traid	pmid	organismid	tissue	diagnosis	familycontrol	platform	method	description	disease	class
1	10814723	9606						DISC2 should be considered a formal candidate gene for susceptibility to psychiatric illness (schizophrenia).	Schizophrenia	Transcriptome
2	10814723	9606						DISC1 and DISC2 should be considered formal candidate genes for susceptibility to psychiatric illness.	Schizophrenia	Transcriptome
3	10903453	9606	Cell lines(HEF)		Case-control based		Northern Blot	The two genes were cloned from a subregion at 6q21 containing a replicative senescence gene, a tumor suppressor gene and a gene involved in hereditary schizophrenia.	Schizophrenia	Transcriptome
4	11074872	9606	Brain	DSM-IV	Case-control based		qRT-PCR	The selective down regulation of RELN and GAD67 in prefrontal cortex of patients with schizophrenia and bipolar discorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis.	Bipolar Disorder	Transcriptome
5	11074872	9606	Brain	DSM-IV	Case-control based		qRT-PCR	The selective down regulation of RELN and GAD67 in prefrontal cortex of patients with schizophrenia and bipolar discorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis.	Schizophrenia	Transcriptome
6	12573262	9606						The Disrupted in Schizophrenia (DISC) locus on human chromosome 1q42 has been strongly implicated by genetic studies as a susceptibility locus for major mental illnesses.DISC2, a putative noncoding transcript partially antisense to DISC1, is not conserved.	Schizophrenia	Transcriptome
7	12647258	9606	Blood		Case-control based	RT-PCR	RT-PCR	Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series.	Bipolar Disorder	Transcriptome
8	12837621	7955	Blood		Case-control based	qRT-PCR	qRT-PCR	However, the level of miR-133b was decreased in 1-week-old neurons treated with morphine. Thus, similar to what we have observed in the zebrafish embryos, only the miR-133b level within the immature neurons was affected by morphine treatment.	Opioid Use Disorder	Transcriptome
9	13130513	9606	Brain	DSM-IV	Case-control based	RT-PCR	RT-PCR	These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors.	Schizophrenia	Transcriptome
10	14671656	10116	Penis tissue		Case-control based	RT-PCR	qRT-PCR	In 24-month-old rats, expression of AR mRNA transcript was significantly reduced (P<0.01, respectively).	Erectile Disorder	Transcriptome
11	14671656	10116	Penis tissue		Case-control based	RT-PCR	qRT-PCR	The expression of PR mRNA transcript was lost in 24-month-old rats. The difference in PR mRNA expression between 24-month-old rats reached statistical significance (P<0.01).	Erectile Disorder	Transcriptome
12	14671656	10116	Penis tissue		Case-control based	RT-PCR	qRT-PCR	ER-脦虏 mRNA was significantly reduced in 24-month-old rats (P<0.01, respectively).	Erectile Disorder	Transcriptome
13	15194506	9606	Blood	DSM-IV	Case-control based	Genotyping	Genotyping	In this work, we have identified statistically significant differences in allele distributions of two markers rs3916965 (P=0.019) and rs2391191 (P=0.0010), and a highly significant association between haplotype AGAC of the G72/G30 locus (P=1.7 x 10(-4)) and schizophrenia.	Schizophrenia	Transcriptome
14	15271585	9606	Brain	DSM-IV	Case-control based	MassARRAY	MassARRAY	Gene expression analysis exhibited correlations between expression levels of the G72 and G30 genes, as well as a tendency toward overexpression of the G72 gene in schizophrenic brain samples of 44 schizophrenic patients compared with 44 control subjects.	Schizophrenia	Transcriptome
15	15474907	9606	Brain		Case-control based	qPCR//Genotyping	qPCR//Genotyping	NR3A mRNA was significantly decreased by 12% in bipolar disorder relative to the comparison group in DLPFC, although there were no gyral versus sulcal differences. As was the case in schizophrenia, no changes in NR3A expression were observed in the inferior temporal cortex in bipolar disorder.	Bipolar Disorder	Transcriptome
16	15474907	9606	Brain		Case-control based	qPCR//Genotyping	qPCR//Genotyping	NR3A mRNA was significantly decreased by 12% in bipolar disorder relative to the comparison group in DLPFC, although there were no gyral versus sulcal differences. As was the case in schizophrenia, no changes in NR3A expression were observed in the inferior temporal cortex in bipolar disorder.	Schizophrenia	Transcriptome
17	15477870	9606	Blood	DSM-IIIR//DSM-IV	Case-control based	MassARRAY	MassARRAY	Panic disorder associated.	Panic Disorder	Transcriptome
18	15478311	9606	Blood		Family based	Array//ISH//qRT-PCR	Array//ISH//qRT-PCR	DISC2 is a likely susceptibility locus for both schizophrenia and affective disorders.	Schizophrenia	Transcriptome
19	15478311	9606	Blood		Family based	Array//ISH//qRT-PCR	Array//ISH//qRT-PCR	Overall, it is clear from the combination of genetic and functional data that DISC1 and/or DISC2 are emerging as important factors in the molecular genetics of psychiatric illness.	Schizophrenia	Transcriptome
20	15653269	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	G72/G30 (DAOA-AS1) are important candidate genes for explaining schizophrenia in the Han Chinese population.	Schizophrenia	Transcriptome
21	15691526	9606	Brain	DSM-IV	Case-control based		qRT-PCR	Confirming other studies, the GABA and developmental/synaptic neurochemical systems are promising areas for research on schizophrenia and bipolar disorder. Research should include tissue from both diseases, and additional brain areas should be assessed.	Schizophrenia	Transcriptome
22	16024602	9606	Cell lines(Neural)		Case-control based	MicroRNA array//Northern blot analysis	Array//Northern blotting	We found a similarly robust increase in miR-21 expression in six commonly used model cell lines derived from human glioblastomas (U373, A172, LN229, U87, LN428, and LN308; Fig. 1C).	Anxiety Disorder	Transcriptome
23	16224024	9606	Blood	DSM-IV//SCID-CV	Case-control based	Array	Array	Abelson et al. [2005] were the first to associate a sequence variant in a miRNA target site with disease. They reported a rare sequence variant disrupting a target site for miR-189 in the SLITRK1 gene in two patients with Tourette芒鈧劉s syndrome and in none of the controls tested.	Panic Disorder	Transcriptome
24	16224024	9606	Blood	DSM-IV//SCID-CV	Case-control based	Array	Array	Abelson et al. [2005] were the first to associate a sequence variant in a miRNA target site with disease. They reported a rare sequence variant disrupting a target site for miR-189 in the SLITRK1 gene in two patients with Tourette芒鈧劉s syndrome and in none of the controls tested.	Tourette's Disorder	Transcriptome
25	16240163	9606	Brain	DSM-IV	Case-control based		qRT-PCR	Our results demonstrate that Tph2 mRNA levels are significantly different between bipolar and control groups. However, Tph2 expression is not significantly different when we compare unaffected control subjects with those who are schizophrenic.	Bipolar Disorder	Transcriptome
26	16240163	9606	Brain	DSM-IV	Case-control based		qRT-PCR	mRNA levels of the Tph2 gene are significantly different across the three diagnostic groups [F(2,102)=3.584; p=0.031]. The mean relative expression levels (脗卤standard error) in the bipolar, schizophrenia, and control groups were as follows: 48.57脗卤10.19, 33.98脗卤4.99, and 22.54脗卤3.68, respectively.	Schizophrenia	Transcriptome
27	16260724	10116	Cell lines(Neural)		Case-control based			Fig. 7. Down-regulation of p250GAP phenocopies miR132 expression.	Anxiety Disorder	Transcriptome
28	16357340	10090	Cell lines		Case-control based	qRT-PCR	qRT-PCR	Using both gain-of-function and loss-of-function approaches, we demonstrate that brain-specific miR-124a and miR-9 molecules affect neural lineage differentiation in the ES cell-derived cultures.	Anxiety Disorder	Transcriptome
29	16402132	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	G72/G30 genes are involved in conferring susceptibility to schizophrenia.	Schizophrenia	Transcriptome
30	16448631	9606	Brain		Case-control based		qRT-PCR	RT real-time PCR for TDO2 in the remaining samples revealed a significant, 1.7-fold elevation in the schizophrenia group as compared to controls (P=0.049; Fig. 3 lower panel)	Schizophrenia	Transcriptome
31	16480819	9606	Blood	DSM-IV	Case-control based		ELISA//qRT-PCR	Serum BDNF levels were decreased in manic (p=0.019) and depressed (p=0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r=-0.37, p=0.005) and depressive (r=-0.30, p=0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD.	Bipolar Disorder	Transcriptome
32	16482088	9606	Amygdala		Case-control based			Pairwise comparisons showed a significantly lower expression of CRF-BP mRNA in the BL in the male bipolar (Z=2.58; p=0.01) and schizophrenic (Z =2.71; p=0.01) groups compared to the normal group (Figure 4).For females, there was no significant difference among diagnostic groups (n=5-6/group) for BL CRF-BP mRNA levels (w2=1.16; df=3; p=0.76; Figure 4)	Bipolar Disorder	Transcriptome
33	16482088	9606	Brain		Case-control based			Pairwise comparisons showed a significantly lower expression of CRF-BP mRNA in the BL in the male bipolar (Z=2.58; p=0.01) and schizophrenic (Z=2.71;p=0.01) groups compared to the normal group (Figure 4).For females, there was no significant difference among diagnostic groups (n=5-6/group) for BL CRF-BP mRNA levels (w2=1.16; df=3; p=0.76; Figure 4)	Major Depressive Disorder	Transcriptome
34	16482088	9606	Brain		Case-control based			Pairwise comparisons showed a significantly lower expression of CRF-BP mRNA in the BL in the male bipolar (Z=2.58; p=0.01) and schizophrenic (Z =2.71;p=0.01) groups compared to the normal group (Figure 4). For females, there was no significant difference among diagnostic groups (n=5-6/group) for BL CRF-BP mRNA levels (w=1.16; df=3; p=0.76; Figure 4)	Schizophrenia	Transcriptome
35	16595163	9606	Blood	DSM-IV	Case-control based		qRT-PCR	The LIM mRNA levels in the peripheral leukocytes from drug-native depressive patients were significantly lower than those from control subjects and increased significantly after 4-week paroxetine treatments, to almost the same level as controls芒鈧劉.	Major Depressive Disorder	Transcriptome
36	16687443	9606	Brain	DSM-IV	Case-control based		qRT-PCR	Table 1. Differentially expressed transcripts in bipolar I postmortem brains (BA46)	Bipolar Disorder	Transcriptome
37	16773125	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	This gene is associated with susceptibility to schizophrenia.	Schizophrenia	Transcriptome
38	16791105	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	Transmission disequilibrium analysis revealed a significant association between the rs947267 polymorphism (A>C) and schizophrenia (P=0.016), with the A allele more commonly transmitted to patients.	Schizophrenia	Transcriptome
39	16847749	9606	Blood	DSM-IV//ICD-10	Case-control based	Affymetrix HG-U133A microarray	Microarray	Our aim was to discover the transcript expression profile of the LEP receptor-coding gene in the peripheral blood mononuclears in AN-R and AN-BP patients.	Anorexia Nervosa	Transcriptome
40	16983391	10116	Brain		Case-control based		qRT-PCR	N-3 PUFA deprivation significantly decreased frontal cortex BDNF protein by 30% (n=10, P=0.040) and BDNF mRNA by 63% (n=6, P=0.040) compared to levels in n-3 PUFA-adequate rats.	Bipolar Disorder	Transcriptome
41	17164265	9606	Brain	DSM-IV	Case-control based		qRT-PCR	ErbB4 mRNA expression was also not significantly different between the groups [F(2,75)=1.4;P=0.20].	Schizophrenia	Transcriptome
42	17179078	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	Meta-analysis revealed that there is weak evidence of association between the G72/G30 genes and schizophrenia.	Schizophrenia	Transcriptome
43	17179866	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	Significant associations of schizophrenia with the A allele of rs947267 (A>C,P=0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P=0.008) were found in early-onset schizophrenic patients.	Schizophrenia	Transcriptome
44	17252001	9606	Blood		Case report	Customized Microarray//qRT-PCR	Microarray//qRT-PCR	Four upregulated and 14 downregulated genes (altogether B5% of total valid transcripts compared) have been obtained that showed statistical significance for at least one of the three statistical methods (Table 1).	Posttraumatic Stress Disorder	Transcriptome
45	17326821	9606	Brain		Case-control based	MiRNA microarray//RT-PCR	MiRNA microarray//RT-PCR	Table 1 Differentially expressed miRNAs from the prefrontal cortex of subjects with schizophrenia compared to psychiatrically healthy subjects	Schizophrenia	Transcriptome
46	17507910	10116	Brain		Case-control based		ISH//RT-PCR	The main findings of this study are: (1) NTNG1 and NTNG2 mRNAs have distinct regional and cellular distributions in the human medial and inferior temporal lobe. (2) Both genes are differentially expressed during rat hippocampal development, and NTNG1 isoforms are developmentally regulated in human brain. (3) Of the five NTNG1 mRNA isoforms detected, G1c mRNA was selectively decreased in bipolar disorder and schizophrenia. (4) NTNG2 mRNA expression was decreased in CA3 in bipolar disorder and schizophrenia, and additionally in CA4 and perirhinal cortex in bipolar disorder. (5) No association was found between NTNG1 and NTNG2 mRNA expression and the two schizophrenia-associated SNPs examined.	Bipolar Disorder	Transcriptome
47	17507910	10116	Blood		Case-control based		ISH//RT-PCR	The main findings of this study are: (1) NTNG1 and NTNG2 mRNAs have distinct regional and cellular distributions in the human medial and inferior temporal lobe. (2) Both genes are differentially expressed during rat hippocampal development, and NTNG1 isoforms are developmentally regulated in human brain. (3) Of the five NTNG1 mRNA isoforms detected, G1c mRNA was selectively decreased in bipolar disorder and schizophrenia. (4) NTNG2 mRNA expression was decreased in CA3 in bipolar disorder and schizophrenia, and additionally in CA4 and perirhinal cortex in bipolar disorder. (5) No association was found between NTNG1 and NTNG2 mRNA expression and the two schizophrenia-associated SNPs examined.	Schizophrenia	Transcriptome
48	17849003	9606	Blood	ICD-10//DSM-IV	Case-control based	Northern blotting//qRT-PCR//Illumina GoldenGate Genotyping Assay	Northern blotting//qRT-PCR//Aray	We found nominal association between brain-expressed miRNAs and schizophrenia for rs17578796 and rs1700 located in mir-206 and mir-198 respectively. These two miRNAs have a surprising large number (15) of targets in common, eight of which are also connected by the same transcription factors.	Schizophrenia	Transcriptome
49	17912248	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders.	Bipolar Disorder	Transcriptome
50	17912248	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders.	Depressive Disorder	Transcriptome
51	17912248	9606	Blood		Case-control based	RT-PCR//Northern blotting	RT-PCR//Northern blotting	The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders.	Schizophrenia	Transcriptome
52	18184693	9606	Brain		Case-control based	Real-time PCR//Northern blotting	RT-PCR//Northern Blotting	Mean normalized microarray fluorescence values for miR-181b (2.8-fold, P=0.001) and let-7g (1.8-fold, P=0.008) in the STG from 7 matched pairs of subjects with schizophrenia and non-psychiatric controls (SZ and CTR 1-7).	Schizophrenia	Transcriptome
53	18283276	9606	Cell lines(HeLa)		Case-control based	PCR-based TaqMan allelic discrimination assay	TaqMan	Thus, we concluded that this element in HTR1B mRNA mediates suppression by miR-96 and that this suppression may be attenuated by a common human variant.	Aggressive Behaviors	Transcriptome
54	18424448	9606	Brain	DSM-IV	Case-control based		qRT-PCR	Schizophrenics with the 芒鈧渁t risk芒鈧劉 PvuII genotype had lower ESR1 mRNA levels in the frontal cortex.	Schizophrenia	Transcriptome
55	18445216	10116	Cell lines(SH-SY5Y)		Case-control based			We also identified that microRNA (miR)-18a inhibited translation of GR mRNA in cultured neuronal cells and that increased expression of miR-18a in the PVN was observed in F344 rats compared with SD rats.	Depressive Disorder	Transcriptome
56	18553389	9606	Brain	DSM-IV	Case-control based		qRT-PCR	In the gene expression study, DAT1 10/10 genotype was associated with significantly reduced DAT1 mRNA transcript in FEF tissue from healthy control donors (p<0.05), but higher expression in schizophrenia donors.	Schizophrenia	Transcriptome
57	18563458	9606	Brain		Case-control based	MiRNA microarray//Multiplex Taqman assays	Microarray//Taqman	This study finds that altered miRNA expression levels are observed in postmortem cerebellar cortex from autism patients, a finding which suggests that dysregulation of miRNAs may contribute to autism spectrum phenotype.	Autism Spectrum Disorder	Transcriptome
58	18563458	9606	Cerebellum		Case-control based	Microarray	Microarray	ESM 3 List and annotation of all differentially expressed mRNAs	Neurodevelopmental Disorders	Transcriptome
59	18563458	9606	Brain(PFC)		Case-control based	Microarray	Microarray	ESM 3 List and annotation of all differentially expressed mRNAs	Neurodevelopmental Disorders	Transcriptome
60	18594913	10090	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Table 4 Summary of miRNA and mRNA correlations and KEGG gene class	Anxiety Disorder	Transcriptome
61	18639233	9606	Blood	DSM-IV//ICD-10	Case-control based	Sequenom MassARRAY	MassARRAY	Our findings suggest that variants in these genes might predispose to specific human anxiety disorders. These results illustrate the potential utility of cross-species approaches in identification of candidate genes for psychiatric disorders.	Anxiety Disorder	Transcriptome
62	18704095	10116	Brain		Case-control based			Consistent with the screening results (Table 1), chronic treatment with either lithium or VPA significantly downregulated levels of let-7b, let-7c, miR-128a, miR-24a, miR-30c, miR-34a, and miR-221 (Figures 1a-g) and significantly upregulated levels of miR-144 (Figure 1h). To evaluate the background difference, we tested 5S rRNA levels for lithium, VPA, and control groups	Anxiety Disorder	Transcriptome
63	18805830	9606	Blood		Case report	Agilent 244k array CGH//Affymetrix 5.0 arrays//MLPA assay//FISH	aCGH//Array//MLPA//FISH	This deletion is ~1.5Mb and includes six reference genes (MTMR15, MTMR10, TRPM1, KLF13, OTUD7A and CHRNA7) and a miRNA gene (hsa-miR-211).	Autism Spectrum Disorder	Transcriptome
64	19011233	9606	Brain(BA9)	DSM-IV//DSM-III-R	Case-control based	Microarray//Illumina Human-6 Expression BeadChip//RT-PCR	Microarray//SNP-array//RT-PCR	Human-6 Expression BeadChip demonstrated that GSCL (GI_48885362-S) and TBX1 (GI_18104949-I) of 28 genes located in the 22q11DS region were expressed at lower levels in schizophrenic brains than in the control brains in the Australian samples (P<.05) (Supplementary Table S2).	Schizophrenia	Transcriptome
65	19030002	10090	Brain		Case-control based		ISH//Biochemistry	Expression of the transgene effectively increases total levels of G脦卤s mRNA in select regions (Figures 1e, f) mRNA in select regions (Figures 1e, f).	Schizophrenia	Transcriptome
66	19095221	10116	Brain		Case-control based		qRT-PCR	Immediately after PSS, the majority of animals demonstrated a significant upregulation of galanin mRNA levels in CA1, CA3 and DG compared to unexposed controls [F(1,23)	Posttraumatic Stress Disorder	Transcriptome
67	19095221	10116	Brain		Case-control based		qRT-PCR	In the hippocampal subregion CA1, there was a significant difference in BDNF mRNA levels between groups [F(1,13)=5.3, p<0002_ .04; Figure 7B].	Posttraumatic Stress Disorder	Transcriptome
68	19110058	10116	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	his possibility is further corroborated by the observation that a statistically significant decrease in miR-106b expression was found in sporadic AD patients.	Anxiety Disorder	Transcriptome
69	19131573	10116	Brain		Case-control based	Pierce protein assay//Western blotting	Western blotting	A549 cells transfected with miR-124a or miR18 exhibited significant (P 0.01) reduction of this induction (69.1 1.2% reduction vs. negative control Fig. 3	Anxiety Disorder	Transcriptome
70	19196972	10090	Brain		Case-control based	RT-PCR//Array//ISH	RT-PCR//Array//ISH	Here we show that pharmacological (dizocilpine) or genetic (NR1 hypomorphism) disruption of NMDA receptor signaling reduces levels of a brain-specific miRNA, miR-219, in the prefrontal cortex (PFC) of mice.	Schizophrenia	Transcriptome
71	19264453	9606	Blood		Case-control based	qRT-PCR//Taqman gene expression assays	qRT-PCR//Taqman	Expression of both miR-346 and GRID1 is lower in SZ patients than that in normal controls (P=0.017 and 0.086, respectively). However, the expression of miR-346 and GRID1 is less correlated in SZ patients than in bipolar patients or in normal controls. This study implicates the importance of a miRNA in SZ.	Bipolar Disorder	Transcriptome
72	19264453	9606	Blood		Case-control based	qRT-PCR//Taqman gene expression assays	qRT-PCR//Taqman	Expression of both miR-346 and GRID1 is lower in SZ patients than that in normal controls (P=0.017 and 0.086, respectively). However, the expression of miR-346 and GRID1 is less correlated in SZ patients than in bipolar patients or in normal controls. This study implicates the importance of a miRNA in SZ.	Schizophrenia	Transcriptome
73	19324536	9606	Blood		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.	Obsessive Compulsive Disorder	Transcriptome
74	19360674	9606	Cell lines(Lymphoblast)	ADI-R	Case-control based	miRNA microarray	Microarray	Table 1 List of microRNAs significantly differentially expressed in autistic subjects compared with controls.	Autism Spectrum Disorder	Transcriptome
75	19370765	9606	Blood	DSM-IV	Case-control based	Northern blotting//qRT-PCR	Northern blotting//qRT-PCR	These data implicate miRNAs as key posttranscriptional regulators of NTRK3 and provide a framework for allele-specific miRNA regulation of NTRK3 in anxiety disorders.	Anxiety Disorder	Transcriptome
76	19393990	9606	Blood	DSM-IV	Case-control based	ABI Prism 7900HT	qPCR	Table 2.The table lists all genes that differentiated persons with current (n=15) PTSD compared with a control group (n=20).	Posttraumatic Stress Disorder	Transcriptome
77	19557767	10090	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	We conclude that miR-132 is an activity-dependent microRNA in vivo, and may contribute to the long-lasting proteomic changes required for experience-dependent neuronal plasticity.	Posttraumatic Stress Disorder	Transcriptome
78	19606485	9606	Blood		Case-control based	aCGH	aCGH	The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders.	Autism Spectrum Disorder	Transcriptome
79	19647049	10116	Brain		Case-control based		ISH	Among rats exposed to social defeat, MS180 rats had increased tph2 mRNA expression in the DR, while MS15 rats had decreased tph2 mRNA expression compared to AFR rats. Social defeat increased tph2 mRNA expression, but only in MS180 rats and only in the "lateral wings" of the DR, a subdivision of the DR that is part of a sympathomotor command center.	Anxiety Disorder	Transcriptome
80	19647049	10116	Brain		Case-control based		ISH	Among rats exposed to social defeat, MS180 rats had increased tph2 mRNA expression in the DR, while MS15 rats had decreased tph2 mRNA expression compared to AFR rats. Social defeat increased tph2 mRNA expression, but only in MS180 rats and only in the "lateral wings" of the DR, a subdivision of the DR that is part of a sympathomotor command center.	Depressive Disorder	Transcriptome
81	19703567	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Our data suggest that miR-124, let-7d and miR-181a may be involved in a complex feedback loop with cocaine-responsive plasticity genes, highlighting the possibility that some miRNAs are key regulators of the reward circuit and may be implicated in addiction.	Cocaine Addiction	Transcriptome
82	19703567	9606	Blood		Case-control based		qRT-PCR	We show a significant downregulation of BDNF and D3R both at mRNA and protein levels by miR-124 and let-7d, respectively.	Cocaine Addiction	Transcriptome
83	19703567	10116	Brain		Case-control based			We found that miR-124 (a brain enriched microRNA) and let-7d (a ubiquitous miRNA) were targeting a large number of classical cocaine up-regulated genes (Table S1, supplementary material)	Cocaine Addiction	Transcriptome
84	19711202	10116	Brain		Case-control based	Spotted Array	Array	Table 1 miRs with a mean LR change > 0.25 in absolute value (p<0.05) 24 h after acute or chronic immobilization stress in rats, sorted by brain region and stress regimen (left to right).	Anxiety Disorder	Transcriptome
85	19711202	10116	Brain		Case-control based	Spotted array//Quantitative RT-PCR	Array//qRT-PCR	We show stress-induced changes in miR-183 and miR-134 and suggest that, by regulating splicing factors and their targets, these changes modify both alternative splicing and cholinergic neurotransmission in the stressed brain.	Major Depressive Disorder	Transcriptome
86	19721432	9606	Brain		Case-control based	Illumina microarray//Northern blot//qRT-PCR	Mmicroarray//Northern blotting//qRT-PCR	Figure 1 Schizophrenia-associated miRNA expression in the superior temporal gyrus (STG).	Schizophrenia	Transcriptome
87	19839996	9606	Brain(ERC)		Case-control based		qRT-PCR	We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the middle temporal gyrus, and increased VGLUT2 mRNA expression in SCZ in the inferior temporal gyrus (ITG). We did not find any changes in VGLUT mRNA expression in the hippocampus in any diagnostic group. We found decreased VGLUT1 mRNA expression in rats treated with haloperidol in the temporal cortex.	Bipolar Disorder	Transcriptome
88	19839996	9606	Brain(ERC)		Case-control based		qRT-PCR	We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the middle temporal gyrus, and increased VGLUT2 mRNA expression in SCZ in the inferior temporal gyrus (ITG). We did not find any changes in VGLUT mRNA expression in the hippocampus in any diagnostic group. We found decreased VGLUT1 mRNA expression in rats treated with haloperidol in the temporal cortex.	Major Depressive Disorder	Transcriptome
89	19839996	9606	Brain(ITG)		Case-control based		qRT-PCR	We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the middle temporal gyrus, and increased VGLUT2 mRNA expression in SCZ in the inferior temporal gyrus (ITG). We did not find any changes in VGLUT mRNA expression in the hippocampus in any diagnostic group. We found decreased VGLUT1 mRNA expression in rats treated with haloperidol in the temporal cortex.	Schizophrenia	Transcriptome
90	19839996	10116	Brain		Case-control based		qRT-PCR	We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the middle temporal gyrus, and increased VGLUT2 mRNA expression in SCZ in the inferior temporal gyrus (ITG). We did not find any changes in VGLUT mRNA expression in the hippocampus in any diagnostic group. We found decreased VGLUT1 mRNA expression in rats treated with haloperidol in the temporal cortex.	Schizophrenia	Transcriptome
91	19913057	10090	Brain		Case-control based	Microarray	Microarray	Fig. 1. miRs expression in the frontal cortex after acute and repeated stress. (A) Representative Northern blot analysis of let-7a, miR-9, miR-26a/b, miR-30b/c, miR-125a, U2 and U6 RNA expression levels in acute stress [A], repeated stress [R], acute stress+5d [A+5d] and naive [N] mice. (B) Quantitative analysis of miRs expression levels (n=5 per group).	Anxiety Disorder	Transcriptome
92	19913057	10090	Brain		Case-control based	Northern blotting//PCR	Northern blotting//PCR	The results indicated a prominent increase in the expression levels of different miRs after acute stress while only minor changes were observed after repeated restraint. The Northern blot analysis on selected miRs confirmed an increase after acute restraint for let-7a,miR-9 and miR26-a/b. Finally, Northern blot analysis of the selected miRs on RNA extracted from the hippocampus of stressed mice demonstrated that such changes were region specific, as no differences were observed in the hippocampus.	Major Depressive Disorder	Transcriptome
93	20347265	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	We also demonstrated that this new variant ss178077483, combined with mir-30e rs7556088 and mir-24-MAPK14 rs3804452, showed a weak gene-gene interaction for schizophrenia risk (P=0.001).	Schizophrenia	Transcriptome
94	20374639	9606	Cell lines(Lymphoblast)		Case-control based	MiRNA microarray//qRT-PCR	MiRNA microarray//qRT-PCR	Additional file 2: List of 3,905 differentially expressed genes between discordant twins and between sib pairs after meta-analysis of combined gene expression data.	Autism Spectrum Disorder	Transcriptome
95	20374639	9606	Cell lines(Lymphoblast)		Case-control based	MiRNA microarray//qRT-PCR	MiRNA microarray//qRT-PCR	This finding validates these differentially expressed miRNAs in neurological tissue from a different cohort as well as supports the use of the lymphoblasts as a surrogate to study miRNA expression in ASD.//Table 1 Significantly differentially expressed human miRNAs	Autism Spectrum Disorder	Transcriptome
96	20374639	9606	Cell lines(Lymphoblast)		Case-control based	MiRNA microarray//qRT-PCR	MiRNA microarray//qRT-PCR	This finding validates these differentially expressed miRNAs in neurological tissue from a different cohort as well as supports the use of the lymphoblasts as a surrogate to study miRNA expression in ASD.//Table 1 Significantly differentially expressed human miRNAs	Global Developmental Delay	Transcriptome
97	20380817	9606	Brain		Case-control based	Array	Array	Herein, we review emerging evidence that highlights the expression and function of lncRNAs in the CNS and suggests that lncRNA deregulation is an important factor in various CNS pathologies including neurodevelopmental, neurodegenerative and neuroimmunological disorders, primary brain tumors, and psychiatric diseases.	Autism Spectrum Disorder	Transcriptome
98	20386568	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays//Microarray//qPCR//ISH	SNP-array//Microarray//qPCR//ISH	Table 2 Results of microarray, qPCR, and ISH experiments. List of genes of interest (subdivided into 4 groups) and their expression changes in MDD and BPD patients evaluated by gene expression microarray, qRT-PCR, and/or ISH. Significant (p芒鈥奥	Depressive Disorder	Transcriptome
99	20457614	9606	Cell lines(HEKHM)		Case-control based	Western Blotting//qRT-PCR	Western blotting//qRT-PCR	This study therefore delineates a signaling pathway that mediates the effects of fentanyl on miR-190 expression.	Opioid Use Disorder	Transcriptome
100	20471092	9606	Blood		Case-control based		qRT-PCR	Individuals with a history of depression had greater Clock (U=320.00, z=-1.92, p=.05), Period 1 (U=292.50, z=-2.33, p=.02), and Bmal1 (U=308.00, z=-2.1, p=.04).	Depressive Disorder	Transcriptome
101	20479761	9606	brain	DSM-IV	Case-control based	Affymetrix Exon 1.0 ST arrays	SNP-array	Table 2 Genes with increased and decreased expression in BA10 of subjects with major depressive disorder	Depressive Disorder	Transcriptome
102	20546789	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	We found that: Plasma miR-134 levels in drug-free, 2-week medicated, and 4-week medicated bipolar mania patients were significantly decreased when compared with controls, and the level was increased on following medication. Decreased circulating miR-134 level both in drug-free and medicated patients did presented negative correlation with the clinical scales.	Bipolar Disorder	Transcriptome
103	20546789	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Overall, these results suggest that the decreased plasma miR-134 levels may be directly associated with the pathophysiology and severity of manic symptoms in BD.	Bipolar Disorder	Transcriptome
104	20557304	10116	Brain//Cell lines	Others	Case-control based	RT-PCR/Western Blotting/miRNA Microarray	RT-PCR/Western Blotting/miRNA Microarray	In this study we investigated the locomotor activity and non-selective attention in spontaneously hypertensive rats (SHR) with control Wistar-Kyoto (WKY) rats, which were employed as an attention deficit hyperactivity disorder (ADHD) model.Our data suggested a novel function of rno-let-7d in regulation of galectin-3 and in ADHD development. Rno-let-7d, which is increased in the PFC of SHR brain, negatively regulated galectin-3, which is coupled with TH expression regulation.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
105	20557304	10116	Brain	Others	Case-control based	qRT-PCR	qRT-PCR	In this study we investigated the locomotor activity and non-selective attention in spontaneously hypertensive rats (SHR) with control Wistar-Kyoto (WKY) rats, which were employed as an attention deficit hyperactivity disorder (ADHD) model.Our data suggested a novel function of rno-let-7d in regulation of galectin-3 and in ADHD development. Rno-let-7d, which is increased in the PFC of SHR brain, negatively regulated galectin-3, which is coupled with TH expression regulation.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
106	20557304	10116	Brain//Cell lines		Case-control based	Array	Array	In conclusion, our data suggested a novel function of rno-let-7d in regulation of galectin-3 and in ADHD development.Rno-let-7d, which is increased in the PFC of SHR brain, negatively regulated galectin-3, which is coupled with TH expression regulation.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
107	20557304	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	Through miRNA microarray screening, rno-let-7d was noted to be solely upregulated in SHR PFC. Interestingly, rno-let-7d had a binding site at galectin-3 mRNA and was shown to regulate galectin-3 3' untranslated region (UTR) directly.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
108	20613834	10116	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Here we report that microRNA-212 (miR-212) is upregulated in the dorsal striatum of rats with a history of extended access to cocaine	Cocaine Addiction	Transcriptome
109	20615253	9606	Blood		Case-control based		qRT-PCR	In cohort A reduced CN of the SELENBP1 locus was found in four patients but in none of the controls. In cohort B we found reduced CN of the SELENBP1 locus in two patients but in none of the controls. In cohort C three patients exhibited drastic CN reduction, not present in their parents, indicating de-novo mutation. A reduction in SELENBP1 mRNA levels in the postmortem cerebellar samples of schizophrenia patients was found.	Schizophrenia	Transcriptome
110	20668208	10090	Cell lines(SH-SY5Y)		Case-control based	qRT-PCR	qRT-PCR	The LNA-let-7 inhibitor decreased brain let-7 levels and partially attenuated opioid antinociceptive tolerance in mice.	Opioid Use Disorder	Transcriptome
111	20675101	9606	Brain		Case-control based	RT-PCR based Taqman Low Density Array	Array	At a FDR of 10%, 22 miRNAs were identified as being differentially expressed between cases and controls, 7 dysregulated in SZ and 15 in BP.	Bipolar Disorder	Transcriptome
112	20675101	9606	Brain		Case-control based	RT-PCR based Taqman Low Density Array	Array	At a FDR of 10%, 22 miRNAs were identified as being differentially expressed between cases and controls, 7 dysregulated in SZ and 15 in BP.	Schizophrenia	Transcriptome
113	20732949	9606	Brain	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Table 1. Link Between Estrogen and Schizophrenia-Related miRNAs	Schizophrenia	Transcriptome
114	20732949	9606	Brain	DSM-IV	Case-control based	Affymetrix miRNA 3.0 GeneChips	Taqman	The results from the comparison between related studies19-33 revealed that many of the miRNAs expressed at altered levels in schizophrenia postmortem brain (29 of 30), and 2 additional miRNAs reported to contain sequence polymorphisms associated with the disease (miR-198 and miR-206) are regulated by estrogen signaling (table 1).	Schizophrenia	Transcriptome
115	20862695	9606	Brain	Others	Case-control based	RT-PCR	RT-PCR	This family based association study has fine mapped a region of the STS gene across intron 1 and 2 previously associated with ADHD, in an extended sample of 450 ADHD probands and their parents. Significant association across this region is demonstrated individually with 7 of the 12 genotyped SNPs, as well as an allele specific haplotype of the 12 SNPs. The over transmitted risk allele of rs12861247 was also associated with reduced STS mRNA expression in normal human post-mortem frontal cortex brain tissue compared to the non-risk allele (P = 0.01).	Attention-Deficit/Hyperactivity Disorder	Transcriptome
116	20862695	9606	Brain		Case-control based			These results are consistent with the hypothesis arising from previous literature demonstrating that boys with deletions of the STS gene, andhence no STS protein are at a significantly increased risk of developing ADHD.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
117	20868653	9606	Cell lines(Lymphoblast)		Family based	Illumina Universal-12 BeadChips	Array	Table 2 Differentially regulated miRNAs in autism.	Autism Spectrum Disorder	Transcriptome
118	20868653	9606	Cell lines(Lymphoblast)		Case-control based		Microarray//qRT-PCR	Table 1 Differentially regulated genes in autism.	Autism Spectrum Disorder	Transcriptome
119	20877302	9606	Blood	DSM-IV	Case-control based		RNA-seq	The genotypes were in Hardy-Weinberg equilibrium. A difference in the CYP2D6 active alleles distribution was found between patients with ED and controls (P<0.05)	Binge Eating Disorder	Transcriptome
120	20951849	9606						MIAT turned out to be one of the top twenty-five, of nearly 39,000, transcripts differentially expressed in the nucleus accumbens,a midbrain region pivotal in drug abuse, in a case-control study of human heroin and cocaine abusers.	Drug Abuse	Transcriptome
121	21048142	10090	Brain		Case-control based	miR array//TaqMan miR assay	Array//TaqMan	Deletion of Dicer1 gene in forebrain leads to loss of a miR124, miR-132, miR-137, miR138, miR29a, miR29c.	Posttraumatic Stress Disorder	Transcriptome
122	21048142	10090	Brain		Case-control based	miRNA array//Taqman assay	Array//Taqman	MicroRNA loss enhances learning and memory in mice.	Posttraumatic Stress Disorder	Transcriptome
123	21068306	10116	Brain		Case-control based	Real-time PCR//Northern blotting	RT-PCR//Northern blotting	Thus, the increased expressions of RE-1-containing genes in the HMS180 rats might be regulated not only by REST4, but also by other transcription factors. However at a minimum, the increased expressions ofGlur2, Nr1, Crh, CamKIIa, Adcy5, 5htr1a, miR132, miR121 and miR-9-3 genes in HMS180 rats might be regulated by REST4, as those expressions were elevated by REST4 overexpression	Anxiety Disorder	Transcriptome
124	21110120	9606	Blood		Case-control based		qRT-PCR	When schizophrenia subgroups were compared among themselves (residual, disorganized and paranoid schizophrenia), there was significant difference (P=0.026) in DRD3 mRNA/b-actin mRNA levels (Table 2). Schizophrenia subgroups were compared with controls and with each others according to the DRD3 mRNA/b-actin mRNA ratio and significant difference (P=0.030) was detected between controls and disorganized schizophrenics (Fig. 1).	Schizophrenia	Transcriptome
125	21111402	9606	Brain	DSM-IV	Case-control based	Illumina miRNA microarray	Microarray	These observations were supported by quantitative reverse transcription-polymerase chain reaction,for miR-328, miR-17-5p, miR-134, miR-652, miR-382, and miR-107 and were consistent with a schizophrenia-associated increase in miRNA processing through elevated Dicer expression.	Schizophrenia	Transcriptome
126	21145962	9606	Blood	DSM-IV	Case-control based		Microarray	TABLE 3 Differentially expressed genes from microarray with qPCR validation for male PTSD+ versus control participants	Posttraumatic Stress Disorder	Transcriptome
127	21183010	9606	Brain	DSM-IV	Case-control based	7900HT Real-Time PCR//TaqMan assays//FlexmiR v2 assay	RT-PCR//TaqMan	19% of miRNAs analyzed exhibited positive evidence of altered expression due to a diagnosis of schizophrenia or bipolar disorder.	Bipolar Disorder	Transcriptome
128	21183010	9606	Brain	DSM-IV	Case-control based	7900HT Real-Time PCR//TaqMan assays//FlexmiR v2 assay	RT-PCR//TaqMan//Array	19% of miRNAs analyzed exhibited positive evidence of altered expression due to a diagnosis of schizophrenia or bipolar disorder.	Schizophrenia	Transcriptome
129	21208484	9606	Blood		Case-control based		qRT-PCR	We found significant increase in mRNA encoding for GABAAb3 and 5-HT2A, 5-HT7 receptors and BDNF and a reduction in PKCb2 mRNA.	Schizophrenia	Transcriptome
130	21275079	10116	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Fig. 1. miRNAs that are significantly up- or down-regulated in the NLH vs. TC comparison. See Supplementary Table S1 for Ct and p values for each miRNA.	Major Depressive Disorder	Transcriptome
131	21275079	10116	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Fig. 2. miRNAs that are significantly up- or down-regulated in the LH vs. TC comparison. See Supplementary Table S2 for Ct and p values for each miRNA.	Major Depressive Disorder	Transcriptome
132	21350482	9606	Blood	DSM-IV	Case-control based			We found a sex x genotype effect (Fig 4D, F(3,99)=4.3, p<0.05) with females with the 芒鈧淐C芒鈧劉 genotype expressing significantly less ADCYAP1R1 mRNA than males(F(1,33)=5.5, p<0.05) or than females who are 芒鈧淕芒鈧劉carriers (one-tailed, F(1, 45)=2.87, p<0.05). Thus, mRNA encoding the PACAP peptide and PAC1 receptor appeared to be tightly regulated within the human cortex, and ADCYAP1R1 mRNA levels were associated with the ADCYAP1R1 rs2267735 SNP.	Posttraumatic Stress Disorder	Transcriptome
133	21352832	10116	Brain		Case-control based		qRT-PCR	QPCR analysis of mRNA expression for: A) dopamine D2 receptor (DRD2), B) serotonin 5-HT2C receptor (HTR2C), and C) nuclear orphan receptor 1 (NOR1) shows that chronic LSD influences the expression of many genes in the mPFC one month after cessation of LSD in schizophrenia.	Schizophrenia	Transcriptome
134	21421043	9606	Blood	DSM-IV	Case-control based		qPCR//ChIP-seq	TREM-1 was statistically significantly increased in the monocytes of SCZ and BD patients (1.56 and 1.46-fold, respectively)	Bipolar Disorder	Transcriptome
135	21421043	9606	Blood	DSM-IV	Case-control based		qPCR//ChIP-seq	In this study, we provide evidence that TREM-1 gene expression is significantly increased in monocytes of SCZ and BD patients and that the TREM-1 gene is a target gene of the TFs ATF3 and EGR3. In MDD patients, PU.1 gene expression was increased with a tendency for TREM-1 gene over expression.	Bipolar Disorder	Transcriptome
136	21421043	9606	Blood	DSM-IV	Case-control based		qPCR//ChIP-seq	In this study, we provide evidence that TREM-1 gene expression is significantly increased in monocytes of SCZ and BD patients and that the TREM-1 gene is a target gene of the TFs ATF3 and EGR3. In MDD patients, PU.1 gene expression was increased with a tendency for TREM-1 gene over expression.	Major Depressive Disorder	Transcriptome
137	21421043	9606	Blood	DSM-IV	Case-control based		qPCR//ChIP-seq	In this study, we provide evidence that TREM-1 gene expression is significantly increased in monocytes of SCZ and BD patients and that the TREM-1 gene is a target gene of the TFs ATF3 and EGR3. In MDD patients, PU.1 gene expression was increased with a tendency for TREM-1 gene over expression.	Schizophrenia	Transcriptome
138	21464311	9606	Brain		Case-control based		RNA-Seq//ChIP-Seq	Table 1. Genes with significant differential expression (FDR<0.2) observed in both chronic cocaine- and alcohol-addicted individuals	Alcohol Use Disorder	Transcriptome
139	21464311	9606	Brain		Case-control based		RNA-Seq//ChIP-Seq	Table 1. Genes with significant differential expression (FDR<0.2) observed in both chronic cocaine- and alcohol-addicted individuals	Cocaine Addiction	Transcriptome
140	21508514	9606	Blood	DSM-IV	Case-control based		Microarray	Microarray results for lifetime PTSD versus controls. These genes differentiated persons with (n=20) and without (n=20) lifetime PTSD. I. Identified in Both Lifetime and Current PTSD	Posttraumatic Stress Disorder	Transcriptome
141	21508514	9606	Blood	DSM-IV	Case-control based		Microarray	Microarray results for lifetime PTSD versus controls. These genes differentiated persons with (n=20) and without (n=20) lifetime PTSD. II. Identified in Lifetime PTSD Only	Posttraumatic Stress Disorder	Transcriptome
142	21508514	9606	Blood	DSM-IV	Case-control based		Microarray	Microarray results for lifetime PTSD versus controls. These genes differentiated persons with (n=20) and without (n=20) lifetime PTSD.III. Identified in Current PTSD Only	Posttraumatic Stress Disorder	Transcriptome
143	21515361	9606	Cell lines(NS1)		Case-control based	Luciferase reporter assay	Reporter assay	miR-18a and miR-124a decrease protein expression of glucocorticoid receptor by luciferase reporter assay in NS1 cells.	Depressive Disorder	Transcriptome
144	21539852	10116	Blood		Case-control based		ISH	Binge Access animals had reduced mu-opioid receptor expression compared with Scheduled Access and Naive controls (p<0.05). A similar reduction in mu opioid receptor mRNA was also demonstrated in the Continuous Access group.	Eating Disorder	Transcriptome
145	21539852	10116	Brain		Case-control based		ISH	Binge Access animals had reduced mu-opioid receptor expression compared with Scheduled Access and Naive controls (p<0.05). A similar reduction in mu opioid receptor mRNA was also demonstrated in the Continuous Access group.	Eating Disorder	Transcriptome
146	21632647	9606	Brain		Case-control based		qRT-PCR	GAD67 m RNA levels were significantly lower in schizophrenia subjects (by 15%), but transcript levels were not associated with predictors or measures of illness severity or chronicity.	Schizophrenia	Transcriptome
147	21651580	9606	Brain		Case-control based			Table 2. miRNAs Whose Targets are Over-Represented Among Down-Regulated mRNAs	Alcohol Use Disorder	Transcriptome
148	21690067	10116	Corpus cavernosa		Case-control based	qRT-PCR	qRT-PCR	The expression of miR-145 was decreased in the corpus cavernosum of diabetic rats with ED.	Erectile Disorder	Transcriptome
149	21708909	7227	Brain//Cell lines		Case-control based	High-throughput sequencing of miRNAs	RNA-Seq	FIGURE 3. Cocaine-regulated miRNAs in NAc total lysates.	Cocaine Addiction	Transcriptome
150	21708909	10090	Brain//Cell lines		Case-control based	High-throughput sequencing of miRNAs	RNA-Seq	FIGURE 3. Cocaine-regulated miRNAs in NAc total lysates.	Cocaine Addiction	Transcriptome
151	21708909	10090	Brain//Cell lines		Case-control based	High-throughput sequencing of miRNAs	RNA-Seq	FIGURE 5. Identification of miRNA families enriched at the PSD	Cocaine Addiction	Transcriptome
152	21708909	10090	Brain//Cell lines		Case-control based	High-throughput sequencing of miRNAs	RNA-Seq	Mtdh is targeted by miR-183 and four miR-8 family members, which are down-regulated by cocaine, and by miR-16, miR-32, miR-33, miR-130b, and miR-153, which are upregulated by cocaine (Fig. 6; Supplemental Fig. S6).	Cocaine Addiction	Transcriptome
153	21727898	9606	Blood	ICD-10//DIP	Case-control based	Illumina miRNA microarray	Microarray	Table 2 miRNA significantly downregulated in schizophrenia compared with non-psychiatric controls	Schizophrenia	Transcriptome
154	21738743	9606	Blood	DSM-IV	Case-control based	Affymetrix miRNA 3.0 GeneChips	Taqman	The putative signature was then validated in the testing set, with an AUC of 85%. Among these miRNAs, miR-34a was differentially expressed between cases and controls in both the learning (P=0.005) and the testing set (P=0.002).	Schizophrenia	Transcriptome
155	21738743	9606	Blood	DSM-IV	Case-control based	Affymetrix miRNA 3.0 GeneChips	Taqman	Table 1 The seven microRNA-signature derived from the learning set (30 patients with schizophrenia and 30 healthy controls).	Schizophrenia	Transcriptome
156	21841775	10090	Brain		Case-control based	Western blotting	Western blotting	Figure 2 mIR-128b functionally interacts with target genes, which decreases target gene expression	Anxiety Disorder	Transcriptome
157	21841775	10090	ILPF		Case-control based	Lentiviral vector for miR knockdown//TaqMan miR assay	TaqMan	miR-134 expression in ILPFC, whereas miR-128b in extinction training only Knockdown of miR-128b fear-conditioning memory, while overexpressing it.	Posttraumatic Stress Disorder	Transcriptome
158	21915259	9606	Cell lines		Case-control based	RNA-Seq//RT-PCR	RNA-Seq//RT-PCR	Consistent with the differentiation of iPSCs into neurons, substantial 10 to >1,000-fold decreases were detected in the expression of genes associated with pluripotency such as OCT4 (POU5F1), JARID2, NANOG, and LIN28A, with a concomitant increase in expression of transcription factors associated with neural differentiation, including POU3F2, MYT1L, NEUROD1, and MEF2C (Table S3).	Psychotic Disorder	Transcriptome
159	21915259	9606	cell lines		Case-control based	RNA-Seq//RT-PCR	RNA-Seq//RT-PCR	Table S5 Top lncRNAs.	Schizophrenia	Transcriptome
160	21976504	10090	Brain		Case-control based	Microarray	Microarray	Figure 5 .miR-34c overexpression in the amygdala 7 d after viral injection of LV-miR-34c relative to LV-EGFP control	Anxiety Disorder	Transcriptome
161	22003227	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	This study showed that dosage effects of MIR137 are associated with 1p21.3 microdeletions and may therefore contribute to the ID phenotype in patients with deletions harbouring this miRNA. A local effect at the synapse might be responsible.	Intellectual Disability	Transcriptome
162	22078298	10116	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Our results suggest that neuroimmune modulation following traumatic stress is mediated by a cascade that involves c-Src-mediated enhancement of miRNA222 expression and downregulation of PAK1, which in turn impairs signaling via IL-1脦虏/IL1-RI, leading to immunosuppression.	Posttraumatic Stress Disorder	Transcriptome
163	22078298	10116	Brain(PFC)		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Table 1 miR levels in clinical and preclinical PTSD-related studies(24759737)	Posttraumatic Stress Disorder	Transcriptome
164	22078298	10116	Brain(PFC)		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	We confirm robust upregulation of c-Src expression following traumatic stress. c-Src upregulation was accompanied by marked increases in levels of miRNA222; other studied miRNAs were not affected by stress.	Posttraumatic Stress Disorder	Transcriptome
165	22094284	9606	Blood	ICD-10	Case-control based	qRT-PCR	qRT-PCR	When compared with family schizophrenia patients, circulating miR-219-2-3p, miR-92a, miR-346, let-7g and miR-17 were significantly higher in sporadic schizophrenia (p<0.001, Fig. 4).	Schizophrenia	Transcriptome
166	22094284	9606	Blood	ICD-10	Case-control based	qRT-PCR	qRT-PCR	On contrary, miR-181b and miR-195 were significantly downregulated in sporadic schizophrenia compared with family schizophrenia patients(p<0.001), miR-1308 was slightly lower in sporadic schizophrenia compared family schizophrenia patients (0.05<p<0.001), and miR-103 was highly consistent between sporadic schizophrenia and family schizophrenia patients(p > 0.05).	Schizophrenia	Transcriptome
167	22094284	9606	Blood	ICD-10	Case-control based	qRT-PCR	qRT-PCR	The results suggested that the miR-181b, miR-219-2-3p, miR-346, miR-195, miR-1308, miR-92a, miR-17, miR-103 and let-7g are the key players to reflect the schizophrenia illnesses status and may serve as candidate biomarkers for diagnosis of schizophrenia.	Schizophrenia	Transcriptome
168	22137507	9606	Cell lines	DSM-IV	Case report	iQ5 RealTime PCR Detection System	RT-PCR	Logistic regression analysis was applied to predict development of a high level of PTSD symptoms based on predeployment GR number, messenger (m)RNA expression of GR target genes FKBP5, GILZ, and SGK1, plasma cortisol, and childhood trauma.	Posttraumatic Stress Disorder	Transcriptome
169	22228753	9606	Brain//Cell lines(HEK293)	DSM-IV	Case-control based	Affymetrix Microarray//qRT-PCR	FISH//Western Blot//Microarray//qRT-PCR//Luciferase Reporter Assay	The reciprocal expression of NPAS3 mRNA and protein during postnatal development mediated by a schizophrenia-associated change in miR-17 suggests that there is complex control over NPAS3 synthesis in the human prefrontal cortex and that if NPAS3 is dysregulated in schizophrenia, it is not evident by large changes in NPAS3 expression.	Schizophrenia	Transcriptome
170	22228753	9606	Brain//Cell lines(HEK293)	DSM-IV	Case-control based	Affymetrix Microarray//qRT-PCR	FISH//Western Blot//Microarray//qRT-PCR//Luciferase Reporter Assay	In schizophrenia prefrontal cortex, we found significant elevations in miR-17 expression. While NPAS3 mRNA was unaltered, reduced NPAS3 protein expression was detected in a subpopulation of people with schizophrenia.	Schizophrenia	Transcriptome
171	22228753	9606	Brain//Cell lines(HEK293)	DSM-IV	Case-control based	Affymetrix Microarray//qRT-PCR	FISH//Western Blot//Microarray//qRT-PCR//Luciferase Reporter Assay	Microarray analysis of neonates, infants, toddlers, school-age children, teenagers, young adults, and adults revealed an age-dependent decline in NPAS3 mRNA expression during the first decade of life (one-way ANOVA P=.0003; regression r=.53, P=.0002) in both males and females (figure 1A).	Schizophrenia	Transcriptome
172	22237309	9606	Blood		Case-control based	Illumina TotalPrep RNA Amplification Kit//qPCR	qRT-PCR	Table 2 (A) Differentially Expressed mRNA Expression at Baseline with Nominal Po0.05 in Both Cohorts and FC41.15. (B) Differentially Regulated mRNA Expression of the Ratio Post/prestimulated mRNA with Po0.05 in Both Cohorts, FC41.15 (in controls) and Alteration in the Same Direction of the 19 Transcripts Which Contributed Most to the Classification.	Depressive Disorder	Transcriptome
173	22315408	9606	Brain		Case-control based	MiRNA microarray	Microarray	Our data suggest miR-132 dysregulation and subsequent abnormal expression of miR-132 target genes contribute to the neurodevelopmental and neuromorphological pathologies present in schizophrenia.(Table 1. MiRNAs with FDR<0.05 in the SMRI samples)	Bipolar Disorder	Transcriptome
174	22315408	9606	Brain		Case-control based	MiRNA microarray	Microarray	Table 1. MiRNAs with FDR<0.05 in the SMRI samples	Bipolar Disorder	Transcriptome
175	22315408	9606	Brain		Case-control based	MiRNA microarray	Microarray	Our data suggest miR-132 dysregulation and subsequent abnormal expression of miR-132 target genes contribute to the neurodevelopmental and neuromorphological pathologies present in schizophrenia.(Table 1. MiRNAs with FDR<0.05 in the SMRI samples)	Schizophrenia	Transcriptome
176	22315408	9606	Brain		Case-control based	MiRNA microarray	Microarray	Table 1. MiRNAs with FDR<0.05 in the SMRI samples	Schizophrenia	Transcriptome
177	22339950	9606	brain	DSM-IV	Case-control based	Microarray Inc. HEEBO arrays	Microarray//qPCR	Table 2 Results of microarray experiments; dysregulated synaptic genes in the hippocampal sub-regions of subjects with major depressive disorder	Depressive Disorder	Transcriptome
178	22339950	9606	brain	DSM-IV	Case-control based	Microarray Inc. HEEBO arrays	Microarray//qPCR	Table 3 Results of microarray experiments ; dysregulated glutamatergic and serotonergic genes in the hippocampal sub-regions of subjects with major depressive disorder	Depressive Disorder	Transcriptome
179	22427989	9606	Blood	DSM-IV	Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Table 2 microRNAs down-regulated in depressed suicide as determined by individual tests of statistical significance.(MicroRNAs decreased by 30% or more (but p>0.05))	Depressive Disorder	Transcriptome
180	22427989	9606	Blood	DSM-IV	Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Table 2 microRNAs down-regulated in depressed suicide as determined by individual tests of statistical significance.	Depressive Disorder	Transcriptome
181	22511363	10116	Brain		Case-control based		qRT-PCR	Tph2 mRNA expression in the DRVL/VLPAG was correlated with increased anxiety-related behavior.	Anxiety Disorder	Transcriptome
182	22560368	10116	Brain		Case-control based		qRT-PCR	After 24 h alcohol withdrawal, a significant upregulation of MALAT-1 expression was observed in rat cortex.	Alcohol Withdrawal	Transcriptome
183	22649234	10116	Brain		Case-control based		qRT-PCR	Acute alcohol withdrawal was accompanied by downregulated GR mRNA in various stress/reward-related brain regions (i.e., prefrontal cortex, nucleus accumbens [NAc], and bed nucleus of the stria terminalis [BNST]), whereas protracted alcohol abstinence was accompanied by upregulated GR mRNA in the NAc core, ventral BNST, and central nucleus of the amygdala.	Alcohol Withdrawal	Transcriptome
184	22733126	9606	Blood	ICD-10//DIP	Case-control based	Infinium Human 610K BeadChips	Array	These findings provide the first evidence for association of the MIR137 SNP with a specific Sz phenotype characterised by severe CDs and negative symptoms, consistent with the emerging role of microRNAs in the regulation of proteins responsible for neural development and function.	Schizophrenia	Transcriptome
185	22817756	9606	Blood		Case-control based	Array	Array	DISC1 is regulated by its lncRNA, DISC2, which may also represent an excellent candidate for susceptibility to these disorders.	Autism Spectrum Disorder	Transcriptome
186	22817756	9606	Blood		Case-control based	Array	Array	DISC1 is regulated by its lncRNA, DISC2, which may also represent an excellent candidate for susceptibility to these disorders.	Bipolar Disorder	Transcriptome
187	22817756	9606	Blood		Case-control based	Array	Array	DISC1 is regulated by its lncRNA, DISC2, which may also represent an excellent candidate for susceptibility to these disorders.	Major Depressive Disorder	Transcriptome
188	22817756	9606	Blood		Case-control based	Array	Array	DISC1 is regulated by its lncRNA, DISC2, which may also represent an excellent candidate for susceptibility to these disorders.	Schizophrenia	Transcriptome
189	22817756	9606	Blood		Case-control based		Western blotting	Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1	Schizophrenia	Transcriptome
190	22850735	9606	Blood	DSM-IV	Case-control based	TaqMan//PCR-based assay	TaqMan//PCR	We have demonstrated a common effect of the MIR137 genotype across controls and two groups of individuals at high risk of major mental illness on activation in the right posterior medial frontal gyrus. We have also shown significant differential effects of the MIR137 genotype across groups in the left amygdala and left pre/postcentral gyrus.	Bipolar Disorder	Transcriptome
191	22850735	9606	Blood	DSM-IV	Case-control based	Affymetrix miRNA 3.0 GeneChips	Taqman	We have demonstrated a common effect of the MIR137 genotype across controls and two groups of individuals at high risk of major mental illness on activation in the right posterior medial frontal gyrus. We have also shown significant differential effects of the MIR137 genotype across groups in the left amygdala and left pre/postcentral gyrus.	Schizophrenia	Transcriptome
192	22875919	10090	Blood		Case-control based		Genotyping	Pitx3 mRNA was increased in the transgenic STM at 6 weeks (p<0.01) and in both STM and SN/VTA at 48 weeks (p<0.05 and p<0.001, respectively) relative to WT littermates (Fig. 4C).	Neurodevelopmental Disorders	Transcriptome
193	22875919	10090	Blood		Case-control based		Genotyping	Herein, we demonstrate that selective overexpression of the stress protein heme oxygenase-1 (HO-1) in astrocytes of novel GFAP.HMOX1 transgenic mice results in subcortical oxidative stress and mitochondrial damage/autophagy; diminished neuronal reelin content (males); induction of Nurr1 and Pitx3 with attendant suppression of their targeting miRNAs, 145 and 133b; increased tyrosine hydroxylase and 脦卤-synuclein expression with downregulation of the targeting miR-7b of the latter; augmented dopamine and serotonin levels in basal ganglia; reduced D1 receptor binding in nucleus accumbens; axodendritic pathology and altered hippocampal cytoarchitectonics; impaired neurovascular coupling; attenuated prepulse inhibition (males); and hyperkinetic behavior.	Neurodevelopmental Disorders	Transcriptome
194	22875919	10090	Blood		Case-control based	qRT-PCR	qRT-PCR	miRNA-133b (targeting Pitx3) declined at 6 weeks in both the transgenic STM and SN/VTA (p<0.01), with recovery to WT values by 48 weeks (p>0.05) (Fig. 4C).	Neurodevelopmental Disorders	Transcriptome
195	22875919	10090	Blood		Case-control based	qRT-PCR	qRT-PCR	Incomparison with Wtlitter mates,miRNA-145(targeting Nurr1) was elevated in the transgenic STM at 6 weeks (p< 0.001)but was significantly suppressed in SN/VTA at 6weeks and in STMat 48 weeks (p<0.05) (Fig. 4B).	Neurodevelopmental Disorders	Transcriptome
196	22875919	10090	Blood		Case-control based		Genotyping	DAT mRNA in the TG mice exhibited a trend toward higher levels in STM and reduced levels in SN/VTA at 6 weeks, and significantly elevated levels in both regions at 48 weeks relative to WT values (p<0.05) (Fig. 4A).	Neurodevelopmental Disorders	Transcriptome
197	22875919	10090	Blood		Case-control based		Genotyping	We found that Nurr1 mRNA declined in the STM (p<0.05) and remained unchanged in SN/VTA (p<0.05) of TG mice at 6 weeks relative to WT controls (Fig. 4B). Conversely, Nurr1 was elevated in the TG SN/VTA (p<0.05) and remained unchanged in STM (p<0.05) at 48 weeks compared with WT littermates.	Neurodevelopmental Disorders	Transcriptome
198	22925464	9606	Blood	ICD-10//DSM-IV	Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Thirty miRNAs were differentially expressed after the AD treatment: 28 miRNAs were up-regulated, and 2 miRNAs were strongly down-regulated. miRNA target gene prediction and functional annotation analysis showed that there was a significant enrichment in several pathways associated with neuronal brain function (such as neuroactive ligand-receptor interaction, axon guidance, long-term potentiation and depression), supporting the hypothesis that the differentially regulated miRNAs may be involved in the AD mechanism.	Major Depressive Disorder	Transcriptome
199	22949041	9606	Brain		Case-control based	Human lncRNA Microarray V2.0	Microarray//qRT-PCR	ESM 2 List and annotation of all differentially expressed lncRNAs	Neurodevelopmental Disorders	Transcriptome
200	22949041	9606	Brain(PFC)		Case-control based	Human lncRNA Microarray V2.0	Microarray//qRT-PCR	ESM 3 Differentially Expressed mRNAs Identified in ASD Prefrontal Cortex versus Control Prefrontal Cortex	Neurodevelopmental Disorders	Transcriptome
201	22949041	9606	Cerebellum		Case-control based	Human lncRNA Microarray V2.0	Microarray//qRT-PCR	ESM 3 Differentially Expressed mRNAs Identified in ASD Prefrontal Cortex versus Control Prefrontal Cortex	Neurodevelopmental Disorders	Transcriptome
202	22952654	9606	Blood		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Over-expression of miR-29a, a miRNA expressed in the brain and in cells of the blood lineage, resulted in the differential expression of a set of proteins.	Depressive Disorder	Transcriptome
203	22968819	9606						Here, we review recent evidence supporting a key role for miRNAs in the ventral striatum in regulating the rewarding and reinforcing properties of cocaine in animals with limited exposure to the drug.	Cocaine Addiction	Transcriptome
204	23087602	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays	SNP-array	Table 3 Functional groups that showed significant alterations in gene expression.(Metabolism)	Depressive Disorder	Transcriptome
205	23087602	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays	SNP-array	Table 3 Functional groups that showed significant alterations in gene expression.(Cell cycle regulation)	Depressive Disorder	Transcriptome
206	23087602	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays	SNP-array	Table 3 Functional groups that showed significant alterations in gene expression.(NRF2-mediated oxidative stress response)	Depressive Disorder	Transcriptome
207	23087602	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays	SNP-array	Table 3 Functional groups that showed significant alterations in gene expression.(Intracellular signaling)	Depressive Disorder	Transcriptome
208	23087602	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays	SNP-array	Table 3 Functional groups that showed significant alterations in gene expression.(Mitochondrial dysfunction)	Depressive Disorder	Transcriptome
209	23087602	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays	SNP-array	Table 3 Functional groups that showed significant alterations in gene expression.(Transcription regulators)	Depressive Disorder	Transcriptome
210	23087602	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays	SNP-array	Table 3 Functional groups that showed significant alterations in gene expression.(Axonal guidance signaling)	Depressive Disorder	Transcriptome
211	23087602	9606	brain		Case-control based	Affymetrix HG-U133 Plus 2.0 arrays	SNP-array	Table 3 Functional groups that showed significant alterations in gene expression.(N-glycan biosynthesis)	Depressive Disorder	Transcriptome
212	23149449	9606	Blood	DSM-IV-TR	Case-control based	RT-PCR//microarray assay	RT-PCR//Microarray	We compared miRNAs expression in MDE and controls and found significantly up- and also downregulated miRNAs (FC>1.20 or<-1.20; P<0.05), as shown in Table 3.	Major Depressive Disorder	Transcriptome
213	23149449	9606	Blood	DSM-IV-TR	Case-control based	Taqman miRNA assay	Taqman	Furthermore, we identified a combination of four mRNAs (PPT1, TNF, IL1B and HIST1H1E) that could be predictive of treatment response.	Major Depressive Disorder	Transcriptome
214	23184316	10090	Brain//Cell lines		Case-control based	qRT-PCR	qRT-PCR	Because of the higher level of pre-miR-183 expression in EE mice, one can expect reduction in the level of SC35 expression.	Anxiety Disorder	Transcriptome
215	23264780	9606	Blood		Case-control based	Affymetrix Genome-Wide Human SNP Array 6.0	Array	Under four statistical scenarios, 38 significantly enriched pathways (P-value<0.01 after multiple testing correction) were identified for the risk of developing BPD, including pathways of ion channels associated (e.g., gated channel activity, ion transmembrane transporter activity, and ion channel activity) and nervous related biological processes (e.g., nervous system development, cytoskeleton, and neuroactive ligand receptor interaction).	Bipolar Disorder	Transcriptome
216	23295264	9606	Blood		Case-control based	qPCR//TaqMan array	TaqMan//qPCR	In a correlation study decreased expression of miR-146a in monocytes was related to decreased natural T regulator cells in PP patients; decreased miR-212 was correlated to increased Adrenomedulin and decreased IL-6 expression in monocytes and to higher Th2 cell levels.	Psychotic Disorder	Transcriptome
217	23345080	10090	Brain		Case-control based		qRT-PCR	The increase in Cnr1 mRNA expression that we observed in the C57BL/6Snca-/- mice in the first experiment suggests that CB1 receptors may be one of the most significantly affected components of the cannabinoid system associated with the spontaneous deletion of Snca.	Alcohol Use Disorder	Transcriptome
218	23345080	10090	Brain		Case-control based		qRT-PCR	The increase in Cnr1 mRNA expression that we observed in the C57BL/6Snca-/- mice in the first experiment suggests that CB1 receptors may be one of the most significantly affected components of the cannabinoid system associated with the spontaneous deletion of Snca.	Drug Abuse	Transcriptome
219	23345246	10116	Brain		Case-control based	miRNA array//Taqman assay	Array//TaqMan	PCR confirmed miR-182 1h after auditory FC in lateral amygdala (LA). Overexpression of miR-182 in LA resulted in of 2 target proteins, disrupted long-term but not short-term auditory fear memory.	Posttraumatic Stress Disorder	Transcriptome
220	23382797	9606	Brain		Case-control based	Luminex miRNA Assay//RT-PCR//Western Blotting	RT-PCR//Western Blotting	The consideration of combined effects of B and C drug classes heightened the significance of the results for miRNAs 219 and 29c (bold; see Table 3), while miRNA 30e-3p and 526b* (bold) acquired significance.	Bipolar Disorder	Transcriptome
221	23382797	9606	Brain		Case-control based	Luminex miRNA Assay//RT-PCR//Western Blotting	RT-PCR//Western Blotting	RT-PCR validation confirmed that two miRNAs, miR-497 in SZ samples and miR-30c in BD samples, have significantly increased expression when compared to control samples. These results warrant future studies to evaluate the potential of exosome-derived miRNAs to serve as biomarkers of SZ and BD.	Bipolar Disorder	Transcriptome
222	23382797	9606	Brain		Case-control based	qRT-PCR//Western blotting	qRT-PCR//Western blotting	The significance of results for miRNAs 31, 33, 96, 30e-5p, and 199a* (bold) was preserved (see Table 2), while miRNAs 15b, 455, 32, and 20b acquire significance (bold) after the adjustment for the drug class A (antipsychotics used in SZ only). After the adjustment for drug classes B (neurotransmitters receptor-site binders) and C (sedatives, hypnotics, anticonvulsants and analgesics) drug classes, the significance for miRNAs 31, 33, 96, 30e-5p, and 199a* (bold) was again preserved (see Table 2) while miR-455 acquired significance together with miR-323 (bold).	Schizophrenia	Transcriptome
223	23382797	9606	Brain		Case-control based	qRT-PCR//Western blotting	qRT-PCR//Western blotting	RT-PCR validation confirmed that two miRNAs, miR-497 in SZ samples and miR-30c in BD samples, have significantly increased expression when compared to control samples. These results warrant future studies to evaluate the potential of exosome-derived miRNAs to serve as biomarkers of SZ and BD.	Schizophrenia	Transcriptome
224	23403177	10116	Brain		Case-control based		ISH	Among vehicle-treated rats, isolation-reared rats had decreased tryptophan hydroxylase 2 (tph2) mRNA expression in ventral and ventrolateral subdivisions of the DR, a pattern observed previously in a rat model of panic disorder.	Anxiety Disorder	Transcriptome
225	23423139	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	In addition, our data argues that increased levels of at least one miR, miR-107, is contributing to the marked loss of cortical CHRM1 in Def-Sz and this may be a differentiating pathophysiology.	Schizophrenia	Transcriptome
226	23423139	9606	Blood	DSM-IV	Case-control based		qRT-PCR	We now report that cortical CHRM1 gene promoter methylation and CHRM1 mRNA are decrease in Sz, Def-Sz and Non-Def-Sz but levels of the micro RNA (miR)-107, a CHRM1 targeting miR, are increased only in Def-Sz.	Schizophrenia	Transcriptome
227	23437274	9606	Blood		Case-control based	array	Array	MS mRNA levels were significantly lower in autistic subjects, especially at younger ages, and this decrease was replicated in cultured human neuronal cells by treatment with TNF-脦卤, whose CSF levels are elevated in autism.	Autism Spectrum Disorder	Transcriptome
228	23451085	9606						Table S1 Details of the 378 autism implicated CNV loci considered for our study with their corresponding microRNA content.	Autism Spectrum Disorder	Transcriptome
229	23451085	9606						A systematic analysis of the CNV-miRNAs based on their interactions with the target genes enabled the identification of top 10 miRNAs namely hsa-miR-590-3p, hsa-miR-944, hsa-miR-570, hsa-miR-34a, hsa-miR-124, hsa-miR-548f, hsa-miR-429, hsa-miR-200b, hsa-miR-195 and hsa-miR-497 as hub molecules.	Autism Spectrum Disorder	Transcriptome
230	23520022	10090	Brain		Case-control based	Lentiviral vector for miR knockdown//TaqMan miR assay	TaqMan	This approach successfully reduced hippocampal miR-132 expression in both native and trace fear conditioned groups, and impaired acquisition of trace fear memory in mice.	Posttraumatic Stress Disorder	Transcriptome
231	23562612	9606						The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression.	Depressive Disorder	Transcriptome
232	23562612	9606						The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression.	Schizophrenia	Transcriptome
233	23580197	10090	Brain	Others	Case-control based	Affymetrix miRNA 2.0 Array	Affymetrix miRNA 2.0 Array	We found long-lasting alterations in DNA methylation as a result of fetal alcohol exposure, specifically in the imprinted regions of the genome harboring ncRNAs and sequences interacting with regulatory proteins.	Fetal Alcohol Spectrum Disorder	Transcriptome
234	23593384	10090	Amygdala		Case-control based		Microarray//qRT-PCR//Western Blotting//Immunohistochemistry	Lcn-2 gene is one of the most highly upregulated transcripts detected by microarray analysis in the amygdala after acute restraint-induced psychological stress	Posttraumatic Stress Disorder	Transcriptome
235	23628989	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Finally, we show that Gomafu is downregulated in post-mortem cortical gray matter from the superior temporal gyrus in SZ. These results functionally link activity-regulated lncRNAs and alternative splicing in neuronal function and suggest that their dysregulation may contribute to neurological disorders.	Schizophrenia	Transcriptome
236	23673188	9606	Blood	ICD-10	Case-control based	qRT-PCR//ELISA	qRT-PCR//ELISA	It was observed that both VEGFA mRNA and protein levels were significantly higher in patients suffering from rDD comparing with the controls (Table 1).	Depressive Disorder	Transcriptome
237	23704927	9606	Blood	ICD-10//DSM-IV	Case-control based	ELISA//RT-PCR//Western Blotting	ELISA//RT-PCR//Western Blotting	Collectively, we provided evidence supporting that miR-182 is a putative BDNF-regulatory miRNA, and suggested that the serum BDNF and its related miRNAs may be utilized as important biomarkers in the diagnosis or as therapeutic targets of depression.	Depressive Disorder	Transcriptome
238	23704927	9606	Blood	ICD-10//DSM-IV	Case-control based	ELISA//RT-PCR//Western Blotting	ELISA//RT-PCR//Western Blotting	Our results showed a significant negative correlation (Spearman rs=-0.307, P=0.006) between the serum BDNF levels and the miR-132 levels in patients with depression (n=40) and controls (n=40, Fig. 4A).	Depressive Disorder	Transcriptome
239	23704927	9606	Blood//Cell lines(SH-SY5Y)	DSM-IV//ICD-10	Case-control based	RT-PCR//Western Blotting	RT-PCR//Western Blotting	First, we identified that miR-182 may be a putative miRNA that regulates BDNF levels by bioinformatic studies, and characterized the effects of miR-182 on the BDNF levels using cell-based studies, side by side with miR-132 (a known miRNA that regulates BDNF expression). We showed that treatment of miR-132 and miR-182 respectively decreased the BDNF protein levels in a human neuronal cell model, supporting the regulatory roles of miR-132 and miR-182 on the BDNF expression. Furthermore, we explored the roles of miR-132 and miR-182 on the BDNF levels in depression using human subjects by assessing their serum levels. Compared with the healthy controls, patients with depression showed lower serum BDNF levels (via the enzyme-linked immunosorbent assays) and higher serum miR-132 and miR-182 levels (via the real-time PCR). Finally, the Pearson芒鈧劉s (or Spearman芒鈧劉s) correlation coefficient was calculated to study whether there was a relationship among the Self-Rating Depression Scale score, the serum BDNF levels, and serum BDNF-related miRNA levels.	Major Depressive Disorder	Transcriptome
240	23704927	9606	Blood	ICD-10	Case-control based	Western Blotting//qRT-PCR	Western blotting//qRT-PCR	Compared with the healthy controls, patients with depression showed lower serum BDNF levels (via the enzyme-linked immunosorbent assays) and higher serum miR-132 and miR-182 levels (via the real-time PCR).	Major Depressive Disorder	Transcriptome
241	23729812	10090	Brain		Case-control based	ELISA//RT-PCR//Western Blotting	ELISA//RT-PCR//Western Blotting	Because the MeCP2 mRNA transcript is a target for miR-132, the reduced miR-132 levels in SR-/- mice could be contributing to the elevated MeCP2 protein via translational inhibition, as we found no change in MeCP2 mRNA expression. Therefore, the reduced miR-132 expression in SR-/- mice could also be indirectly reducing BDNF expression by, in part, increasing the amount of MeCP2.	Schizophrenia	Transcriptome
242	23747354	9606	Brain		Case-control based	GeneChip miRNA 2.0 Array//Human Exon 1.0 ST (sense target) Array	Array	Table 1 Increased miRNA Expression in Alcoholics Relative to Non-Alcoholic Controls	Alcohol Use Disorder	Transcriptome
243	23747354	9606	Brain		Case-control based	GeneChip miRNA 2.0 Array//Human Exon 1.0 ST (sense target) Array	Array	A total of two human miRNAs (miR-572, miR-3162) or <1% from an overall mean of 514 (脗卤33) expressed miRNAs from our two subject groups were significantly down-regulated (p<0.05, RMA followed by multiple linear regression, less than or equal to -1.5 fold, FDR 芒鈥奥	Alcohol Use Disorder	Transcriptome
244	23778302	9606	Blood	DSM-IV//DSM-IV-TR	Case-control based		RNA-seq	We found 564 genes whose expression was nominally significantly different following weight restoration (p<0.01, 231 increased and 333 decreased). With a more stringent significance threshold (false discovery rate q<0.05), 67 genes met criteria for differential expression.(Figure S4//Figure S5)	Anorexia Nervosa	Transcriptome
245	23783805	9606	Blood		Case-control based	Western Blotting//qRT-PCR	Western blotting//qRT-PCR	Therefore, our study demonstrated that miR-26a promoted neurite outgrowth via the suppression of PTEN expression, indicating that miR-26a is important in neuronal development and morphogenesis. miR-26a has the potential to serve as a therapeutic target for patients with Alzheimer's disease (AD).	Depressive Disorder	Transcriptome
246	23791884	9606	Blood		Case-control based	Array//Meta-analysis	Array//Meta-analysis	Genomic context links lncRNAs to disease genes/loci and related pathways	Autism Spectrum Disorder	Transcriptome
247	23791884	9606	Blood		Case-control based	Array//Meta-analysis	Array//Meta-analysis	Genomic context links lncRNAs to disease genes/loci and related pathways	Bipolar Disorder	Transcriptome
248	23791884	9606	Blood		Case-control based	Array//Meta-analysis	Array//Meta-analysis	Genomic context links lncRNAs to disease genes/loci and related pathways	Major Depressive Disorder	Transcriptome
249	23791884	9606	Blood		Case-control based	Array//Meta-analysis	Array//Meta-analysis	Genetic variation in lncRNA genes causes disease and influences susceptibility	Neurodevelopmental Disorders	Transcriptome
250	23791884	9606	Blood		Case-control based	Array//Meta-analysis	Array//Meta-analysis	Genomic context links lncRNAs to disease genes/loci and related pathways	Schizophrenia	Transcriptome
251	23792790	9606	Blood		Case report	aCGH//qPCR	aCGH//qPCR	This report supports the newly recognized role of miR17w92 gene dosage in digital developmental anomalies, and suggests a possible role of GPC5 in growth regulation and in cognitive development.	Autism Spectrum Disorder	Transcriptome
252	23805108	9606	Blood		Case-control based			In the study of deployed personnel, those who did not develop PTSD had reduced %5-mC levels of H19 and IL18 after deployment, while those who did develop PTSD had increased levels of IL18.	Posttraumatic Stress Disorder	Transcriptome
253	23805108	9606	Blood		Case-control based			Those who did not develop PTSD had, i.a., DNAm levels of the ncRNA H19 post deployment.	Posttraumatic Stress Disorder	Transcriptome
254	23815974	9606	Brain//Blood		Case-control based		Western Blotting//RT-PCR	A diagnosis of schizophrenia is a significant predictor for increased GLP, SETDB1 mRNA expression and H3K9me2 levels in both postmortem brain and lymphocyte samples. G9a mRNA is significantly increased in the UIC lymphocyte samples as well. Increased HMT mRNA expression is associated with worsening of specific symptoms, longer durations of illness and a family history of schizophrenia.	Schizophrenia	Transcriptome
255	23847554	10090	Brain		Case-control based	MicroRNA microarray//RT-PCR	Array//qRT-PCR	Taken together, target prediction and GO analyses revealed several predicted target genes of mmu-miR-1971 and several validated target genes mmu-miR-33-5p which might possibly be involved inter alia in PTSD pathobiology or fluoxetine-mediated alterations of molecular pathways.	Posttraumatic Stress Disorder	Transcriptome
256	23851595	9606	Blood	DSM-IV	Case-control based		qRT-PCR	The mRNA expression level results also showed statistically significant differences (P<0.0001) between cases and healthy controls for the DRD2, DRD4, and DRD5 genes, but not for DRD1.	Schizophrenia	Transcriptome
257	23873704	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	Table 1 The aberrantly expressed miRNAs in NAc from rats after treatment with alcohol. Source data is available for this figure in the Supporting Information	Alcohol Use Disorder	Transcriptome
258	23873704	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	The results suggest that multiple miRNAs were aberrantly expressed in rat NAc after alcohol injection. Among them, miR-382 was down-regulated in alcohol-treated rats. Moreover, overexpression of miR-382 significantly attenuated alcohol-induced up-regulation of DRD1 and DeltaFosB, decreased voluntary intake of and preference for alcohol and inhibited the DRD1-induced action potential responses.	Alcohol Use Disorder	Transcriptome
259	23895427	10116	Brain		Case-control based		qRT-PCR	Twenty-four-hours after withdrawal from 15 days of 7% ethanol-diet (Chronic ethanol), cytokine-mRNAs for CCL2, IL1-脦虏, and TNF脦卤 are significantly increased compared to nontreated controls (CD) (t(15)=4.53, p=0.0004; t(20)=3.42, p=0.0027; t(21)=5.443, p<0.0001, respectively.	Alcohol Withdrawal	Transcriptome
260	23895427	10116	Brain		Case-control based		qRT-PCR	Chronic-Ethanol significantly increased HMGB1 mRNA exposure [t(16)=3.618, p=0.0023].	Alcohol Withdrawal	Transcriptome
261	23895427	10116	Brain		Case-control based		qRT-PCR	Chronic-ethanol significantly increased TLR4 mRNA expression [t(23)=2.669,p=0.0137].	Alcohol Withdrawal	Transcriptome
262	23906647	9606	Blood//Saliva	DSM-IV	Case-control based	Genotyping	Genotyping	Our results provide preliminary evidence for the contribution of two sequence variants at the miR-183-96-182 cluster to ADHD without comorbid SUD, and emphasize the need to take comorbidities into account in genetic studies to minimize the effect of heterogeneity and to clarify these complex phenotypes-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
263	23906647	9606	Blood//Saliva	DSM-IV	Case-control based	Sequenom MassArray	MassArray	Our results provide preliminary evidence for the contribution of two sequence variants at the miR-183-96-182 cluster to ADHD without comorbid SUD, and emphasize the need to take comorbidities into account in genetic studies to minimize the effect of heterogeneity and to clarify these complex phenotypes.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
264	23915435	10090	Brain		Case-control based	qRT-PCR	qRT-PCR	Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders	Alcohol Spectrum Disorders	Transcriptome
265	23947143	10116	Brain		Case-control based	MicroRNA micro-array//RT-PCR	Microarray	Among them, down-regulating miRNAs included miR298, miR-130b, miR-135a, miR-323, miR-503, miR-15b, miR-532, and miR-125a, and the up-regulation miRNAs included miR7a, miR-212, miR-124, miR-139, and miR-182.	Depressive Disorder	Transcriptome
266	23947143	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Table 1 miR levels in clinical and preclinical PTSD-related studies(24759737)	Posttraumatic Stress Disorder	Transcriptome
267	23949389	9606	Blood					Table 1. Common miRNAs (RefSeq ID) of dyslexia, dyspraxia, and SLI genes	Developmental Dyslexia	Transcriptome
268	23949389	9606	Blood					Table 1. Common miRNAs (RefSeq ID) of dyslexia, dyspraxia, and SLI genes	Developmental Dyslexia	Transcriptome
269	23949389	9606	Blood					Table 1. Common miRNAs (RefSeq ID) of dyslexia, dyspraxia, and SLI genes	Language Disorder	Transcriptome
270	24025154	9606	Brain	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	BA44 expression levels of miR-34c-5p (p<0.01, FC: 2.56), miR-139-5p(p< 0.01, FC: 1.84), miR-195 (p <0.01, FC: 1.68), and miR-320c (p<0.01, FC: 1.95) showed a significant up-regulation in suicide completers as compared to controls (Fig. 2).	Major Depressive Disorder	Transcriptome
271	24027266	9606	Brain		Case-control based	qRT-PCR	qRT-PCR	Therefore, upregulation of miR-26b in neurons causes pleiotropic phenotypes that are also observed in AD. Elevated levels of miR-26b may thus contribute to the AD neuronal pathology.	Depressive Disorder	Transcriptome
272	24080187	9606	Blood//Saliva	DSM-IV	Case-control based	Infinium HD Assay	Array	We found genome-wide significant association for one marker mapping to a novel RNA gene, lincRNA AC068718.1, for which we found suggestive evidence of replication in NHSII.	Posttraumatic Stress Disorder	Transcriptome
273	24080187	9606	Blood//Saliva	DSM-IV	Case-control based		Genotyping	Our findings implicate a novel RNA gene, lincRNA AC068718.1, as risk factor for PTSD in women and add to emerging evidence that non-coding RNA genes may play a crucial role in shaping the landscape of gene regulation with putative pathological effects that lead to phenotypic differences.	Posttraumatic Stress Disorder	Transcriptome
274	24148570	10090	Brain		Case-control based	Illumina microarray	Microarray	Table 1 Differentially expressed miRNAs in mouse frontal cortex	Alcohol Use Disorder	Transcriptome
275	24167348	10090	Brain		Case-control based	MicroRNA micro-array//RT-PCR	Array//qRT-PCR	Therapeutic action of fluoxetine in shocked mice was associated with levels of mmu-miR-1971 in PFC.	Posttraumatic Stress Disorder	Transcriptome
276	24290382	9606	Blood		Case-control based		Genotyping	Table 2.1 LncRNAs implicated in neurodevelopmental and neurodegenerative disorders	Neurodevelopmental Disorders	Transcriptome
277	24296977	9606	Blood	DSM-IV	Case-control based	Illumina Omni1-Quad microarray//llumina HiSeq 2000	Microarray//RNA-seq	Table 4 IFN 脦卤/脦虏 signaling pathway genes with the strongest associations with MDD	Major Depressive Disorder	Transcriptome
278	24296977	9606	Blood	DSM-IV	Case-control based	Illumina Omni1-Quad microarray//llumina HiSeq 2000	Microarray//RNA-seq	Table 2 Top MDD-associated genes at 0.25 FDR	Major Depressive Disorder	Transcriptome
279	24359524	10116	Brain		Case-control based	MicroRNA micro-array//RT-PCR	Microarray//qRT-PCR	The current study demonstrated dynamic changes in miRNA expression in rat hippocampus during the acquisition and extinction of cocaine-induced CPP. Some miRNAs which have been previously reported to be involved in brain disorders and drug abuse, including miR-133b, miR-134, miR-181c, miR-191, miR-22, miR-26b, miR-382, miR-409-3p and miR-504, were found to be changed in their expression following repeated cocaine exposure and subsequent abstinence from cocaine treatment.	Cocaine Addiction	Transcriptome
280	24359524	10116	Brain		Case-control based	MiRNA microarray	Microarray	Some miRNAs which have been previously reported to be involved in brain disorders and drug abuse, including miR-133b, miR-134, miR-181c, miR-191, miR-22, miR-26b, miR-382, miR-409-3p and miR-504, were found to be changed in their expression following repeated cocaine exposure and subsequent abstinence from cocaine treatment	Drug Abuse	Transcriptome
281	24391530	10090	Brain		Case-control based		qRT-PCR	OX2脦卤 mRNA levels were higher in OX- 1 /- samples (20 samples from 10 mice) than in either C57 (14 samples from 7 mice) or 129s (16 samples from 8 mice) samples (P<0.02)	Narcolepsy	Transcriptome
282	24391914	9606	Buccal cells	Others	Case-control based	PCR-RFLP	PCR-RFLP	In this study we aimed to investigate if polymorphisms in the regulatory regions of the SNAP-25 gene are in association with normal variability of impulsivity-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
283	24391914	9606	Buccal swabs		Case-control based	PCR-RFLP	PCR-RFLP	It was observed that haplotypes altering one or two nucleotides in the binding site of the seed region of microRNA-641 significantly increased the amount of generated protein in vitro.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
284	24393808	9606	Brain		Case-control based	RNA-seq	RNA-Seq	Table 1 Differentially expressed genes and transcripts identified by RNA-seq	Bipolar Disorder	Transcriptome
285	24436253	9606	Blood	DSM-IV	Case-control based	Illumina HumanOmni1-Quad v1.0 microarray	Microarray	MiR-330-3p and MAP2K5 are potentially important contributors to mood and anxiety-related traits.	Depressive Disorder	Transcriptome
286	24475125	9606	Brain		Case-control based	TLDA platform version 2.0//RT-PCR assays//Illumina small RNA sequencing	RT-PCR//RNA-seq	Similarly, a total of 9 miRNAs were significantly altered (4 up, 5 down) in bipolar subjects (Table 2).	Bipolar Disorder	Transcriptome
287	24475125	9606	Brain		Case-control based	TLDA platform version 2.0//RT-PCR assays//Illumina small RNA sequencing	RT-PCR//RNA-seq	In contrast, only two miRNAs showed significant changes in the depression group at p<0.05 (mir-508-3p and mir-152, both down-regulated).	Depressive Disorder	Transcriptome
288	24475125	9606	Brain		Case-control based	TLDA platform version 2.0//RT-PCR assays//Illumina small RNA sequencing	RNA-Seq//RT-PCR	As shown in Table 1, a total of 19 miRNAs showed altered expression (13 up, 6 down) in schizophrenia subjects by t-test.	Schizophrenia	Transcriptome
289	24500031	9606	Blood	ICD-10	Case-control based		ELISA//qRT-PCR	Analysis of covariance (ANCOVA) revealed this result in accordance with significant reductions in BDNF mRNA expression in ASD, observed in the mRNA expression study (F=3.65; df=2.43; p.05); neither age nor IQ confounded the result, as indicated by ANCOVA (F=3.961;df=2.41; p=0.05, g2=0.162).	Autism Spectrum Disorder	Transcriptome
290	24516145	10090	Heart		Case-control based	Illumina HiSeq2000//RT-PCR	Array//RT-PCR	PTSD-like symptoms were accompanied by heart injury that wasaccompanied by 芒鈥犫€	Posttraumatic Stress Disorder	Transcriptome
291	24516145	10090	Heart		Case-control based	Illumina HiSeq2000//RT-PCR	Array//RT-PCR	miRNA analysis on the heart tissues was performed, and we identified three miRNAs (miR-29b, miR-302a, and let-7d) that showed a statistically significant concentration decrease (greater than 脗卤1.5-fold changes with FDR<0.1) in the short exposure and short rest group (T5R1). No significant change in miRNA expression levels was observed in the other experimental conditions.	Posttraumatic Stress Disorder	Transcriptome
292	24535612	10090	Blood		Case-control based	qRT-PCR	qRT-PCR	Specifically, we show that expression changes of miR-191 and miR-135 are required for maintenance but not induction of spine restructuring.	Major Depressive Disorder	Transcriptome
293	24586483	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Additionally, the AA genotype of rs57095329 exhibited significantly higher miR146a expression than the GG+GA genotypes of rs2910164 in the peripheral blood cells (PBMCs) of healthy individuals and had a stronger effect on the production of IL-6 and IL-1脦虏 when the cells were stimulated with LPS.	Mild Neurocognitive Disorder Due to Alzheimer's Disease	Transcriptome
294	24666365	10116	Brain		Case-control based		qRT-PCR	Two-way ANOVA revealed significant effect of SPS on NOP receptor mRNA levels in amygdala [F(1, 28)=4.689, P=0.039] and PAG [F(1, 28)=5.169, P=0.03], indicating that SPS up-regulated NOP receptor mRNA expression in these two brain regions (Figure 6C).	Posttraumatic Stress Disorder	Transcriptome
295	24667286	9606						Table 3 List of 24 microRNA genes overrepresented in de novo CNVs.	Autism Spectrum Disorder	Transcriptome
296	24675081	9606	Blood	DSM-IV	Case-control based	TaqMan Pre-Designed SNP Genotyping Assay//qRT-PCR//Western Blotting	TaqMan//qRT-PCR//Western Blotting	Our study provides empirical evidence suggesting that miR-326 and miR-9 may regulate dopaminergic signaling, and miR-326 and miR-9 may be considered as potential drug targets for the treatment of disorders involving abnormal DRD2 function, such as schizophrenia.	Schizophrenia	Transcriptome
297	24676134	9606	Blood	DSM-IV	Case-control based	Glue Grant Human Transcriptome Array//rtPCR	qRT-PCR//Array	Cut-off:fold<1.5//we found that 2007 lncRNAs were differentially expressed, which consisted of 1556 up-regulated and 441 down-regulated lncRNAs, and of these, 404 up-regulated lncRNAs had a higher fold change.	Major Depressive Disorder	Transcriptome
298	24676134	9606	Blood	DSM-IV	Case-control based	Glue Grant Human Transcriptome Array//rtPCR	qRT-PCR//Array	Meanwhile, 1766 differentially expressed mRNAs were identified consisting of 759 up-regulated and 1007 down-regulated mRNAs, and of these, 157 were up-regulated with a higher fold change.	Major Depressive Disorder	Transcriptome
299	24694668	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Compared with the normal control group, the expression levels of miRNA-181b, miRNA-30e, miRNA-34a and miRNA-7 of the patients group were significantly higher (p<0.05). Compared with those before treatment in the patient group, the symptomatology scores were significantly lower (p<0.001), and the expression level of microRNA-181b was significantly down-regulated after treatment (p<0.05).	Schizophrenia	Transcriptome
300	24722204	9606	Cell lines(U937 cells//HEK-293T cells)		Case-control based	TaqMan genotyping//AccuStart genotyping ToughMix low ROX	TaqMan	We show that miR-608 targets acetylcholinesterase (AChE) and demonstrate weakened miR-608 interaction with the rs17228616 AChE allele having a single-nucleotide polymorphism (SNP) in the 3芒鈧	Anxiety Disorder	Transcriptome
301	24728267	10090	Blood//Brain//Cell lines(N2a)		Case-control based	RNA-seq//qRT-qPCR//Western blotting	RNA-seq//qRT-qPCR//Western blotting	These results strongly suggest that sncRNAs are sensitive to environmental factors in early life, and contribute to the inheritance of trauma-induced phenotypes across generations. They may offer potential diagnostic markers for associated pathologies in humans.	Posttraumatic Stress Disorder	Transcriptome
302	24728267	10116	Brain//Sperm//Serum		Case-control based	miR array//TaqMan miR assay	Array//TaqMan	Validation by quantitative RT-PCR confirmed that miR-375-3p and -5p, miR-200b-3p, miR-672-5p and miR-466-5p were up-regulated in F1 MSUS sperm (Fig. 3a).	Posttraumatic Stress Disorder	Transcriptome
303	24728267	10116	Brain//Sperm//Serum		Case-control based	miR array//TaqMan miR assay	Array//TaqMan	These results strongly suggest that sncRNAs are sensitive to environmental factors in early life, and contribute to the inheritance of trauma-induced phenotypes across generations.	Posttraumatic Stress Disorder	Transcriptome
304	24739087	9606	Blood		Case report	SNP-array	Array	This case represents the smallest reported microduplication to date at 13q31.3 and provides evidence supporting the important role of miR-17~92 gene dosage in normal growth and skeletal development.	Autism Spectrum Disorder	Transcriptome
305	24759737	9606	Blood	CAPS//PCL-M	Case-control based	miRNA array//qRT-PCR	Array//qRT-PCR	Table 2 Down-regulated miRNAs (>2.5 fold changes) detected by miRNA array hybridization assay in patients with post-traumatic stress disorder.	Posttraumatic Stress Disorder	Transcriptome
306	24759737	9606	Blood	CAPS//PCL-M	Case-control based	Illumina HiSeq2000//RT-PCR	Array//RT-PCR	High-throughput analysis of PBMCs for 1163 miRs showed that the expression of a significant number of miRs was altered in PTSD patients.	Posttraumatic Stress Disorder	Transcriptome
307	24782725	10116	Blood		Case-control based		PCR//Western Bloting	As shown in Figure 1A, Pde10a mRNA levels were significantly elevated in the infralimbic (ilPFC; F1,18=10.84, p<0.005) and anterior cingulate (ACC; F1,20=6.89, p<0.05) subdivisions of the mPFC during acute alcohol withdrawal.	Alcohol Use Disorder	Transcriptome
308	24802307	9606	Brain	DSM-IV	Case-control based		Northern blotting//ISH	We compared BDNF and trkB-TK+ mRNA levels across all layers of the prefrontal cortex (dorsolateral prefrontal cortex, DLPFC), orbital frontal cortex (OFC), anterior cingulate cortex (ACC), inferior temporal gyrus (ITG) and superior temporal gyrus (STG) in four groups: schizophrenia, BPD, MDD and unaffected controls (n=60). BDNF mRNA levels were significantly decreased in layers IV and V of DLPFC in schizophrenia patients, in layer VI of ACC in schizophrenia and MDD and in layer VI of ITG in schizophrenia, BPD and MDD. BDNF mRNA levels were also significantly decreased in layer V and/or VI of STG in schizophrenia, BPD and MDD. TrkB-TK+ mRNA levels were only significantly decreased in the cortical layer VI of OFC in BPD.	Psychotic Disorder	Transcriptome
309	24840790	9606	Blood	DSM-IV	Case-control based	RT-PCR/Western Blotting	RT-PCR/Western Blotting	We studied the correlation of the expression of KCNJ5 and the antisense transcript in brain tissues from control individuals and found that the antisense transcript and the short KCNJ5 isoform are co-expressed in three brain regions- The results of this study indicate that KCNJ5 is associated with TS and ADHD in our samples, however, the functional variant(s) remain to be identified-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
310	24840790	9606	Blood	DSM-IV	Case-control based	RT-qPCR//Western Blotting	RT-PCR//Western Blotting	We observed that circulating miRNA let-7d was significantly higher in ADHD subjects than in control (p<0.05).	Attention-Deficit/Hyperactivity Disorder	Transcriptome
311	24886127	9606	Blood	DSM-IV	Case-control based	Affymetrix HU95A oligonucleotide array	SNP-array	Out of a total of 15 genes, the VAMP-2 is significantly down-regulated after correcting for the number of multiple non-independent tests using a prediction of false discovery rate of PFP <0.05 (Table 3).	Major Depressive Disorder	Transcriptome
312	24886127	10090	Brain		Case-control based	Affymetrix mouse whole-genome oligonucleotide arrays	SNP-array	Table 1 Summary of genes found to be differentially expressed in response to the unpredictable chronic mild stress protocol and previously associated with stress response.	Major Depressive Disorder	Transcriptome
313	24952960	10090	Brain		Case-control based	MicroRNA micro-array//RT-PCR	Microarray	RN46A cells infected with miR135 KD lentiviruses expressed significantly lower levels of both miR135a and miR135b and higher levels of Htr1a and Slc6a4 mRNA, as tested by real-time PCR, compared to cells infected by the KD control lentiviruses (Figure 5C).	Major Depressive Disorder	Transcriptome
314	24990518	10090	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Selective inhibition of endogenous miR-92 in CA1 hippocampal neurons, by a sponge lentiviral vector expressing multiple sequences imperfectly complementary to mature miR-92 under the control of the neuronal specific synapsin promoter, leads to up-regulation of KCC2, CPEB3 and MEF2D, impairs contextual fear conditioning, and prevents a memory-induced increase in the spine density.	Posttraumatic Stress Disorder	Transcriptome
315	24990518	10090	Brain		Case-control based	Lentiviral vector for miR knockdown//TaqMan miR assay	TaqMan	Selective inhibition of miR92 in CA1 neurons leads to up-regulation of 3 miR 92a target genes.	Posttraumatic Stress Disorder	Transcriptome
316	24998397	9606	Serum		Case-control based	miRNA array//Taqman assay	Array//Taqman	Differentially expressed and statistically significant miRNAs in serum were validated for their presence in amygdala of corresponding animals. (Table 1 Posttraumatic stress exposure altered miRNAs in serum.)	Posttraumatic Stress Disorder	Transcriptome
317	24998397	10090	Serum		Case-control based	miRNA array//Taqman assay	Array//Taqman	Differentially expressed and statistically significant miRNAs in serum were validated for their presence in amygdala of corresponding animals. (Table 1 Posttraumatic stress exposure altered miRNAs in serum.)	Posttraumatic Stress Disorder	Transcriptome
318	24998397	10090	Blood		Case-control based	miRNA array//Taqman assay	Array//Taqman	A panel of nine stress-responsive miRNAs viz., miR-142-5p, miR-19b, miR-1928, miR-223-3p, miR-322*, miR-324, miR-421-3p and miR-463* and miR-674* were identified, and may have potential as biomarker(s) for PTSD.	Posttraumatic Stress Disorder	Transcriptome
319	24998397	10116	Amygdala//Serum		Case-control based	miR array//TaqMan miR assay	Array//TaqMan	Differentially expressed and statistically significant miRNAs in serum were validated for their presence in amygdala of corresponding animals. (Table 3 Posttraumatic stress altered day 14 common miRNAs in serum and amygdala)	Posttraumatic Stress Disorder	Transcriptome
320	24998397	10116	Blood		Case-control based	miRNA array//Taqman assay	Array//Taqman	A panel of nine stress-responsive miRNAs viz., miR-142-5p, miR-19b, miR-1928, miR-223-3p, miR-322*, miR-324, miR-421-3p and miR-463* and miR-674* were identified, and may have potential as biomarker(s) for PTSD.	Posttraumatic Stress Disorder	Transcriptome
321	24998397	10116	Serum		Case-control based	miRNA array//Taqman assay	Array//Taqman	Differentially expressed and statistically significant miRNAs in serum were validated for their presence in amygdala of corresponding animals. (Table 1 Posttraumatic stress exposure altered miRNAs in serum.)	Posttraumatic Stress Disorder	Transcriptome
322	25001178	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	MiR-125b expression was significantly increased by 1.6-fold in AD patients compared to healthy controls. In contrast, several other miRNAs, including miR-16, miR-23b, miR-127, and miR-134, were not changed in AD patient's brains.	Mild Neurocognitive Disorder Due to Alzheimer's Disease	Transcriptome
323	25016317	9606	Dermal fibroblasts	DSM-IV-TR//DSM-IV	Case-control based	GeneChip HT HG-U133+ PM Array//miRNome Arrays//qPCR	Array//qPCR	Table 2 Regulated miRNAs in MDD and their target mRNAs.	Major Depressive Disorder	Transcriptome
324	25044277	9606	Brain		Case-control based	qRT-PCR	qRT-PCR	Several brain regions in both analyses demonstrated the expected main effect of participant group (i.e. schizophrenics<controls), yet there were no regions where we observed an impact of rs1635579 genotype on brain volume. Our analyses suggest that the mechanism by which miR-137 confers risk for schizophrenia and impacts upon cognitive function may not be mediated by changes in local brain volume.	Schizophrenia	Transcriptome
325	25123309	10090	Brain		Case-control based	miR array//TaqMan miR assay	Array//TaqMan	Together, these data suggest that within the BLA, a transient decrease in Notch signaling, via miR-34a regulation, is important for the consolidation of fear memory.	Posttraumatic Stress Disorder	Transcriptome
326	25123309	10090	Brain		Case-control based	miRNA array//qRT-PCR	Array//qRT-PCR	It is important to note that we observe an increase in miR-34a levels in the amygdala shortly (30 minutes) after auditory fear conditioning, and in a learning-specific manner.	Posttraumatic Stress Disorder	Transcriptome
327	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients- The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls- There was no significant difference in age and sex between the two groups (p>0-05)- miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0-05)- miRNA 155a-5p levels were increased in patients group (p<0-06)-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
328	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients- The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls- There was no significant difference in age and sex between the two groups (p>0-05)- miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0-05)- miRNA 155a-5p levels were increased in patients group (p<0-05)-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
329	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients- The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls- There was no significant difference in age and sex between the two groups (p>0-05)- miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0-05)- miRNA 155a-5p levels were increased in patients group (p<0-07)-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
330	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients- The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls- There was no significant difference in age and sex between the two groups (p>0-05)- miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0-05)- miRNA 155a-5p levels were increased in patients group (p<0-08)-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
331	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients- The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls- There was no significant difference in age and sex between the two groups (p>0-05)- miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0-05)- miRNA 155a-5p levels were increased in patients group (p<0-09)-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
332	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients- The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls- There was no significant difference in age and sex between the two groups (p>0-05)- miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0-05)- miRNA 155a-5p levels were increased in patients group (p<0-10)-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
333	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients- The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls- There was no significant difference in age and sex between the two groups (p>0-05)- miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0-05)- miRNA 155a-5p levels were increased in patients group (p<0-11)-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
334	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients- The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls- There was no significant difference in age and sex between the two groups (p>0-05)- miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0-05)- miRNA 155a-5p levels were increased in patients group (p<0-12)-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
335	25123444	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	MiRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0.05). miRNA 155a-5p levels were increased in patients group (p<0.05).	Attention-Deficit/Hyperactivity Disorder	Transcriptome
336	25126405	9606	Blood	DSM-IV-TR//ADI-R	Case-control based	Human Neurological Development & Disease miRNA PCR array	Array	Thirteen miRNAs were differentially expressed in ASD individuals compared to the controls. MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated.	Autism Spectrum Disorder	Transcriptome
337	25142559	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Four miRNAs differed significantly between type 1 narcolepsy patients and healthy controls. Levels of miR-30c, let-7f, and miR-26a were higher, whereas the level of miR-130a was lower in type 1 narcolepsy than healthy controls.	Narcolepsy	Transcriptome
338	25162540	9606	Brain		Case-control based	qRT-PCR//Western Blotting	qRT-PCR//Western Blotting	ZNF804AE3E4 mRNA expression was decreased in patients with schizophrenia (P=.006) and increased in those with major depressive disorder (P<.001), and there was a genotype-by-diagnosis interaction in bipolar disorder (P=.002).	Bipolar Disorder	Transcriptome
339	25162540	9606	Brain		Case-control based	qRT-PCR//Western Blotting	qRT-PCR//Western Blotting	ZNF804AE3E4 mRNA expression was decreased in patients with schizophrenia (P=.006) and increased in those with major depressive disorder (P<.001), and there was a genotype-by-diagnosis interaction in bipolar disorder (P=.002).	Major Depressive Disorder	Transcriptome
340	25162540	9606	Brain		Case-control based	qRT-PCR//Western Bloting	qRT-PCR//Western Bloting	ZNF804AE3E4 mRNA expression was decreased in patients with schizophrenia (P=.006) and increased in those with major depressive disorder (P<.001), and there was a genotype-by-diagnosis interaction in bipolar disorder (P=.002).	Schizophrenia	Transcriptome
341	25199956	9606	Brain		Case-control based		RNA-Seq	We found 434 DEGs in the caudate and 368 in the putamen (FDR<0.05; Table S3b and c). (Table S3B. Differential gene expression within the Caudate region by edgeR.)	Tourette's Disorder	Transcriptome
342	25199956	9606	Brain		Case-control based		RNA-Seq	We found 434 DEGs in the caudate and 368 in the putamen (FDR<0.05; Table S3b and c). (Table S3C. Differential gene expression within the Putamen region by edgeR.)	Tourette's Disorder	Transcriptome
343	25201637	9606	Blood	DSM-IV	Case-control based	Affymetrix miRNA 3.0 GeneChips	Array	Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis in a larger cohort of 81 MDD patients and 46 healthy controls confirmed that the expression levels of 5 miRNAs (miRNA-26b, miRNA-1972, miRNA-4485, miRNA-4498, and miRNA-4743) were up-regulated.	Major Depressive Disorder	Transcriptome
344	25236294	10090	Brain		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Searching for non-genetic molecular and imaging PTSD risk and resilience markers: Systematic review of literature and design of the German Armed Forces PTSD biomarker study	Posttraumatic Stress Disorder	Transcriptome
345	25250332	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	The results of our study and meta-analysis provide convincing evidence that rs1625579 is significantly associated with schizophrenia. Furthermore, the miR-137 polymorphism influences the working memory performance of schizophrenic patients in a Chinese Han population.	Schizophrenia	Transcriptome
346	25315250	9606	Brain		Case-control based	qRT-PCR	qRT-PCR	The study provides evidence from a number of different experimental paradigms that miR-1202 exists in a dose-dependent relationship with expression of the gene GRM4 (encoding metabotropic glutamate receptor 4) in the human prefrontal cortex and that the expression of miR-1202 is related to successful antidepressant treatment.	Depressive Disorder	Transcriptome
347	25330738	10090	Brain		Case-control based	Western Blotting//qRT-PCR//ELISA	Western Blotting//qRT-PCR//ELISA	We show that miR-30a-5p binds the 3芒鈧	Alcohol Use Disorder	Transcriptome
348	25378171	10090	Brain		Case-control based	Illumina HiSeq2000//RT-PCR	Array//RT-PCR	Interestingly, adult mice injected bilaterally with miR-19b into the BLA showed lower freezing time relative to control in the cue fear conditioning test, and deregulation of noradrenergic circuits, consistent with downregulation of Adrb1 levels.	Posttraumatic Stress Disorder	Transcriptome
349	25406064	10090	Brain//Cell lines(HEK293)		Case-control based	qRT-PCR	qRT-PCR	Using this novel approach, we found that miR-9 controls dendritic growth and synaptic transmission in vivo. Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.	Depressive Disorder	Transcriptome
350	25434007	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Our results suggest that rare noncoding risk variants are associated with SZ and BP at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression.	Schizophrenia	Transcriptome
351	25444166	10090	Brain		Case-control based	qRT-PCR//Western Bloting	qRT-PCR//Western Bloting	As shown in Figure 2A and 2B, the expression of DNMT1 and TET1 mRNA was significantly higher in the FC and HP of PRS offspring compared to NS mice at PND75	Schizophrenia	Transcriptome
352	25444170	9606	Scalp hair follicles	DSM-IV-TR	Case-control based		qRT-PCR	Finally,we tested the expression of nine putative autism candidate genes in hair follicles and found decreased CNTNAP2 expression in the autism cohort.	Autism Spectrum Disorder	Transcriptome
353	25444170	9606	Scalp hair follicles	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Additionally, microarraybased microRNA analysis showed a trend of increased expression of hsa-miR-4449 (p<.0634) in hair follicles from schizophrenia. hsa-miR-4449 expression was increased in Brodmann area 46 from schizophrenia (p<.0007).	Schizophrenia	Transcriptome
354	25444170	9606	Scalp hair follicles	DSM-IV	Case-control based		qRT-PCR	QRT-PCR analysis showed that seven genes, namely CALB2, SST, CNP, PMP22, FABP4, FABP7, and FAAH were differentially expressed (p<0.05) in samples from schizophrenia compared with control subjects (Table 2; Figure S1 in Supplement 1).	Schizophrenia	Transcriptome
355	25444170	9606	Scalp hair follicles	DSM-IV	Case-control based		qRT-PCR	Among mRNA examined, FABP4 was downregulated in schizophrenia subjects by two independent sample sets. Receiver operating characteristic curve analysis determined that the sensitivity and specificity were 71.8% and 66.7%, respectively.	Schizophrenia	Transcriptome
356	25487174	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	We observed significantly increased expressions of miR-132, miR-195, miR-30e and miR-7 in plasma samples (p<0.05 to p<0.001), and miR-212, miR-34a and miR-30e in PBMC samples (p<0.05 to p<0.01).	Schizophrenia	Transcriptome
357	25497042	9606	Blood	DSM-IV	Case-control based	Affymetrix miRNA 3.0 GeneChips	Taqman	This is the first evidence that the MIR-137 risk variant may be associated with a specific subgroup of psychosis patients. Although the effect of this single SNP was not clinically relevant, investigation of the impact of carrying multiple risk SNPs in the MIR-137 regulatory network on diagnosis and illness profile may be warranted.	Schizophrenia	Transcriptome
358	25523828	10116	Cavernosa		Case-control based		Microarray//RT-qPCR	The results revealed that the gene expression levels of Cxcl12 and Cdh3 were signifcantly downregulated in the ED rat group compared with the normal control rat group (0.16- and 0.25-fold change, respectively;P=0.000294 and P=0.0001, respectively).	Erectile Disorder	Transcriptome
359	25523828	10116	Cavernosa		Case-control based		Microarray//RT-qPCR	By contrast, Tgfbr1 expression was signifcantly upregulated in the ED rat group (4.53-fold; P=0.028).	Erectile Disorder	Transcriptome
360	25535174	9606	Blood	DSM-IV	Case-control based		qRT-PCR	No significant differences in gene expression were determined for BDNF mRNA levels (P=0.259 using the Mann-Whitney U test).	Autism Spectrum Disorder	Transcriptome
361	25535174	9606	Blood	DSM-IV	Case-control based		qRT-PCR	Regarding neurotrophin receptors (Fig. 1b), expression of p75NTR was significantly higher in ASD patients compared to controls (P=0.027). The mean value of p75NTR gene expression was 100 (脗卤48) % inhealthy controls versus 184 (脗卤112) % in the ASD patients. 	Autism Spectrum Disorder	Transcriptome
362	25535174	9606	Blood	DSM-IV	Case-control based		qRT-PCR	Expression of NT3 and NT4 was significantly lower in ASD patients compared to controls (P<0.05 for each using the Mann-Whitney U test).	Autism Spectrum Disorder	Transcriptome
363	25535174	9606	Blood	DSM-IV	Case-control based		qRT-PCR	The variation in NT4 gene expression was less pronounced, with mean values of 100 (脗卤52) % in healthy controls versus 50 (脗卤28) % in the ASD patients (median of 0.18 units and 0.08 units, respectively; P= 0.011). 	Autism Spectrum Disorder	Transcriptome
364	25535174	9606	Blood	DSM-IV	Case-control based		qRT-PCR	No significant differences in gene expression were seen for either TrkA or TrkB receptors (P=0.427 and P=0.326 using the Mann-Whitney U test, respectively).	Autism Spectrum Disorder	Transcriptome
365	25556700	10090	Brain		Case-control based	Northern blotting	Northern blotting	Our results place miR-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability.	Intellectual Disability	Transcriptome
366	25568313	10090	Neocortex		Case-control based	Agilent	Microarray//RT-PCR	Here, we report that forebrain-specific inactivation of the mouse Brpf1 gene caused early postnatal lethality, neocortical abnormalities, and partial callosal agenesis.(FIGURE 9. Dual role of Brpf1 in regulating gene expression.)	Intellectual Disability	Transcriptome
367	25589731	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	As shown in Fig. 1 and Table 2, expressions of miR-206 (p<0.001) (Fig. 1A) and miR-132 (p<0.001) (Fig. 1B) were significantly upregulated in MCI patients芒鈧劉 serum compared with control group	Mild Neurocognitive Disorder	Transcriptome
368	25613509	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Schizophrenia risk genes were more likely to be regulated by miRs, as revealed by gene set analyses with the strongest enrichment for targets of miR-9-5p, miR-485-5p and miR-137.	Schizophrenia	Transcriptome
369	25623948	9606	Brain		Case-control based	qRT-PCR//Western blotting	qRT-PCR//Western blotting	Taken together, these results validate three genes implicated in BD risk as miR-34a targets and suggest that miR-34a may function to regulate an interacting molecular network important to BD pathogenesis through effects on neurodevelopment.	Bipolar Disorder	Transcriptome
370	25628968	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Interestingly, we did find significant down-regulation of U55 in PBMC of non-TBI/PTSD compared to non-TBI/non-PTSD. This evidence suggests that PTSD has an effect on the regulation of U55, which may contribute to the down-regulation of U55 seen in mTBI vs. non-TBI cases in the context of PTSD comorbidity (Figure 1A,1B).	Posttraumatic Stress Disorder	Transcriptome
371	25665552	9606	Blood		Case-control based	Affymetrix Scanner 3000//qRT-PCR	Array//qPCR	Table 2 Differentially expressed microRNAs identified by microarray analysis in PBMCs from SZ patients versus controls	Schizophrenia	Transcriptome
372	25675938	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Compared to controls, we found that the expression level of miR-19b is downregulated in patients with idiopathic rapid eye movement sleep behavior disorder and antedates the diagnosis of Parkinson disease and dementia with Lewy bodies after 4.67脗卤2.61 years of follow-up.	Rapid Eye Movement Sleep Behavior Disorder	Transcriptome
373	25675938	9606	Blood		Case-control based			We found nearly 2-fold downregulated serum miRNA levels of miR-19b in IRBD patients before diagnosis of PD and DLB (RBD2) as compared to controls (foldchange [FC] 5 21.77, adjusted p 5 0.0136) but not for miR-29a and miR-29c (Table 2; Fig. 1A).	Rapid Eye Movement Sleep Behavior Disorder	Transcriptome
374	25703036	10090	Brain(Hippocampus//Cerebellum)	Others	Case-control based	RT-PCR	RT-PCR	In EtOH-treated animals compared with controls, cytokines interleukin-1囟 and tumor necrosis factor-汐 mRNA levels were increased significantly in the hippocampus, cerebellum, and cerebral cortex. Chemokine CCL2 mRNA was increased significantly in the hippocampus and cerebellum.	Fetal Alcohol Spectrum Disorder	Transcriptome
375	25708817	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Of the sixteen reliably detected miRNAs, three, miR-15b, miR-132, and miR-652, showed a nominally significant increase in expression in the high-risk subjects compared to the control subjects (miR-15b: p=0.0166, fold-change (FC)=1.29; miR-132:p=0.0249, FC=1.34; miR-652: p=0.0108, FC =1.26; Fig. 1;Table 2).	Bipolar Disorder	Transcriptome
376	25724585	9606	Blood	DSM-IV	Case-control based	RT-PCR/Western Blotting	RT-PCR/Western Blotting	Our data demonstrated that miRNA let-7d was elevated in the serum of ADHD subjects, which might be a novel, useful molecule signature for ADHD-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
377	25724585	10116	Blood	Others	Case-control based	RT-PCR/Western Blotting	RT-PCR/Western Blotting	Our data demonstrated that miRNA let-7d was elevated in the serum of ADHD subjects, which might be a novel, useful molecule signature for ADHD.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
378	25724585	9606	Blood	DSM-IV	Case-control based	RT-qPCR//Western Blotting	RT-PCR//Western Blotting	Our data demonstrated that miRNA let-7d was elevated in the serum of ADHD subjects, which might be a novel, useful molecule signature for ADHD.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
379	25724585	10116	Blood		Case-control based	RT-qPCR//Western Blotting	RT-PCR//Western Blotting	Our data demonstrated that miRNA let-7d was elevated in the serum of ADHD subjects, which might be a novel, useful molecule signature for ADHD.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
380	25740916	10116	Brain		Case-control based	qRT-PCR//Western blotting	qRT-PCR//Western blotting	Early life stress enhanced the susceptibility to late life stress and resistance to escitalopram treatment through decreasing microRNA-9 expression and subsequently upregulating dopamine receptor D2 expression in the nucleus accumbens. microRNA-326 may be a novel target of escitalopram.	Depressive Disorder	Transcriptome
381	25754082	9606	Blood	DSM-IV	Case-control based	Affymetrix Hu-Gene 1.0 ST Array//RNA-seq	RNA-seq//SNP-array	Supplementary Table 7. Lists of differentially expressed genes. Lists correspond to differential expression analyses performed at pre-deployment, post-deployment and longitudinally within Dataset 1 and Dataset 2. Abbreviations: logFC=log fold-change, FDR=false discovery rate (i.e. adjusted p-value).	Posttraumatic Stress Disorder	Transcriptome
382	25755749	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	We found that the expression level of BDNF decreased as the expression of miR-10B increased in all of the examples.	Depressive Disorder	Transcriptome
383	25757715	9606	Brain		Case-control based		qRT-PCR	The relative expression of MARCKS mRNA was increased significantly in both SZ (fold change: 1.6, p=0.01) and BD (fold change: 1.4, p=0.02) subjects.	Bipolar Disorder	Transcriptome
384	25757715	9606	Brain		Case-control based		qRT-PCR	PPP1R9A mRNA expression was increased significantly in BD (fold change: 4.5, p<0.0005) subjects and non-significantly increased in SZ (fold change: 2.2, p=0.25) subjects.	Bipolar Disorder	Transcriptome
385	25757715	9606	Brain		Case-control based		qRT-PCR	The relative expression of MARCKS mRNA was increased significantly in both SZ (fold change: 1.6, p=0.01) and BD (fold change: 1.4, p=0.02) subjects.	Schizophrenia	Transcriptome
386	25763923	9606	Cerebrospinal fluid//Serum	ICD-10//DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Our results suggested that differentially altered miRNAs in CSF might be involved in MDD, and serum miR-221-3p, miR-34a-5p, let-7d-3p, and miR-451a might be able to serve as biomarkers for MDD.	Major Depressive Disorder	Transcriptome
387	25779937	9606	Blood	DSM-IV	Case-control based	qRT-PCR//ELISA	qRT-PCR//ELISA	CSF miR-16 in MDD patients was significantly lower than that in controls. It was negatively correlated with Hamilton scores and positively associated with CSF serotonin. However, blood miR-16 was not significantly different between two groups and it was not statistically correlated with CSF miR-16. In animal study, anti-miR-16-treated rats were evaluated to exhibit depression-like behaviors, extremely lower CSF miR-16, significantly higher CSF serotonin, and obviously higher raphe SERT protein than control rats.	Major Depressive Disorder	Transcriptome
388	25785698	9606	Blood	DSM-IV	Family based		PCR	For the family-based study, the S allele of 5-HTTLPR was preferentially transmitted rather than non-transmitted from the parents to affected offspring (P=0.013).	Anorexia Nervosa	Transcriptome
389	25792222	10090	Brain		Case-control based	Illumina TruSeq//qRT-PCR	Array//qRT-PCR	Interestingly, in the pre-training test used to induce stress in these subjects, mice treated with Crybb1 KD spent significantly more time in the open arms, also supporting the idea that decreased Crybb1 led to a decrease in anxiety (Fig. 6C). We therefore show that Crybb1 directed knockdown within the mPFC has a role in stress-associated responses in mice.	Anxiety Disorder	Transcriptome
390	25792222	10090	Brain		Case-control based	Illumina TruSeq//qRT-PCR	Array//qRT-PCR	Our results revealed that Gomafu plays a role in mediating anxiety-like behavior, and suggest that this may occur through an interaction with a key member of the polycomb repressive complex 1, BMI1, which regulates the expression of the schizophrenia-related gene beta crystallin (Crybb1). We also demonstrated a novel role for Crybb1 in mediating fear-induced anxiety-like behavior.	Anxiety Disorder	Transcriptome
391	25817407	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Within our enriched group of SNPs used in stage 1, we identified 116 SNPs to act as miRNA eQTLs at the nominal p 芒鈥奥	Bipolar Disorder	Transcriptome
392	25817407	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Within our enriched group of SNPs used in stage 1, we identified 116 SNPs to act as miRNA eQTLs at the nominal p 芒鈥奥	Schizophrenia	Transcriptome
393	25847876	9606	Cell lines(HepG2//Huh7//L02)		Case-control based	RT-PCR//Western blotting//Luciferase reporter assay	RT-PCR//Western blotting//Reporter assay	Hsa-miR-4717-5p showed the most robust effect on RGS2 and regulated two other candidate genes of anxiety disorders (CNR1 and IKBKE) as well.	Anxiety Disorder	Transcriptome
394	25867994	9606	Blood	DSM-IV	Case-control based		Microarray	The GR gene (NR3C1), BDNF, and the thioredoxin reductase 1 (TXNRD1) gene were significantly associated with PTSD in our discovery cohort (pcor<0.05 when adjusted for 14 candidate genes examined; Table 2). For both BDNF and NR3C1, expression was lower in PTSD cases than controls while the opposite was true for TXNRD1 (Figure 1)	Posttraumatic Stress Disorder	Transcriptome
395	25878287	10116	Blood		Case-control based		Western blot//Immunohistochemistry//Whole transcriptome sequencing	We showed that a history of alcohol dependence is associated with increased DNA methylation specifically in the mPFC. Importantly, we demonstrated that DNA methylation is causally related to alcohol intake and seeking behaviors. (Table3.Top6 GO functional enrichment analysis for the list of 784 significantly altered mRNAs)	Alcohol Use Disorder	Transcriptome
396	25903372	9606	Blood	DSM-IV-TR//ADI-R//ADOS	Case-control based	Genotyping//Meta-analysis	Genotyping//Meta-analysis	The most significant association in the discovery sample was obtained for the miR-133b/miR-206 cluster (rs16882131, P=0.00037). (Table III. Rare variants identifi ed in miRNA genes by whole-exome sequencing (WES) in 41 ASD probands from multiplex and singleton families.)	Autism Spectrum Disorder	Transcriptome
397	25912394	9606	Blood	ADI-R 	Case-control based		qRT-PCR	There were no differences in the mRNA levels of GR脦虏 and BAG1 in ASD subjects as compared to controls.	Autism Spectrum Disorder	Transcriptome
398	25912394	9606	Blood	ADI-R 	Case-control based		qRT-PCR	However,significant increases in FKBP5 (42 %) and PTGES3 (35 %) mRNA levels were observed in ASD subjects.	Autism Spectrum Disorder	Transcriptome
399	25912394	9606	Blood	ADI-R 	Case-control based		qRT-PCR	Moreover,we observed significant increases in IL-1脦虏 and IFN-脦鲁 mRNA levels in ASD subjects, and these cytokines were negatively associated with GR levels.	Autism Spectrum Disorder	Transcriptome
400	25921437	9606	Brain		Case-control based		Genotyping	miR-34a levels were found to be increased more prominently in postmortem cerebellar tissue from bipolar disorder patients, as well as in bipolar disorder patient-derived iNs and iPSC-derived neuronal cultures.	Bipolar Disorder	Transcriptome
401	25921703	9606	Blood	DSM-IV	Case-control based	Illumina HumanHap 250 K//317 K Beadchips	SNP-array	First, we found that risk TT genotype of MIR137 was associated with decreased white matter integrity within involving the frontal and striatal brain regions in schizophrenia	Schizophrenia	Transcriptome
402	25921703	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Our findings suggested that the MI137 risk variants were associated with decreased fronto-striatal brain white matter integrity which may underlie poorer attention, processing speed, and greater negative symptoms in schizophrenia.	Schizophrenia	Transcriptome
403	25930075	9606	Brain		Case-control based		qRT-PCR//Western Blotting	In contrast, in MDD there was a significant up-regulation in the expression of CNPase mRNA (109 percent, ANCOVA, F(1, 20)=6.958, p=0.016), MOG mRNA (51 percent, ANCOVA, F(1, 15)=9.477, p=0.008) and Olig1 mRNA (47 percent, ANCOVA, F(1,21)=4.081, p=0.05) (Fig. 6B, C, D).	Major Depressive Disorder	Transcriptome
404	25935703	9606	Blood	DSM-IV	Case-control based		qRT-PCR	Our results showed that ZNF804A mRNA level in peripheral blood mononuclear cells was significantly higher in BD patients than that in controls (P=0.01).	Bipolar Disorder	Transcriptome
405	25966629	10116	Cell lines(CECs)		Case-control based	ELISA//RT-PCR//Western Blotting	ELISA//RT-PCR//Western Blotting	As a result, miR-200a was upregulated while the SIRT1, the levels of eNOS and cGMP were all downregulated in the CCs from AE group. After transfection in vitro, the miR-200a was upregulated while the SIRT1 and levels of eNOS and cGMP were obviously downregulated.	Erectile Disorder	Transcriptome
406	25986729	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	This analysis showed a significant increase in miR-181c and miR-30d expression in the amygdala of VPA rats as compared to saline-injected controls (Fig. 2B).	Autism Spectrum Disorder	Transcriptome
407	25986729	10116	Brain		Case-control based	qRT-PCR//Microarray	qRT-PCR//Microarray	Collectively, these results implicate the small non-coding miR-181c in neuronal morphology, and provide a framework of understanding how dysregulation of a neurodevelopmentally relevant miR in the amygdala may contribute to the pathophysiology of ASD.	Autism Spectrum Disorder	Transcriptome
408	26004688	9606	Blood	DSM-IV	Case-control based	TaqMan//RT-PCR//Sanger sequencing	TaqMan//RT-PCR//Sanger sequencing	The present studies showed that lncRNA MIAT was a novel susceptibility gene for paranoid schizophrenia in the Chinese Han population. Considering that most lncRNAs locate in non-coding regions, our result may explain why most susceptibility loci for schizophrenia identified by genome wide association studies were out of coding regions.	Paranoid Schizophrenia	Transcriptome
409	26004688	9606	Blood	DSM-IV	Case-control based	TaqMan//RT-PCR//Sanger sequencing	TaqMan//RT-PCR//Sanger sequencing	The present studies showed that lncRNA MIAT was a novel susceptibility gene for paranoid schizophrenia in the Chinese Han population. Considering that most lncRNAs locate in non-coding regions, our result may explain why most susceptibility loci for schizophrenia identified by genome wide association studies were out of coding regions.	Schizophrenia	Transcriptome
410	26005852	10090	Cell lines(HEK293T/17//Neuro-2a//SH-SY5Y//HT22)		Case-control based	Dual Luciferase assay//qRT-PCR//Western blot//Genotyping	Reporter assay//qRT-PCR//Western blotting//Genotyping	In this study, we investigated the functional impact of psychiatric risk SNPs in MIR137. We observed an upregulation of endogenous MIR137 in induced human neurons harboring the minor allele of four schizophrenia-associated SNPs in the putative MIR137 region.	Schizophrenia	Transcriptome
411	26008736	9606	Blood	DSM-IV	Case-control based	Affymetrix U219 arrays//Affymetrix U219 microarrays	Microarray	We identified 13 gene expression clusters with specific clusters enriched for genes involved in NK cell activation (downregulated in current MDD, FDR=5.8 脙鈥	Major Depressive Disorder	Transcriptome
412	26008736	9606	Blood	DSM-IV	Case-control based	Affymetrix U219 array	SNP-array	Table 2. P-values, FDR and betas of 18 genes differentially expressed between control and current MDD groups (FDR<0.05)	Major Depressive Disorder	Transcriptome
413	26008736	9606	Blood	DSM-IV	Case-control based	Affymetrix U219 arrays//Affymetrix U219 microarrays	Microarray	Table 4. The 129 genes associated with current MDD in the baseline cross-sectional analysis were validated in a longitudinal design.	Major Depressive Disorder	Transcriptome
414	26008736	9606	Blood	DSM-IV	Case-control based	Affymetrix U219 array	SNP-array	We identified 13 gene expression clusters with specific clusters enriched for genes involved in NK cell activation (downregulated in current MDD, FDR=5.8 脙鈥	Major Depressive Disorder	Transcriptome
415	26031216	10090	Brain//Cell lines		Case-control based	Illumina HiSeq2000//RT-PCR	Array//RT-PCR	These highly abundant miRNAs were miR-124-3p, miR-101a-3p, miR-138-5p, miR-29c-3p, miR-101b-3p, miR-30a-5p, miR-29b-5p, miR-34c-5p, miR-376a-3p, miR-341-3p, and miR-154-5p.	Methamphetamine Use Disorder	Transcriptome
416	26058807	9606	Buccal cells	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	We have found significant relationships between ADHD and the 40 bp VNTR polymorphisms of DAT1/SLC6A3 gene (P < 0-01)- The 9/9 genotype appeared to reduce the risk of ADHD about 0-4-fold (p < 0-04)- We also noted an occurrence of rare genotypes in ADHD (frequency different from controls at p < 0-01)- No association between alcoholism and genotype frequencies of 40 bp VNTR polymorphism of DAT1/SLC6A3 gene has been detected-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
417	26058807	9606	Buccal swabs	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Using miRBase software [29] we found in VNTR part of DAT1 gene that is transcribed as part of mRNA the following miRNA binding regions: mir-1972, miR-30b-5p, miR-1301 and miR-6070.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
418	26061495	9606	Blood	DSM-IV-TR	Case-control based	RiboArray miDETECT Human Array	Array	Table 1 The differentially expressed miRNAs obtained from the microarray data	Autism Spectrum Disorder	Transcriptome
419	26105134	10090	Brain		Case-control based	GeneChip microRNA 3.0 Arrays (Affymetrix)//qRT-PCR	SNP-array//qRT-PCR	Table 3 Alcohol-sensitive microRNAs with the Largest Fold Change in TH (right)	Alcohol Use Disorder	Transcriptome
420	26105134	10090	Brain		Case-control based	GeneChip microRNA 3.0 Arrays (Affymetrix)//qRT-PCR	SNP-array//qRT-PCR	Table 3 Alcohol-sensitive microRNAs with the Largest Fold Change in SN (left)	Alcohol Use Disorder	Transcriptome
421	26133963	9606	Brain		Case-control based		qRT-PCR	Quantification of these transcriptional regulators revealed higher mean mRNA levels for NF-脦潞B1 (+18%; F=15.1,df=1, 117, p=0.0002)andNF-脦潞B2(+86%; F=25.7, df=1, 117, p<0.0001) and lower mean mRNA levels for Schnurri-2 (-10%; F=7.5, df=1, 117, p=0.007) in the prefrontal cortex of schizophrenia subjects (Figure 2).	Schizophrenia	Transcriptome
422	26133963	9606	Brain		Case-control based		qRT-PCR	Schizophrenia subjects had markedly higher mean mRNA levels for IL-6 (+379%; F=5.1, df=1, 117, p=0.026) and interferon-脦虏 (+29%; F=8.3, df=1, 117, p=0.005) (Figure 2).	Schizophrenia	Transcriptome
423	26133963	10090	Brain		Case-control based		qRT-PCR	Frontal cortex homogenates from these adult mice had a pattern of alterations in immune markers (Figure 4B) remarkably similar to that seen in schizophrenia, including markedly elevated mRNA levels for IFITM1 (+149%, t=4.7, df=14, p=0.0003), IFITM2 (+82%, t=3.5, df=14, p=0.004), IFITM3 (+304%, t=11.8, df=14, p<0.0001), IL-1B (+132%, t=2.4, df=14, p=0.028), IL-6 (+493%, t=2.8, df=14, p=0.015), NF-脦潞B1 (+22%, t=3.9, df=14, p=0.002), and NF-脦潞B2 (+151%, t=5.9, df=14, p<0.0001).	Schizophrenia	Transcriptome
424	26135882	10090	Brain		Case-control based	qRT-PCR	qRT-PCR	These results suggest that exercise exerts a positive impact on stress resilience in single-housed mice that could be mediated by decreasing miR-124 and increasing Nr3c1 expression in the hippocampus. However, pair-housing reverses these effects possibly due to stress from dominance disputes between pairs.	Anxiety Disorder	Transcriptome
425	26146533	9606	Blood		Case-control based	Affymetrix miRNA 3.0 microarray	Microarray	Table 4. Comparison of the results of the current study and previous serum miRNA ASD research(PMID:28384108).	Autism Spectrum Disorder	Transcriptome
426	26146533	9606	Brain		Case-control based	Affymetrix miRNA 3.0 microarray	Microarray	Two mature miRNAs (miR-4753-5p and miR-1) were differentially expressed in ASD relative to control in STS and four (miR-664-3p, miR-4709-3p, miR-4742-3p, and miR-297) in PAC.	Autism Spectrum Disorder	Transcriptome
427	26146533	9606	Brain		Case-control based	Affymetrix miRNA 3.0 microarray	Microarray	Table 2 Differentially expressed sncRNA between ASD and CTRL	Autism Spectrum Disorder	Transcriptome
428	26170937	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Therefore, the expression levels of miR-93, miR-320 and miR-16 may be useful for the early diagnosis of ED in patients with diabetes.	Erectile Disorder	Transcriptome
429	26173148	9606	Skin fibroblasts	DSM-IIIR//DSM-IV	Case-control based	Illumina HiSeq2500//qPCR	Array//qPCR	45 differentially expressed miRNAs were detected (13 lower in SZ and 32 higher). Of these, 6 were significantly down-regulated in patients after correcting for genome wide significance (FDR<0.05), including 4 miRNAs that map to the 22q11.2 del region. In addition, a nominally significant increase in the expression of several miRNAs was found in the 22q11.2 neurons that were previously found to be differentially expressed in autopsy samples and peripheral blood in SZ and autism spectrum disorders (e.g., miR-34, miR-4449, miR-146b-3p, and miR-23a-5p).	Schizophrenia	Transcriptome
430	26188473	10116	Brain		Case-control based	Microarray	Microarray	Table 1 Differential expression of mRNA from methamphetamine self-administration rats	Methamphetamine Use Disorder	Transcriptome
431	26199675	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	In linear regression analysis, the plasma miR-144-5p expression level was inversely related to the depression score (MADRS-S) (脦虏=-0.02, p<0.01), after adjustment for sex and age, at baseline. In addition, plasma miR-144-5p levels at baseline in the depression/anxiety patients were significantly lower compared with the healthy controls (p<0.001)	Anxiety Disorder	Transcriptome
432	26199675	9606	Plasma//Serum	MADRS-S	Case-control based	qRT-PCR	qRT-PCR	In linear regression analysis, the plasma miR-144-5p expression level was inversely related to the depression score (MADRS-S) (脦虏=-0.02, p<0.01), after adjustment for sex and age, at baseline. In addition, plasma miR-144-5p levels at baseline in the depression/anxiety patients were significantly lower compared with the healthy controls (p<0.001)	Depressive Disorder	Transcriptome
433	26199675	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	In linear regression analysis, the plasma miR-144-5p expression level was inversely related to the depression score (MADRS-S) (脦虏=-0.02, p<0.01), after adjustment for sex and age, at baseline. In addition, plasma miR-144-5p levels at baseline in the depression/anxiety patients were significantly lower compared with the healthy controls (p<0.001)	Depressive Disorder	Transcriptome
434	26199675	9606	Blood	MADRS-S	Case-control based	qRT-PCR	qRT-PCR	Our findings show that plasma miR-144-5p levels are associated with depressive symptoms. Although confirmatory analyses are required, plasma miRNA-144-5p is a potential peripheral biomarker for pathologic processes related to depression.	Depressive Disorder	Transcriptome
435	26205656	9606	Blood	DSM-5	Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Circulating miR-429 may be immediately useful as sensitive molecular biomarker to support TS diagnosis, actually based only on DSM-V criteria.	Tourette's Disorder	Transcriptome
436	26206863	9606	Brain	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	We detected the first genome-wide significant association of schizophrenia with CALN1, which is a predicted target of MIR137, and thus provide new evidence for the associations between MIR137 targets and schizophrenia.	Schizophrenia	Transcriptome
437	26239616	10116	Brain//Blood		Case-control based	ELISA//Western blotting//qPCR	ELISA//Western blotting//qPCR	The reduced expression levels of BDNF, as induced by MeCP2 knockdown, were enhanced by miR-132 mimics, and were rescued by miR-132 inhibitors. These results suggested that homeostatic interactions between MeCP2 and miR-132 may regulate hippocampal BDNF levels, which may have a role in the pathogenesis of MDD.	Major Depressive Disorder	Transcriptome
438	26241353	9606	Brain		Case-control based		qRT-PCR	In BA9, SELENBP1 mRNA was significantly higher in subjects with schizophrenia (4.20脗卤0.47) compared with control (2.36脗卤0.25; t58=3.47, P=0.001; Figure 2a). SELENBP1 mRNA was also higher in subjects with schizophrenia in BA44 (2.01脗卤0.16 schizophrenia, 1.25脗卤0.15 control; t58=3.57, P=0.0007; Figure 2b) and BA8 (1.77脗卤0.17 schizophrenia, 1.04脗卤0.15 control; t58=3.15, P=0.003; Figure 2c).	Schizophrenia	Transcriptome
439	26273428	9606	Brain		Case-control based	Illumina芒鈧劉s TruSeq//miRNA-Seq	RNA-Seq	Table 1 List of differentially expressed microRNAs according to whole RNA sequencing analysis	Autism Spectrum Disorder	Transcriptome
440	26273428	9606	Brain		Case-control based	Illumina芒鈧劉s TruSeq//miRNA-Seq	RNA-Seq	We determined that miR-142-5p, miR-142-3p, miR-451a, miR-144-3p, and miR-21-5p are overexpressed in the asd brain.	Autism Spectrum Disorder	Transcriptome
441	26280760	10090	Brain					This effect required protein kinase C-脦虏II and was influenced by miR-33, a microRNA that regulates several GABA-related proteins.	Posttraumatic Stress Disorder	Transcriptome
442	26284581	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Table II List of microRNA pairs that discriminate cognitively impaired from non-impaired HIV+ patients obtained with qRT-PCR arrays.	Neurocognitive Disorder Due to HIV	Transcriptome
443	26314506	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Here we reported using cellular assays and blood samples from MDD patients and showed that miR-335 was downregulated in individuals with depression compared with healthy controls.	Major Depressive Disorder	Transcriptome
444	26341662	9606	Blood	DSM-IV	Case-control based	Affymetrix GeneChip miRNA 2.0 arrays	SNP-array	Examination of the miRNAs that were most robustly changed in our AUD subjects indicated that most were increased in expression (Table 3).	Alcohol Use Disorder	Transcriptome
445	26343596	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	We found miR-320a significantly downregulated and miR-451a significantly upregulated in depressed patients. We also found miR-17-5p and miR-223-3p upregulated, but not as significantly as miR-451a.	Depressive Disorder	Transcriptome
446	26350727	9606	Brain		Case-control based	Affymetrix miRNA 3.0 microarray	Microarray	We assessed small noncoding RNAs, including microRNA and small nucleolar RNA, in superior temporal sulcus association cortex and primary auditory cortex in typical and ASD brains from early childhood to adulthood. (Table 3. Age-Regulated sncRNAs in STS in Brains of TYP and ASD Subjects.)	Autism Spectrum Disorder	Transcriptome
447	26350727	9606	Brain		Case-control based	Affymetrix miRNA 3.0 microarray	Microarray	We assessed small noncoding RNAs, including microRNA and small nucleolar RNA, in superior temporal sulcus association cortex and primary auditory cortex in typical and ASD brains from early childhood to adulthood.(Table 4. Age-Regulated sncRNAs in PAC in Brains of TYP and ASD Subjects.)	Autism Spectrum Disorder	Transcriptome
448	26350727	9606	Brain		Case-control based	Affymetrix miRNA 3.0 microarray	Microarray	We assessed small noncoding RNAs, including microRNA and small nucleolar RNA, in superior temporal sulcus association cortex and primary auditory cortex in typical and ASD brains from early childhood to adulthood.(Table 2.Regionally Regulated sncRNAs Between STS and PAC in Brains of TYP and ASD Subjects.)	Autism Spectrum Disorder	Transcriptome
449	26350727	9606	Brain		Case-control based	Affymetrix miRNA 3.0 microarray	Microarray	We assessed small noncoding RNAs, including microRNA and small nucleolar RNA, in superior temporal sulcus association cortex and primary auditory cortex in typical and ASD brains from early childhood to adulthood.(Table 5.Age-Regulated Mature miRNAs in STS and PAC in Brains of TYP and ASD Subjects.)	Autism Spectrum Disorder	Transcriptome
450	26357588	9606	Brain		Case-control based	RT-PCR//microRNA microarray	Microarray//RT-PCR	microRNA profiling in neurons undergoing AW revealed upregulation in the expression of miR-155, miR-186, miR-24, and miR-375 after 8 h of AW.	Alcohol Withdrawal	Transcriptome
451	26357588	10090	Brain		Case-control based	RT-PCR//microRNA microarray	Microarray//RT-PCR	microRNA profiling in neurons undergoing AW revealed upregulation in the expression of miR-155, miR-186, miR-24, and miR-375 after 8 h of AW.	Alcohol Withdrawal	Transcriptome
452	26357588	10090	Brain		Case-control based	RT-PCR//microRNA microarray	Microarray//RT-PCR	Eleven hours after removal of alcohol, Gabra4 was downregulated, with a modest increase in the expression of Gabrg2, but no change in the expression of Gabra1, Gabrd, or Gabrb2.	Alcohol Withdrawal	Transcriptome
453	26361067	9606	Blood	DSM-IV	Case-control based	PCR-RFLP	PCR-RFLP	His is the first report to show possible associations of miR-22 and miR-491 with genetic susceptibility to PD in a Korean population.	Agoraphobia	Transcriptome
454	26361067	9606	Blood	DSM-IV	Case-control based	PCR-RFLP	PCR-RFLP	His is the first report to show possible associations of miR-22 and miR-491 with genetic susceptibility to PD in a Korean population.	Panic Disorder	Transcriptome
455	26368940	10116	Brain		Case-control based	RT-PCR//Western blotting//Luciferase reporter assay	RT-PCR//Western blotting//Reporter assay	In contrast, miR-182 overexpression exacerbated depression-like behaviors and decreased BDNF.	Depressive Disorder	Transcriptome
456	26381263	9606	Brain		Case-control based	Affymetrix Genome-Wide Human SNP Array 6.0	SNP-array	Integration of hub gene expression with genome-wide genotypic data resulted in 591 mRNA cis-eQTLs and 62 miRNA cis-eQTLs. mRNA cis-eQTLs were significantly enriched for AD diagnosis and AD symptom counts (adj. p=0.014 and p=0.024, respectively) in AD GWAS signals in a large, independent genetic sample from the Collaborative Study on Genetics of Alcohol (COGA).	Alcohol Use Disorder	Transcriptome
457	26461262	9606	Blood	DSM-IV	Case-control based	Taqman allelic discrimination assay	Taqman	This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression.	Psychotic Disorder	Transcriptome
458	26475507	10116	Blood		Case-control based		qRT-PCR	GAT1 (1.31-fold, p<0.01) and GAT3 (1.50-fold, p<0.0005) were significantly upregulated in METH-treated rats compared with saline-treated controls (Fig. 2B)	Chronic Meth Psychosis	Transcriptome
459	26475507	10116	Blood		Case-control based		qRT-PCR	GABAB1 (1.40-fold, p<0.0001) mRNA was significantly upregulated in METH-treated rats compared with saline controls (Fig. 3C).	Chronic Meth Psychosis	Transcriptome
460	26485544	9606	Blood//Cell lines(lymphoblast)	DSM-IV	Case-control based	Arraystar Human LncRNA Array v2.0	Array	A total of 3929 lncRNAs were found to be differentially expressed in ASD peripheral leukocytes, including 2407 that were upregulated and 1522 that were downregulated. 	Autism Spectrum Disorder	Transcriptome
461	26485544	9606	Blood//Cell lines(lymphoblast)	DSM-IV	Case-control based	Arraystar Human LncRNA Array v2.0	Array	A total of 3929 lncRNAs were found to be differentially expressed in ASD peripheral leukocytes, including 2407 that were upregulated and 1522 that were downregulated.	Autism Spectrum Disorder	Transcriptome
462	26485544	9606	Blood//Cell lines(lymphoblast)	DSM-IV	Case-control based	Arraystar Human LncRNA Array v2.0	Array	A total of 3929 lncRNAs were identified as differentially expressed in Chinese ASD peripheral blood cells, including 2407 that were upregulated and 1522 that were downregulated.Simultaneously, 2610 mRNAs, including 1789 upregulated and 821 downregulated, that were differentially expressed in ASD blood cells genome-wide were also identified. The entire data set has been deposited in a public domain (DataDryad.org, DOI: doi:10.5061/dryad.d8f84).	Autism Spectrum Disorder	Transcriptome
463	26485544	9606	Blood//Cell lines(lymphoblast)	DSM-IV	Case-control based	Arraystar Human LncRNA Array v2.0	Array	Simultaneously, 2591 messenger RNAs (mRNAs), including 1789 upregulated and 821 downregulated, were also identified in ASD leukocytes.	Autism Spectrum Disorder	Transcriptome
464	26506154	9606	Brain	DSM-IV	Case-control based	Microarray//qRT-PCR	Microarray//qRT-PCR	Real-time qPCR was conducted to verify the microarray findings. Data are expressed as a mean fold change脗卤standard error of the mean (SEM) (n=6), compared to healthy controls (n=6). [t(10)=5.966 for SGK1; t(8)=4.275 for SGK2; t(8)=2.057 for SGK3, Student芒鈧劉s t test, *p<0.05, **p<0.01, ***p<0.001]	Posttraumatic Stress Disorder	Transcriptome
465	26513665	10116	Corpus cavernosa		Case-control based	Microarray//qRT-PCR	Microarray//qRT-PCR	Table 4 The top 50 up-regulated mRNAs in the A-ED group compared with the NC group and filtered by a fold-change >3.0	Erectile Disorder	Transcriptome
466	26513665	10116	Corpus cavernosa		Case-control based	Microarray//qRT-PCR	Microarray//qRT-PCR	We identified 608 up-regulated and 406 down-regulated lncRNAs in A-ED compared with NC samples, by setting a filter of fold-change >2.0. Gene Ontology and pathway analysis revealed that a muscle contraction disorder induced by abnormal ion channels might play a critical role in the pathogenesis of A-ED.(Table 3 Top 50 down-regulated lncRNAs in the A-ED group compared with the NC group and filtered by a fold-change >3.0)	Erectile Disorder	Transcriptome
467	26513665	10116	Corpus cavernosa		Case-control based	Microarray//qRT-PCR	Microarray//qRT-PCR	We identified 608 up-regulated and 406 down-regulated lncRNAs in A-ED compared with NC samples, by setting a filter of fold-change >2.0. Gene Ontology and pathway analysis revealed that a muscle contraction disorder induced by abnormal ion channels might play a critical role in the pathogenesis of A-ED.(Table 2 Top 50 up-regulated lncRNAs in the A-ED group compared with the NC group and filtered by a fold-change >3.0)	Erectile Disorder	Transcriptome
468	26513665	10116	Corpus cavernosa		Case-control based	Microarray//qRT-PCR	Microarray//qRT-PCR	Table 5 The top 50 down-regulated mRNAs in the A-ED group compared with the NC group and filtered by a fold-change >3.0	Erectile Disorder	Transcriptome
469	26523118	9606	Brain		Case-control based	RNA-seq	RNA-seq	LncRNAs overlapping pathogenic CNVs are ranked based on maximum correlation with known ID genes.	Intellectual Disability	Transcriptome
470	26539909	9606	Testicular tissues		Case-control based	qRT-PCR//FISH//Northern blotting	qRT-PCR//FISH//Northern blotting	After 48h of Nucleolin knockdown (Figure 4c), the expression of primary and mature miR-320a/miR-383 was increased (Figure 4d-f), similar to NLC1-C knockdown.	Narcolepsy	Transcriptome
471	26539909	9606	Testicular tissues		Case-control based	qRT-PCR//FISH//Northern blotting	qRT-PCR//FISH//Northern blotting	Interestingly, NLC1-C, also known as long intergenic non-protein-coding RNA162 (LINC00162), was down-regulated in the cytoplasm and accumulated in the nucleus of spermatogonia and primary spermatocytes in the testes of infertile men with mixed patterns of MA compared with normal control.	Narcolepsy	Transcriptome
472	26554713	9606	Cell lines(iPSCs cells)	DSM-III//DSM-IV	Case-control based		Immunocytochemistry//PCR//Microarray	Table 1. List of differentially expressed genes (DEGs) in control and BPD L neurons.	Bipolar Disorder	Transcriptome
473	26555429	10090	Brain//Cell lines		Case-control based	qRT-PCR	qRT-PCR	Furthermore, NFKBIA (inhibits the NF-B transcription factor) was upregulated in female (t13=4.15, p<0.05) but not male (p > 0.05) miR-155 ko mice compared to wt mice.	Anxiety Disorder	Transcriptome
474	26555429	10090	Brain//Cell lines		Case-control based	qRT-PCR	qRT-PCR	Furthermore, NFKBIA (inhibits the NF-B transcription factor) was upregulated in female (t13=4.15, p<0.05) but not male (p > 0.05) miR-155 ko mice compared to wt mice.	Depressive Disorder	Transcriptome
475	26556287	9606	Brain	DSM-IV	Case-control based			Table 1. Results of the gene-based tests for the nine microRNAs that withstood Bonferroni correction	Bipolar Disorder	Transcriptome
476	26557050	9606	Cell lines(SK-N-SH)		Case-control based	RNA-seq//qPCR	RNA-seq//qPCR	Differential expression analysis in the two cell lines identified altered gene expression in both protein coding and noncoding RNAs as they undergo neural differentiation with 222 differentially expressed genes observed in SK-N-SH cells and 19 differentially expressed genes in ReNcell CX.(Supplementary Table 3: List of expressed genes,SK-N-SH)	Autism Spectrum Disorder	Transcriptome
477	26557050	9606	Cell lines(ReNcell CX)		Case-control based	RNA-seq//qPCR	RNA-seq//qPCR	Differential expression analysis in the two cell lines identified altered gene expression in both protein coding and noncoding RNAs as they undergo neural differentiation with 222 differentially expressed genes observed in SK-N-SH cells and 19 differentially expressed genes in ReNcell CX.(Supplementary Table 3: List of expressed genes,ReNcell CX)	Autism Spectrum Disorder	Transcriptome
478	26559723	10090	Brain		Case-control based		qRT-PCR	qRT-PCR experiments revealed that these mRNAs were significantly downregulated in the hippocampus of En2-/-mice compared with WT littermates (Fmr1: -28%, P=0.0079; mGluR5: -31%, P=0.0021; Gabrb3: -33%, P=0.0015; Fig. 1b).	Autism Spectrum Disorder	Transcriptome
479	26572867	9606	Cell lines(HEK293T)		Case-control based	qRT-PCR	qRT-PCR	Together, these results suggest that miR-7, miR-34a, and miR-504 directly bind to the SHANK3 3芒鈧睻TR and downregulate its expression.	Bipolar Disorder	Transcriptome
480	26574140	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	MiR-122 increased with moderate ethanol consumption, but the fold change was modes.	Alcohol Use Disorder	Transcriptome
481	26575223	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	To replicate the findings obtained using TLDA array plate, we selected three miRNAs that were upregulated (mir-124, miR-218, miR-29a) and three, miRNAs that were downregulated (miR-146a, miR-200c, miR-155) based on their highest degree of significance by chronic CORT treatment and re-analyzed their expression individually by qPCR.	Depressive Disorder	Transcriptome
482	26592480	10116	Blood		Case-control based			Compared with saline control group, miR-186 was verified to be up-regulated while miR-195 and miR-329 were down-regulated in the rats with controlled methamphetamine use. In the rats with escalated drug use, miR-127, miR-186, miR-222 and miR-24 were verified to be up-regulated while miR-329 was down-regulated compared with controls.	Methamphetamine Use Disorder	Transcriptome
483	26628105	10116	Brain//Serum		Case-control based			After correcting for multiple comparisons, the serum level of miR-16 was significantly altered by stress.	Depressive Disorder	Transcriptome
484	26632874	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Genome-wide differential expression survey of miRNAs in blood in PTSD&Dep reveals miRNAs to be significantly downregulated in cases versus controls.	Depressive Disorder	Transcriptome
485	26632874	9606	Blood	DSM-IV	Case-control based	MicroRNA micro-array//RT-PCR	Microarray	At genome-wide FDR<0.05, two miRNAs were significantly differentially expressed, and both were downregulated in the cases compared with the controls after sex, age and genotypic principal components were adjusted for: miR-212-3p (log2 fold change=-1.72; Wald test P=4.48E-05, adjusted P=0.048) and miR-3130-5p (log2 fold change=-1.61; Wald test P=4.97E-05, adjusted P=0.048; Fig. 3a,b).	Posttraumatic Stress Disorder	Transcriptome
486	26632874	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Genome-wide differential expression survey of miRNAs in blood in PTSD&Dep reveals miRNAs to be significantly downregulated in cases versus controls.	Posttraumatic Stress Disorder	Transcriptome
487	26632874	9606	Blood	DSM-IV	Case-control based	MicroRNA micro-array//RT-PCR	Microarray	Supplementary Table 3: list B of 59 up-regulated genes in the cases of PTSD&Dep versus controls in the genome-wide differential gene expression analysis in the GTP Discovery Sample	Posttraumatic Stress Disorder	Transcriptome
488	26632874	9606	Blood	DSM-IV	Case-control based		qRT-PCR	The other SNP, rs10144436, is located in the 3芒鈧睻TR of DICER1 and its minor allele (A) was also associated with lower DICER1 mRNA level (Fig. 2a).	Posttraumatic Stress Disorder	Transcriptome
489	26714269	9606	Cell lines(SH-SY5Y)		Case-control based	qRT-PCR//Microarray//small RNA-seq	qRT-PCR//Microarray//RNA-seq	Thereby we found variant rs7861254 located near the MIR204 gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells. Analysis of the consequences of the altered miR-204 expression on the transcriptome of these cells uncovered a new mode of action for miR-204, being the regulation of noncoding RNAs (ncRNAs), including several miRNAs, such as MIR296.	Schizophrenia	Transcriptome
490	26722632	9606	Blood	ICSD	Case-control based	MicroRNA micro-array//RT-PCR	Array//RT-PCR	The validation test showed that levels of hsa-mir-1267, hsa-miR-4309, hsa-miR-554, hsa-miR-1272, hsa-miR-4501, hsa-miR-182-3p were higher, whereas the level of hsa-miR-625-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-197-3p, hsa-miR-4522, hsa-miR-493-5p was lower in narcolepsy patients than healthy controls. The levels of 12 miRNAs differed significantly in peripheral blood from narcolepsy patients which suggested that alterations of miRNAs expression may be involved in the pathophysiology of narcolepsy.	Narcolepsy	Transcriptome
491	26728011	9606	Blood	DSM-IV	Case-control based	Agilent Whole Human Genome 4 脙鈥	SNP-array	Supplementary Table S2.Differentially expressed genes in depressed patients compared with controls, as defined by the hybrid threshold of p-value for the t-test<0.01 and absolute fold change value > 1.5 (sorted by p value in ascending order).	Major Depressive Disorder	Transcriptome
492	26733279	9606	Brain		Case-control based		Genotyping	Table 3. Differentially expressed genes in two or more depression studies overrepresenting immune and inflammation related processes.(Immune Response)	Depressive Disorder	Transcriptome
493	26733279	9606	Brain		Case-control based		Genotyping	Table 3. Differentially expressed genes in two or more depression studies overrepresenting immune and inflammation related processes.(Innate Immune Response)	Depressive Disorder	Transcriptome
494	26733279	9606	Brain		Case-control based		Genotyping	Table 3. Differentially expressed genes in two or more depression studies overrepresenting immune and inflammation related processes.(Immune System Process)	Depressive Disorder	Transcriptome
495	26733279	9606	Brain		Case-control based		Genotyping	Table 3. Differentially expressed genes in two or more depression studies overrepresenting immune and inflammation related processes.(Immune System Development)	Depressive Disorder	Transcriptome
496	26733279	9606	Brain		Case-control based		Genotyping	Table 3. Differentially expressed genes in two or more depression studies overrepresenting immune and inflammation related processes.(Inflammatory Response)	Depressive Disorder	Transcriptome
497	26733343	9606	PBMCs	DSM-IV	Case-control based	RT-PCR//Agilent Array//LncRNA Array v2.0	qRT-PCR//Microarray	We detected predominant up-regulation of mRNAs in the SZ group, with 82 out of 84 DE genes being increased.	Schizophrenia	Transcriptome
498	26744330	10090	Blood//Cell lines		Case-control based	qRT-PCR	qRT-PCR	Together these data show that lack of miR-379/miR-410 expression is associated with enhanced anxiety-related behaviour that is not accompanied by any obvious depression-like symptoms.	Anxiety Disorder	Transcriptome
499	26753090	9606	Olfactory mucosal stem cells//PBMCs//Skin fibroblasts		Case-control based	Microarray	Microarray	This analysis showed a significant deregulation of miR-146a, miR-221, and miR-654-5p in the ASD group compared to controls in the same trend as in OMSC (see Fig. 1b).	Autism Spectrum Disorder	Transcriptome
500	26753090	9606	OMSC//Skin fibroblasts	DSM-5	Case-control based	Affymetrix miRNA 3.0 GeneChips	Taqman	We identified a signature of four miRNAs (miR-146a, miR-221, miR-654-5p, and miR-656) commonly deregulated in ASD. This signature is conserved in primary skin fibroblasts and may allow discriminating between ASD and intellectual disability samples.	Autism Spectrum Disorder	Transcriptome
501	26753090	9606	OMSC//Skin fibroblasts	DSM-5	Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Yet, miR-146a was also found significantly upregulated in the ID group, supporting the role of this miRNAs in shared pathways affected in both conditions.	Intellectual Disability	Transcriptome
502	26784971	9606	Brain//Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	In the postmortem brain samples, there was a weak correlation between hsa-miR-34a level and age in people with schizophrenia (r=0.31, P=0.067, Figure 4a) and a moderate correlation in controls (r=0.61, P<0.001, Figure 4b). Adjusting for gender had little impact on these correlations in the schizophrenia (r=0.32, P=0.067) and control (r=0.63, P=0.002) cases, respectively.	Schizophrenia	Transcriptome
503	26786313	10116	Brain		Case-control based	QIAgen RNeasy Mini Kit//Microfluidic biochip	Array	These results indicate that ethanol-induced reductions in the expression of miR-494 may increase the mRNA levels of Cited2, CBP and p300 in the amygdala and regulate anxiolytic-like effects.	Alcohol Use Disorder	Transcriptome
504	26786313	10116	Brain		Case-control based	QIAgen RNeasy Mini Kit//Microfluidic biochip	Array	Expression of miR-494 (p<0.001) and miR-130a (p<0.001) were significantly reduced and expression of miR-191 (p<0.05) was significantly increased in the amygdala following acute alcohol exposure, thereby validating the findings obtained by the miRNA profiling microarray method.	Alcohol Use Disorder	Transcriptome
505	26786313	10116	Brain		Case-control based	QIAgen RNeasy Mini Kit//Microfluidic biochip	Array	Expression of miR-494 was significantly decreased whereas expression of CREB binding protein (CBP), p300 and CBP/p300-interacting transactivator 2 (Cited2) were increased in the amygdala during ethanol-induced anxiolysis.	Alcohol Use Disorder	Transcriptome
506	26807671	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Differentially Notch-associated miRNAs expressions in peripheral blood might be involved in MDD, and the miR-34b-5p and miR-34c-5p levels in peripheral blood leukocytes are closely related to suicide idea and cognitive function, further studies with large sample size are warranted to test the feasibility of these miRNAs serving as biomarkers for MDD.	Major Depressive Disorder	Transcriptome
507	26820676	10116	Brain//Cell lines	Others	Case-control based	qRT-PCR/Reporter Assay	qRT-PCR/Reporter Assay	This suggests that, in this case, the IL-1? and TNF? activation pathways are differentially affected	Attention-Deficit/Hyperactivity Disorder	Transcriptome
508	26820676	10116	Brain//Cell lines		Case-control based	qRT-PCR//Luciferase Assay	qRT-PCR//Reporter Assay	Based on promoter sequence analysis and activity assay, glucocorticoid receptor (Nr3c1) was identified for the inhibition of the promoter activity of miR-138-1, 34c*, 296, and 494 genes and their transcription.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
509	26843422	10090	Brain		Case-control based	qRT-PCR//Western blotting	qRT-PCR//Western blotting	Taken together, we therefore proposed that PTEN dephosphorylated CREB at Ser133 and repressed miR-132, resulting in the reciprocal regulation of MeCP2. Thus, knockdown PTEN leads to increased phosphorylation level of CREB Ser-133 site, which in turn promotes expression of miR-132 and then decreases expression of MeCP2 (Fig. 4D).	Autism Spectrum Disorder	Transcriptome
510	26921097	10090	Brain		Case-control based	qRT-PCR	qRT-PCR	Taken together, our study suggests that social isolation mediated anxiety like behavior is associated with up-regulation of BDNF expression and concomitant increase in the expression of CBP, CREB-1, Limk-1 and miRNA-132, and decrease in the expression of HDAC-2 and miRNA-134 in the cerebral cortex.	Anxiety Disorder	Transcriptome
511	26925271	10116	Hypothalamus		Case-control based	qRT-PCR	qRT-PCR	The results of our study proved that exposure to acute traumatic stress in early adolescent can cause permanent changes in neural network, resulting in dysregulation of CRFR1 expression and CRFR1 mRNA and miR-34c expression in hypothalamus, anxiety-like behavior, and memory impairment, suggesting that the miR-34c expression in hypothalamus may be an important factor involved in susceptibility to PTSD.	Posttraumatic Stress Disorder	Transcriptome
512	26926397	9606	Blood		Case-control based		qRT-PCR	Fig 3. Quantitative analysis of CIDEC, RNASE1, SLC36A1, and STYXL1 mRNA expression in the first cohort. The data represent the means+Ses. *p<0.05, **p<0.01 between the indicated groups (Tukey芒鈧劉s HSD test).	Major Depressive Disorder	Transcriptome
513	26996510	10116	Brain(Hippocampus)	Others	Case-control based	Taqman	Taqman	Alcohol increased expression of cytokines CCL4 and TGF-囟, while alcohol and intubation both increased IL-1囟, TNF-汐 and CD11b.	Fetal Alcohol Spectrum Disorder	Transcriptome
514	27026110	10090	Blood		Case-control based	qRT-PCR	qRT-PCR	Our data demonstrate that the miR-34 has a critical function in regulating the behavioral and neurochemical response to acute stress and in inducing stress-related amygdala neuroplasticity.	Anxiety Disorder	Transcriptome
515	27030512	9606	Blood		Case-control based		qRT-PCR	Expression of 14-3-3脧茠 was signifcantly increased in SZ patients compared with control subjects (2.29-fold, p<0.0001, Fig. 1a).	Schizophrenia	Transcriptome
516	27105825	9606	Saliva	DSM-5//ADOS//CARS	Case-control based	RNA-seq	RNA-Seq	Ten of the miRNAs were up-regulated in ASD subjects and four were down-regulated. The miRNA with the largest mean difference in abundance between ASD and control subjects was miR-628-5p (it also had the most significant difference) (p=0.0001, Z score difference=1.13). 	Autism Spectrum Disorder	Transcriptome
517	27105825	9606	Saliva	DSM-5//ADOS//CARS	Case-control based	RNA-seq	RNA-Seq	This analysis revealed significant correlations between multiple measures included in the Vineland scores and 13 of the 14 miRNAs (only miR-140-3p failed to show significant correlations).	Autism Spectrum Disorder	Transcriptome
518	27117414	9606	Cell lines(Fibroblasts)		Case-control based	qPCR//RNA-seq	qPCR//RNA-seq	Together these data indicate that aberrant levels and activity of miR-9 may be one of the many factors that contribute to SZ risk, at least in a subset of patients.	Schizophrenia	Transcriptome
519	27152760	9606	Blood	DSM-IV-TR	Case-control based	MiRNA microarray	Microarray	Thirteen miRNAs were altered in13 BD patients as compared to controls: hsa-miR-720, hsa-miR-140-3p, hsa-miR-1973, hsa-miR-30d-5p, hsa-miR-3158-3p, hsa-miR-330-5p, hsa-miR-378a-5p, hsa-miR-4521, hsa-miR-21-3p (upregulated) and hsa-miR-1915-5p, hsa-miR-1972, hsa-miR-4793-3p, hsa-miR-4440 (downregulated).	Bipolar Disorder	Transcriptome
520	27152760	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	Thirteen miRNAs were altered in13 BD patients as compared to controls: hsa-miR-720, hsa-miR-140-3p, hsa-miR-1973, hsa-miR-30d-5p, hsa-miR-3158-3p, hsa-miR-330-5p, hsa-miR-378a-5p, hsa-miR-4521, hsa-miR-21-3p (upregulated) and hsa-miR-1915-5p, hsa-miR-1972, hsa-miR-4793-3p, hsa-miR-4440 (downregulated).	Bipolar Disorder	Transcriptome
521	27152760	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	In particular, as shown in the Venn Diagram (Figure 1), 7 miRNAs were differentially expressed in MD patients with respect to controls: hsa-let-7a-5p, hsa-let-7d-5p, has-let-7f-5p, hsa-miR-1915-3p (down-regulated) and hsamiR-199a-5p, hsa-miR-24-3p, hsa-miR-425-3p (up-regulated).	Major Depressive Disorder	Transcriptome
522	27152760	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR	qRT-PCR	Table 3: A, significant microarray results comparing miRNA blood levels in MD patients vs controls (CTRL)	Major Depressive Disorder	Transcriptome
523	27177356	9606	Blood	DSM-5	Case-control based	Affymetrix GeneChip miRNA 4.0 Array//RT-qPCR	qRT-PCR//Array	A total of 16 miRNAs were differentially expressed after treatment in the asenapine group, 14 of which were significantly upregulated and the other two significantly downregulated. However, all three differentially expressed miRNAs in the risperidone group were downregulated.	Bipolar I Disorder	Transcriptome
524	27191977	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Fig. 4: Functional classes of genes targeted by HAND-associated miRNAs	Neurocognitive Disorder Due to HIV	Transcriptome
525	27211062	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	Our novel findings attribute neonatal isolation-inducible cognitive impairments to induction of miR124a and consequently suppressed BDNF mRNA, opening venues for intercepting these miR124a-mediated damages. They also highlight the importance of studying microRNAs in the context of ASD and identify miR124a as a novel potential therapeutic target for improving mood disorders.	Autism Spectrum Disorder	Transcriptome
526	27211062	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	Our novel findings attribute neonatal isolation-inducible cognitive impairments to induction of miR124a and consequently suppressed BDNF mRNA, opening venues for intercepting these miR124a-mediated damages. They also highlight the importance of studying microRNAs in the context of ASD and identify miR124a as a novel potential therapeutic target for improving mood disorders.	Psychotic Disorder	Transcriptome
527	27254754	10090	Brain		Case-control based		Immunohistochemistry//HPLC//Immunoblotting	We identified abnormal behaviors and biomarkers reflecting dopaminergic dysfunction in mice lacking Magel2.	Anorexia Nervosa	Transcriptome
528	27258654	10116	Brain		Case-control based			This indicates that miRNA-30e-transfected rats have impairments in working memory.	Cognitive Disorders	Transcriptome
529	27300263	10090	Blood		Case-control based	RT-PCR//RNA-Seq	RT-PCR//RNA-Seq	Our study found 188 differentially expressed small noncoding RNA sequences that mapped to the current mouse genome (false discovery rate-adjusted P<0.1; Figure 5d).	Anxiety Disorder	Transcriptome
530	27300263	10090	Blood		Case-control based	RT-PCR//RNA-Seq	RT-PCR//RNA-Seq	Our study found 188 differentially expressed small noncoding RNA sequences that mapped to the current mouse genome (false discovery rate-adjusted P<0.1; Figure 5d).	Depressive Disorder	Transcriptome
531	27318824	10116	Brain(Hippocampus//Cortex)	Others	Case-control based	qPCR	qPCR	All significant results are summarized inTable 1. The genes that were not affected by prenatal alcohol exposure or sex are listed inSupplementary Table 2.	Fetal Alcohol Spectrum Disorder	Transcriptome
532	27319317	9606	Adrenal gland//Brain//Breast//Colon//Heart//Kidney//Lung//Liver		Case-control based	ChIP-seq	ChIP-seq	Based on the presence of this feature and GWAS hits for CNS disorders, we identified 53 candidate lncRNA genes. Extensive expression profiling on human brain samples and other tissues, followed by Gene Set Enrichment Analysis indicates that at least 24 of these lncRNAs are indeed implicated in processes such as synaptic transmission, nervous system development and neurogenesis.	Intellectual Disability	Transcriptome
533	27321975	9606	Blood//Urine		Case-control based	Illumina Human HT-12 v4.0 Expression BeadChip	SNP-array	Table 3 Mean and standard deviations of normalized, log-transformed expression of the 11 differentially expressed microRNAs.	Methamphetamine Use Disorder	Transcriptome
534	27348532	10090	Brain//Blood		Case-control based		qRT-PCR	Shati/Nat8l mRNA expression was increased by the repeated administration of Meth (1 mg/kg for 6 days, s.c.) in the NAc (Fig 1a) 138.12脗卤6.36%, p<0.05) but not in the hippocampus (HIP) (Fig 1b) (95.99脗卤10.09%) or the cerebellum (CB) (Fig 1c) (92.52脗卤8.08%).	Schizophrenia	Transcriptome
535	27350034	9606	Dorsal striatum		Case-control based		qRT-PCR	Table 1. Genes differentially expressed between control and bipolar disorder samples	Bipolar Disorder	Transcriptome
536	27424800	9606	Cell lines(Lymphoblastoid)		Case-control based	Dual-Glo Luciferase assay	Reporter assay	Table 1 Potentially functional schizophrenia risk variants with p-value o10-4. Only the most significant SNP for each miRNA/gene in a category is presented.	Schizophrenia	Transcriptome
537	27424800	9606	Cell lines(Lymphoblastoid)		Case-control based	Dual-Glo Luciferase assay	Reporter assay	Our study therefore suggests that miR-206 may contribute to schizophrenia risk through allele-dependent regulation of the genome-wide significant gene NT5C2.	Schizophrenia	Transcriptome
538	27468165	9606	Brain	DSM-IV	Case-control based	TaqMan Low Density Array	TaqMan	NCOA1 showed an inverse correlation with miR-34a in BP, while NCOR2 demonstrated a positive correlation. In sum, this is the first study to demonstrate miRNA changes in AnCg in psychiatric illness and validate miR-34a as differentially expressed in CNS in MDD.	Bipolar Disorder	Transcriptome
539	27468165	9606	Brain	DSM-IV	Case-control based	TaqMan Low Density Array	TaqMan	Four miRNAs (miR-132, miR-133a, miR-212 and miR-34a) showed nominal p-values<0.05 (downregulation in BD compared to controls), but not after multiple testing correction. A trend was found for miR-195, as well.	Bipolar Disorder	Transcriptome
540	27468165	9606	Brain	DSM-IV	Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	NCOA1 showed an inverse correlation with miR-34a in BP, while NCOR2 demonstrated a positive correlation. In sum, this is the first study to demonstrate miRNA changes in AnCg in psychiatric illness and validate miR-34a as differentially expressed in CNS in MDD.	Major Depressive Disorder	Transcriptome
541	27468165	9606	Brain	DSM-IV	Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	Four miRNAs (miR-132, miR-133a, miR-212 and miR-34a) showed nominal p-values<0.05 (downregulation in BD compared to controls), but not after multiple testing correction. A trend was found for miR-195, as well.	Major Depressive Disorder	Transcriptome
542	27477270	10090	Blood		Case-control based	RNA-Seq	RNA-seq	miR-17-92 knockout mice show anxiety- and depression-like behaviors, whereas miR-17-92 overexpressing mice exhibit anxiolytic and antidepression-like behaviors. Furthermore, we show that miR-17-92 expression in the adult mouse hippocampus responds to chronic stress, and miR-17-92 rescues proliferation defects induced by corticosterone in hippocampal neural progenitors. Our study uncovers a crucial role for miR-17-92 in adult neural progenitors through regulation of neurogenesis and anxiety- and depression-like behaviors.	Anxiety Disorder	Transcriptome
543	27477270	10090	Blood		Case-control based	RNA-Seq	RNA-seq	miR-17-92 knockout mice show anxiety- and depression-like behaviors, whereas miR-17-92 overexpressing mice exhibit anxiolytic and antidepression-like behaviors. Furthermore, we show that miR-17-92 expression in the adult mouse hippocampus responds to chronic stress, and miR-17-92 rescues proliferation defects induced by corticosterone in hippocampal neural progenitors. Our study uncovers a crucial role for miR-17-92 in adult neural progenitors through regulation of neurogenesis and anxiety- and depression-like behaviors.	Depressive Disorder	Transcriptome
544	27483380	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Compared with controls, the baseline expression of the microRNA let-7b was less by ~40% in TRD patients compared with controls. The baseline expression of let-7c was also lower by ~50% in TRD patients who received ECT.	Major Depressive Disorder	Transcriptome
545	27502736	9606	Blood	DSM-IV	Case-control based		qRT-PCR	As shown in Fig. 2, we observed a marginally signifcant association between the rs1800797 and IL6 expression in the frontal cortex (P=0.087). Data showed that carriers with A allele have signifcantly higher levels of IL6 expression in frontal cortex that those without A allele.	Major Depressive Disorder	Transcriptome
546	27510991	9606	Blood	DSM-5	Case-control based	RNA-Seq//miRNA array	RNA-Seq//Array	Supplementary Table S4: List of significantly altered miRNAs in PTSD with p value <0.05 and linear fold change of at least 1.5 units.	Posttraumatic Stress Disorder	Transcriptome
547	27537871	9606	Blood		Case-control based	HumanOmniExpress Illumina BeadChip	Array	In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption.	Alcohol Use Disorder	Transcriptome
548	27571009	9606	Brain	ADI-R 	Case-control based	RNA-Seq	RNA-Seq	(c,d) Enrichment (Fisher芒鈧劉s exact test) for ASD-affected mRNAs and mRNA modules in the strongest (c) or the most conserved (d) targets of individual candidate miRNAs.	Autism Spectrum Disorder	Transcriptome
549	27576168	9606	Blood	Others	Case-control based	qRT-PCR	qRT-PCR	Our results provide preliminary evidence for the contribution to ADHD of a functional variant in the pri-miR-34b/c promoter, possibly through dysregulation of the expression of mature forms of miR-34b and miR-34c and some target genes- These data highlight the importance of abnormal miRNA function as a potential epigenetic mechanism contributing to ADHD-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
550	27576168	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Our results provide preliminary evidence for the contribution to ADHD of a functional variant in the pri-miR-34b/c promoter, possibly through dysregulation of the expression of mature forms of miR-34b and miR-34c and some target genes.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
551	27634569	7227	Brain		Case-control based	qRT-PCR	qRT-PCR	Blocking the expression of miR-iab8-3p during the development of the organism leads to hypertrophy of individual mushroom body neuron soma, a reduction in the field size occupied by axonal projections, and adult intellectual disability.	Intellectual Disability	Transcriptome
552	27650396	9606	Blood		Case-control based	qRT-PCR//Agilent Human lncRNA array	qRT-PCR//Array	Concurrent with the significant decrease of the PANSS scores of patients after the treatment, the PBMC levels of lncRNA NONHSAT089447 and NONHSAT041499 were strikingly decreased (P<0.05). Down-regulation of PBMC expression of NONHSAT041499 was significantly correlated to the improvement of positive and activity symptoms of patients (r=-0.444 and -0.423, respectively, P<0.05, accounting for 16.9% and 15.1%, respectively), and was also significantly associated with better outcomes (odds ratio 2.325 for positive symptom and 12.340 for activity symptom).	Schizophrenia	Transcriptome
553	27650867	9606	Blood		Case-control based	qPCR//Western blotting//Genotyping	qPCR//Western blotting//Genotyping	In summary, this study would improve our understanding of the role of miR-137 in schizophrenia-associated signaling pathways and identify the genetic basis of rs550067317 for schizophrenia. Furthermore, we provided new evidence for the involvement of miR-137 in the etiology and diagnosis of schizophrenia, which might contribute to the discovery of new biomarkers and therapeutic targets for the disease.	Schizophrenia	Transcriptome
554	27661005	9606	Brain		Case-control based	RNA-seq	RNA-seq	Our results showed that these DELincRNAs exhibited brain region-specific patterns. Applying weighted gene co-expression network analysis, we revealed that DELincRNAs together with other genes can function as modules to perform different functions in different brain regions, such as immune system development in BA24 and oligodendrocyte differentiation in BA9. Additionally, we found that DNA methylation alteration could partly explain the dysregulation of lincRNAs, some of which could function as enhancers in the pathogenesis of major psychosis.	Psychotic Disorder	Transcriptome
555	27671199	7955	Epaxial muscle		Case-control based			While the majority of miRNAs were decreased in fish skeletal muscle after ethanol treatment, the microRNA miR-146a was elevated in skeletal muscle approximately 2-fold after ethanol treatment (Fig. 3A)	Alcohol Use Disorder	Transcriptome
556	27681254	10090	Corpus cavernosa		Case-control based	qRT-PCR	qRT-PCR	Fig. 2 Real-time quantifcation results of the four differentially expressed miRNAs in the two groups. a The expression levels of the four miRNAs in DB group (analysed by qRT-PCR). For comparison, the CT value of sno RNA U6 (18.06脗卤0.204) was subtracted from the CT value of the other miRNAs (脦鈥滳T). The y-axis showed the 脦鈥滳T and represents relative miRNA expression levels. b Relative folds of the four miRNAs in two experimental groups. The experiments were repeated at least three times. *p<0.05 compared with NC group.	Narcolepsy	Transcriptome
557	27690106	9606	Cell lines(SK-N-SH)		Case-control based	qRT-PCR//RNA-seq	qRT-PCR//RNA-seq	The mechanisms by which MSNP1AS overexpression impacts neuronal differentiation may involve protein synthesis and chromatin structure.	Autism Spectrum Disorder	Transcriptome
558	27748930	9606	Blood		Case-control based	MiRNA microarray	Microarray	A substantial downregulation of let-7p-5p, miR-98-5p and of miR-183-5p was observed in those with a solid tumor or with a solid tumor and SZ, but not in those with SZ alone, providing an indication of their role in the occurrence of Ca. 	Schizophrenia	Transcriptome
559	27748930	9606	Blood		Case-control based	MiRNA microarray	Microarray	It was shown that in total of the 345 different miRNAs which were analyzed by the miRCURY LNA miRNA array system (Exiqon A/S, Vedbaek, Denmark), only miR-183 was upregulated significantly in the first group, indicating a possible protective function of this miRNA against Ca in SZ patients. These results suggested the possibility that the expression level of miR-183 may be directly related to the absence of a solid tumor in the presence of SZ. On the contrary, the absence of miR-183 expression in the group of patients with SZ and Ca may be an indication that this miRNA is a protective factor against Ca.	Schizophrenia	Transcriptome
560	27757134	9606	Blood	DSM-IV-TR	Case-control based	miScript miRNA PCR Array	Array	Of all analyzed miRs, 222 were detected in all plasma samples of MDD patients in our study. Of these, 40 miRs (Escitalopram-miRs, or E-miRs) were differentially expressed after treatment, as presented in Table 2. Twenty-three miRs were significantly overexpressed with fold changes ranging between 1.85 and 25.42, the majority (17) with a fold change greater than 2.5. The rest of 17 miRs were significantly downregulated after treatment with fold changes ranging from 0.28 to 0.68.	Major Depressive Disorder	Transcriptome
561	27773352	10090	Brain//Cell lines		Case-control based	Western Blotting//qRT-PCR	Western blotting//qRT-PCR	These data are the first demonstration of microRNA regulation of DCC and suggest that, by regulating DCC, miR-218 may be a switch of susceptibility versus resilience to stress-related disorders.	Depressive Disorder	Transcriptome
562	27864917	9606	Blood//Saliva		Case-control based	High-resolution melting	HRM	Three variants detected by HRM were selected to be genotyped. rs754333774 was detected in three cases of BD, two cases of schizophrenia, and no controls. This variant is located 260 base pairs upstream from miR-708 and may play a role in controlling the expression of the miR.	Bipolar Disorder	Transcriptome
563	27864917	9606	Blood//Saliva		Case-control based	qRT-PCR	qRT-PCR	Three variants detected by HRM were selected to be genotyped. rs754333774 was detected in three cases of BD, two cases of schizophrenia, and no controls. This variant is located 260 base pairs upstream from miR-708 and may play a role in controlling the expression of the miR.	Schizophrenia	Transcriptome
564	27872469	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	Serum expression of miRNA-155 was shown by multiple logistic regression analysis to be an independent predictive indicator for POCD after surgery (OR: 2.732; 95%CI 1.415-5.233; P=0.002).	Cognitive Disorders	Transcriptome
565	27877044	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Our study suggests that increased miR-132 expression levels were associated with visual memory deficits, which may underlie the pathophysiology of MDD. In individuals with depression, immediate visual memory defects were positively correlated with anxiety symptoms.	Depressive Disorder	Transcriptome
566	27919067	9606	Brain		Case-control based	RNA-Seq	RNA-Seq	Our analysis reveals ASD-associated dysregulation of primate-specific long noncoding RNAs (lncRNAs), downregulation of the alternative splicing of activity-dependent neuron-specific exons, and attenuation of normal differences in gene expression between the frontal and temporal lobes.	Autism Spectrum Disorder	Transcriptome
567	27940106	9606	Blood	DSM-IV	Case-control based	Sanger sequencing	Sanger sequencing	The results showed that rs12526133 present in LINC01108 was strongly associated with MDD (脧鈥	Major Depressive Disorder	Transcriptome
568	28000768	9606	Blood	DSM-IV	Case-control based		RT-PCR	Finally, 11 miRNAs were screened as putative autism biomarkers, where eight miRNAs (72.7%) were significantly dysregulated in ASD samples according to previous reports.//Table 1 Candidate miRNA biomarkers identified by our proposed model.	Autism Spectrum Disorder	Transcriptome
569	28030860	9606	Cell lines(SK-N-SH)		Case-control based	Illumina Hiseq 2000 platform	Array	These data indicate multiple transcriptional and translational functions of MSNP1AS that impact ASD-relevant biological processes.	Autism Spectrum Disorder	Transcriptome
570	28035180	9606	Brain//Blood		Case-control based	TaqMan microRNA assays//Affymetrix GeneChip Human Exon 1.0 ST Array//Luciferase assay//qRT-PCR	TaqMan//Array//qRT-PCR	In our preliminary experiments, the expression of miR-1908-5p was increased after chronic treatment with valproate but not lithium in control human neural progenitor cells. In contrast, it was decreased by valproate in neural progenitor cells derived from dermal fibroblasts of a BD subject.	Bipolar Disorder	Transcriptome
571	28039689	9606	Blood	DSM-IV	Case-control based	Human LncRNA 3.0 microarray//RT-PCR	Microarray//RT-PCR	These six lncRNAs (TCONS_00019174, ENST00000566208, NONHSAG045500, ENST00000517573, NONHSAT034045, and NONHSAT142707) may be used as stable biomarkers for MDD in those of Han Chinese ethnic origin, regardless of gender or age.	Major Depressive Disorder	Transcriptome
572	28073061	9606	Blood		Case-control based	qRT-PCR	qRT-PCR	(miRNA-26b, miRNA-1972, miRNA-4485, miRNA-4498, miRNA-4743) were upregulated. Camkurt et al. [56] found that miR-320a were significantly downregulated and miR-451a significantly upregulated in depressed patients.	Recurrent Depressive Disorder	Transcriptome
573	28092086	10090	Brain//Cell lines		Case-control based			As shown in Figs. 5b and S5, miR-206-3p was significantly upregulated in both the hippocampus.	Anxiety Disorder	Transcriptome
574	28092449	9606	Blood	DSM-IV	Case-control based		RT-PCR	Table 2. The differentially expressed long noncoding RNAs in schizophrenia, major depressive disorder and generalized anxiety disorder.	Generalized Anxiety Disorder	Transcriptome
575	28092449	9606	Blood	DSM-IV	Case-control based		RT-PCR	Table 2. The differentially expressed long noncoding RNAs in schizophrenia, major depressive disorder and generalized anxiety disorder.	Major Depressive Disorder	Transcriptome
576	28092449	9606	Blood	DSM-IV	Case-control based		qRT-PCR	Table 2. The differentially expressed long noncoding RNAs in schizophrenia, major depressive disorder and generalized anxiety disorder.	Major Depressive Disorder	Transcriptome
577	28190298	9606	Brain	DSM-5	Case-control based	qRT-PCR	qRT-PCR	Finally, we report altered expression of both miR-149 and miR-29c in EVs extracted from brains of Flinders Sensitive Line rats, a well-validated animal model exhibiting depressive-like behaviors and glial (astrocytic) dysfunction.	Bipolar Disorder	Transcriptome
578	28190298	10116	Brain		Case-control based	qRT-PCR	qRT-PCR	We next examined the expression of miR-29c and miR-149 in EVs extracted from whole brain lysates of FSL and control animals. Interestingly, both miR-29c (Fig. 4B) and miR-149 (Fig. 4C) showed significant down-regulation (higher Delta CT) in FSL brains compared to controls.	Bipolar Disorder	Transcriptome
579	28218896	9606	Cell lines(PC-3 cells)		Case-control based	ELISA//RT-PCR//Luciferase assay//Western blotting//ABI 3730xl sequencing platform	ELISA//RT-PCR//Reporter assay//Western blotting	The binding site of miR-146a was found to be located within the 3'-UTR of the NOS1 by searching an online miRNA database (www.mirdb.org), and luciferase reporter assay was done to confirm that NOS1 is a direct target gene of miR-146a. We also found that mRNA and protein expression level of NOS1 in PC-3 cells treated with miR-146a mimics and NOS1 siRNA was substantially down-regulated compared with scramble control, while cells treated with miR-146a inhibitors showed increased expression of NOS1.	Erectile Disorder	Transcriptome
580	28222310	9606	Blood		Case-control based			Table 2 Differentially expressed miRNA in PTSD compared to control subjects.	Posttraumatic Stress Disorder	Transcriptome
581	28224622	9606	Blood	Others	Case-control based	aCGH/RT-qPCR	aCGH/RT-qPCR	Our results provide preliminary evidence for the contribution to ADHD of a functional variant in the pri-miR-34b/c promoter, possibly through dysregulation of the expression of mature forms of miR-34b and miR-34c and some target genes. These data highlight the importance of abnormal miRNA function as a potential epigenetic mechanism contributing to ADHD.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
582	28224622	9606	Blood		Case-control based	aCGH//qRT-PCR	aCGH//qRT-PCR	Duplication carriers displayed elevated SLC2A3 mRNA expression in peripheral blood cells and altered event-related potentials reflecting deficits in working memory and cognitive response control, both endophenotypic traits of ADHD, and an underestimation of energy units of high-caloric food.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
583	28225916	10116	Blood//Cavernous tissue		Case-control based	qRT-PCR	qRT-PCR	Immunohistochemistry for eNOS and iNOS showed an increase in cavernosal smooth muscle cells in the alcoholic, diabetic and alcoholic-diabetic groups when compared with the control group. Similarly, the mRNA levels for eNOS were increased in cavernosal smooth muscle (CSM) in the alcoholic, diabetic and alcoholic-diabetic groups and miRNA-27b were decreased in CSM in the alcoholic, diabetic and alcoholic-diabetic groups.	Alcohol Use Disorder	Transcriptome
584	28384108	9606	Blood	DSM-5	Case-control based	qRT-PCR	qRT-PCR	Table 4. Comparison of the results of the current study and previous serum miRNA ASD research.	Autism Spectrum Disorder	Transcriptome
585	28384108	9606	Blood	DSM-5	Case-control based	qRT-PCR	qRT-PCR	Our results suggested that differentially expressed miRNAs in serum might be involved in ASD molecular pathways, and serum miR-424-5p, miR-197- 5p, miR-328-3p, miR-500a-5p, miR-619-5p, miR-3135a, miR-664a-3p, and miR- 365a-3p might be able to serve as potential biomarkers for ASD because they displayed significant alterations in the expression profile in children diagnosed with ASD.	Autism Spectrum Disorder	Transcriptome
586	28463242	10090	Blood		Case-control based	Illumina HiSeq2000//RT-PCR	Array//RT-PCR	Surprisingly, miR-133a was upregulated (t(8)=2.59, P=0.0320) and miR-19b was downregulated (t(8)=2.75, P=0.0250) in the validation study.	Anxiety Disorder	Transcriptome
587	28463242	10090	Blood		Case-control based	Illumina HiSeq2000//RT-PCR	Array//RT-PCR	We confirmed that miR-455 was significantly decreased (t(8)=3.16, P=0.0134) in sperm of runners.	Anxiety Disorder	Transcriptome
588	28463242	10090	Blood		Case-control based	Illumina HiSeq2000//RT-PCR	Array//RT-PCR	There was a 40% decrease in miR-190b, but this was not significant (t(8)=1.59, P=0.151).	Anxiety Disorder	Transcriptome
589	28488209	10090	Brain//Cell lines		Case-control based			We recently identified a downregulation of miR-135a in the mouse amygdala during early stress response	Anxiety Disorder	Transcriptome
590	28498394	10116	Brain		Case-control based	RT-PCR//Western blotting//Luciferase reporter assay	RT-PCR//Western blotting//Reporter assay	The overexpression of miR-34b in the paraventricular nucleus (PVN) by a miRNA agomir using a drug delivery system decreased the hyperactivity of the HPA axis and anxiety-like behavior.	Anxiety Disorder	Transcriptome
591	28514291	9606	Blood	OSAHS 	Case-control based	qRT-PCR//Western blotting	qRT-PCR//Western blotting	In comparison to the control, mimic-NC, and inhibitor-NC groups, the miR-130a mimic group had an increase of ET-1 and VEGF expressions, whereas the expressions of NO and SOD were reduced. However, the miR-130a inhibitor group exhibited an opposite trend. The apoptosis rate and tube formation number in the miR-130a mimic group were obviously increased, whereas the miR-130a inhibitor group showed an obvious decrease.	Obstructive Sleep Apnea Hypopnea	Transcriptome
592	28520763	9606	Blood	AASM	Case-control based		Microarray	Table 2 Differentially expressed genes associated with OSA and reversed with CPAP treatment in the microarray gene expression experiment.	Obstructive Sleep Apnea Hypopnea	Transcriptome
593	28520926	9606	Blood		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	MiR-16 was decreased in responders but unchanged after treatment (Figure 1D-E).	Major Depressive Disorder	Transcriptome
594	28520926	9606	Blood		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	MiR-135a showed a similar pattern of expression as miR-1202, with a decrease at baseline and increase in responders after treatment (Figure 2F).	Major Depressive Disorder	Transcriptome
595	28520926	9606	Blood		Case-control based	TaqMan miRNA assay//qRT-PCR	TaqMan//qRT-PCR	In both cohorts, responders displayed lower baseline miR-1202 levels compared with nonresponders, which increased following treatment.	Major Depressive Disorder	Transcriptome
596	28522826	9606	Blood	DSM-IV	Case-control based	Direct sequencing//TaqMan technology//RT-PCR	TaqMan//RT-PCR	Since 14-3-3脦露 is one of the isoforms most implicated in the regulation of melatonin synthesis23, 24, 36 and since 14-3-3脦露 was reported to be repressed by miR-45125-27, we measured this micro-RNA in plasma and pineals. Plasmatic and pineal miR-451 were significantly increased in patients with ASD compared to controls (Fig. 4d and e), thus suggesting a post-transcriptional epigenetic mechanism for 14-3-3 impairment.	Autism Spectrum Disorder	Transcriptome
597	28529365	9606	Blood	DSM-IV	Case-control based	Human LncRNA 3.0 microarray//RT-PCR	Microarray//RT-PCR	Using long noncoding RNA (lncRNA) microarray profiling and reverse transcription polymerase chain reaction, six downregulated lncRNAs and three upregulated lncRNAs had been identified to be the potential biomarkers for MDD and generalized anxiety disorder (GAD), respectively. Then, the lncRNAs were cross-checked in forty MDD patients, forty GAD patients, and forty normal controls.	Generalized Anxiety Disorder	Transcriptome
598	28529365	9606	Blood	DSM-IV	Case-control based	Human LncRNA 3.0 microarray//RT-PCR	Microarray//RT-PCR	Using long noncoding RNA (lncRNA) microarray profiling and reverse transcription polymerase chain reaction, six downregulated lncRNAs and three upregulated lncRNAs had been identified to be the potential biomarkers for MDD and generalized anxiety disorder (GAD), respectively. Then, the lncRNAs were cross-checked in forty MDD patients, forty GAD patients, and forty normal controls.	Major Depressive Disorder	Transcriptome
599	28562671	9606	Brain		Case-control based	RNA-Seq	RNA-Seq	Interestingly, we detected 263 lncRNAs differentially expressed between ASD and control cortical brain samples (FDR adjusted p-value<0.05; |Log2 fold change| 芒鈥奥	Autism Spectrum Disorder	Transcriptome
600	28562671	9606	Brain		Case-control based	RNA-Seq	RNA-Seq	Interestingly, the highest ranked lncRNA, HTR5A-AS1, is highly brain-specific and its most highly correlated gene in the network is AGBL4, a known ASD risk gene which is also down-regulated in the ASD cortex (Pearson correlation=0.98) (S2 Table).	Autism Spectrum Disorder	Transcriptome
601	28594894	9606	Blood		Case-control based	Affymetrix miRNA 3.0 GeneChips	Array	Our analyses revealed differential expression of 17 miRNAs in brain tissue from HAND patients. A subset of the upregulated miRNAs (miR-500a-5p, miR-34c-3p, miR-93-3p and miR-381-3p), are predicted to target peroxisome biogenesis factors (PEX2, PEX7, PEX11B and PEX13).	Neurocognitive Disorder Due to HIV	Transcriptome
602	28599252	10116	Blood//Penile tissues		Case-control based	Western Blotting//qRT-PCR//ELISA	Western Blotting//qRT-PCR//ELISA	The diabetic control group showed higher cGMP production level transcription and protein levels of eNOS and DKK3 and lower production levels of AGEs and miR-328 than the diabetic ED and diabetic ED+NC groups. Our results indicated that miR-328 antagomir could improve ED in STZ-induced diabetic rats by regulating cGMP and AGEs.	Erectile Disorder	Transcriptome
603	28617822	9606	Brain		Case-control based	RT-PCR//SNaPshot	RT-PCR//SNaPshot	For ESR1-203, levels were significantly lower in tissues homozygous for the main CC allele (p=0.02), and for ESR1-008, levels trended to be higher in bipolar compared schizophrenia subjects in CT & TT carriers (p=0.03) (Figure C in S1 File).	Bipolar Disorder	Transcriptome
604	28617822	9606	Brain		Case-control based	RT-PCR//SNaPshot	RT-PCR//SNaPshot	For ESR1-203, levels were significantly lower in tissues homozygous for the main CC allele (p=0.02), and for ESR1-008, levels trended to be higher in bipolar compared schizophrenia subjects in CT & TT carriers (p=0.03) (Figure C in S1 File).	Schizophrenia	Transcriptome
605	28635542	9606	Blood	DSM-5	Case-control based		qRT-PCR	Table 2. Gene mRNA levels of the cases; ratio (mean ratio of gene mRNA levels in patient groups in comparison with non-psychiatric subjects) and statistical results (group comparisons for mRNA levels of 44 genes of interest versus four housekeeping genes, due to 0.05/44=0.001042)	Paranoid Personality Disorder	Transcriptome
606	28635542	9606	Blood	DSM-5	Case-control based		qRT-PCR	Table 2. Gene mRNA levels of the cases; ratio (mean ratio of gene mRNA levels in patient groups in comparison with non-psychiatric subjects) and statistical results (group comparisons for mRNA levels of 44 genes of interest versus four housekeeping genes, due to 0.05/44=0.001042)	Schizophrenia	Transcriptome
607	28638716	9606	Blood	DSM-IV	Case-control based	Human LncRNA 3.0 microarray//RT-PCR	Microarray//RT-PCR	This study indicated that the expression of six down-regulated lncRNAs had a negative association with suicide risk in MDD patients, and the expression of lncRNAs in PBMCs could have the potential to help clinician judge the suicide risk of MDD patients to provide timely treatment and prevent suicide.	Major Depressive Disorder	Transcriptome
608	28645778	9606	Blood	DSM-IV	Family based	Illumina HiSeq platform	WGS//PCR	Table 2 The de novo mutations in the probands and differential expression of the hit genes.	Schizophrenia	Transcriptome
609	28647289	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Our study has shown a lower expression level of miR-499 (p=0.008), miR-708 (p=0.02) and miR-1908 (p=0.004) in depression episodes of the bipolar disorder patients in comparison to remission state.	Bipolar Disorder	Transcriptome
610	28647289	9606	Blood	DSM-IV	Case-control based	qRT-PCR	qRT-PCR	Obtained results indicate that miRNAs: miR-499, miR-708 and miR-1908 are the most promising candidates for biomarkers of depression episodes of bipolar disorder.	Bipolar Disorder	Transcriptome
611	28710909	9606	Brain	DSM-IV	Case-control based	Illumina GoldenGate Genotyping Assay	Array	Table 3 The top scoring results for interacting miRNAs with rs3749034.	Bipolar Disorder	Transcriptome
612	28755962	9606	Blood//Cavernous tissue		Case-control based	qRT-PCR	qRT-PCR	In ROC curve, miRNA 200a showed cutoff value of 1.135 with 95% sensitivity and 100% specificity while miRNA 206 showed cutoff value of 1.125 with 100% sensitivity and 100% specificity (Figure 1).	Erectile Disorder	Transcriptome
613	28778129	9606	Blood	DSM-IV-TR	Case-control based	Genotyping	Genotyping	We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder.	Bipolar Disorder	Transcriptome
614	28794131	9606	Blood//Skin fibroblasts		Case report		Sanger sequencing//qRT-PCR	In two subjects, cerebrospinal fluid and primary skin fibroblasts were analysed showing similarly low 5-hydroxyindolacetic acid and homovanillic acid concentrations but more reduced expressions of mRNA and DNAJC12 compared with previously described patients.	Intellectual Disability	Transcriptome
615	28802862	10090	Blood		Case-control based		qRT-PCR	Levels of mRNA of miR-21 targets SOX5 and TGF脦虏R2 were reduced in the overall population of psychiatrically-diagnosed subjects (F(1,31)=6.02, p=0.02; F(1,31)=7.221,p=0.012, respectively) as compared to controls (Fig. 10 A-D).	Alcohol Use Disorder	Transcriptome
616	28802862	10090	Blood		Case-control based	qRT-PCR	qRT-PCR	Pairwise contrasts revealed that miR-21 was significantly lower in each of the psychiatric groups as compared to controls (ALC vs control: d=0.723, p<0.001; MDD vs control: d=-0.816, p<0.001; MDA vs. control: d=-0.807, p<001).	Alcohol Use Disorder	Transcriptome
617	28802862	10090	Blood		Case-control based		qRT-PCR	We also determined STAT3 mRNA levels in WM because STAT3 is a well-known upstream regulator of miR-21 (Ou, Li, & Kang, 2014). STAT3 was considerably decreased in psychiatric patients when all diseased subjects were combined as compared to non-psychiatric subjects (F(1,31)=7.02, p=0.013) (Fig. 10E, F).	Alcohol Use Disorder	Transcriptome
618	28802862	10090	Blood		Case-control based		qRT-PCR	Levels of mRNA of miR-21 targets SOX5 and TGF脦虏R2 were reduced in the overall population of psychiatrically-diagnosed subjects (F(1,31)=6.02, p=0.02; F(1,31)=7.221,p=0.012, respectively) as compared to controls (Fig. 10 A-D).	Major Depressive Disorder	Transcriptome
619	28802862	10090	Blood		Case-control based	qRT-PCR	qRT-PCR	Pairwise contrasts revealed that miR-21 was significantly lower in each of the psychiatric groups as compared to controls (ALC vs control: d=0.723, p<0.001; MDD vs control: d=-0.816, p<0.001; MDA vs. control: d=-0.807, p<001).	Major Depressive Disorder	Transcriptome
620	28802862	10090	Blood		Case-control based		qRT-PCR	We also determined STAT3 mRNA levels in WM because STAT3 is a well-known upstream regulator of miR-21 (Ou, Li, & Kang, 2014). STAT3 was considerably decreased in psychiatric patients when all diseased subjects were combined as compared to non-psychiatric subjects (F(1,31)=7.02, p=0.013) (Fig. 10E, F).	Major Depressive Disorder	Transcriptome
621	28826069	10116	Brain		Case-control based	RT-PCR	RT-PCR	We found that CUMS and dexamethasone administration in the adolescent period induced permanent depressive-like behaviours and memory impairment, decreased GR expression, and increased FKBP5 and miR-124a expression in the BLA of both adolescent and adult rats.	Major Depressive Disorder	Transcriptome
622	28848387	9606	Blood	DSM-IV-TR	Case-control based	TaqMan Low Density Array	TaqMan	Figure 1 MiR-140-3p is significantly dysregulated in serum of ASD patients.	Autism Spectrum Disorder	Transcriptome
623	28850112	9606	Blood	DSM-5	Case-control based	qRT-PCR//RNA-seq	qRT-PCR//RNA-seq	Figure 1(b) The volcano plot shows all the miRNAs with at least (脗卤1.5) linear fold-difference. The green dots represents miRNAs significantly dysregulated in PTSD patients. (On y axis, 1.301 units is ~0.05). A total of 190 miRNAs were found to be significantly (P-value<0.05) up- (7 miRNAs) or downregulated (183 miRNAs) by a linear fold-change value of(脗卤1.5)or more.	Posttraumatic Stress Disorder	Transcriptome
624	28850112	9606	Blood	DSM-5	Case-control based	qRT-PCR//RNA-seq	qRT-PCR//RNA-seq	Table 2 Differentially expressed lncRNAs in PTSD detected after RNA-Seq analysis	Posttraumatic Stress Disorder	Transcriptome
625	28881034	10090	Blood		Case-control based	Assay//Western blotting//qRT-PCR	Western blotting//qRT-PCR	Our results revealed that PPAR脦鲁 expression was downregulated by miR-27a-3p following sevoflurane treatment in hippocampal neurons. Downregulation of miR-27a-3p expression decreased sevoflurane-induced hippocampal neuron apoptosis by decreasing inflammation and oxidative stress-related protein expression through the upregulation of PPAR脦鲁.	Cognitive impairments resulting from sevoflurane treatment	Transcriptome
626	28925389	9606	Blood	DSM/PCL	Case-control based	Meta-analysis	Meta-analysis	We performed a combined analysis of five independent PTSD blood transcriptome studies covering seven types of trauma in 229 PTSD and 311 comparison individuals to synthesize the extant data.	Posttraumatic Stress Disorder	Transcriptome
627	28925389	9606	Blood	DSM/PCL	Case-control based	Meta-analysis	Meta-analysis	We performed a combined analysis of five independent PTSD blood transcriptome studies covering seven types of trauma in 229 PTSD and 311 comparison individuals to synthesize the extant data-	Posttraumatic Stress Disorder	Transcriptome
628	28942956	9606	Cell lines(Monocyte)//Blood		Case-control based		qRT-PCR	Additionally, there was no significant difference in IFN-脦鲁 mRNA expression (p=.35) in participants with schizophrenia (M=37.79, SD=35.34) compared to controls (M=51.13, SD=42.44).	Schizophrenia	Transcriptome
629	28942956	9606	Cell lines(Monocyte)//Blood		Case-control based		qRT-PCR	IL-6 (p=.05) and TNF-脦卤 (p=.004) mRNA expression levels as earlier reported are significantly elevated in participants with schizophrenia.	Schizophrenia	Transcriptome
630	28942956	9606	Cell lines(Monocyte)//Blood		Case-control based		qRT-PCR	We measured the expression of TMEVPG1, NRON, HERV-W env and HERV-W gag in blood cells from participants with schizophrenia and controls. We report that a) expression levels of these non-coding RNAs are correlated with proinflammatory cytokine mRNA expression in all participants.	Schizophrenia	Transcriptome
631	28970082	10116	Penis tissue		Case-control based	Microarray//Western Blotting//Immunofluorescence histochemistry	Microarray//Western Blotting//Immunofluorescence histochemistry	Table 1 Significantly upregulated miRNAs	Erectile Disorder	Transcriptome
632	28970082	10116	Penis tissue		Case-control based	Microarray//Western Blotting//Immunofluorescence histochemistry	Microarray//Western Blotting//Immunofluorescence histochemistry	Table 2 Significantly downregulated miRNAs	Erectile Disorder	Transcriptome
633	28975998	9606	Blood	DSM-IV	Case-control based	SOLiD//HTSeq//qRT-PCR	SOLiD//HTSeq//qRT-PCR	In patients with psychotic depression, there was a statistically significant decrease in miR-942 (t=6.41, P=0.023), miR-106a-5p (t=4.76, P=0.041) and miR-126-5p(t=12.07, P=0.007), n=3.	Depressive Disorder	Transcriptome
634	28975998	9606	Blood	DSM-IV	Case-control based	SOLiD//HTSeq//qRT-PCR	SOLiD//HTSeq//qRT-PCR	Baseline VEGFA levels were significantly higher in patients with psychotic (n=21) and non-psychotic (n=76) depression compared to healthy controls (n=53) (see Fig. 3a).	Depressive Disorder	Transcriptome
635	29036835	10090	Brain		Case-control based		qRT-PCR	We found that elevated lncRNA TCONS_00019174 expression level could alleviate depression-like behaviors in CUMS mice.	Major Depressive Disorder	Transcriptome
636	29112193	9606	Brain	Others	Case-control based	Microarray Profiling	Microarray Profiling	Top differentially-expressed genes in PV cells with > 40% increase in expression in schizophrenia subjects relative to unaffected comparison subjects.Top differentially-expressed genes in PV cells with > 40% decrease  in expression in schizophrenia subjects relative to unaffected comparison subjects.	Schizophrenia	Transcriptome
637	29115444	9606	Blood		Case-control based		qRT-PCR	The present study identified miR-124-3p as one of the most dysregulated miRNAs in MDD, with decreased expression in the post-mortem BA44 brain area of male patients with MDD.	Major Depressive Disorder	Transcriptome
638	29127368	9606	Blood	DSM-IV	Case-control based	RT-qPCR//Meta-analysis	RT-qPCR//Meta-analysis	Validation revealed that miR-181b-5p, miR-21-5p, miR-195-5p, miR-137, miR-346 and miR-34a-5p in PBMNCs had high diagnostic sensitivity and specificity in the context of schizophrenia. In conclusion, blood-derived miRNAs might be promising biomarkers for SZ diagnosis.	Schizophrenia	Transcriptome
639	29146111	9606	Brain(Anterior cingulate//Motor cortex)	Others	Case-control based	Microarray/RT-qPCR	Microarray/RT-qPCR	A subset of miRNAs (some previously associated with α-synucleinopathy and/or directly targeting α-synuclein mRNA) were differentially expressed in AC and MO	Neurocognitive Disorder With Lewy Bodies	Transcriptome
640	29175309	9606	Dentate gyrus	DSM-IV	Case-control based	Illumina NextSeq 500	RNA-seq	Analysis revealed 30 genes differentially expressed in MDD compared to controls (FDR<0.05). Down-regulated genes included several with inflammatory function (ISG15, IFI44L, IFI6, NR4A1/Nur-77) and GABBR1 while up-regulated genes included several with cytokine function (CCL2/MCP-1), inhibitors of angiogenesis (ADM, ADAMTS9), and the KANSL1 gene, a histone acetyltransferase.(Table 1: Differentially expressed genes in Control vs. MDD (N=23 subjects per cohort).)	Major Depressive Disorder	Transcriptome
641	29178897	9606	Blood	ADOS//ADI-R	Case-control based	RNA-Seq	RNA-Seq	Table 2 Differences of microRNA (miRNA) expression in ASD subjects with high, normal, and low IL-1脦虏/IL-10 ratio	Autism Spectrum Disorder	Transcriptome
642	29187813	9606	Blood	AUDIT//WAIS-IV	Case-control based	qRT-PCR	qRT-PCR	Figure 1 Differentially regulated miRNAs and miRNA pairs in persons living with HIV-1/AIDS (PLWHA) with alcohol use disorder (AUD) at LSU Health Sciences Center (LSUHSC).	Alcohol Use Disorder With HIV/AIDS	Transcriptome
643	29249826	9606	Blood	DSM-IV	Case-control based		RNA-seq	These genes were NDUFA1, CCDC85B, SNORD54, FKBP5, and SNORD46 (boxplots Fig. 2a-e), of which all except FKBP5 were down-regulated in current PTSD.	Posttraumatic Stress Disorder	Transcriptome
644	29348839	10116	Brain		Case-control based	Second-generation lncRNA microarray	Microarray	We used a second-generation lncRNA microarray to detect 394 up-regulated and 554 down-regulated lncRNAs in three PTSD-like syndrome groups compared to the control group (fold-change > 2.0). Different profiles of lncRNA and coding transcript expression were observed in PTSD-like syndrome rats at four time points and confirmed by RT-PCR, thus suggesting that numerous lncRNAs were involved in the development of PTSD-like syndrome conditions in rats.	Posttraumatic Stress Disorder	Transcriptome
645	29391398	9606	Brain		Case-control based		qRT-PCR	one lncRNA that was overexpressed in SCZ, AC005009.2, also maps to a region previously associated with SCZ based on GWAS and overlapped SCZ-related genes.	Schizophrenia	Transcriptome
646	30050107	9606	Brain	Others	Case-control based	Illumina HiSeq2000//Illumina HumanHap//Illumina Human 1M-Duo//Illumina Omni5	Illumina HiSeq2000//Illumina HumanHap//Illumina Human 1M-Duo//Illumina Omni5	GWAS-significant index variants and eQTL associations, for those GWAS loci associating with only one or two genes following conditional analysis.	Schizophrenia	Transcriptome
647	30050107	9606	Brain	Others	Case-control based	GWAS	GWAS	GWAS-significant index variants and eQTL associations, for those GWAS loci associating with only one or two genes following conditional analysis.	Schizophrenia	Transcriptome
648	30076325	9606	Blood	DSM-IV/HAM-D	Case-control based	microarray	microarray	To discover genes and mechanisms related to the pathophysiology of MDD and antidepressant treatment response, we performed gene expression analyses using peripheral blood specimens from 38 MDD patients and 14 healthy individuals at baseline and at 6 weeks after the initiation of either selective serotonin reuptake inhibitor (SSRI) or mirtazapine treatment. The results were compared with results from public microarray data. Seven differentially expressed genes (DEGs) between MDD patients and controls were identified in our study and in the public microarray data: CD58, CXCL8, EGF, TARP, TNFSF4, ZNF583, and ZNF587.	Major Depressive Disorder	Transcriptome
649	30177255	9606	Brain	Others	Case-control based	RNA-seq/Meta-analysis	RNA-seq/Meta-analysis	In both bipolar disorder and schizophrenia, we consistently observed an increase in the expression profiles of cortical astrocytes and a decrease in the expression profiles of fast-spiking parvalbumin interneurons. No changes in astrocyte expression profiles were observed in subcortical regions. Furthermore, we found that many of the genes previously identified as differentially expressed in schizophrenia are highly correlated with the expression profiles of astrocytes or fast-spiking parvalbumin interneurons.	Schizophrenia	Transcriptome
650	30177255	9606	Brain	Others	Case-control based	RNA-seq/Meta-analysis	RNA-seq/Meta-analysis	In both bipolar disorder and schizophrenia, we consistently observed an increase in the expression profiles of cortical astrocytes and a decrease in the expression profiles of fast-spiking parvalbumin interneurons- No changes in astrocyte expression profiles were observed in subcortical regions- Furthermore, we found that many of the genes previously identified as differentially expressed in schizophrenia are highly correlated with the expression profiles of astrocytes or fast-spiking parvalbumin interneurons-	Schizophrenia	Transcriptome
651	30220511	10090	Brain	Others	Case-control based	qRT-PCR	qRT-PCR	We found thatMen1protein and mRNA levels are significantly attenuated in cortex from both CUMS- and LPS-treated mice bywestern blottingand RT-PCR (Figures 1C and 1D).	Major Depressive Disorder	Transcriptome
652	30270454	10116	Brain(Hippocampus)	Others	Case-control based	Illumina HiSeq/RT-PCR	Illumina HiSeq/RT-PCR	Meanwhile, quantitative real-time PCR was used to validate the HiSeq results, revealing that three miRNAs (miR-1-b, miR-741-3p, and miR-206-3p) were upregulated and four (miR-182, miR-471-5p, miR-183-5p, and miR-211-5p) were downregulated in the SHR group compared with the WKY group. In addition, we confirmed that Dyrk1a is regulated by miR-211-5p.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
653	30420267	9606	Blood	Others	Case-control based	Ion Torrent	Ion Torrent	We sequenced 187 genes, selected for prior evidence of association with schizophrenia, in a new dataset of 5207 cases and 4991 controls.	Schizophrenia	Transcriptome
654	30478419	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	We calculated the enrichment of PGC2 loci protein-coding genes.We selected only 309 protein-coding genes because 40 had especially low abundance in our data set (RPKM<0.1) and therefore were not analyzed.Overall, we found that almost half of the GWAS significant PGC2 loci protein-coding genes (148/309) were distributed in modules across the co-expression networks.	Schizophrenia	Transcriptome
655	30518751	9606	NA	Others	Case-control based	Illumina HiSeq2500	Illumina HiSeq2500	This study aims at assessing the burden of rare (minor allele frequency < 1%) predicted damaging variants in the whole exome of 92 bipolar I disorder (BD) patients and 1051 controls of French ancestry.	Bipolar Disorder	Transcriptome
656	30545856	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	In this work, we integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder, as well as controls. More than 25% of the transcriptome exhibits differential splicing or expression, with isoform-level changes capturing the largest disease effects and genetic enrichments.	Schizophrenia	Transcriptome
657	30545856	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	Based on Gencode annotations, we identify 944 ncRNAs exhibiting gene- or isoform-level DE in at least one disorder (herein referred to as ＆neuropsychiatric (NP) ncRNAs＊), 693 of which were DE in SCZ, 178 in ASD, and 174 in BD, of which 208, 60, and 52 are annotated as intergenic long non-coding RNAs (LncRNAs), in each disorder, respectively.	Schizophrenia	Transcriptome
658	30545856	9606	Brain	Others	Case-control based	RNA-Seq	RNA-Seq	Here, we investigated long non-coding RNAs (lncRNAs) within ten SCZ risk-associated CNV deletion regions (CNV-lncRNAs) and examined their potential contribution to SCZ risk. We used RNA-Seq transcriptomics data derived from postmortem brain tissue from control individuals without psychiatric disease as part of the PsychENCODE BrainGVEX and Developmental Capstone projects. We carried out weighted gene coexpression network analysis (WGCNA) to identify protein-coding genes coexpressed with CNV-lncRNAs in the human brain. We identified one neuronal function-related coexpression module shared by both data sets. This module contained a lncRNA within the 22q11.2 CNV region called DGCR5, which was identified as a hub gene.	Schizophrenia	Transcriptome
659	30545856	9606	Brain	Others	Case-control based	qPCR/RNA-seq	qPCR/RNA-seq	Here, we investigated long non-coding RNAs (lncRNAs) within ten SCZ risk-associated CNV deletion regions (CNV-lncRNAs) and examined their potential contribution to SCZ risk. We used RNA-Seq transcriptomics data derived from postmortem brain tissue from control individuals without psychiatric disease as part of the PsychENCODE BrainGVEX and Developmental Capstone projects. We carried out weighted gene coexpression network analysis (WGCNA) to identify protein-coding genes coexpressed with CNV-lncRNAs in the human brain. We identified one neuronal function-related coexpression module shared by both data sets. This module contained a lncRNA within the 22q11.2 CNV region called DGCR5, which was identified as a hub gene.	Schizophrenia	Transcriptome
660	30557705	9606	Blood	DSM-IV/The Conners＊ Parent Symptom QuestionOthersire (PSQ) and Conners＊Teacher Rating Scale/SCID(TRS)	Case-control based	miRNA PCR Array/ABI 7900HT Real-Time PCR System	miRNA PCR Array/ABI 7900HT Real-Time PCR System	Further analysis confirmed four miRNAs (hsa-miR-101-3p, hsa-miR-130a-3p, hsa-miR-138-5p and hsa-miR-195-5p) upregulated and one miRNA (hsa-miR-106b-5p) downregulated- These miRNAs showed significant predictive values for discriminating ADHD individuals-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
661	30557705	9606	Blood	DSM-IV/The Conners＊ Parent Symptom QuestionOthersire (PSQ) and Conners＊ Teacher Rating Scale/SCID(TRS)	Case-control based	miRNA PCR Array/ABI 7900HT Real-Time PCR System	miRNA PCR Array/ABI 7900HT Real-Time PCR System	Further analysis confirmed four miRNAs (hsa-miR-101-3p, hsa-miR-130a-3p, hsa-miR-138-5p and hsa-miR-195-5p) upregulated and one miRNA (hsa-miR-106b-5p) downregulated- These miRNAs showed significant predictive values for discriminating ADHD individuals-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
662	30599263	9606	Blood	DSM-V	Case-control based	PCR	PCR	Given that lncRNAs may be diagnostic biomarkers for BD, we aimed to quantify the levels of DISC1 and DISC2 lncRNA transcripts. In addition, we performed ROC curve analysis as well as correlation analysis between the gene expression and some clinical features of BD cases.	Bipolar I Disorder	Transcriptome
663	30635639	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	We prioritized ten features that were most strongly associated with clinical risk SNPs across all five datasets, including two exon?exon splice junctions (junc8.8a, junc8c.9) that tagged transcript classes not found in the ENSEMBL v75 transcript database.In summary, we have identified SNX19 as the primary risk gene for schizophrenia in region 11q25.	Schizophrenia	Transcriptome
664	30658207	9606	Blood	DSM-ｍ	Case-control based	PCR	PCR	Both the miR-142-3p and miR-378 values of the children with ADHD that have immediate relatives with a psychiatric disorder were lower, compared to control group-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
665	30664621	9606	Blood(CD4T)	DSM-IV	Case-control based	RNA-seq	RNA-seq	Furthermore, given notable differences between cell subpopulations in gene expression associated with PTSD, the results also indicate that it may be valuable to analyze different cell populations separately.	Posttraumatic Stress Disorder	Transcriptome
666	30664621	9606	Blood(CD8T)	DSM-IV	Case-control based	RNA-seq	RNA-seq	Furthermore, given notable differences between cell subpopulations in gene expression associated with PTSD, the results also indicate that it may be valuable to analyze different cell populations separately.	Posttraumatic Stress Disorder	Transcriptome
667	30664621	9606	Blood(Monocytes)	DSM-IV	Case-control based	RNA-seq	RNA-seq	Furthermore, given notable differences between cell subpopulations in gene expression associated with PTSD, the results also indicate that it may be valuable to analyze different cell populations separately.	Posttraumatic Stress Disorder	Transcriptome
668	30664621	9606	Blood(B-cells)	DSM-IV	Case-control based	RNA-seq	RNA-seq	Furthermore, given notable differences between cell subpopulations in gene expression associated with PTSD, the results also indicate that it may be valuable to analyze different cell populations separately.	Posttraumatic Stress Disorder	Transcriptome
669	30664621	9606	Blood	DSM-IV	Case-control based	RNA-seq	RNA-seq	Furthermore, given notable differences between cell subpopulations in gene expression associated with PTSD, the results also indicate that it may be valuable to analyze different cell populations separately.	Posttraumatic Stress Disorder	Transcriptome
670	30771789	9606	Blood//Brain	Others	Case-control based	RNA-seq	RNA-seq	We further examined the expression level of FLOT1 in MDD cases and controls and found that FLOT1 was significantly upregulated in brains and peripheral blood of MDD cases compared with controls (European sample).	Major Depressive Disorder	Transcriptome
671	30772744	9606	Blood	DSM-V	Case-control based	RT-PCR	RT-PCR	In the current study, we evaluated expression levels of six apoptosis-related lncRNAs (CCAT2, TUG1, PANDA, NEAT1, FAS-AS1 and OIP5-AS1) in the peripheral blood of bipolar disorder (BD) patients and healthy subjects to assess their contribution in the pathogenesis of BD.	Bipolar I Disorder	Transcriptome
672	30911161	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci.	Schizophrenia	Transcriptome
673	30926572	9606	Saliva	DSM-ｍ/ICD-10/ADOS-II	Case-control based	Illumina NextSeq500	Illumina NextSeq500	Fourteen microRNAs displayed differential expression (false discovery rate < 0-05) among ASD, TD, and DD groups-	Autism Spectrum Disorder	Transcriptome
674	31010680	9606	Cell lines(Stem cells from human exfoliated deciduous teeth)	Others	Case-control based	RT-qPCR	RT-qPCR	In the absence of exogenous BDNF in the cell culture media, DNs derived from boys with ADHD (ADHD-DNs) exhibited impaired neurite outgrowth and branching, decreased mitochondrial mass in neurites, and abnormal intracellular ATP levels. In addition, BDNF mRNA was significantly decreased in ADHD-DNs. Supplementation with BDNF, however, significantly improved neurite development and mitochondrial function in ADHD-DNs.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
675	31039430	9606	Blood	PCL-M	Case-control based	Affymetrix HG-U133 Plus 2.0 MicroArray	Affymetrix HG-U133 Plus 2.0 MicroArray	Expression analysis revealed 98 probesets, representing 89 distinct genes, and 4 uncharacterized genes, differentially expressed between participants with PTSD and controls (Supplementary Table 2).	Posttraumatic Stress Disorder	Transcriptome
676	31081034	9606	NA	Others	Case-control based	DNA Binding Assay//Crystallography	DNA Binding Assay//Crystallography	Human transcription factor 4 (TCF4) is essential for brain development, memory and cognition, and has been associated with schizophrenia, autism-spectrum intellectual disability, and Pitt-Hopkins syndrome.Our analyses indicate, and suggest a structural basis for, the preferential recognition of 5caC by a transcription factor centrally important in brain development.	Autism Spectrum Disorder	Transcriptome
677	31097668	9606	Brain(Prefrontal cortex//Anterior cingulate cortex)	Others	Case-control based	RNA-seq	RNA-seq	Data S4. List of cell type-specific genes differentially expressed in ASD and epilepsy, as well as region-specific and individual-specific gene expression changes in ASD.	Autism Spectrum Disorder	Transcriptome
678	31125858	9606	Blood	DSM-IV-TR	Case-control based	exoRNeasy/SureScan	exoRNeasy/SureScan	We assessed peripheral blood EVs＊ microRNAs from 20 patients with BD type I and 21 age- and sex-matched healthy controls by microarray, and further explored the predicted biological functions of significantly differentially expressed microRNAs- Our results identified 33 nominally significant microRNAs (p < 0-05 and fold-change >1-5) altered in BD patients, including miRNAs previously reported to be altered in post-mortem tissues of patients-	Bipolar Disorder	Transcriptome
679	31127088	9606	Brain(Cerebral cortex//Anterior prefrontal cortex//Frontal cortex//Anterior cingulate cortex)	Others	Case-control based	RNA-seq	RNA-seq	We identify eight gene sets with dysregulated expression shared by AUT, SCZ and BPD, 23 by AUT and SCZ, four by AUT and BPD, and two by SCZ and BPD.	Autism Spectrum Disorder	Transcriptome
680	31127088	9606	Brain(Cerebral cortex//Anterior prefrontal cortex//Frontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	We identify eight gene sets with dysregulated expression shared by AUT, SCZ and BPD, 23 by AUT and SCZ, four by AUT and BPD, and two by SCZ and BPD.	Autism Spectrum Disorder	Transcriptome
681	31127088	9606	Brain(Cerebral cortex//Anterior prefrontal cortex//Frontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	We identify eight gene sets with dysregulated expression shared by AUT, SCZ and BPD, 23 by AUT and SCZ, four by AUT and BPD, and two by SCZ and BPD.	Schizophrenia	Transcriptome
682	31127088	9606	Brain(Cerebral cortex//Anterior prefrontal cortex//Frontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	We identify eight gene sets with dysregulated expression shared by AUT, SCZ and BPD, 23 by AUT and SCZ, four by AUT and BPD, and two by SCZ and BPD.	Bipolar Disorder	Transcriptome
683	31129473	9606	NA	Others	Case-control based	NA	NA	Recently, microdeletions or coding-region missense or nonsense mutations in the MEF2C gene associate with a newly described neurodevelopmental disorder, MEF2C Haploinsufficiency Syndrome (MCHS), which is characterized by varying degrees of intellectual disability (ID), absence of speech, autism symptoms, variable seizures and various motor abnormalities including hyperactivity.	Neurodevelopmental Disorders	Transcriptome
684	31138894	9606	NA	Others	Case-control based	NA	NA	Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders	Neurodevelopmental Disorders	Transcriptome
685	31142820	10090	Brain(Basolateral amygdala complex)	Others	Case-control based	smRNA-seq/FISH	smRNA-seq/FISH	We compared the two datasets and identified 42 miRNAs that were differentially expressed between SS and SR groups in both datasets	Posttraumatic Stress Disorder	Transcriptome
686	31142820	9606	Blood(Serum)//Brain(Amygdala)	Others	Case-control based	qPCR	qPCR	mir-135b is conserved in humans and elevated in serum of military personnel with PTSD	Posttraumatic Stress Disorder	Transcriptome
687	31146084	9606	Blood	DSM-ｍ/T-DSM-IV-S	Case-control based	RT-PCR	RT-PCR	Compared to controls, levels of miR-5692b (p = 0-006) were found higher and levels of miR-let-7d (p = 0-017) were found lower in the ADHD group- There was no significant difference in terms of miR-124-3p, miR-4447, and miR-107 levels between the groups-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
688	31150948	9606	NA	Others	Case-control based	GWAS//ES//Western Blotting	GWAS//ES//Western Blotting	To gain insights into the genetic and physiological foundation of BPD, we conduct the physical PPI analysis of 184 BPD risk genes distilled from genome-wide association studies and exome sequencing studies. We have identified several hub genes (CAMK2A, HSP90AA1 and PLCG1) among those risk genes, and observed significant enrichment of the BPD risk genes in certain pathways such as calcium signaling, oxytocin signaling and circadian entrainment.	Bipolar Disorder	Transcriptome
689	31168067	9606	Brain	DSM-IV	Case-control based	qPCR	qPCR	Relative to unaffected comparison subjects, OCD subjects had significantly lower levels of several transcripts related to excitatory signaling in both cortical and striatal regions.	Obsessive Compulsive Disorder	Transcriptome
690	31168067	9606	Brain(Orbitofrontal cortex)	DSM-IV	Case-control based	qPCR	qPCR	Relative to unaffected comparison subjects, OCD subjects had significantly lower levels of several transcripts related to excitatory signaling in both cortical and striatal regions.	Obsessive Compulsive Disorder	Transcriptome
691	31184401	9606	Blood//Cell lines(HEK293//HeLa)	Others	Case-control based	Sanger Sequencing//WES//qRT-PCR//Western Blotting//Immunoflurorescence	Sanger Sequencing//WES//qRT-PCR//Western Blotting//Immunoflurorescence	Our report of two missense variants affecting the normal localization of NLGN3 in a total of five affected individuals reinforces the involvement of the NLGN3 gene in a neurodevelopmental disorder characterized by ID and ASD.	Autism Spectrum Disorder	Transcriptome
692	31230729	9606	Brain(Cerebral cortex//Anterior prefrontal cortex//Frontal cortex)	Others	Case-control based	GWAS/TWAS	GWAS/TWAS	This study identified 14 genes as significantly differentially expressed in ASD, 13 of which were outside of known genome-wide significant loci (㊣500 kb).	Autism Spectrum Disorder	Transcriptome
693	31230729	9606	Brain//Blood//Adipose	Others	Case-control based	GWAS//TWAS//Meta-analysis	GWAS//TWAS//Meta-analysis	We compared the frequency of de novo variants in patient-parent trios with (n = 2,030) versus without (n = 2,755) NDDs. We identified de novo variants in TAOK1 (thousand and one [TAO] amino acid kinase 1), which encodes the serine/threonine-protein kinase TAO1, in three individuals with NDDs but not in persons who did not have NDDs. Through further screening and the use of GeneMatcher, five additional individuals with NDDs were found to have de novo variants. All eight variants were absent from gnomAD (Genome Aggregation Database).	Autism Spectrum Disorder	Transcriptome
694	31303374	9606	Brain	Others	Case-control based	Illumina HumanOmni2.5//Illumina HiSeq2500	Illumina HumanOmni2.5//Illumina HiSeq2500	We first examined enrichment of high confidence autism spectrum disorder (ASD) risk genes, defined by harboring high risk likely protein-disrupting mutations. The majority of ASD-risk genes were expressed in developing glutamatergic neurons, both deep and upper layer, consistent with previous studies.	Autism Spectrum Disorder	Transcriptome
695	31319085	9606	NA	Others	Case-control based	NA	NA	Increasing evidence from genome-wide association studies (GWAS) and transcriptome analyses have revealed the association of lncRNAs with a variety of NPDs such as ASD, schizophrenia, intellectual disability, Rett syndrome, depression and anxiety disorder and other mental disorders. Here, we briefly tabulated several recent studies that have shown the association of lncRNAs with NPDs.	Neurodevelopmental Disorders	Transcriptome
696	31374203	9606	Brain	Others	Case-control based	TWAS	TWAS	Transcriptome-wide association analysis (TWAS) was carried out via S-Predixcan to identify top expressed genes within GTEXv746 and CommonMind Consortium brain tissue models. The top brain-expressed genes unique to the discordant subsets were CYP21A1P (MIM: 613815), CFB (MIM: 138470), and C4A (MIM: 120810), along with 177 additional genes that were significantly expressed in the discordant, but not the concordant, subsets.	Schizophrenia	Transcriptome
697	31374203	9606	Blood//Brain	Others	Case-control based	GWAS//Meta-analysis	GWAS//Meta-analysis	Very recently, new GWASs have been published for schizophrenia, cognitive ability, and educational attainment, and these studies are larger than the input GWAS used for our ASSET analysis. We found that 75% of the loci were in fact reported as significant in the later GWASs with larger sample sizes, and 28 of the 110 loci were independent from other single-phenotype GWAS reports. MAGMA gene-based analysis was conducted on all ASSET subsets. 772 genes survived Bonferroni correction in the overall ASSET analysis, with 306 genes in the concordant subset and 304 genes within the discordant subset.	Schizophrenia	Transcriptome
698	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
699	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 17 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
700	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 18 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
701	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 19 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
702	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 20 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
703	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 21 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
704	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 22 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
705	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 23 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
706	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 24 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
707	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 25 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
708	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 26 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
709	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 27 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
710	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 28 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
711	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 29 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
712	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 30 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
713	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 31 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
714	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 32 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
715	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 33 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
716	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 34 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
717	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 35 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
718	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 36 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
719	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 37 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
720	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 38 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
721	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 39 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
722	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 40 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
723	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 41 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
724	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 42 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
725	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 43 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
726	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 44 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
727	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 45 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
728	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 46 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
729	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 47 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
730	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 48 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
731	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 49 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
732	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 50 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
733	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 51 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
734	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 52 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
735	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 53 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
736	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 54 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
737	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 55 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
738	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 56 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
739	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 57 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
740	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 58 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
741	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 59 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
742	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 60 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
743	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 61 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
744	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 62 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
745	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 63 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
746	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 64 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
747	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 65 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
748	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 66 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
749	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 67 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
750	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 68 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
751	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 69 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
752	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 70 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
753	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 71 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
754	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 72 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
755	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 73 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
756	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 74 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
757	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 75 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
758	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 76 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
759	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 77 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
760	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 79 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
761	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 80 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
762	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 81 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
763	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 82 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
764	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 83 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
765	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 84 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
766	31398340	9606	Blood	Others	Case-control based//Family based	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	Illumina Infinium Human Exome//Illumina Infinium Human Core Exome MicroArray	We performed a comprehensive assessment of rare inherited variation in autism spectrum disorders (ASD) by analyzing whole-genome sequences (WGS) of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD-risk, including 24 passing genome-wide Bonferroni correction and 78 new ASD-risk genes, most supported by rare inherited variants, a substantial extension of previous findings.	Autism Spectrum Disorder	Transcriptome
767	31422452	9606	Blood	DSM-IV	Case-control based	Nanostring/qPCR	Nanostring/qPCR	The main objective of the present study was to evaluate the expression profiles of circulating microRNAs (miRNAs) in drug-free manic psychotic bipolar patients versus healthy controls (HC), to identify possible non-invasive molecular markers of the disorder- 15 drug-free manic psychotic bipolar patients and 9 HC were enrolled and 800 miRNAs expression profile was measured by Nanostring nCounter technology on plasma samples and validated through qPCR-	Bipolar Disorder	Transcriptome
768	31452935	9606	Saliva	DSM-IV	Case-control based//Family based	Illumina HiSeq//Illumina HumanCoreExome550 SNP Array	Illumina HiSeq//Illumina HumanCoreExome550 SNP Array	We conducted a pilot study for SPARK (SPARKForAutism.org) of 457 families with ASD, all consented online. Whole exome sequencing (WES) and genotyping data were generated for each family using DNA from Saliva. We identified variants in genes and loci that are clinically recognized causes or significant contributors to ASD in 10.4% of families without previous genetic findings. In addition, we identified variants that are possibly associated with ASD in an additional 3.4% of families. A meta-analysis using the TADA framework at a false discovery rate (FDR) of 0.1 provides statistical support for 26 ASD risk genes.	Autism Spectrum Disorder	Transcriptome
769	31455887	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	To identify RNA editing sites associated with SCZ, a compendium of high quality and high confident RNA editing sites was assembled by imposing a series of detection-based thresholds. After thorough quality control, we identified a high confidence set of 11,242 RNA editing sites in the ACC and 7,594 sites in the DLPFC with no systematic differences in the mapping, base quality, and read coverage between SCZ and control samples.	Schizophrenia	Transcriptome
770	31455887	9606	NA	Others	Case-control based	GWAS	GWAS	We examined whether any genes contained an enrichment of differentially edited sites beyond what could be expected by chance. As expected, gene length functions as a correlate of the total number of RNA editing sites per gene. Therefore, we computed over-representation of differential RNA editing sites within each gene by setting a rotating background specific to the total number of known RNA editing events for a particular gene in order to systematically correct for gene length.	Schizophrenia	Transcriptome
771	31455887	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	To identify RNA editing sites associated with SCZ, a compendium of high quality and high confident RNA editing sites was assembled by imposing a series of detection-based thresholds- After thorough quality control, we identified a high confidence set of 11,242 RNA editing sites in the ACC and 7,594 sites in the DLPFC with no systematic differences in the mapping, base quality, and read coverage between SCZ and control samples-	Schizophrenia	Transcriptome
772	31477693	9606	Cell lines(iPSCs)	DSM-IV	Case-control based	Illumina HiSeq2500	Illumina HiSeq2500	RNA expression analysis of affected (ST) and unaffected (HT) twins using hiPSC-derived neurons.	Schizophrenia	Transcriptome
773	31491383	9606	Brain//Blood	Others	Case-control based	Meta-analysis	Meta-analysis	ASD susceptibility genes are interconnected at the level of transcriptional and protein networks, and many function as genetic regulators of neurodevelopment or synaptic proteins that regulate neural activity. So that the core underlying neuropathologies can be further elucidated, we emphasize the importance of first defining subtypes of ASDs based on the phenotypic signatures of genes in model systems and humans.	Autism Spectrum Disorder	Transcriptome
774	31500805	9606	Brain	Others	Case-control based	WGS	WGS	The 22q11.2 locus formed a large protein network during development that disproportionately affected SCZ- and ASD-associated neurodevelopmental modules, including loading highly onto synaptic and gene regulatory pathways. SEPT5, PI4KA, and SNAP29 genes are candidate drivers of 22q11.2 synaptic pathology relevant to SCZ and ASD, and DGCR8 and HIRA are candidate drivers of disease-relevant alterations in gene regulation.	Schizophrenia	Transcriptome
775	31500805	9606	Brain	Others	Case-control based	Genotyping	Genotyping	The 22q11.2 locus formed a large protein network during development that disproportionately affected SCZ- and ASD-associated neurodevelopmental modules, including loading highly onto synaptic and gene regulatory pathways. SEPT5, PI4KA, and SNAP29 genes are candidate drivers of 22q11.2 synaptic pathology relevant to SCZ and ASD, and DGCR8 and HIRA are candidate drivers of disease-relevant alterations in gene regulation.	Schizophrenia	Transcriptome
776	31508503	9606	Saliva	Others	Family based	GWAS//Illumina HumanHap550 Quad Chip	GWAS//Illumina HumanHap550 Quad Chip	We test this using a genome-wide association study (N=51,564) of a non-social trait related to autism, systemising, defined as the drive to analyse and build systems.	Autism Spectrum Disorder	Transcriptome
777	31540669	9606	Cell lines(iPSCs)	Others	Case-control based	Immunocytochemistry/MicroArray/qRT-PCR/RNA-seq	Immunocytochemistry/MicroArray/qRT-PCR/RNA-seq	Our genetic findings provide strong evidence that PTCHD1-AS deletions are risk factors for ASD	Autism Spectrum Disorder	Transcriptome
778	31548722	9606	DLPFC	Others	Case-control based	Illumina HiSeq2500//CRISPR//Whole-cell patch clamp electrophysiology	Illumina HiSeq2500//CRISPR//Whole-cell patch clamp electrophysiology	By integrating CRISPR-mediated gene editing, activation and repression technologies to study one putative SZ-eQTL (FURIN rs4702) and four top-ranked SZ-eQTL genes (FURIN, SNAP91, TSNARE1, CLCN3), our platform resolves pre- and post-synaptic neuronal deficits, recapitulates genotype-dependent gene expression differences, and identifies convergence downstream of SZ-eQTL gene perturbations.	Schizophrenia	Transcriptome
779	31551593	9606	Blood(Leukocyte)	ADOS	Case-control based	RNA-seq/Microarray	RNA-seq/Microarray	We analyzed leukocyte gene expression profiles obtained from 226 male toddlers (119 ASD and 107 TD,Table S1). Robust linear regression modeling of the data identified 1236 differentially expressed (DE) genes (437 downregulated and 799 upregulated; FDR <0.05;Table S2).	Autism Spectrum Disorder	Transcriptome
780	31551593	9606	Blood(Leukocyte)	ADOS	Case-control based	RNA-seq/Microarray	RNA-seq/Microarray	We analyzed leukocyte gene expression profiles obtained from 226 male toddlers (119 ASD and 107 TD,Table S1)- Robust linear regression modeling of the data identified 1236 differentially expressed (DE) genes (437 downregulated and 799 upregulated; FDR <0-05;Table S2)-	Autism Spectrum Disorder	Transcriptome
781	31570194	9606	Brain(Cerebral cortex//Cerebellum)	Others	Case-control based	RNA-seq/RT-PCR	RNA-seq/RT-PCR	We identified hundreds of novel circRNAs and demonstrated that circRNAs are not expressed stochastically, but rather as major isoforms. A total of 205 of the 496 circRNAs were replicated as significant in DS2 (false discovery rate < .05) (Supplemental MethodsinSupplement 1;TableS5AinSupplement 2), with high agreement of directionality (Figure6C).	Autism Spectrum Disorder	Transcriptome
782	31579823	9606	Blood	DSM-IV/DSM-V	Case-control based	smMIP//HITS-CLIP//q-PCR//	smMIP//HITS-CLIP//q-PCR//	Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission	Autism Spectrum Disorder	Transcriptome
783	31600826	9606	NA	Others	Case-control based	Automated Patch Clamp	Automated Patch Clamp	In this study, we performed high-throughput functional studies of 19 KCNB1 variants (17 missense, 1 frameshift, 1 nonsense) to determine their effect on protein function and provide functional evidence for weighing potential pathogenicity.KCNB1 [NM004975] encodes the KV2.1 voltage-gated potassium (K) channel α-subunit that conducts delayed rectifier K current++, a key modulator of membrane repolarization in electrically excitable cells, including various neuron subtypes.	Neurodevelopmental Disorders	Transcriptome
784	31605836	9606	Blood	DSM-IV TR	Case-control based	RT-PCR	RT-PCR	Our results showed greater miRNA dysregulation in the manic patients than in the euthymic patients- Two microRNAs could be more selective for bipolar manic episodes- Future studies should include depressive patients along with euthymic and manic patients-	Bipolar I Disorder	Transcriptome
785	31616042	9606	Blood	Others	Case-control based	GWAS	GWAS	Here we review a GRB-based approach to assign loci in non-coding regions to potential target genes, and apply it to reanalyse the results of one of the largest schizophrenia GWAS (SWG PGC, 2014).	Schizophrenia	Transcriptome
786	31626773	9606	Blood	Others	Case-control based	RNA-seq//Genotypig//qPCR//Meta-Analysis	RNA-seq//Genotypig//qPCR//Meta-Analysis	We characterized the genetic control of the transcriptome in 201 mid-gestational human brains, identifying 7,962 expression quantitative trait loci (eQTL) and 4,635 spliceQTL (sQTL), including several thousand prenatal-specific regulatory regions. We show that significant genetic liability for neuropsychiatric disease lies within prenatal eQTL and sQTL. Integration of eQTL and sQTL with genome-wide association studies (GWAS) via transcriptome-wide association identified dozens of novel candidate risk genes, highlighting shared and stage-specific mechanisms in schizophrenia (SCZ).	Schizophrenia	Transcriptome
787	31652596	9606	Blood	DSM-ｍ	Case-control based	qPCR/Illumina HiSeq2500/TaqMan	qPCR/Illumina HiSeq2500/TaqMan	We identified six DE miRNAs (miR-652-3p, miR-942-5p, let-7b-5p, miR-181a-5p, miR-320a, and miR-148b-3p) in children with ADHD compared to TDs, although only three of them (miR-652-3p, miR-148b-3p, and miR-942-5p) survived from the multiple comparisons correction-	Attention-Deficit/Hyperactivity Disorder	Transcriptome
788	31664177	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	ID database (http://www.ccgenomics.cn/IDGenetics/gene.php?dataset=IDGD_gene_detail) identified unique and shared mutated gene mutations.	Intellectual Disability	Transcriptome
789	31680857	9606	Blood	Others	Case-control based	miRNA PCR array/qRT-PCR	miRNA PCR array/qRT-PCR	Cell-free circulating miRNAs in biofluids are extraordinarily stable and considered to represent the next-generation of clinical, non-invasive, biomarkers for many pathologies including neurological and neurodevelopmental disorders- Here, we conducted a review of all peer-reviewed articles addressing the circulating profiles of miRNAs, mostly performed in serum and saliva samples in individuals with ASD-	Autism Spectrum Disorder	Transcriptome
790	31680857	9606	Blood	Others	Case-control based	Microarray/qRT-PCR	Microarray/qRT-PCR	Cell-free circulating miRNAs in biofluids are extraordinarily stable and considered to represent the next-generation of clinical, non-invasive, biomarkers for many pathologies including neurological and neurodevelopmental disorders- Here, we conducted a review of all peer-reviewed articles addressing the circulating profiles of miRNAs, mostly performed in serum and saliva samples in individuals with ASD-	Autism Spectrum Disorder	Transcriptome
791	31680857	9606	Saliva	Others	Case-control based	RNA-seq	RNA-seq	Cell-free circulating miRNAs in biofluids are extraordinarily stable and considered to represent the next-generation of clinical, non-invasive, biomarkers for many pathologies including neurological and neurodevelopmental disorders- Here, we conducted a review of all peer-reviewed articles addressing the circulating profiles of miRNAs, mostly performed in serum and saliva samples in individuals with ASD-	Autism Spectrum Disorder	Transcriptome
792	31680857	9606	Blood	Others	Case-control based	qRT-PCR	qRT-PCR	Cell-free circulating miRNAs in biofluids are extraordinarily stable and considered to represent the next-generation of clinical, non-invasive, biomarkers for many pathologies including neurological and neurodevelopmental disorders- Here, we conducted a review of all peer-reviewed articles addressing the circulating profiles of miRNAs, mostly performed in serum and saliva samples in individuals with ASD-	Autism Spectrum Disorder	Transcriptome
793	31680857	9606	Blood	Others	Case-control based	TLDA/RT-qPCR	TLDA/RT-qPCR	Cell-free circulating miRNAs in biofluids are extraordinarily stable and considered to represent the next-generation of clinical, non-invasive, biomarkers for many pathologies including neurological and neurodevelopmental disorders- Here, we conducted a review of all peer-reviewed articles addressing the circulating profiles of miRNAs, mostly performed in serum and saliva samples in individuals with ASD-	Autism Spectrum Disorder	Transcriptome
794	31712720	9606	Blood	Others	Case-control based	GWAS//Meta-analysis//Illumina Infinium HumanCoreExome	GWAS//Meta-analysis//Illumina Infinium HumanCoreExome	The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden).	Major Depressive Disorder	Transcriptome
795	31723243	9606	NA	Others	Case-control based	GWAS//RNA-seq	GWAS//RNA-seq	Here, we conduct summary data-based Mendelian randomization (SMR) analyses through combining the statistical data from genome-wide association studies (GWAS) of both schizophrenia and BPD and multiple expression quantitative trait loci (eQTL) datasets of the human brain dorsolateral prefrontal cortex (DLPFC) tissues. These integrative investigations identify a lead risk locus at the chromosome 3p21.1 region, which contains numerous single-nucleotide polymorphisms (SNPs) in varied linkage disequilibrium (LD) and encompasses more than 20 genes.	Bipolar Disorder	Transcriptome
796	31726266	9606	Blood	DSM-IV	Case-control based	qPCR	qPCR	The exosomes were precipitated from plasma samples of patients with BD (n=69; 15 depressed, 27 manic, 27 euthymic) and healthy controls (n=41)- Thirteen miRNAs showed significant differences between patients with BD and healthy individuals; among these, MiR-484, -652每3p, -142每3p remained significantly downregulated and miR-185每5p remained significantly upregulated after accounting for multiple comparisons and adjustments for potential confounders-	Bipolar I Disorder	Transcriptome
797	31752442	9606	Brain	Others	Case-control based	Illumina HiSeq2500	Illumina HiSeq2500	The molecular mechanisms underlying bipolar disorder (BPD) have remained largely unknown. Postmortem brain tissue studies comparing BPD patients with healthy controls have produced a heterogeneous array of potentially implicated protein-coding RNAs.	Bipolar Disorder	Transcriptome
798	31752442	9606	Brain	Others	Case-control based	Illumina HiSeq2500/PCR	Illumina HiSeq2500/PCR	The molecular mechanisms underlying bipolar disorder (BPD) have remained largely unknown. Postmortem brain tissue studies comparing BPD patients with healthy controls have produced a heterogeneous array of potentially implicated protein-coding RNAs.	Bipolar Disorder	Transcriptome
799	31768057	9606	Blood	ICD-10	Case-control based	Illumina HiSeq	Illumina HiSeq	The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across ASD and ADHD, identifying microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders	Attention-Deficit/Hyperactivity Disorder	Transcriptome
800	31768057	9606	Blood	ICD-10	Case-control based	Illumina HiSeq	Illumina HiSeq	This motivates a combined analysis across ASD and ADHD, which identifies microtubule-associated protein 1A (MAP1A) as a novel exome-wide significant gene conferring risk for childhood psychiatric disorders.	Autism Spectrum Disorder	Transcriptome
801	31768057	9606	Blood	ICD-10	Case-control based	Illumina HiSeq	Illumina HiSeq	In summary, we used DNA from archived bloodspots to conduct an exome sequencing study of ASD and ADHD. To place our study in the context of previous de novo variant studies of ASD, we examined our rare PTVs in the top published ASD genes and found an overwhelming burden in ASD cases compared to controls, suggesting that we are at least partly tapping into the same signal.	Autism Spectrum Disorder	Transcriptome
802	31881254	9606	Blood	Others	Case-control based	RT-PCR	RT-PCR	Discrepancy had been found between MA users and healthy individuals (P< 0-01) in terms of the expression of miR-181a, miR-15b, miR-let-7e and miR-let-7d-	Methamphetamine Use Disorder	Transcriptome
803	31932766	9606	NA	DSM-IV/ICD-10	Case-control based	Illumina//Sanger Sequencing	Illumina//Sanger Sequencing	Genes disrupted by 2 or more LoF de novo variants. Individual gene enrichment P values were generated using a one-sided Poisson test. The most significant gene, SETD1A, has been previously identified as a schizophrenia risk gene.Specifically, we show that people with schizophrenia who are carriers of DNVs in gene sets proposed to be relevant to schizophrenia have a lower common risk allele burden than people with schizophrenia who are not carriers.	Schizophrenia	Transcriptome
804	31980721	9606	Blood	SADS-L	Case-control based	Illumina MiSeq/qRT-PCR	Illumina MiSeq/qRT-PCR	This study explored the possibility of miRNA in peripheral blood (serum) as a specific biomarker for BD-II- We identified 6 candidate miRNAs to differentiate BD-II patients from controls using next-generation sequencing-	Bipolar I Disorder	Transcriptome
805	32001654	9606	NA	Others	Case-control based	Genotyping	Genotyping	To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine.	Schizophrenia	Transcriptome
806	32015465	9606	Blood	DSM	Case-control based	WGS//Affymetrix Genome-Wide Human SNP 6.0 Array	WGS//Affymetrix Genome-Wide Human SNP 6.0 Array	Our results indicate that, despite its high impact, the risk conferred by the 22q11.2 deletion is even greater when present with the genome-wide risk factors that also have a key role in schizophrenia risk in the general population.These findings suggest that in addition to the deletion conferring a greatly increased risk to schizophrenia, the risk is higher when the 22q11.2 deletion and common polygenic risk factors that contribute to schizophrenia in the general population are both present.	Schizophrenia	Transcriptome
807	32036213	9606	Blood(Serum)	Others	Case-control based	Microarray/RT-qPCR	Microarray/RT-qPCR	Microarray analysis identified 116 and 109 significantly altered miRNAs in heroin abusers and MA abusers, respectively-	Drug Abuse	Transcriptome
808	32051083	9606	Blood	DSM-V	Case-control based	RT-PCR	RT-PCR	Drug therapy can significantly improve the clinical symptoms of children with ADHD- The expression of miR-4655-3p and miR-7641 in serum can be used as biomarkers for the diagnosis and outcome evaluation of ADHD	Attention-Deficit/Hyperactivity Disorder	Transcriptome
809	32066700	9606	Cerebrospinal fluid//Blood	DSM-IV	Case-control based	PsychChip//Affymetrix 6.0//Illumina OmniExpress	PsychChip//Affymetrix 6.0//Illumina OmniExpress	To explore the genetic associations with immune biomarker levels in cerebrospinal fluid (CSF) and blood serum which previously showed differences in bipolar disorder, we performed a study involving 291 individuals (184 bipolar disorder patients and 107 controls). The biomarkers assayed in both CSF and serum were: chitinase-3-like protein-1 (YKL-40), monocyte chemoattractant protein-1 (MCP-1), soluble cluster of differentiation (sCD14), tissue inhibitor of metalloproteinases-1 and 2 (TIMP-1 and TIMP-2).	Bipolar Disorder	Transcriptome
810	32127416	9606	Brain(Frontal cortex//Temporal cortex//Cerebellar vermis)	Others	Case-control based	RNA-seq/Microarray	RNA-seq/Microarray	Here, we performed genome-wide circRNA expression profiling in postmortem brains from individuals with ASD and controls and identified 60 circRNAs and three coregulated modules that were perturbed in ASD. By integrating circRNA, microRNA, and mRNA dysregulation data derived from the same cortex samples, we identified 8170 ASD-associated circRNA-microRNA-mRNA interactions	Autism Spectrum Disorder	Transcriptome
811	32127416	9606	Brain(Frontal cortex//Temporal cortex//Cerebellar vermis)	Others	Case-control based	RNA-seq/Microarray	RNA-seq/Microarray	Here, we performed genome-wide circRNA expression profiling in postmortem brains from individuals with ASD and controls and identified 60 circRNAs and three coregulated modules that were perturbed in ASD- By integrating circRNA, microRNA, and mRNA dysregulation data derived from the same cortex samples, we identified 8170 ASD-associated circRNA-microRNA-mRNA interactions	Autism Spectrum Disorder	Transcriptome
812	32143829	9606	NA	DSM-IV	Case-control based	RNA-seq//DESeq2	RNA-seq//DESeq2	Using our analysis model, 80 genes were DEX between SCZ and CTL samples at an FDR of 10%, corresponding to a maximum p value of 3.3 × 10-4.	Schizophrenia	Transcriptome
813	32147531	9606	NA	Others	Case-control based	NA	NA	In this review, epigenetic evidences that obtained from DNA methylation, post-translational histone modifications and non-coding RNA studies in SZ and BD were summarized and the importance of this evidences for advances in the diagnosis and treatment of SZ and BD were discussed briefly-	Bipolar Disorder	Transcriptome
814	32183904	9606	NA	Others	Case-control based	ES	ES	Forty-three significantly enriched gene families in the combined de novo paralog-conserved missense and PTV analysis for 10,068 NDD trios. Only enriched gene families significant after applying the Bonferroni significance threshold for testing 5×2871 gene families (3.48×10-6) are included.	Neurodevelopmental Disorders	Transcriptome
815	32186681	9606	Cell lines(iPSCs)	Others	Case-control based	RNA-seq	RNA-seq	Schizophrenia GWAS Genes That Were Differentially Expressed in Schizophrenia Cerebral Organoids, Showing the Direction of Change Compared With Control Cerebral Organoids as Well as the Fold Change.	Schizophrenia	Transcriptome
816	32241689	9606	Brain	DSM-IV/SADS-L	Case-control based	miRNeasy Mini Kit/Nanostring/RT-qPCR	miRNeasy Mini Kit/Nanostring/RT-qPCR	We used nCounter miRNA Expression assay to measure miRNAs expression in lymphoblastoid cell lines (LCLs) from patients with Bipolar Disorder (BD) who died by suicide (SC, n = 7) and with low risk of suicide (LR, n = 11)- In conclusion, our study suggests that miR-4286 could be a biomarker of suicide but further studies are warranted to investigate its targeted genes and how these could be involved in the neurobiology of suicide-	Bipolar Disorder	Transcriptome
817	32242086	9606	Blood(Peripheral blood mononuclear cells)	Others	Case-control based	RT-qPCR	RT-qPCR	We then compared the expression levels of those markers in PBMCs taken from ASD patients in response to orally-delivered sulforaphane. The mRNA levels of cytoprotective enzymes (NQO1, HO-1, AKR1C1), and heat shock proteins (HSP27 and HSP70), increased. Conversely, mRNA levels of pro-inflammatory markers (IL-6, IL-1汕, COX-2 and TNF-α) decreased.	Autism Spectrum Disorder	Transcriptome
818	32296054	9606	Blood	Others	Case-control based	Illumina HiSeqX	Illumina HiSeqX	We screened for repeat expansions in 16 genes known to be associated with diseases. This shows the range of repeat units for all subjects and the numbers of subjects that carried potentially pathological repeats.	Schizophrenia	Transcriptome
819	32296054	9606	NA	Others	Case-control based	Illumina HiSeqX	Illumina HiSeqX	We screened for repeat expansions in 16 genes known to be associated with diseases. This shows the range of repeat units for all subjects and the numbers of subjects that carried potentially pathological repeats.	Schizophrenia	Transcriptome
820	32304043	9606	Brain	Others	Case-control based	qPCR	qPCR	This review aims to critically evaluate the potential advantages and disadvantages of miRNAs as diagnostic/prognostic biomarkers in psychiatric disorders as well as in treatment response-	Bipolar Disorder	Transcriptome
821	32304043	9606	Brain	Others	Case-control based	Microarray/qPCR	Microarray/qPCR	This review aims to critically evaluate the potential advantages and disadvantages of miRNAs as diagnostic/prognostic biomarkers in psychiatric disorders as well as in treatment response-	Bipolar Disorder	Transcriptome
822	32304043	9606	Brain	Others	Case-control based	TLDA	TLDA	This review aims to critically evaluate the potential advantages and disadvantages of miRNAs as diagnostic/prognostic biomarkers in psychiatric disorders as well as in treatment response-	Bipolar Disorder	Transcriptome
823	32304043	9606	Brain	Others	Case-control based	Microarray	Microarray	This review aims to critically evaluate the potential advantages and disadvantages of miRNAs as diagnostic/prognostic biomarkers in psychiatric disorders as well as in treatment response-	Bipolar Disorder	Transcriptome
824	32306996	9606	Cell lines(iPSCs)	DSM-IV	Case-control based	Illumina NovaSeq6000	Illumina NovaSeq6000	Our studies in cerebral organoids from bipolar disorder showed dysregulation in genes involved in cell adhesion, immune signaling, and endoplasmic reticulum biology; implicated a central role for the GWAS hit NCAN in the biology of BPI; and showed evidence of deficits in neurotransmission.	Bipolar Disorder	Transcriptome
825	32398653	9606	NA	DSM/ICD-10	Case-control based//Family based	GWAS//Meta-analysis	GWAS//Meta-analysis	Pairwise meta-analysis of schizophrenia and each psychiatric phenotype was implemented and identified 330 significantly associated genes (PMeta < 2.7 × 10 6) that were only nominally associated with each disorder individually (P < 0.05).Supplementary Table 2b - ADHD MAGMA gene-based association	Attention-Deficit/Hyperactivity Disorder	Transcriptome
826	32398677	9606	Brain	DSM-IV/DSM-ｍ/DSM-IV- TR /CTQ	Case-control based	qRT-PCR	qRT-PCR	An independent postmortem study found no differential gene expression in 22 PTSD vs. 22 controls, but showed lower relative expression ofTSPOand microglia-associated genesTNFRSF14andTSPOAP1in a female PTSD subgroup.	Posttraumatic Stress Disorder	Transcriptome
827	32438891	9606	Skin////Cell lines(iPSCs)	Others	Case-control based	qPCR/Illumina miRNA 4-1 Microarray	qPCR/Illumina miRNA 4-1 Microarray	Because there are no viable cellular models to study BP, we have taken advantage of the recent discovery that somatic cells can be reprogrammed to pluripotency then directed to form the full complement of neural cells- Analysis of RNAs extracted from Control and BP patient-derived neurons identified 58 miRNAs that were differentially expressed between the two groups-	Bipolar Disorder	Transcriptome
828	32458337	9606	Blood	DSM-V	Case-control based	RT-PCR	RT-PCR	We aim to investigate the expression of two long non coding RNAs, MALAT1 and UCA1, in patients in bipolar disorder. The levels of MALAT1 and UCA1 lncRNA were evaluated in peripheral blood mononuclear cells (PBMCs) of 50 bipolar patients and 50 healthy controls with real-time PCR.	Bipolar Disorder	Transcriptome
829	32464545	10090	NA	Others	Case-control based	qRT-PCR	qRT-PCR	We found that SI mice exhibited a higher level of microRNA 206 (miR-206) compared with GH mice.	Aggressive Behaviors	Transcriptome
830	32492425	9606	Blood	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
831	32492425	9606	Brain(Brodmann Area 9)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
832	32492425	9606	Brain(Putamen)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
833	32492425	9606	Brain(Cerebellar hemisphere)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
834	32492425	9606	Brain(Hypothalamus)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
835	32492425	9606	Brain(Cerebellum)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
836	32492425	9606	Brain(Artery aorta)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
837	32492425	9606	Thyroid	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
838	32492425	9606	Brain(Anterior cingulate cortex)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
839	32492425	9606	Brain(Pituitary)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
840	32492425	9606	Brain(Nucleus accumbens)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
841	32492425	9606	Blood(Artery tibial)	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
842	32492425	9606	Brain	CAPS/PCL	Case-control based	Meta-analysis	Meta-analysis	Table1:Study-wide and Tissue-wide Significant GReX Associations with PTSD	Posttraumatic Stress Disorder	Transcriptome
843	32492425	9606	Cell lines(HEK293)	Others	Case-control based	qPCR	qPCR	SNRNP35 knockdown in cells validates its functional role in U12-intron splicing	Posttraumatic Stress Disorder	Transcriptome
844	32507511	9606	NA	Others	Case-control based	NA	NA	Finally, exogenous glucocorticoids in mice downregulate prefrontalSnrnp35expression.	Neurodevelopmental Disorders	Transcriptome
845	32507511	9606	NA	Others	Case-control based	NGS	NGS	One example of a two-hit model comes from mutations in DEPDC5. Germline heterozygous loss-of-function mutations affecting DEPDC5 are a major cause of familial refractory focal epilepsies. A second somatic variant causing biallelic inactivation of DEPDC5 was found to be responsible for the additional development of focal cortical dysplasia in patients with a severe phenotype.	Neurodevelopmental Disorders	Transcriptome
846	32507511	9606	NA	Others	Case-control based	NGS	NGS	Loss-of-function monoallelic mutations in the sodium channels CACNA1A and SCN8A are commonly associated with a variety of clinical features including movement disorder, ID, ASD, and benign familial infantile seizures.	Neurodevelopmental Disorders	Transcriptome
847	32507511	9606	NA	Others	Case-control based	NGS	NGS	The recently reported CACNA1A and SCN8A compound heterozygous probands are characterized by the presence of epileptic encephalopathy, while the heterozygous parents and siblings only exhibit mild cognitive impairment without seizure.	Neurodevelopmental Disorders	Transcriptome
848	32634746	9606	Blood(Lymphocytes)	DSM-IV	Case-control based	RT-PCR	RT-PCR	This study described the expression levels of a comprehensive set of HPA axis genes according to childhood maltreatment in a sample of patients with BD type 1 and suggested that emotional abuse decreased the expression of NR3C1 and DGKH. Our results require further replication in independent larger samples.	Bipolar I Disorder	Transcriptome
849	32651461	9606	Brain(Frontal cortex)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
850	32651461	9606	Brain(Cerebellar hemisphere)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
851	32651461	9606	Brain(Hippocampus)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
852	32651461	9606	Brain(Dorsal anterior cingulate cortex)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
853	32651461	9606	Brain(Cerebellum)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
854	32651461	9606	Brain(Putamen basal ganglia)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
855	32651461	9606	Tibial nerve	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
856	32651461	9606	Brain(Caudate basal ganglia)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
857	32651461	9606	Nerve tibial	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
858	32651461	9606	Brain(Cortex)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
859	32651461	9606	Brain(Nucleus accumbens basal ganglia)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
860	32651461	9606	Brain(Pituitary)	Others	Case-control based	TWAS	TWAS	The top TWAS genes with the strongest associations with a |Z-score|>3.50,P<5×104are listed in Supplementary Table2(with the results from the multi-tissue TWAS presented in Fig.2).	Restless Legs Syndrome	Transcriptome
861	32653108	9606	Blood//Brain	Others	Case-control based	Meta-analysis	Meta-analysis	We searched for all case-control studies on major depressive disorder that reported microarray or RNA sequencing measurements on whole blood or peripheral blood mononuclear cells. Primary datasets were reanalyzed, when openly accessible, to estimate case-control differences and to evaluate the functional roles of differentially expressed gene lists by technically harmonized methods.	Major Depressive Disorder	Transcriptome
862	32748469	9606	Blood(Plasma)	DSM-V	Case-control based	Microarray/qRT-PCR	Microarray/qRT-PCR	We identified significant miRNAs using the microarray method and then validated the hsa-miR-181a expression levels in 53 heroin addiction patients and 49 normal controls using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR)-	Heroin Addiction	Transcriptome
863	32755611	9606	NA	Others	Case-control based	NGS	NGS	We obtained a total of 420 references (Figure 1) to which other 3 relevant articles found through bibliography search were added. After title and abstract review, 119 articles were further selected for full-text review. The detailed review of those articles allowed excluding 72 articles due to absence of BDII patients or information. Forty seven articles were then included in the final review.	Bipolar II Disorder	Transcriptome
864	32755611	9606	NA	Others	Case-control based	NGS	NGS	We obtained a total of 420 references (Figure 1) to which other 3 relevant articles found through bibliography search were added. After title and abstract review, 119 articles were further selected for full-text review. The detailed review of those articles allowed excluding 72 articles due to absence of BDII patients or information. Forty seven articles were then included in the final review.	Bipolar Disorder	Transcriptome
865	32755611	9606	NA	Others	Case-control based	NGS	NGS	We obtained a total of 420 references (Figure 1) to which other 3 relevant articles found through bibliography search were added. After title and abstract review, 119 articles were further selected for full-text review. The detailed review of those articles allowed excluding 72 articles due to absence of BDII patients or information. Forty seven articles were then included in the final review.	Bipolar I Disorder	Transcriptome
866	32839513	9606	NA	Others	Case-control based	Illumina//Sanger Sequencing	Illumina//Sanger Sequencing	In the present study, we used genetic tools combined with human cellular models and transcriptome profiling to understand the role of the IMPA1 loss-of-function in ID and showed a specific importance of the inositol cycle in human neuronal development.	Intellectual Disability	Transcriptome
867	32875100	9606	Cell lines(iPSCs)	Others	Case-control based	Illumina HiSeq4000/DESeq2	Illumina HiSeq4000/DESeq2	Differential gene expression analysis was performed using DESeq2. The comparison of untreated and treated neurons revealed 751 DEGs.	Neurodevelopmental Disorders	Transcriptome
868	32875100	9606	Cell lines(iPSCs)	Others	Case-control based	Illumina HiSeq4000/DESeq2	Illumina HiSeq4000/DESeq2	Differential gene expression analysis was performed using DESeq2- The comparison of untreated and treated neurons revealed 751 DEGs-	Neurodevelopmental Disorders	Transcriptome
869	32919404	9606	Brain	DSM-V	Case-control based	Illumina NextSeq500	Illumina NextSeq500	Here, we examined the role of miRNAs and their functioning at the synapse in MDD by examining miRNA processing machinery at synapse and sequencing miRNAs and analyzing their functions in synaptic and total tissue fractions obtained from dorsolateral prefrontal cortex (dlPFC) of 15 MDD and 15 matched non-psychiatric control subjects-	Major Depressive Disorder	Transcriptome
870	32929213	9606	Cell lines(NPCs)	Others	Case-control based	Illumina NextSeq500	Illumina NextSeq500	We examined three published lists of SCZ candidate genes.	Schizophrenia	Transcriptome
871	32958647	9606	NA	Others	Case-control based	miRNA Microarray/RT-qPCR/TrUSeq	miRNA Microarray/RT-qPCR/TrUSeq	Here we identified altered protein expression in Fmr1 KO astroglia and defined a FMRP-dependent cell-autonomous miR pathway that alters developmental astroglial mGluR5 signaling in human and mouse FXS models-	Intellectual Disability	Transcriptome
872	33168801	9606	Blood	DSM-III-R	Case-control based	WGS//Sequenom MassARRAY	WGS//Sequenom MassARRAY	Here, we performed quantitative proteomics and whole-genome sequencing (WGS). Quantitative proteomics revealed NLRP2 as the most significantly up-regulated protein in neural stem cells and mature neural cells obtained from BD-patient cell samples. These results are in concordance with our previously published transcriptome analysis. Furthermore, the levels of FEZ2 and CADM2 proteins were also significantly differentially expressed in BD compared to control derived cells. The levels of FEZ2 were significantly downregulated in neural stem cells (NSC) while CADM2 was significantly up-regulated in mature neuronal cell culture. Promising novel candidate mutations were identified in the ANK3, NEK3, NEK7, TUBB, ANKRD1, and BRD2 genes.	Bipolar Disorder	Transcriptome
873	33192625	9606	Blood	DSM-IV	Case-control based	Affymetrix/qRT-PCR	Affymetrix/qRT-PCR	We identified plasma microRNAs (miRNAs) that distinguished BD from UD and explored the relationship between miRNA expression levels and clinical characteristics- Total miRNAs from blood plasma from seven UD patients, seven BD patients, and six controls were analyzed-	Bipolar Disorder	Transcriptome
874	33214552	9606	NA	ICD-10	Case-control based	Illumina HiSeq//qRT-PCR	Illumina HiSeq//qRT-PCR	We sequence two cohorts of individuals with severe SZ.Our results suggest PCM1 plays a role in some SZ cases, and point to a postnatal role for the cilia in maintaining brain structure and function.	Schizophrenia	Transcriptome
875	33216461	9606	Brain(Amygdala)	DSM-IV/AUDIT	Case-control based	qPCR	qPCR	Our study is the first to find upregulated TSPO mRNA levels in AMY and PFC in postmortem brains from AUD consistent with neuroinflammation, and in the amygdala, they implicate epigenetic regulation ofTSPOby HDAC2 and HDAC6.	Alcohol Use Disorder	Transcriptome
876	33219358	9606	Brain	DSM-IV	Case-control based	Illumina TruSeq Small RNA Protocol/RT-PCR	Illumina TruSeq Small RNA Protocol/RT-PCR	Major Depressive Disorderr (MDD) is a complex and debilitating illness whose etiology remains unclear- Small RNA molecules, such as micro RNAs (miRNAs) have been implicated in MDD, where they display differential expression in the brain and the periphery- In this study, we quantified miRNA expression by small RNA sequencing in the anterior cingulate cortex and habenula of individuals with MDD and psychiatrically-healthy controls-	Major Depressive Disorder	Transcriptome
877	33238484	10116	Brain(Striatum)	Others	Case-control based	RNA-seq	RNA-seq	A total of 87 genes (false discovery rate (FDR) <0.05, |fold change (FC)| √ 1.5) were found to be differentially expressed in the striatum in the MA group relative to the SA group (Table S1), and 253 DEGs with FDR< 0.05 and |FC| √ 1.5 were identified in whisker follicles (Table S2).	Methamphetamine Use Disorder	Transcriptome
878	33238484	10116	Whisker follicle	Others	Case-control based	RNA-seq	RNA-seq	A total of 87 genes (false discovery rate (FDR) <0.05, |fold change (FC)| √ 1.5) were found to be differentially expressed in the striatum in the MA group relative to the SA group (Table S1), and 253 DEGs with FDR< 0.05 and |FC| √ 1.5 were identified in whisker follicles (Table S2).	Methamphetamine Use Disorder	Transcriptome
879	33274367	9606	Brain	Others	Case-control based	TaqMan	TaqMan	Reduced levels of trophic factors are associated with inhibitory interneuron dysfunction in the prefrontal cortex and hippocampus in psychiatric disorders. We found that IGF1 mRNA was decreased in schizophrenia and bipolar disorder compared with controls (P ≒ .006), whereas both IGF1 receptor (IGF1R) and IGF binding protein 2 (IGFBP2) mRNAs were reduced in schizophrenia compared with controls (P ≒ .02).	Bipolar Disorder	Transcriptome
880	33328875	10090	Brain(Nucleus accumbens)	Others	Case-control based	Integrated Bioinformatics Analysis/RT-qPCR	Integrated Bioinformatics Analysis/RT-qPCR	Morphine also increasedADCY9mRNA expression in the mouse NAc, which was consistent with our previous results in human NAc (Figure 6J).	Opioid Use Disorder	Transcriptome
881	33349712	9606	Brain(Orbitofrontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	A comparison of the combined male and female control and PTSD cohorts identified 393 differentially expressed genes (DEGs) in the dlPFC, 170 DEGs in the OFC, 74 DEGs in the dACC and 1 in the sgPFC (false discovery rate (FDR)<0.05) (Fig. 1a)	Posttraumatic Stress Disorder	Transcriptome
882	33349712	9606	Brain(Dorsal anterior cingulate cortex)	Others	Case-control based	RNA-seq	RNA-seq	A comparison of the combined male and female control and PTSD cohorts identified 393 differentially expressed genes (DEGs) in the dlPFC, 170 DEGs in the OFC, 74 DEGs in the dACC and 1 in the sgPFC (false discovery rate (FDR)<0.05) (Fig. 1a)	Posttraumatic Stress Disorder	Transcriptome
883	33349712	9606	Brain(Subgenual prefrontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	A comparison of the combined male and female control and PTSD cohorts identified 393 differentially expressed genes (DEGs) in the dlPFC, 170 DEGs in the OFC, 74 DEGs in the dACC and 1 in the sgPFC (false discovery rate (FDR)<0.05) (Fig. 1a)	Posttraumatic Stress Disorder	Transcriptome
884	33414381	9606	Brain	Others	Case-control based	GWAS//Meta-analysis	GWAS//Meta-analysis	It causes significant psychosocial impairments and is a major cause of disability. A recent consortium study identified 102 genetic variants and 269 genes associated with depression. To provide targets for future depression research, we prioritized these recently identified genes using expression data. We examined the differential expression of these genes in three studies that profiled gene expression of MDD cases and controls across multiple brain regions.	Major Depressive Disorder	Transcriptome
885	33526774	9606	NA	Others	Case-control based	ExpandionHunter v3.0.2	ExpandionHunter v3.0.2	The range of genetic variation with potential clinical implications in schizophrenia, beyond rare copy number variants (CNVs), remains uncertain. We therefore analyzed genome sequencing data for 259 unrelated adults with schizophrenia from a well-characterized community-based cohort previously examined with chromosomal microarray for CNVs (none with 22q11.2 deletions).	Schizophrenia	Transcriptome
886	33530007	9606	Blood	SCID-IV	Case-control based	Illumina NovaSeq6000	Illumina NovaSeq6000	We found 288 differentially expressed genes in insomnia patients when compared to controls.	Insomnia Disorder	Transcriptome
887	33530007	9606	Blood	SCID-IV	Case-control based	Illumina NovaSeq6000	Illumina NovaSeq6000	We found 288 differentially expressed genes in insomnia patients when compared to controls-	Insomnia Disorder	Transcriptome
888	33558674	9606	Brain	Others	Case-control based	Illumina HiSeq2500//Illumina Genome-wide SNP Array	Illumina HiSeq2500//Illumina Genome-wide SNP Array	Here we investigate expressed genes and gene transcripts in postmortem subgenual anterior cingulate cortex (sgACC), a key component of limbic circuits linked to mental illness.	Bipolar Disorder	Transcriptome
889	33610945	9606	Blood	DSM-IV-TR	Case-control based	qRT-PCR/Genotyping	qRT-PCR/Genotyping	In this study, we plan to explore the correlation between the peripheral levels of the proposed candidate miRNAs including miR-7-5p, miR-142-3p, miR-221-5p, and miR-370-3p with BDNF levels- Because the BDNF Val66Met polymorphism may affect BDNF level, we will also investigate whether BDNF Val66Met polymorphism may modulation the above correlation- The present cross-section study reports positive correlations between the miR-7-5p, miR-221-5p, and miR-370-3p with plasma BDNF level-	Bipolar I Disorder	Transcriptome
890	33649454	9606	Brain	Others	Case-control based	RNAScope/BaseScope	RNAScope/BaseScope	We quantified the distribution of SNX19 and AS3MT schizophrenia risk-related transcripts in different cell types of human DLPFC using multiplex smFISH in combination with machine learning approaches. We found that SNX19 and AS3MT transcripts are more highly localized in neurons compared to glia.	Schizophrenia	Transcriptome
891	33658519	9606	NA	Others	Case-control based	qPCR	qPCR	Previous RNA-seq analyses of forebrain cortical neurons differentiated from a schizophrenia patient iPSC line with the 4-bp deletion in DISC1 gene revealed significant upregulation of multiple transcripts related to the PDE4 family.We validated the expression changes with q-PCR and further confirmed with an additional DISC1 mutant line from the same family and an additional control line (C1) from outside of the family.	Schizophrenia	Transcriptome
892	33686213	9606	NA	Others	Case-control based	Meta-analysis	Meta-analysis	Therefore, decreased ZNF804AE3E4 expression during early brain development likely explains the molecular mechanism underlying genetic risk of schizophrenia in this GWAS locus.	Schizophrenia	Transcriptome
893	33686213	9606	Brain	Others	Case-control based	RNA-seq	RNA-seq	A recent nanopore long-read sequencing analysis characterized the alternative splicing of CACNA1C in human brains, a psychiatric risk gene encoding the CaV1.2 voltage-gated calcium channel alpha1 subunit.	Schizophrenia	Transcriptome
894	33686213	9606	NA	Others	Case-control based	RNA-seq	RNA-seq	The schizophrenia risk gene NRXN1 can be transcribed into NRXN1-α and NRXN1-β depending on the usage of two alternative promoters.	Schizophrenia	Transcriptome
895	33686214	9606	NA	Others	Case-control based	NA	NA	ARID1B haploinsufficiency is a frequent cause of intellectual disability (ID) and autism spectrum disorder (ASD), and also leads to emotional disturbances. In this review, we examine past and present clinical and preclinical research into the neurobiological function of ARID1B. The presentation of ARID1B-related disorders (ARID1B-RD) is highly heterogeneous, including varying degrees of ID, ASD, and physical features.	Intellectual Disability	Transcriptome
896	33712584	9606	Brain	HAMD/DSM-IV	Case-control based	ISH//Morphometric Similarity Network Analysis	ISH//Morphometric Similarity Network Analysis	Here, we examine the link between brain-wide gene expression and morphometric changes in individuals with MDD, using neuroimaging data from two independent cohorts and a publicly available transcriptomic dataset. Morphometric similarity network (MSN) analysis shows replicable cortical structural differences in individuals with MDD compared to control subjects.Notably, we found that the PLS1 weighted gene expression map was spatially correlated with the case-control t-map (Pearson’s r(150)?=?0.60, pspin?<?0.0001; Fig. 3c). We ranked the normalized weights of PLS1 based on univariate one-sample Z tests. We found 1747 PLS1+?(Z?>?5) and 1237 PLS1??(Z?<???5) (all pFDR?<?0.005; Fig. 3d) positively (or negatively) weighted gene expressions were overexpressed (or under-expressed) as increased (or decreased) regional changes in MSN, respectively. In total, 2984 genes constituted the regional change in MSN gene list in individuals with MDD.	Major Depressive Disorder	Transcriptome
897	33723209	9606	Brain	DSM-IV	Case-control based	Illumina NextSeq500	Illumina NextSeq500	In a joint analysis of all three regions, 904 transcripts were differentially expressed between 7 OCD versus 8 unaffected comparison subjects.	Obsessive Compulsive Disorder	Transcriptome
898	33814920	10116	Brain(Hippocampus)	Others	Case-control based	qRT-PCR/ELISA/Western Blotting	qRT-PCR/ELISA/Western Blotting	The low expression of miR-138-5p after LPS administration may contribute to the activation of the NLRP3/caspase-1 pathway, leading to hippocampal neuroinflammation and cognitive impairment in rat models.	Cognitive Disorders	Transcriptome
899	33837273	9606	Blood	DSM-IV/DSM-IV-TR/DSM-V	Family based	Illumina HiSeq	Illumina HiSeq	Tourette's Disorder (TD) is a neurodevelopmental disorder (NDD) that affects about 0.7% of the population and is one of the most heritable NDDs. Nevertheless, because of its polygenic nature and genetic heterogeneity, the genetic etiology of TD is not well understood. In this study, we combined the segregation information in 13 TD multiplex families with high-throughput sequencing and genotyping to identify genes associated with TD.	Neurodevelopmental Disorders	Transcriptome
900	33843443	9606	NA	Others	Case-control based	NA	NA	The WDR45 gene is localized on the X-chromosome and variants in this gene are linked to six different neurodegenerative disorders, i.e., <U+00DF>-propeller protein associated neurodegeneration, Rett-like syndrome, intellectual disability, and epileptic encephalopathies including developmental and epileptic encephalopathy, early-onset epileptic encephalopathy and West syndrome and potentially also specific malignancies.	Neurodevelopmental Disorders	Transcriptome
901	33863995	9606	NA	Others	Case-control based	RNA-seq//Immunohistochemistry//RT-PCR	RNA-seq//Immunohistochemistry//RT-PCR	FXR1, a high confident risk gene for SCZ, is indispensable but its role in the brain is largely unknown. We show that deleting FXR1 from PVIs of medial prefrontal cortex (mPFC) leads to reduced PVI excitability, impaired mPFC gamma oscillation, and SCZ-like behaviors.	Schizophrenia	Transcriptome
902	33866329	9606	Brain	Others	Case-control based	GWAS	GWAS	We aimed to prioritize genes that were pleiotropically or potentially causally associated with MDD. We applied the summary data-based Mendelian randomization (SMR) method integrating GWAS and gene expression quantitative trait loci (eQTL) data in 13 brain regions to identify genes that were pleiotropically associated with MDD.	Major Depressive Disorder	Transcriptome
903	33874999	9606	NA	Others	Case-control based	Meta-analysis//Protein Homology Analysis//Mutation Analyses//Gene Expression Analyses//Phenotypic Characterization	Meta-analysis//Protein Homology Analysis//Mutation Analyses//Gene Expression Analyses//Phenotypic Characterization	Overall, our novel approach of exploiting gene families in NDDs identifies new HNRNP-related disorders, expands the phenotypes of known HNRNP-related disorders, strongly implicates disruption of the hnRNPs as a whole in NDDs, and supports that NDD subtypes likely have shared molecular pathogenesis.From our analyses, we identified 12 HNRNPs as particularly relevant to NDDs, which we term NDD HNRNPs.	Neurodevelopmental Disorders	Transcriptome
904	33896623	9606	Brain	DSM-IV	Case-control based	RNA-seq	RNA-seq	We discovered that SLIT1, a secreted protein essential for axonal navigation and molecular guidance during development, is downregulated in the adult ventromedial prefrontal cortex (vmPFC) of women with depression compared with healthy control subjects, but not in men with depression. This sex-specific downregulation of Slit1 was also observed in the vmPFC of mice exposed to chronic variable stress.	Major Depressive Disorder	Transcriptome
905	33941859	10090	Brain(Cortex)	Others	Case-control based	Microarray/RT-qPCR	Microarray/RT-qPCR	Collectively, this study reveals that CPEB3, as a potential PTSD-risk gene, downregulatesNr3c1translation to maintain proper GR-BDNF signaling for fear extinction.	Posttraumatic Stress Disorder	Transcriptome
906	33963278	9606	Blood	BDI-II/DSM-IV	Case-control based	Illumina	Illumina	Our study utilizes a novel approach to computationally integrate blood-based transcriptomics, genomics, and interactomics to understand the development of risk vs. resilience in the months following trauma exposure. In a two-site longitudinal, observational prospective study, we assessed over 10,000 individuals and enrolled >700 subjects in the immediate aftermath of trauma (average 5.3 h post-trauma (range 0.5-12 h)) in the Grady Memorial Hospital (Atlanta) and Jackson Memorial Hospital (Miami) emergency departments. RNA expression data and 6-month follow-up data were available for 366 individuals, while genotype, transcriptome, and phenotype data were available for 297 patients.	Major Depressive Disorder	Transcriptome
907	34016951	9606	Brain(Hippocampus)	DSM-IV	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Notably, pSTAT3 and its target genes were elevated in the postmortem hippocampus of human subjects with AUD when compared with control subjects.	Alcohol Use Disorder	Transcriptome
908	34020708	9606	NA	Others	Family based	WES//WGS//Sanger Sequencing	WES//WGS//Sanger Sequencing	Based on the clinical course, the variant location, and type we establish two distinct clinical subtypes. DHX30 loss-of-function variants cause a milder phenotype whereas a severe phenotype is caused by HCM missense variants that, in addition to the loss of ATPase and helicase activity, lead to a detrimental gain-of-function with respect to SG formation.	Neurodevelopmental Disorders	Transcriptome
909	34035170	9606	Blood	Others	Case-control based	PCR//Sanger Sequencing	PCR//Sanger Sequencing	Heterozygous NRXN1 deletions predispose to schizophrenia and other neurodevelopmental disorders. Engineered heterozygous NRXN1 deletions impair neurotransmitter release in human neurons, suggesting a synaptic pathophysiological mechanism. In a multicenter effort to test the generality and robustness of this pivotal observation, we used, at two laboratories, independent analyses of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions.	Schizophrenia	Transcriptome
910	34068138	9606	Blood//Brain	Others	Case-control based	Meta-analysis	Meta-analysis	Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs). We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder.	Bipolar Disorder	Transcriptome
911	34068138	9606	Blood//Brain	Others	Case-control based	Meta-analysis	Meta-analysis	Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes- Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs)- We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder-	Bipolar Disorder	Transcriptome
912	34068160	10090	Brain(Medial prefrontal cortex)	Others	Case-control based	TaqMan	TaqMan	In conclusion, our results indicate that PTSD susceptibility/resilience might be shaped by brain-area-dependent modulation of miRNAs targeting FKBP5, BDNF, and other stress-related genes.	Posttraumatic Stress Disorder	Transcriptome
913	34068160	10090	Brain(Hypothalamus)	Others	Case-control based	TaqMan	TaqMan	In conclusion, our results indicate that PTSD susceptibility/resilience might be shaped by brain-area-dependent modulation of miRNAs targeting FKBP5, BDNF, and other stress-related genes.	Posttraumatic Stress Disorder	Transcriptome
914	34093168	9606	Blood	Others	Case-control based	Microarray/RT-qPCR	Microarray/RT-qPCR	Verified by the RT-qPCR, we identified 14 DE lncRNAs that may relate to the pathogenesis of POD.	Delirium	Transcriptome
915	34100076	9606	Brain	Others	Case-control based	RT-PCR	RT-PCR	Our initial trio-based exome sequencing study of bipolar disorder showed enrichment of de novo, loss-of-function (LOF) or protein-altering mutations in a combined group with bipolar I and schizoaffective disorders, and the identified de novo mutations were enriched in calcium-related genes. These findings suggested a role for de novo mutations in bipolar disorder. The validity of these statistical associations will be strengthened if the functional impact of the mutations on cellular function and behavior are identified. In this study, we focused on two de novo LOF mutations in calcium-related genes, EHD1 and MACF1, found in patients with bipolar disorder.	Bipolar Disorder	Transcriptome
916	34158615	9606	Blood//Brain	CIDI-SF	Case-control based	TWAS	TWAS	Major Depressive Disorderr (MDD) is the single largest contributor to global disability and up to 20-30% of patients do not respond to at least two antidepressants (treatment-resistant depression, TRD). This study leveraged imputed gene expression in TRD to perform a drug repurposing analysis. Among those with MDD, we defined TRD as having at least two antidepressant switches according to primary care records in UK Biobank (UKB). We performed a transcriptome-wide association study (TWAS) of TRD (n = 2165) vs healthy controls (n = 11,188) using FUSION and gene expression levels from 21 tissues.	Major Depressive Disorder	Transcriptome
917	34188182	9606	Blood	DSM-IV-TR	Case-control based	Illumina HiSeq2000	Illumina HiSeq2000	GRIN3BandAMOTL1blood mRNA levels were associated with chronic vs. resilient post-trauma symptom trajectories at a transcriptome-wide significant level (N=153, FDR-correctedpvalue=0.0063 and 0.0253, respectively).	Posttraumatic Stress Disorder	Transcriptome
918	34267687	9606	Blood(Plasma)	DSM-IV	Case-control based	RT-PCR/Microarray	RT-PCR/Microarray	Increased Expression of Plasma miRNA-320a and let-7b-5p in Heroin-Dependent Patients and Its Clinical Significance	Heroin Addiction	Transcriptome
919	34272489	9606	Brain	Others	Case-control based	Affymetrix GeneChip Human Gene 1.0 ST Array	Affymetrix GeneChip Human Gene 1.0 ST Array	We performed a cell-subtype specific study of mRNA expression in schizophrenia, and found changes in enriched populations of pyramidal neurons in several pathways previously only implicated in studies employing homogenized region-level samples.	Schizophrenia	Transcriptome
920	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 9 of OUD subjects.	Opioid Use Disorder	Transcriptome
921	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 10 of OUD subjects.	Opioid Use Disorder	Transcriptome
922	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 11 of OUD subjects.	Opioid Use Disorder	Transcriptome
923	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 12 of OUD subjects.	Opioid Use Disorder	Transcriptome
924	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 14 of OUD subjects.	Opioid Use Disorder	Transcriptome
925	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 15 of OUD subjects.	Opioid Use Disorder	Transcriptome
926	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 16 of OUD subjects.	Opioid Use Disorder	Transcriptome
927	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 18 of OUD subjects.	Opioid Use Disorder	Transcriptome
928	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 19 of OUD subjects.	Opioid Use Disorder	Transcriptome
929	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 20 of OUD subjects.	Opioid Use Disorder	Transcriptome
930	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 21 of OUD subjects.	Opioid Use Disorder	Transcriptome
931	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 23 of OUD subjects.	Opioid Use Disorder	Transcriptome
932	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 24 of OUD subjects.	Opioid Use Disorder	Transcriptome
933	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 25 of OUD subjects.	Opioid Use Disorder	Transcriptome
934	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 26 of OUD subjects.	Opioid Use Disorder	Transcriptome
935	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 27 of OUD subjects.	Opioid Use Disorder	Transcriptome
936	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 28 of OUD subjects.	Opioid Use Disorder	Transcriptome
937	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 13 of OUD subjects.	Opioid Use Disorder	Transcriptome
938	34385598	9606	Brain(Brodmann Area 9)	Others	Case-control based	RNA-seq/qPCR	RNA-seq/qPCR	Using next-generation RNA sequencing and proteomics techniques, we identified 394 differentially expressed (DE) coding and long noncoding (lnc) RNAs as well as 213 DE proteins in Brodmann Area 17 of OUD subjects.	Opioid Use Disorder	Transcriptome
939	34454697	9606	NA	Others	Case-control based	GWAS//PWAS	GWAS//PWAS	NA	Schizophrenia	Transcriptome
940	34504065	9606	NA	DSM-IV	Case-control based	ES	ES	Using data from 3444 schizophrenia trios and 37,488 neurodevelopmental disorder trios, we show that within shared risk genes, de novo variants in schizophrenia and neurodevelopmental disorders are generally of the same functional category, and that specific de novo variants observed in neurodevelopmental disorders are enriched in schizophrenia (P=5.0 × 106).	Schizophrenia	Transcriptome
941	34508068	9606	Blood	MINI	Case-control based	Illumina Infinium HumanMethylationEPIC BeadChip	Illumina Infinium HumanMethylationEPIC BeadChip	As chronic stress promotes neurotoxicity there are alterations in the expression of genes and gene-regulatory molecules. The hippocampus is particularly sensitive to the effects of stress and its posterior volumes can deliver clinically valuable information about the outcomes of antidepressant treatment. the association between expression of BASP1-AS1 and right hippocampal tail volume in the MDD group remained significant when we added clinical features.	Major Depressive Disorder	Transcriptome
942	34535768	9606	Brain	Others	Case-control based	RNA-seq/ChIP-seq/qRT-PCR	RNA-seq/ChIP-seq/qRT-PCR	In the present study, we set out to characterize the molecular function of TCF7L2 in the CNS with the goal of understanding its possible role in the comorbidity of BD and obesity. These studies began with a review of human brain single-nucleus and single-cell RNA-seq data for TCF7L2, results which showed that it is most highly expressed in astrocytes.	Bipolar Disorder	Transcriptome
943	34535768	9606	NA	Others	Case-control based	qRT-PCR	qRT-PCR	To further investigate possible disease pathway(s) that might be related to the 186 TCF7L2 target genes in astrocytes, disease pathway enrichment was performed. BD was the most significantly enriched disease for these genes (FDR<0.05) based on the Jensen disease database.	Bipolar Disorder	Transcriptome
944	34572310	9606	Blood	DSM-V	Case-control based	qPCR/ELISA	qPCR/ELISA	In the present study, we set out to characterize the molecular function of TCF7L2 in the CNS with the goal of understanding its possible role in the comorbidity of BD and obesity. These studies began with a review of human brain single-nucleus and single-cell RNA-seq data for TCF7L2, results which showed that it is most highly expressed in astrocytes.	Major Depressive Disorder	Transcriptome
945	34601489	9606	Brain(Cerebellum)	Others	Case-control based	RNA-seq	RNA-seq	Table S5 rRNA depletion RNA-seq analysis identified mRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
946	34601489	9606	Brain(Hippocampus)	Others	Case-control based	RNA-seq	RNA-seq	Table S5 rRNA depletion RNA-seq analysis identified mRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
947	34601489	9606	Brain(Nucleus accumbens)	Others	Case-control based	RNA-seq	RNA-seq	Table S5 rRNA depletion RNA-seq analysis identified mRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
948	34601489	9606	Brain(Prefrontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	Table S5 rRNA depletion RNA-seq analysis identified mRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
949	34601489	9606	Brain(Putamen)	Others	Case-control based	RNA-seq	RNA-seq	Table S5 rRNA depletion RNA-seq analysis identified mRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
950	34601489	9606	Brain(Ventral tegmental area)	Others	Case-control based	RNA-seq	RNA-seq	Table S5 rRNA depletion RNA-seq analysis identified mRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
951	34601489	9606	Brain(Amygdala)	Others	Case-control based	RNA-seq	RNA-seq	Table S6 Microarray analysis identified mRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
952	34601489	9606	Brain(Caudate nucleus)	Others	Case-control based	RNA-seq	RNA-seq	Table S6 Microarray analysis identified mRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
953	34601489	9606	Brain(Hippocampus)	Others	Case-control based	RNA-seq	RNA-seq	Table S6 Microarray analysis identified mRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
954	34601489	9606	Brain(Putamen)	Others	Case-control based	RNA-seq	RNA-seq	Table S6 Microarray analysis identified mRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
955	34601489	9606	Brain(Amygdala)	Others	Case-control based	RNA-seq	RNA-seq	Table S2 Small RNA-seq analysis identified miRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
956	34601489	9606	Brain(Hippocampus)	Others	Case-control based	RNA-seq	RNA-seq	Table S2 Small RNA-seq analysis identified miRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
957	34601489	9606	Brain(Putamen)	Others	Case-control based	RNA-seq	RNA-seq	Table S2 Small RNA-seq analysis identified miRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
958	34601489	9606	Brain(Hippocampus)	Others	Case-control based	RNA-seq	RNA-seq	Table S3 Microarray analysis identified miRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
959	34601489	9606	Brain(Prefrontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	Table S3 Microarray analysis identified miRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
960	34601489	9606	Brain(Putamen)	Others	Case-control based	RNA-seq	RNA-seq	Table S3 Microarray analysis identified miRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
961	34601489	9606	Brain(Caudate nucleus)	Others	Case-control based	RNA-seq	RNA-seq	Table S2 Small RNA-seq analysis identified miRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
962	34601489	9606	Brain(Cerebellum)	Others	Case-control based	RNA-seq	RNA-seq	Table S2 Small RNA-seq analysis identified miRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
963	34601489	9606	Brain(Nucleus accumbens)	Others	Case-control based	RNA-seq	RNA-seq	Table S2 Small RNA-seq analysis identified miRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
964	34601489	9606	Brain(Prefrontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	Table S2 Small RNA-seq analysis identified miRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
965	34601489	9606	Brain(Ventral tegmental area)	Others	Case-control based	RNA-seq	RNA-seq	Table S2 Small RNA-seq analysis identified miRNAs with differential expression in eight brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
966	34601489	9606	Brain(Amygdala)	Others	Case-control based	RNA-seq	RNA-seq	Table S3 Microarray analysis identified miRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
967	34601489	9606	Brain(Caudate nucleus)	Others	Case-control based	RNA-seq	RNA-seq	Table S3 Microarray analysis identified miRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
968	34601489	9606	Brain(Cerebellum)	Others	Case-control based	RNA-seq	RNA-seq	Table S3 Microarray analysis identified miRNAs with differential expression in six brain regions of AUD subjects	Alcohol Use Disorder	Transcriptome
969	34627873	9606	Brain(Prefrontal cortex)	Others	Case-control based	Meta-analysis	Meta-analysis	Table 3-Alterations of non-coding RNA expression induced by alcohol exposure-	Alcohol Use Disorder	Transcriptome
970	34627873	9606	Blood	Others	Case-control based	Meta-analysis	Meta-analysis	Table 3-Alterations of non-coding RNA expression induced by alcohol exposure-	Alcohol Use Disorder	Transcriptome
971	34627873	10116	Brain(Medial prefrontal cortex)	Others	Case-control based	Meta-analysis	Meta-analysis	Table 3.Alterations of non-coding RNA expression induced by alcohol exposure.	Alcohol Use Disorder	Transcriptome
972	34627873	10116	Brain(Prefrontal cortex)	Others	Case-control based	Meta-analysis	Meta-analysis	Table 3.Alterations of non-coding RNA expression induced by alcohol exposure.	Alcohol Use Disorder	Transcriptome
973	34627873	10116	Brain(Amygdala)	Others	Case-control based	Meta-analysis	Meta-analysis	Table 3.Alterations of non-coding RNA expression induced by alcohol exposure.	Alcohol Use Disorder	Transcriptome
974	34627873	10116	Brain(Nucleus accumbens)	Others	Case-control based	Meta-analysis	Meta-analysis	Table 3.Alterations of non-coding RNA expression induced by alcohol exposure.	Alcohol Use Disorder	Transcriptome
975	34667146	9606	Blood(Lymphocytes)	DSM-IV-TR	Family based	Microarray	Microarray	Here we used the microarray approach and compared gene expression profiling of peripheral blood lymphocytes from 6 sib-pairs discordant on lifetime history of MDD. Comprehensive protein interaction network analysis revealed two key genes PTH and FGF2 in a dominant network where the majority of the genes were significantly down-regulated.	Major Depressive Disorder	Transcriptome
976	34680545	9606	Blood	DSM-V	Case-control based	qRT-PCR	qRT-PCR	In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR-21-5p, miR-223, miR-145, miR-146a, and miR-155- We also investigated the changes of these exosomal microRNAs after antidepressant treatment and their association with clinical changes in scores on the Hamilton Depression Rating Scale-	Major Depressive Disorder	Transcriptome
977	34690045	9606	NA	Others	Case-control based	RNA-seq	RNA-seq	Genes expressed in embryonic stem cells which are associated with a neurodevelopmental disorder.	Neurodevelopmental Disorders	Transcriptome
978	34750502	9606	NA	Others	Case-control based	Meta-analysis	Meta-analysis	By taking advantage of the specific localization of the GC-boxes bound by SP4 transcription factors, I analyzed the relative abundance of these GC-boxes in the proximal promoter regions of schizophrenia-risk genes. I found that the GC-box containing genes are significantly over-represented within schizophrenia-risk genes, suggesting that SP4 is not only a high-risk gene for schizophrenia, but may also act as a hub of network in the regulation of many other schizophrenia-risk genes via these GC-boxes in the pathogenesis of schizophrenia.	Schizophrenia	Transcriptome
979	34818031	9606	Blood//Brain	Others	Case-control based	Illumina HiSeq2500	Illumina HiSeq2500	Here, we present a model of disease pathogenesis that builds on our observation that the synaptic immediate early gene NPTX2 is reduced in cerebrospinal fluid of individuals with recent onset schizophrenia.	Schizophrenia	Transcriptome
980	34829888	9606	Brain	Others	Case-control based	Meta-analysis	Meta-analysis	Due to their implication in multiple cellular and physiological processes, miRNAs have been established as promising biomarkers with suggested applications as diagnostic tools, prognostic or predictive markers as well as critical agents to understand the entire pathophysiology of different psychiatric disorders such as MDD, having been proposed as potential therapeutic targets- In this sense throughout this review, we will analyze the implication of miRNAs with special focus on their pathogenesis, diagnosis, prognosis, and therapy of such an intricated disease-	Major Depressive Disorder	Transcriptome
981	34848679	9606	Cell lines(iPSCs)	HAMD-17/QIDS-C16	Case-control based	RT-PCR/Illumina	RT-PCR/Illumina	Here, we have developed an in vitro model of "chronic stress" using human induced pluripotent stem cell (iPSC)-derived astrocytes treated with cortisol for 7 days. Whole transcriptome sequencing reveals differentially expressed genes (DEGs) uniquely regulated in chronic cortisol compared to acute cortisol treatment. Utilizing this paradigm, we examined the stress response transcriptome of astrocytes generated from MDD patient iPSCs.	Major Depressive Disorder	Transcriptome
982	34848679	9606	Cell lines(iPSCs)	HAMD-17/QIDS-C16	Case-control based	RT-PCR/Illumina	RT-PCR/Illumina	Here, we have developed an in vitro model of "chronic stress" using human induced pluripotent stem cell (iPSC)-derived astrocytes treated with cortisol for 7 days- Whole transcriptome sequencing reveals differentially expressed genes (DEGs) uniquely regulated in chronic cortisol compared to acute cortisol treatment- Utilizing this paradigm, we examined the stress response transcriptome of astrocytes generated from MDD patient iPSCs-	Major Depressive Disorder	Transcriptome
983	34857913	9606	NA	Others	Case-control based	qRT-PCR	qRT-PCR	We also analyzed expression of SLC7A11 in individuals with AUD and controls using human postmortem brain tissues.	Alcohol Use Disorder	Transcriptome
984	34913274	10090	Cell lines(Microglial cell)	Others	Case-control based	qRT-PCR/Small RNAseq/ELISA Assay	qRT-PCR/Small RNAseq/ELISA Assay	In summary, our work suggests that EV-associated miR-29a-3p plays a crucial role in MUD and might be used as a potential blood-based biomarker for detecting chronic inflammation and synaptic damage.	Methamphetamine Use Disorder	Transcriptome
985	34914762	9606	NA	DSM-III-R	Case-control based	SMRT Sequencing	SMRT Sequencing	We have used long-read single molecule, real-time (SMRT) sequencing to fully characterize a ~12Mb genomic region on chromosome Xq24-q27, significantly linked to bipolar disorder (BD) in an extended family from a genetic sub-isolate. This family segregates BD in at least four generations with 24 affected individuals. Among the three genetically linked SVs, additional evidence supported the Alu element deletion in RBMX2 as the leading candidate for contributing directly to the disease development of BD type I in this extended family.	Bipolar I Disorder	Transcriptome
986	34924174	9606	Blood	DSM-V	Case-control based	GWAS//Meta-analysis	GWAS//Meta-analysis	The Australian Genetics of Depression Study is the largest stand-alone depression cohort with both genetic data and in-depth phenotyping and comprises a total of 15,792 participants of European ancestry, 92% of whom met diagnostic criteria for MDD. We leveraged the unique nature of this cohort to conduct a meta-analysis with the largest publicly available depression genome-wide association study to date and subsequently used polygenic scores to investigate genetic heterogeneity across various clinical subtypes of MDD.	Major Depressive Disorder	Transcriptome
987	34974922	9606	NA	Others	Case-control based	GWAS	GWAS	In this review, we discuss insights from recent genome-wide association study, copy number variant, and exome sequencing analyses of schizophrenia, together with functional genomics data from the pre- and postnatal brain, in relation to synaptic development and function.	Schizophrenia	Transcriptome
988	34987319	9606	Blood	Others	Case-control based	Meta-analysis	Meta-analysis	Seven upregulated miRNAs (hsa-miR-7107-5p, hsa-miR-7110-5p, hsa-miR-595, hsa-miR-1268b, hsa-miR-3064-5p, hsa-miR-68565p, and hsa-miR-1180-3p) and one downregulated miRNA (hsa-miR-22-3p) were obtained from theGSE112093dataset-	Obstructive Sleep Apnea Hypopnea	Transcriptome
989	35091668	9606	NA	Others	Case-control based	GWAS	GWAS	The aim of this work is to conduct a systematic review and synthesis of case–control studies of genome-wide gene expression in schizophrenia. Comprehensive literature searches were completed in PubMed, EmBase, and Web of Science, and after a systematic review of the studies, data were extracted from those that met the following inclusion criteria.	Schizophrenia	Transcriptome
990	35098407	9606	Blood	DSM-ｍ	Case-control based	RT-qPCR	RT-qPCR	Dose-dependent upregulation of miR-155-5p and miR-187-5p was evident at opium dose >1500 g/month, with a corresponding increase of TNF-帢 and IL-10-	Drug Abuse	Transcriptome
991	35104608	9606	NA	Others	Case-control based	GWAS//Meta-analysis	GWAS//Meta-analysis	In the present review, we first briefly summarize main findings from two decades of studies that investigated single molecular processes in relation to mood disorders.	Major Depressive Disorder	Transcriptome
992	35126089	9606	NA	Others	Case-control based	Meta-analysis	Meta-analysis	In this study, we compiled the genes reported to be associated with AD or MDD by a comprehensive search of human genetic studies and genes curated in disease-related database. Then, we investigated the features of the shared genes between AD and MDD using the functional enrichment analysis. Furthermore, the major biochemical pathways enriched in the AD- or MDD-associated genes were identified, and the cross talks between the pathways were analyzed.	Major Depressive Disorder	Transcriptome
993	35126468	9606	Saliva	Others	Case-control based	miRNA Microarray/TaqMan Low-Density Array/qPCR	miRNA Microarray/TaqMan Low-Density Array/qPCR	Comparison of microRNA expression levels between alcohol abusers and controls revealed 38 significantly (p< 0-05) changed microRNA species	Alcohol Use Disorder	Transcriptome
994	35163214	9606	Blood	HAMD/DSM-IV/MADRS	Case-control based	Meta-analysis	Meta-analysis	We systemically reviewed the literature to explore various cimiRNAs contributing to MDD diagnosis and underlying molecular pathways- A comprehensive literature survey was conducted, employing four databases from 2012 to January 2021- Out of 1004 records, 157 reports were accessed for eligibility criteria, and 32 reports meeting our inclusion criteria were considered for in-silico analysis- This study identified 99 dysregulated cimiRNAs in MDD patients, out of which 20 cimiRNAs found in multiple reports were selected for in-silico analysis-	Major Depressive Disorder	Transcriptome
995	35163214	9606	Blood	HAMD/DSM-IV/DSM-V/MADRS	Case-control based	Meta-analysis	Meta-analysis	We systemically reviewed the literature to explore various cimiRNAs contributing to MDD diagnosis and underlying molecular pathways- A comprehensive literature survey was conducted, employing four databases from 2012 to January 2021- Out of 1004 records, 157 reports were accessed for eligibility criteria, and 32 reports meeting our inclusion criteria were considered for in-silico analysis- This study identified 99 dysregulated cimiRNAs in MDD patients, out of which 20 cimiRNAs found in multiple reports were selected for in-silico analysis-	Major Depressive Disorder	Transcriptome
996	35176017	10090	Blood//Brain(Amygdala)	Others	Case-control based	RNA-seq	RNA-seq	Genes Differentially Expressed between CIE and Air C57Bl/6J Mice in Amygdala with Expression Levels that are also Correlated between Blood and Amygdala.	Alcohol Use Disorder	Transcriptome
997	35176017	10090	Blood//Brain(Prefrontal cortex)	Others	Case-control based	RNA-seq	RNA-seq	Genes Differentially Expressed between CIE and Air C57Bl/6J Mice in Amygdala with Expression Levels that are also Correlated between Blood and Amygdala.	Alcohol Use Disorder	Transcriptome
998	35176017	10090	Blood//Brain(Hypothalamus)	Others	Case-control based	RNA-seq	RNA-seq	Genes Differentially Expressed between CIE and Air C57Bl/6J Mice in Amygdala with Expression Levels that are also Correlated between Blood and Amygdala.	Alcohol Use Disorder	Transcriptome
999	35177824	9606	Blood	Others	Case-control based	Meta-analysis	Meta-analysis	We established a well-phenotyped sample of 371 WTC responders, recruited from a longitudinal WTC responder cohort using stratified random sampling, by obtaining blood, self-reported and clinical interview data. Using bulk RNA-sequencing from whole blood, we examined the association between gene expression and WTC-related PTSD symptom severity. Finally, we performed a meta-analysis with existing PTSD studies (total N = 1016), using case/control status as the predictor and correcting for these variables. We identified 66 genes significantly associated with total highest lifetime CAPS score (FDR-corrected p < 0.05), and 31 genes associated with total past-month CAPS score. Our more granular analyses of PTSD symptom dimensions identified additional genes that did not reach statistical significance in our analyses with total CAPS scores. In particular, we identified 82 genes significantly associated with lifetime anxious arousal symptoms. Several genes significantly associated with multiple PTSD symptom dimensions and total lifetime CAPS score (SERPINA1, RPS6KA1, and STAT3) have been previously associated with PTSD. Geneset enrichment of these findings has identified pathways significant in metabolism, immune signaling, other psychiatric disorders, neurological signaling, and cellular structure. Our meta-analysis revealed 10 genes that reached genome-wide significance, all of which were downregulated in cases compared to controls (CIRBP, TMSB10, FCGRT, CLIC1, RPS6KB2, HNRNPUL1, ALDOA, NACA, ZNF429 and COPE).	Posttraumatic Stress Disorder	Transcriptome
1000	35177824	9606	Blood	DSM-IV	Case-control based	Illumina HiSeq/Meta-analysis	Illumina HiSeq/Meta-analysis	We established a well-phenotyped sample of 371 WTC responders, recruited from a longitudinal WTC responder cohort using stratified random sampling, by obtaining blood, self-reported and clinical interview data. Using bulk RNA-sequencing from whole blood, we examined the association between gene expression and WTC-related PTSD symptom severity. Finally, we performed a meta-analysis with existing PTSD studies (total N = 1016), using case/control status as the predictor and correcting for these variables. We identified 66 genes significantly associated with total highest lifetime CAPS score (FDR-corrected p < 0.05), and 31 genes associated with total past-month CAPS score. Our more granular analyses of PTSD symptom dimensions identified additional genes that did not reach statistical significance in our analyses with total CAPS scores. In particular, we identified 82 genes significantly associated with lifetime anxious arousal symptoms. Several genes significantly associated with multiple PTSD symptom dimensions and total lifetime CAPS score (SERPINA1, RPS6KA1, and STAT3) have been previously associated with PTSD. Geneset enrichment of these findings has identified pathways significant in metabolism, immune signaling, other psychiatric disorders, neurological signaling, and cellular structure. Our meta-analysis revealed 10 genes that reached genome-wide significance, all of which were downregulated in cases compared to controls (CIRBP, TMSB10, FCGRT, CLIC1, RPS6KB2, HNRNPUL1, ALDOA, NACA, ZNF429 and COPE).	Posttraumatic Stress Disorder	Transcriptome
1001	35177824	9606	Blood	DSM-IV	Case-control based	Illumina HiSeq/Meta-analysis	Illumina HiSeq/Meta-analysis	We established a well-phenotyped sample of 371 WTC responders, recruited from a longitudinal WTC responder cohort using stratified random sampling, by obtaining blood, self-reported and clinical interview data. Using bulk RNA-sequencing from whole blood, we examined the association between gene expression and WTC-related PTSD symptom severity. Finally, we performed a meta-analysis with existing PTSD studies (total N = 1016), using case/control status as the predictor and correcting for these variables. We identified 66 genes significantly associated with total highest lifetime CAPS score (FDR-corrected p < 0.05), and 31 genes associated with total past-month CAPS score. Our more granular analyses of PTSD symptom dimensions identified additional genes that did not reach statistical significance in our analyses with total CAPS scores. In particular, we identified 82 genes significantly associated with lifetime anxious arousal symptoms. Several genes significantly associated with multiple PTSD symptom dimensions and total lifetime CAPS score (SERPINA1, RPS6KA1, and STAT3) have been previously associated with PTSD. Geneset enrichment of these findings has identified pathways significant in metabolism, immune signaling, other psychiatric disorders, neurological signaling, and cellular structure. Our meta-analysis revealed 10 genes that reached genome-wide significance, all of which were downregulated in cases compared to controls (CIRBP, TMSB10, FCGRT, CLIC1, RPS6KB2, HNRNPUL1, ALDOA, NACA, ZNF429 and COPE).	Anxiety Disorder	Transcriptome
1002	35178127	9606	Blood	Others	Case-control based	Illumina NextSeq550/qRT-PCR	Illumina NextSeq550/qRT-PCR	Evidence shows that microRNAs (miRNAs) could play a key role in the homeostasis and development of major depressive disorder and bipolar disorder-To identify putative circulating miRNAs as candidates for BD and MDD diagnostic biomarkers, plasma miRNA expression profiles have been evaluated- We identified 5 miRNAs in BD and 11 miRNAs in MDD that were significantly upregulated compared to the control group-	Bipolar Disorder	Transcriptome
1003	35241783	9606	NA	DSM-IV-TR	Case-control based	GWAS	GWAS	In this study, we characterized the biological heterogeneity of PTSD symptom clusters by performing a multi-omics investigation integrating genetically regulated gene, splicing, and protein expression in dorsolateral prefrontal cortex tissue within a sample of US veterans enrolled in the Million Veteran Program (N total = 186,689). We identified 30 genes in 19 regions across the three PTSD symptom clusters.	Posttraumatic Stress Disorder	Transcriptome
1004	35265999	9606	Brain	Others	Case-control based	GWAS	GWAS	Major psychiatric disorders and cortical structures risk genes identified by F-MAGMA (Bonferroni P value<0.05)	Attention-Deficit/Hyperactivity Disorder	Transcriptome
1005	35265999	9606	Brain	Others	Case-control based	GWAS	GWAS	Major psychiatric disorders and cortical structures risk genes identified by F-MAGMA (Bonferroni P value<0.05)	Autism Spectrum Disorder	Transcriptome
1006	35265999	9606	Brain	Others	Case-control based	GWAS	GWAS	Major psychiatric disorders and cortical structures risk genes identified by F-MAGMA (Bonferroni P value<0.05)	Bipolar Disorder	Transcriptome
1007	35265999	9606	Brain	Others	Case-control based	GWAS	GWAS	Major psychiatric disorders and cortical structures risk genes identified by F-MAGMA (Bonferroni P value<0.05)	Schizophrenia	Transcriptome
1008	35279108	9606	Blood	DSM-V	Case-control based	PCR	PCR	We measured expression of VDR-associated lncRNAs and mRNAs (SNHG6, MALAT1, Linc00511, Linc00346, VDR and CYP27B1) in the peripheral blood of BD patients vs. healthy individuals.	Bipolar I Disorder	Transcriptome
1009	35283726	9606	Blood	DSM-IV	Case-control based	Illumina HumanMethylation450 BeadChip	Illumina HumanMethylation450 BeadChip	Methylation data from 533 samples were extracted from the Gene Expression Omnibus (GEO) database, of which, 324 individuals were diagnosed with MDD. Statistical difference of DNA Methylation between Promoter and Other body region (SIMPO) score for each gene was calculated based on the DNA methylation data. Based on SIMPO scores, we selected the top genes that showed a correlation with MDD in random resampling, then proposed a methylation-derived Depression Index (mDI) by combining the SIMPO of the selected genes to predict MDD.	Major Depressive Disorder	Transcriptome
1010	35301253	9606	Blood	DSM-IV	Case-control based	BGIseq-500	BGIseq-500	Patients with schizophrenia had higher TGF-汕1 at both the mRNA level (log2 fold change = 0.24; adjusted p = 0.026) and the protein level (12.85 ㊣ 6.01 米g/mL v. 8.46 ㊣ 5.15 米g/mL, adjusted p < 0.001) compared to controls. Genes coexpressed with TGFB1 in the dlPFC were less abundant in patients with schizophrenia compared to healthy controls. In patients with schizophrenia, TGF-汕1 protein levels were inversely correlated with cortical thickness, especially of the lateral occipital cortex (r = -0.47, adjusted p = 0.001), and with the MATRICS Consensus Cognitive Battery visual learning and memory domain (r = -0.50, adjusted p < 0.001). We found a complete mediation effect of the thickness of the lateral occipital cortex on the negative relationship between TGF-汕1 and visual cognition (p < 0.05).	Schizophrenia	Transcriptome
1011	35306338	9606	Blood	NA	Case-control based	GWAS//MR Analysis	GWAS//MR Analysis	Using single-nucleotide polymorphisms as instruments, the study suggested increased levels of MAPKAPK3 (OR: 1.09; 95% CI: 1.05-1.13; P = 1.43 × 10-6) and MRPL33 (OR: 1.07; 95% CI: 1.04-1.11; P = 5.37 × 10-6) were causally associated with a higher risk of ASD, and increased MANBA level was associated with a lower risk of ADHD (OR: 0.91; 95% CI: 0.88-0.95; P = 8.97 × 10-6). The causal associations were robust in sensitivity analysis, leave-one-out analysis and Multivariable MR, and no pleiotropy was observed.	Autism Spectrum Disorder	Transcriptome
1012	35306338	9606	Blood	NA	Case-control based	GWAS//MR Analysis	GWAS//MR Analysis	Using single-nucleotide polymorphisms as instruments, the study suggested increased levels of MAPKAPK3 (OR: 1.09; 95% CI: 1.05-1.13; P = 1.43 × 10-6) and MRPL33 (OR: 1.07; 95% CI: 1.04-1.11; P = 5.37 × 10-6) were causally associated with a higher risk of ASD, and increased MANBA level was associated with a lower risk of ADHD (OR: 0.91; 95% CI: 0.88-0.95; P = 8.97 × 10-6). The causal associations were robust in sensitivity analysis, leave-one-out analysis and Multivariable MR, and no pleiotropy was observed.	Attention-Deficit/Hyperactivity Disorder	Transcriptome
1013	35410190	9606	Blood	DSM-V	Case-control based	qRT-PCR	qRT-PCR	In the current study, we evaluated the expression levels of H19, SCAL1 (LUCAT1), RMST, MEG3 and MT1DP lncRNAs in the PBMC from 50 patients with BD and 50 control subjects (male/female ratio in each group: 70%/30%). Expression levels of SCAL1, RMST and MEG3 but not H19 and MT1DP were considerably decreased in BD patients compared with healthy individuals. Such significant decrease in the expression of MEG3, RMST and SCAL1 was only reported in male BD patients compared with male controls. Substantial pairwise correlations were observed between expression levels of these lncRNAs in BD subjects. The area under curve values for RMST, MEG3 and SCAL1 were 0.70, 0.63 and 0.61 respectively. On the basis of this finding, RMST had the best efficiency in the discrimination of disease status between BD patients and controls.	Bipolar Disorder	Transcriptome
1014	35412455	9606	NA	NA	Case-control based	GWAS	GWAS	eDESE initially performed the association analysis by mapping variants to genes according to their physical distance. We further demonstrated that the isoform-level eQTLs could be more powerful than the gene-level eQTLs in the association analysis using a simulation study. Then the eQTL-guided strategies, that is, mapping variants to genes according to their gene/isoform-level variant-gene cis-eQTLs associations, were also integrated with eDESE. We then applied eDESE to predict the potential susceptibility genes of schizophrenia and found that the potential susceptibility genes were enriched with many neuronal or synaptic signaling-related terms in the Gene Ontology knowledgebase and antipsychotics-gene interaction terms in the drug-gene interaction database (DGIdb). More importantly, seven potential susceptibility genes identified by eDESE were the target genes of multiple antipsychotics in DrugBank. Comparing the potential susceptibility genes identified by eDESE and other benchmark approaches (i.e., MAGMA and S-PrediXcan) implied that strategy based on the isoform-level eQTLs could be an important supplement for the other two strategies (physical distance and gene-level eQTLs).	Schizophrenia	Transcriptome
1015	35495153	9606	NA	Others	Case-control based	Affymetrix Genome-Wide Human SNP Array 6-0	Affymetrix Genome-Wide Human SNP Array 6-0	We found a significantly higher proportion of individuals in the schizophrenia than in the non-psychotic group to have an additional rare CNV that overlapped one or more miRNA target genes (odds ratio = 2-12, p = 0-0138)- Gene set analyses identified an enrichment of FMRP targets and genes involved in nervous system development and postsynaptic density amongst these miRNA target genes in the schizophrenia group- The miRNAs most implicated included miR-17-5p, miR-34a-5p and miR-124-3p-	Schizophrenia	Transcriptome
1016	35523833	9606	Blood	DSM-V	Case-control based	qRT-PCR	qRT-PCR	In this study, we compared expression levels of lincRNA-p21, lincRNA-ROR, and lincRNA-PINT in the peripheral blood mononuclear cells (PBMC) from BD patients (n = 50) and healthy individuals (n = 50). Expression levels of lincRNA-p21, lincRNA-ROR, and lincRNA-PINT were significantly reduced in patients with BD compared to controls. In sex-based analyses, down-regulation of these lncRNAs was revealed only in male BD patients compared to male healthy subjects. Also, in BD patients, all three lncRNAs showed a significant pairwise positive correlation in expression level. The area under curve values for lincRNA-p21, lincRNA-ROR, and lincRNA-PINT was 0.66, 0.75, and 0.66, respectively. Thus, the ROC curve analysis showed that lncRNA-ROR might serve as a diagnostic biomarker for distinguishing between BD patients and controls.	Bipolar Disorder	Transcriptome
1017	35599275	9606	Blood	ICD-10	Case-control based	Illumina HiSeq2500	Illumina HiSeq2500	The level of miR-9-5p in FES patients was downregulated, and miR-4467 was upregulated with better diagnostic performance (AUC = 0-719)- The target genes of miR-9-5p engage in the biological processes (BP) such as body behaviour, neuronal differentiation regulation, nervous system development, and neurotrophin signaling pathways- Their hub target genes were also located, including NEDD4, EIF4G1, FBXL16, and FBXL3- Summarily, miR-9-5p and miR-4467 hold promise in blood diagnosis for SCZ, and miR-9-5p might affect the onset and development of SCZ through target regulation of neurodevelopment-related mRNAs-	Schizophrenia	Transcriptome
1018	35633815	9606	Blood	SCID	Case-control based	Illumina NovaSeq6000/Illumina HiSeq2500	Illumina NovaSeq6000/Illumina HiSeq2500	A whole transcriptome sequencing were performed on the peripheral blood of 15 patients with MDD and 15 matched healthy controls (HCs). The differential expression of miRNAs, lncRNAs, circRNAs, and mRNAs was examined between MDD and HCs using empirical analysis of digital gene expression data in R (edgeR). Weighted correlation network analysis (WGCNA) was used to identify RNA co-expression modules associated with MDD. A ceRNA network was constructed for interpretation of interactions between different RNA species. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to explore potential biological mechanisms associated with MDD.	Major Depressive Disorder	Transcriptome
1019	35633815	9606	Blood	SCID	Case-control based	Illumina NovaSeq6000/Illumina HiSeq2500	Illumina NovaSeq6000/Illumina HiSeq2500	A whole transcriptome sequencing were performed on the peripheral blood of 15 patients with MDD and 15 matched healthy controls (HCs)- The differential expression of miRNAs, lncRNAs, circRNAs, and mRNAs was examined between MDD and HCs using empirical analysis of digital gene expression data in R (edgeR)- Weighted correlation network analysis (WGCNA) was used to identify RNA co-expression modules associated with MDD- A ceRNA network was constructed for interpretation of interactions between different RNA species- Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to explore potential biological mechanisms associated with MDD-	Major Depressive Disorder	Transcriptome
1020	35719055	9606	NA	NA	Case-control based	RNA-seq//PCR//Western Blotting	RNA-seq//PCR//Western Blotting	In this study we explored the function of AS3MT using a neuronal cell line (SH-SY5Y). We confirm previous findings of isoform specific expression of AS3MT during SH-SY5Y differentiation toward neuronal fates. Using CRISPR-Cas9 gene editing we generated AS3MT knockout SH-SY5Y cell lines and used RNA-seq to identify significant changes in gene expression in pathways associated with neuronal development, inflammation, extracellular matrix formation, and RNA processing, including dysregulation of other genes strongly implicated in schizophrenia. We did not observe any morphological changes in cell size and neurite length following neuronal differentiation and MAP2 immunocytochemistry.	Schizophrenia	Transcriptome
1021	35735607	9606	Foreskin tissue	Others	Case-control based	Immunofluorescence/RT-qPCR/Western Blotting	Immunofluorescence/RT-qPCR/Western Blotting	In this study, we used neural progenitor cells (NPCs) derived from ASD-hiPSCs as well as from neurotypical controls to examine the effects of miR-92a-2-5p on ASD-NPCs proliferation and neuronal differentiation, and whether miR-92a-2-5p could interact with genetic risk factor,DLG3for ASD- We observed that miR-92a-2-5p upregulated in ASD-NPCs results in decreased proliferation and neuronal differentiation- Inhibition of miR-92a-2-5p could promote proliferation and neuronal differentiation of ASD-NPCs-DLG3was negatively regulated by miR-92a-2-5p in NPCs- Our results suggest that miR-92a-2-5p is a strong risk factor for ASD and potentially contributes to neuropsychiatric disorders-	Autism Spectrum Disorder	Transcriptome
1022	35743705	9606	Lymphoblastoid cell lines	Others	Case-control based	Illumina Hiseq4000/Illumina Hiseq2500	Illumina Hiseq4000/Illumina Hiseq2500	Herein, we studied lymphoblastoid cell lines (LCLs) from children diagnosed with autistic disorder (n= 10) and controls (n= 7) using RNA and miRNA sequencing profiles. The sequencing analysis identified 1700 genes and 102 miRNAs differentially expressed between the ASD and control LCLs (p≒ 0.05).	Autism Spectrum Disorder	Transcriptome
1023	35743705	9606	Lymphoblastoid cell lines	Others	Case-control based	Illumina Hiseq4000/Illumina Hiseq2500/RT-PCR	Illumina Hiseq4000/Illumina Hiseq2500/RT-PCR	Herein, we studied lymphoblastoid cell lines (LCLs) from children diagnosed with autistic disorder (n= 10) and controls (n= 7) using RNA and miRNA sequencing profiles. The sequencing analysis identified 1700 genes and 102 miRNAs differentially expressed between the ASD and control LCLs (p≒ 0.05).	Autism Spectrum Disorder	Transcriptome
1024	35743705	9606	Lymphoblastoid cell lines	Others	Case-control based	Illumina Hiseq4000/Illumina Hiseq2500	Illumina Hiseq4000/Illumina Hiseq2500	Herein, we studied lymphoblastoid cell lines (LCLs) from children diagnosed with autistic disorder (n= 10) and controls (n= 7) using RNA and miRNA sequencing profiles- The sequencing analysis identified 1700 genes and 102 miRNAs differentially expressed between the ASD and control LCLs (p≒ 0-05)-	Autism Spectrum Disorder	Transcriptome
1025	35743705	9606	Lymphoblastoid cell lines	Others	Case-control based	Illumina Hiseq4000/Illumina Hiseq2500/RT-PCR	Illumina Hiseq4000/Illumina Hiseq2500/RT-PCR	Herein, we studied lymphoblastoid cell lines (LCLs) from children diagnosed with autistic disorder (n= 10) and controls (n= 7) using RNA and miRNA sequencing profiles- The sequencing analysis identified 1700 genes and 102 miRNAs differentially expressed between the ASD and control LCLs (p≒ 0-05)-	Autism Spectrum Disorder	Transcriptome
1026	35759154	9606	Blood	DSM-V	Family based	Illumina HiSeq	Illumina HiSeq	Herein, we explored de novo TE insertions (dnTEIs) and de novo variants (DNVs) across the genomes of dizygotic twins with ASD and their parents. The neuronal regulatory elements had a tendency to harbor dnTEIs that were shared between twins, but ASD-risk genes had dnTEIs that were unique to each twin. The dnTEIs were 4.6-fold enriched in enhancers that are active in embryonic stem cell (ESC)-neurons (p < 0.001), but DNVs were 1.5-fold enriched in active enhancers of astrocytes (p = 0.0051). Our findings suggest that dnTEIs and DNVs play a role in ASD etiology by disrupting enhancers of neurons and astrocytes.	Autism Spectrum Disorder	Transcriptome
1027	35769969	9606	NA	NA	Case report	Illumina Truseq DNA PCR Free Sample Prep Kit//Illumina HiSeq 2500//Sanger Sequencing	Illumina Truseq DNA PCR Free Sample Prep Kit//Illumina HiSeq 2500//Sanger Sequencing	Here we report a male patient who has moderate intellectual disability, mild behavioral difficulties, and severe expressive speech impairment resulting from a de novo balanced chromosome translocation, t(12;18)(q22;q12.3). By whole genome sequencing, we determined the breakpoints at the nucleotide level. The 18q12.3 breakpoint was located between exons 2 and 3 of SETBP1 . Phenotypic features of our patient are compatible with those with MRD29. This is the first reported BCA disrupting SETBP1 .	Intellectual Disability	Transcriptome
1028	35810398	9606	Blood	ICSD-3	Case-control based	Illumina TruSeq Stranded Total RNA Ribo Zero	Illumina TruSeq Stranded Total RNA Ribo Zero	We performed a transcriptome analysis based on RNA-seq in the whole blood samples from the 42 NT1 patients and 42 healthy controls to identify DGE in NT1. SLC25A20 encoding carnitine-acylcarnitine translocase (CACT) and CPT2 encoding carnitine palmitoyltransferase 2 (CPT2), which are involved in carnitine shuttle (Supplementary Figure S1), had the second and fifth lowest p-values, respectively (SLC25A20: p=0.000051, CPT2: p=0.00014) (Table 4). Expression levels of the two genes were lower in the patient group compared to the control group (SLC25A20: log fold change [FC]=0.28, CPT2: log fold FC=0.20). The expression levels of these two genes were significantly correlated with each other in the 84 participants (r=0.73, p=0.0016). Meanwhile, no significant differences in expression levels of CPT1B were observed between the patient and control groups (Supplementary Table S6). A list of 30 DEG with p-values less than 0.001 in the analysis of the RNA-seq expression data were used for pathway analyses using g:Profiler and DAVID. Pathways related CPT system and carnitine shuttle were identified to be enriched in the both pathway analyses, and SLC25A20 and CPT2 were involved in these pathways (Supplementary Tables S7 and S8).	Narcolepsy	Transcriptome
1029	9144786	9606	Cell lines(NMB//SHSY-5Y)		Case-control based	qRT-PCR	qRT-PCR	Using a translational luciferase reporter assay, these authors observed morphine-dependent suppression of reporter activity through the MOR1 3芒鈧	Opioid Use Disorder	Transcriptome
1030	9144786	10090	Cell lines(NMB//SHSY-5Y)		Case-control based	qRT-PCR	qRT-PCR	Using a translational luciferase reporter assay, these authors observed morphine-dependent suppression of reporter activity through the MOR1 3芒鈧	Opioid Use Disorder	Transcriptome
1031	DOI:10.5504/BBEQ.2012.0093	9606	Blood	DSM-IV-TR	Case-control based	Microarray	Microarray	Our analysis also identifed a dysregulated miRNA - has-miR-128, which is in consistency with another study.	Autism Spectrum Disorder	Transcriptome
1032	DOI:10.5504/BBEQ.2012.0093	9606	Blood	DSM-IV-TR	Case-control based	Microarray	Microarray	Using miRNA microarray assay we found that miR-486-3p is differentially expressed in blood with statistical signifcance (P=0.0304) (Fig. 1).	Autism Spectrum Disorder	Transcriptome
