proteomic analysis of the blood samples from patients with high D2R-DISC1 complex levels that were normalized with antipsychotic treatment revealed a number of altered proteins and pathways associated with D2R, DISC1 and the D2R-DISC1 complex.	Schizophrenia	Proteome
337	35383319	9606	Saliva	DSM-V	Case-control based	Genotyping//PET	To our knowledge, this is the first in vivo quantification of brain TSPO in ASD participants with a second-generation radiotracer and full kinetic modeling using state-of-the-art methodology (arterial input function in HRRT) that includes both female and male participants. Contrary to our hypothesis, participants with ASD either had no significant differences when compared to typically developing controls, or significantly lower levels of TSPO in the brain (when excluding participants with MDE). To a greater extent this contrasts postmortem studies, and to a lesser extent previous neuroimaging findings.	Autism Spectrum Disorder	Proteome
338	35448545	9606	Blood	ICD-10	Case-control based	ELISA	We recruited 31 female patients diagnosed with BD or MDD who were hospitalized due to current depressive episodes. The patients had their serum BDNF, proBDNF, and S100B levels evaluated using the ELISA method upon admission and after the symptoms improved, at discharge. We found that proBDNF levels decreased significantly with the treatment (p = 0.0478), while BDNF and S100B levels were not altered significantly. No differences in biochemical parameters between MDD and BD subjects were observed. Consequently, we concluded that a decrease in serum proBDNF levels could be considered a biomarker of recovery from depressive episodes.	Depressive Episodes	Proteome
339	35459277	9606	Brain	DSM-V	Case-control based	Immunocytochemistry//LC-MS Analysis//Western blotting//qPCR	Here, we apply an unbiased proteomics approach to evaluate combinatorial histone PTMs in human induced pluripotent stem cell (hiPSC)-derived forebrain neurons from individuals with SZ. We observe hyperacetylation of H2A.Z and H4 in neurons derived from SZ cases, results that were confirmed in postmortem human brain. We demonstrate that the bromodomain and extraterminal (BET) protein, BRD4, is a bona fide 'reader' of H2A.	Schizophrenia	Proteome
340	35533500	9606	Blood	NA	Case-control based	Simoa Single Molecular Array	The majority of critically ill patients already had a high NfL level on admission. Patients with higher plasma NfL levels at days one and three spent more days in delirium or deep sedation. Patients with zero or one day in delirium or deep sedation had day one mean concentrations of 37.8 pg/ml (SD 32.6) compared with 96.5 pg/ml (SD 106.1)) for patients with two days or more, p-value 0.002 linear mixed effects model. Survivors discharged before 14 days had lower mean plasma NfL concentrations compared to those with longer hospital stays and/or who died within six months. The area under ROC curve for predicting death within six months using day one NfL was 0.81 (0.7,0.9).	Delirium	Proteome
341	35546939	9606	Blood	DSM-IV	Case-control based	qRT-PCR	We recruited 130 patients with SCZ and 111 healthy individuals, and the ELISA and qRT-PCR assays were used to measure serum FGF9 levels in the participants. ELISA assay demonstrated that serum FGF9 protein levels were dramatically reduced in first-episode, drug-free patients, but not in chronically medicated patients when compared to healthy control subjects. Further analysis showed that treatment of the first-episode, drug-free SCZ patients with antipsychotics for 8 weeks significantly increased the serum FGF9 levels. In addition, we found that blood FGF9 mRNA levels were significantly lower in first-onset SCZ patients than controls.	Schizophrenia	Proteome
342	35563307	9606	NA	NA	Case-control based	Meta-analysis	Here, we evaluate the efficacy of MS proteomics applied to human peripheral fluids of schizophrenia (SCZ) patients to identify disease biomarkers and relevant networks of biological pathways. Meta-analysis results suggest the upregulation of FCN3 and downregulation of APO1, APOA2, APOC1, and APOC3 in SCZ patients. Despite the proven ability of MS proteomics to characterize SCZ, several confounding factors contribute to the heterogeneity of the findings.	Schizophrenia	Proteome
343	35615451	9606	Urine	DSM-V	Case-control based	LC-20AB//DIA Analysis	A total of 2,700 proteins were identified using a DIA-based proteomic method. There were 77 DEPs (56 upregulated and 21 downregulated) between the ASD and TD groups (Table 2andSupplementary Figure 1). Of these, 31 (40%) were associated with neuroinflammation (Figure 1), including 26 that were upregulated and 5 that were downregulated in the ASD group compared with the TD group. Immunoglobulins accounted for the largest proportion of these proteins; the remaining proteins were neural adhesion factors, glycoproteins, leukocyte antigens, and GSH.	Autism Spectrum Disorder	Proteome
344	35618886	9606	Cell lines(iPSC)	DSM-V	Case-control based	Immunocytochemistry//GC-MS	It was detected thatheat shock protein 27(hsp27) phosphorylated at Ser15 is upregulated in ASD derived cerebral organoids. The downregulated proteins werePyk (FAK2), Elk-1, Rac1/cdc42, S6 ribosomal protein phospho Ser 240/Ser 244, Ha-ras, mTOR (FRAP) phospho Ser 2448, PKCα, FoxO3a, Src family phospho Tyr 416.	Autism Spectrum Disorder	Proteome
345	35650610	10090	Embryonic stem cells	NA	Case-control based	RT-qPCR//RNA-seq//co-IP//ChIP//ChIP-seq	We show that POGZ is required for the maintenance of ESC identity and the up-regulation of neural genes during ESC differentiation toward a neural fate. Genome-wide binding analysis shows that POGZ is primarily localized to gene promoter and enhancer regions. POGZ functions as both a transcriptional activator and repressor, and its loss leads to deregulation of differentiation genes, including neural genes. POGZ physically associates with the SWI-SNF (esBAF) chromatin remodeler complex, and together they modulate enhancer activities via epigenetic modifications such as chromatin remodeling and histone modification. During ESC neural induction, POGZ-mediated recruitment of esBAF/BRG1 and H3K27ac are important for proper expression of neural progenitor genes.	Autism Spectrum Disorder	Proteome
346	35697758	9606	Blood	NA	Case-control based	qPCR	We used a nested case-control study design where a large cohort of patients with bipolar disorder (N = 5 110) were followed up to 8 years after blood sampling. We included patients that attempted suicide during follow-up (N = 348) and matched bipolar disorder patients from the same cohort who did not attempt suicide during the study period (N = 348) and analyzed a total of 92 proteins with a neuro exploratory multiplex panel. Using a multivariate classification algorithm devised to minimize bias in variable selection, we identified a parsimonious set of proteins that best discriminated bipolar disorder patients with and without prospective suicide attempts.	Bipolar Disorder	Proteome
347	35743392	9606	Blood	ICD-10	Case-control based	RT-PCR//TaqMan//ELISA	The expression of the PON2 and PON3 genes at the protein level was significantly higher in depressive patients than in healthy controls. mRNA expression of the PON1, PON2 and PON3 genes was slightly higher in patients with depressive disorders than in the control group, however, this relationship was not statistically significant. On the other hand, the expression of the MPO gene at both mRNA and protein levels was significantly lower in patients with depressive disorder than in the control group.	Major Depressive Disorder	Proteome
348	35794636	9606	Brain	NA	Case-control based	Immunohistochemistry//Immunoblotting//MS	Here, using a multi-disciplinary approach employing immunohistochemistry, immunoblot, and mass-spectrometry (MS), we confirm aSynNuc in post-mortem brain tissue obtained from DLB and control cases. Highly dependent on antigen retrieval methods, in optimal conditions, intra-nuclear pan and phospho-S129 positive aSyn puncta were observed in cortical neurons and non-neuronal cells in fixed brain sections and in isolated nuclear preparations in all cases examined. Furthermore, an increase in nuclear phospho-S129 positive aSyn immunoreactivity was apparent in DLB cases compared to controls, in both neuronal and non-neuronal cell types. Our initial histological investigations identified that aSynNuc is affected by epitope unmasking methods but present under optimal conditions, and this presence was confirmed by isolation of nuclei and a combined approach of immunoblotting and mass spectrometry, where aSynNuc was approximately tenfold less abundant in the nucleus than cytoplasm.	Neurocognitive Disorder With Lewy Bodies	Proteome
349	35810398	9606	Blood	ICSD-3	Case-control based	PCR//Illumina TruSeq Stranded Total RNA Ribo Zero	Blood samples from 57 NT1, 51 other hypersomnia patients and 61 healthy controls were analyzed. The levels of 25 major individual acylcarnitines were determined and the C0/(t[C16]+t[C18]) ratio was used as a CPT1 activity marker. We further performed transcriptome analysis using independent blood samples from 42 NT1 and 42 healthy controls to study the relevance of fatty acid metabolism. NT1 specific changes in CPT1 activity and in expression of related genes were investigated. CPT1 activity was lower in patients with NT1 (p = 0.00064) and other hypersomnia (p = 0.0014) than in controls.	Narcolepsy	Proteome
350	35821008	9606	Brain	DSM-IV	Case-control based	TMT//LC-MS	Over 3000 proteins were accurately quantified, with more than 100 protein expressions identified as significantly changed in these two brain areas of MDD and BD patients as compared to their respective controls. These include OGDH, SDHA and COX5B in the DLPFC in MDD patients; PFN1, HSP90AA1 and PDCD6IP in the ACC of MDD patients; DBN1, DBNL and MYH9 in the DLPFC in BD patients. Impressively, depending on brain area and distinct diseases, the most notable change we found in the DLPFC of MDD was 'suppressed energy metabolism'; in the ACC of MDD it was 'suppressed tissue remodeling and suppressed immune response'; and in the DLPFC of BD it was differentiated 'suppressed tissue remodeling and suppressed neuronal projection'.	Major Depressive Disorder	Proteome
351	35821415	10090	NA	NA	Case-control based	Affymetrix GeneChip//Immunohistochemistry//Western Blotting	We started to show a hitherto unknown role for the Dys1A isoform in astrocytic-related modulation of basal ganglia behavioral and dopaminergic phenotypes, with relevance to schizophrenia.	Schizophrenia	Proteome
352	8118537	9606	Blood(Plasma)	Others	Case-control based//Family based	ELISA	Decreased protein concentrations of C4B may be associated with autism	Autism Spectrum Disorder	Proteome
353	9513736	9606	Blood(Plasma)	Others	Case-control based	Radioimmunoassay	Although making inferences to central OT functioning from peripheral measurement is difficult, the data suggest that OT abnormalities may exist in autism, and that more direct investigation of central nervous system OT function is warranted.	Autism Spectrum Disorder	Proteome
354	DOI: 10.4172/jpb.S14-004	9606	Urine	Others	Case-control based	iTRAQ//LC-MALDI-MS//MS	These research data fit with some current hypotheses regarding autism and suggest a relationship between ASD, inflammation and gastrointestinal disease. Specific urinary proteins are identified which could potentially serve as biomarkers for ASD.	Autism Spectrum Disorder	Proteome
